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Optimal Control Applied To Biological Models
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Book Synopsis Optimal Control Applied to Biological Models by : Suzanne Lenhart
Download or read book Optimal Control Applied to Biological Models written by Suzanne Lenhart and published by CRC Press. This book was released on 2007-05-07 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: From economics and business to the biological sciences to physics and engineering, professionals successfully use the powerful mathematical tool of optimal control to make management and strategy decisions. Optimal Control Applied to Biological Models thoroughly develops the mathematical aspects of optimal control theory and provides insight into the application of this theory to biological models. Focusing on mathematical concepts, the book first examines the most basic problem for continuous time ordinary differential equations (ODEs) before discussing more complicated problems, such as variations of the initial conditions, imposed bounds on the control, multiple states and controls, linear dependence on the control, and free terminal time. In addition, the authors introduce the optimal control of discrete systems and of partial differential equations (PDEs). Featuring a user-friendly interface, the book contains fourteen interactive sections of various applications, including immunology and epidemic disease models, management decisions in harvesting, and resource allocation models. It also develops the underlying numerical methods of the applications and includes the MATLAB® codes on which the applications are based. Requiring only basic knowledge of multivariable calculus, simple ODEs, and mathematical models, this text shows how to adjust controls in biological systems in order to achieve proper outcomes.
Book Synopsis An Introduction to Optimal Control Problems in Life Sciences and Economics by : Sebastian Aniţa
Download or read book An Introduction to Optimal Control Problems in Life Sciences and Economics written by Sebastian Aniţa and published by Springer Science & Business Media. This book was released on 2011-05-05 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combining control theory and modeling, this textbook introduces and builds on methods for simulating and tackling concrete problems in a variety of applied sciences. Emphasizing "learning by doing," the authors focus on examples and applications to real-world problems. An elementary presentation of advanced concepts, proofs to introduce new ideas, and carefully presented MATLAB® programs help foster an understanding of the basics, but also lead the way to new, independent research. With minimal prerequisites and exercises in each chapter, this work serves as an excellent textbook and reference for graduate and advanced undergraduate students, researchers, and practitioners in mathematics, physics, engineering, computer science, as well as biology, biotechnology, economics, and finance.
Book Synopsis Control Theory and Systems Biology by : Pablo A. Iglesias
Download or read book Control Theory and Systems Biology written by Pablo A. Iglesias and published by MIT Press. This book was released on 2010 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: A survey of how engineering techniques from control and systems theory can be used to help biologists understand the behavior of cellular systems.
Book Synopsis Nonlinear Optimal Control Theory by : Leonard David Berkovitz
Download or read book Nonlinear Optimal Control Theory written by Leonard David Berkovitz and published by CRC Press. This book was released on 2012-08-25 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nonlinear Optimal Control Theory presents a deep, wide-ranging introduction to the mathematical theory of the optimal control of processes governed by ordinary differential equations and certain types of differential equations with memory. Many examples illustrate the mathematical issues that need to be addressed when using optimal control techniques in diverse areas. Drawing on classroom-tested material from Purdue University and North Carolina State University, the book gives a unified account of bounded state problems governed by ordinary, integrodifferential, and delay systems. It also discusses Hamilton-Jacobi theory. By providing a sufficient and rigorous treatment of finite dimensional control problems, the book equips readers with the foundation to deal with other types of control problems, such as those governed by stochastic differential equations, partial differential equations, and differential games.
Book Synopsis Advances in Applied Nonlinear Optimal Control by : Gerasimos Rigatos
Download or read book Advances in Applied Nonlinear Optimal Control written by Gerasimos Rigatos and published by Cambridge Scholars Publishing. This book was released on 2020-11-19 with total page 741 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume discusses advances in applied nonlinear optimal control, comprising both theoretical analysis of the developed control methods and case studies about their use in robotics, mechatronics, electric power generation, power electronics, micro-electronics, biological systems, biomedical systems, financial systems and industrial production processes. The advantages of the nonlinear optimal control approaches which are developed here are that, by applying approximate linearization of the controlled systems’ state-space description, one can avoid the elaborated state variables transformations (diffeomorphisms) which are required by global linearization-based control methods. The book also applies the control input directly to the power unit of the controlled systems and not on an equivalent linearized description, thus avoiding the inverse transformations met in global linearization-based control methods and the potential appearance of singularity problems. The method adopted here also retains the known advantages of optimal control, that is, the best trade-off between accurate tracking of reference setpoints and moderate variations of the control inputs. The book’s findings on nonlinear optimal control are a substantial contribution to the areas of nonlinear control and complex dynamical systems, and will find use in several research and engineering disciplines and in practical applications.
Book Synopsis Stochastic Controls by : Jiongmin Yong
Download or read book Stochastic Controls written by Jiongmin Yong and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: As is well known, Pontryagin's maximum principle and Bellman's dynamic programming are the two principal and most commonly used approaches in solving stochastic optimal control problems. * An interesting phenomenon one can observe from the literature is that these two approaches have been developed separately and independently. Since both methods are used to investigate the same problems, a natural question one will ask is the fol lowing: (Q) What is the relationship betwccn the maximum principlc and dy namic programming in stochastic optimal controls? There did exist some researches (prior to the 1980s) on the relationship between these two. Nevertheless, the results usually werestated in heuristic terms and proved under rather restrictive assumptions, which were not satisfied in most cases. In the statement of a Pontryagin-type maximum principle there is an adjoint equation, which is an ordinary differential equation (ODE) in the (finite-dimensional) deterministic case and a stochastic differential equation (SDE) in the stochastic case. The system consisting of the adjoint equa tion, the original state equation, and the maximum condition is referred to as an (extended) Hamiltonian system. On the other hand, in Bellman's dynamic programming, there is a partial differential equation (PDE), of first order in the (finite-dimensional) deterministic case and of second or der in the stochastic case. This is known as a Hamilton-Jacobi-Bellman (HJB) equation.
Book Synopsis Introduction to Modeling Biological Cellular Control Systems by : Weijiu Liu
Download or read book Introduction to Modeling Biological Cellular Control Systems written by Weijiu Liu and published by Springer Science & Business Media. This book was released on 2012-04-26 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook contains the essential knowledge in modeling, simulation, analysis, and applications in dealing with biological cellular control systems. In particular, the book shows how to use the law of mass balance and the law of mass action to derive an enzyme kinetic model - the Michaelis-Menten function or the Hill function, how to use a current-voltage relation, Nernst potential equilibrium equation, and Hodgkin and Huxley's models to model an ionic channel or pump, and how to use the law of mass balance to integrate these enzyme or channel models into a complete feedback control system. The book also illustrates how to use data to estimate parameters in a model, how to use MATLAB to solve a model numerically, how to do computer simulations, and how to provide model predictions. Furthermore, the book demonstrates how to conduct a stability and sensitivity analysis on a model.
Book Synopsis Optimal Control Theory Applied to a Class of Biological Population Growth Models by : John Anthony Fleming
Download or read book Optimal Control Theory Applied to a Class of Biological Population Growth Models written by John Anthony Fleming and published by . This book was released on 1973 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modeling Paradigms and Analysis of Disease Transmission Models by : Abba B. Gumel
Download or read book Modeling Paradigms and Analysis of Disease Transmission Models written by Abba B. Gumel and published by American Mathematical Soc.. This book was released on 2010 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume stems from two DIMACS activities, the U.S.-Africa Advanced Study Institute and the DIMACS Workshop, both on Mathematical Modeling of Infectious Diseases in Africa, held in South Africa in the summer of 2007. It contains both tutorial papers and research papers. Students and researchers should find the papers on modeling and analyzing certain diseases currently affecting Africa very informative. In particular, they can learn basic principles of disease modeling and stability from the tutorial papers where continuous and discrete time models, optimal control, and stochastic features are introduced.
Book Synopsis Mathematics for the Life Sciences by : Erin N. Bodine
Download or read book Mathematics for the Life Sciences written by Erin N. Bodine and published by Princeton University Press. This book was released on 2014-08-17 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: An accessible undergraduate textbook on the essential math concepts used in the life sciences The life sciences deal with a vast array of problems at different spatial, temporal, and organizational scales. The mathematics necessary to describe, model, and analyze these problems is similarly diverse, incorporating quantitative techniques that are rarely taught in standard undergraduate courses. This textbook provides an accessible introduction to these critical mathematical concepts, linking them to biological observation and theory while also presenting the computational tools needed to address problems not readily investigated using mathematics alone. Proven in the classroom and requiring only a background in high school math, Mathematics for the Life Sciences doesn't just focus on calculus as do most other textbooks on the subject. It covers deterministic methods and those that incorporate uncertainty, problems in discrete and continuous time, probability, graphing and data analysis, matrix modeling, difference equations, differential equations, and much more. The book uses MATLAB throughout, explaining how to use it, write code, and connect models to data in examples chosen from across the life sciences. Provides undergraduate life science students with a succinct overview of major mathematical concepts that are essential for modern biology Covers all the major quantitative concepts that national reports have identified as the ideal components of an entry-level course for life science students Provides good background for the MCAT, which now includes data-based and statistical reasoning Explicitly links data and math modeling Includes end-of-chapter homework problems, end-of-unit student projects, and select answers to homework problems Uses MATLAB throughout, and MATLAB m-files with an R supplement are available online Prepares students to read with comprehension the growing quantitative literature across the life sciences A solutions manual for professors and an illustration package is available
Book Synopsis Delay Differential Equations and Applications to Biology by : Fathalla A. Rihan
Download or read book Delay Differential Equations and Applications to Biology written by Fathalla A. Rihan and published by Springer Nature. This book was released on 2021-08-19 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the numerical treatment of delay differential equations and their applications in bioscience. A wide range of delay differential equations are discussed with integer and fractional-order derivatives to demonstrate their richer mathematical framework compared to differential equations without memory for the analysis of dynamical systems. The book also provides interesting applications of delay differential equations in infectious diseases, including COVID-19. It will be valuable to mathematicians and specialists associated with mathematical biology, mathematical modelling, life sciences, immunology and infectious diseases.
Book Synopsis Optimal Control Theory with Applications in Economics by : Thomas A. Weber
Download or read book Optimal Control Theory with Applications in Economics written by Thomas A. Weber and published by MIT Press. This book was released on 2011-09-30 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: A rigorous introduction to optimal control theory, with an emphasis on applications in economics. This book bridges optimal control theory and economics, discussing ordinary differential equations, optimal control, game theory, and mechanism design in one volume. Technically rigorous and largely self-contained, it provides an introduction to the use of optimal control theory for deterministic continuous-time systems in economics. The theory of ordinary differential equations (ODEs) is the backbone of the theory developed in the book, and chapter 2 offers a detailed review of basic concepts in the theory of ODEs, including the solution of systems of linear ODEs, state-space analysis, potential functions, and stability analysis. Following this, the book covers the main results of optimal control theory, in particular necessary and sufficient optimality conditions; game theory, with an emphasis on differential games; and the application of control-theoretic concepts to the design of economic mechanisms. Appendixes provide a mathematical review and full solutions to all end-of-chapter problems. The material is presented at three levels: single-person decision making; games, in which a group of decision makers interact strategically; and mechanism design, which is concerned with a designer's creation of an environment in which players interact to maximize the designer's objective. The book focuses on applications; the problems are an integral part of the text. It is intended for use as a textbook or reference for graduate students, teachers, and researchers interested in applications of control theory beyond its classical use in economic growth. The book will also appeal to readers interested in a modeling approach to certain practical problems involving dynamic continuous-time models.
Book Synopsis Complexity, Analysis and Control of Singular Biological Systems by : Qingling Zhang
Download or read book Complexity, Analysis and Control of Singular Biological Systems written by Qingling Zhang and published by Springer. This book was released on 2012-02-16 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Complexity, Analysis and Control of Singular Biological Systems follows the control of real-world biological systems at both ecological and phyisological levels concentrating on the application of now-extensively-investigated singular system theory. Much effort has recently been dedicated to the modelling and analysis of developing bioeconomic systems and the text establishes singular examples of these, showing how proper control can help to maintain sustainable economic development of biological resources. The book begins from the essentials of singular systems theory and bifurcations before tackling the use of various forms of control in singular biological systems using examples including predator-prey relationships and viral vaccination and quarantine control. Researchers and graduate students studying the control of complex biological systems are shown how a variety of methods can be brought to bear and practitioners working with the economics of biological systems and their control will also find the monograph illuminating.
Book Synopsis Geometric and Numerical Optimal Control by : Bernard Bonnard
Download or read book Geometric and Numerical Optimal Control written by Bernard Bonnard and published by Springer. This book was released on 2018-07-27 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces readers to techniques of geometric optimal control as well as the exposure and applicability of adapted numerical schemes. It is based on two real-world applications, which have been the subject of two current academic research programs and motivated by industrial use – the design of micro-swimmers and the contrast problem in medical resonance imaging. The recently developed numerical software has been applied to the cases studies presented here. The book is intended for use at the graduate and Ph.D. level to introduce students from applied mathematics and control engineering to geometric and computational techniques in optimal control.
Book Synopsis Optimal Control for Mathematical Models of Cancer Therapies by : Heinz Schättler
Download or read book Optimal Control for Mathematical Models of Cancer Therapies written by Heinz Schättler and published by Springer. This book was released on 2015-09-15 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents applications of geometric optimal control to real life biomedical problems with an emphasis on cancer treatments. A number of mathematical models for both classical and novel cancer treatments are presented as optimal control problems with the goal of constructing optimal protocols. The power of geometric methods is illustrated with fully worked out complete global solutions to these mathematically challenging problems. Elaborate constructions of optimal controls and corresponding system responses provide great examples of applications of the tools of geometric optimal control and the outcomes aid the design of simpler, practically realizable suboptimal protocols. The book blends mathematical rigor with practically important topics in an easily readable tutorial style. Graduate students and researchers in science and engineering, particularly biomathematics and more mathematical aspects of biomedical engineering, would find this book particularly useful.
Book Synopsis Optimal Control of Greenhouse Cultivation by : Gerrit van Straten
Download or read book Optimal Control of Greenhouse Cultivation written by Gerrit van Straten and published by CRC Press. This book was released on 2010-11-08 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Greenhouse control system manufacturers produce equipment and software with hundreds of settings and, while they hold training courses on how to adjust these settings, there is as yet no integrated instruction on when or why. Despite rapid growth in the greenhouse industry, growers are still faced with a multitude of variables and no unifying framework from which to choose the best option. Consolidating 30 years of research in greenhouse climate control, Optimal Control of Greenhouse Cultivation utilizes mathmatical models to incorporate the wealth of scientific knowledge into a feasible optimal control methodology for greenhouse crop cultivation. Discussing several different paradigms on greenhouse climate control, it integrates the current research into physical modeling of the greenhouse climate in response to heating, ventilation, and other control variables with the biological modeling of variables such as plant evapo-transpiration and growth. Key topics include state-space greenhouse and crop modeling needed for the design of integrated optimal controllers that exploit rather than mitigate outside weather conditions, especially sunlight, given widely different time scales. The book reviews classical rule-based and multivariable feedback controllers in comparison with the optimal hierarchical control paradigm. It considers real and hypothetical examples including lettuce, tomato, and solar greenhouses and examines experimental results of greenhouse climate control using optimal control software. The book concludes with a discussion of open issues as well as future perspectives and challenges. Providing a tool to automatically determine the most economical controls and settings for their operation, this much-needed book relieves growers of unnecessary control tasks, and allows them to achieve the best possible trade-off between short term savings and optimal harvest yield.
Book Synopsis Collective Behavior In Systems Biology by : Assaf Steinschneider
Download or read book Collective Behavior In Systems Biology written by Assaf Steinschneider and published by Academic Press. This book was released on 2019-09-04 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Collective Behavior In Systems Biology: A Primer on Modeling Infrastructure offers a survey of established and emerging methods for quantifying process behavior in cellular systems. It introduces and applies mathematics and related abstract methods to processes in biological systems - why they are used, how they work, and what they mean. Emphasizing differential equations in an interdisciplinary approach, this book discusses infrastructure for kinetic modeling, technological system and control theories, optimization, and process behavior in cellular networks. The knowledge that the reader gains will be valuable for entering and keeping up with a rapidly developing discipline. Introduces basics of mathematical and abstract methods for understanding, predicting, and modifying collective behavior in cellular systems Targets biomedical professionals as well as computational specialists who are willing to take advantage of novel high-throughput data acquisition technologies
