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Opioid Peptides In Substance Abuse
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Book Synopsis Opioid Peptides in Substance Abuse by : Joseph I. Szekely
Download or read book Opioid Peptides in Substance Abuse written by Joseph I. Szekely and published by CRC Press. This book was released on 1993-10-22 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Opioid Peptides in Substance Abuse presents an encyclopedic survey of in vivo data examining the interrelationship between endogenous opioids and substance abuse. It emphasizes two main groups of abused substances (morphine congeners and psychostimulants) and addresses the following questions:
Book Synopsis Opioid Peptides by : National Institute on Drug Abuse
Download or read book Opioid Peptides written by National Institute on Drug Abuse and published by . This book was released on 1988 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Opioid Peptides written by Rao S. Rapaka and published by . This book was released on 1986 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This monograph is based upon papers and discussion from the technical review on the medicinal chemistry and molecular pharmacology of opioid peptides and the opiates which took place on September 4-6, 1984, at Bethesda, Maryland. The meeting was sponsored by the Office of Science and the Division of Preclinical Research, National Institute on Drug Abuse. The papers on molecular pharmacology, biosynthesis, and analysis of opioid peptides are presented in this volume. Those on the medical chemistry of opioid peptides appear in NIDA Research Monograph 69" [entitled Opioid peptides : medicinal chemistry] -- page iv.
Download or read book Opioid Peptides written by Rao S. Rapaka and published by . This book was released on 1986 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pharmacology of Opioid Peptides by : L F Tseong
Download or read book Pharmacology of Opioid Peptides written by L F Tseong and published by CRC Press. This book was released on 1995-09-01 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is being published at a time when opioid receptors have recently been cloned. The structural characteristics of opioid receptors and the recent advances in their molecular cloning and expression are explicated. Connecting these cloned opioid receptors with the pharmacology of opioid receptor actions is of particular importance. The use of antisense oligodeoxynucleotides to opioid receptors to elucidate the neural mechanisms of opioid action is detailed. As analgesia is one of the most important clinical functions for opioids and opioid peptides, this book concentrates on the detailed mechanisms of action of opioids and opioid peptides for the production of analgesia. The significant pharmacologic actions of opioids and opioid peptides in gastrointestinal function, immune function, cardiovascular and respiratory regulation, addiction and the cellular mechanisms involved in tolerance and dependence of opioids are also described. The book will be of interest both to researchers investigating the neural mechanisms of the pharmacologic and physiologic functions of the endogenous opioid system and to clinicians who are involved in pain management and assessment.
Book Synopsis Molecular and Cellular Aspects of the Drug Addictions by : Avram Goldstein
Download or read book Molecular and Cellular Aspects of the Drug Addictions written by Avram Goldstein and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1970 I gave up the chairmanship of the Department of Pharmacology at Stanford University Schoel of Medicine to devote full time to basic and clinical research on problems of drug addiction. In 1971 I developed the method of radioligand binding that led to the important characterization of opioid receptors in several laboratories. The extraordinary specificity of these receptors for morphine and related opiates suggested the likelihood that there were naturally occurring morphine-like molecules in the brain and other tissues. The systematic search for these molecules culminated in 1979 in the discovery, by my group, ofthe dynorphin peptides-one of the three families of opioid peptides, the first of which (the enkephalin family) had been discovered in Aberdeen, Scotland, in 1975. I also became involved in clinical research on the pharmacologic treatment of heroin addicts, for which I established the first large methadone mainte nance treatment program in California. My basic and clinical research experience convinced me that an institution encompassing laboratory research, studies on normal human volunteers, and treatment research, under a single roof, could expedite progress in understanding the drug addictions. That concept was transformed into reality by the founding, in 1974, of the Addiction Research Foundation of Palo Alto, California. The funds for construction of a laboratory were provided by a generous grant from the Drug Abuse Council (a consortium of several foundations), the president of which was Thomas L. Bryant.
Book Synopsis Discovery of Novel Opioid Medications by :
Download or read book Discovery of Novel Opioid Medications written by and published by . This book was released on 1995 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Drugs of Abuse by : Phuong Thi Kim Pham
Download or read book Drugs of Abuse written by Phuong Thi Kim Pham and published by . This book was released on 1990 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Endogenous Opioid Peptides in Drug Addiction by : Britta Schürmann
Download or read book Endogenous Opioid Peptides in Drug Addiction written by Britta Schürmann and published by . This book was released on 2009 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular and Cellular Aspects of the Drug Addictions by : Avram Goldstein
Download or read book Molecular and Cellular Aspects of the Drug Addictions written by Avram Goldstein and published by . This book was released on 1989-01-01 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Opiate Receptors, Neurotransmitters, and Drug Dependence by : Barry Stimmel
Download or read book Opiate Receptors, Neurotransmitters, and Drug Dependence written by Barry Stimmel and published by Routledge. This book was released on 2014-06-03 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experts address the role of neuromodulators and opiate receptors in alcohol and drug dependence. They present innovative research techniques, new discoveries, and possible clinical correlates that allow for a much greater understanding of the clinical phenomena surrounding alcohol and narcotic use. Included in this thought-provoking volume are a comprehensive review of the current knowledge of the endogenous opiates, their interactions with the opiate receptors, and the potential relationship that these substances might have in promoting the development of dependence, tolerance, and withdrawal; the translation of the basic physiologic findings occuring during withdrawal to treatment of withdrawal symptoms in the clinical setting; and a physiological explanation for the rationale of using clonidine and naltrexone to accelaerate the detoxification process without undue discomfort.
Book Synopsis Molecular Approaches to Drug Abuse Research by :
Download or read book Molecular Approaches to Drug Abuse Research written by and published by . This book was released on 1991 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Neurobiology of Opiates by : Ronald P. Hammer, Jr.
Download or read book The Neurobiology of Opiates written by Ronald P. Hammer, Jr. and published by CRC Press. This book was released on 1992-11-24 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of reports by eminent researchers provides a complete description of the effects of opiates on the central nervous system of developing and adult animals. The work is useful to investigators interested in opiate neurobiology and clinicians seeking to understand opiate abuse. The Neurobiology of Opiates is organized into sections which describe the wide diversity of opiate actions from cellular and molecular to developmental and behavioral. Normal functions of endogenous opioid peptides and functional effects of exogenous opiate exposure are examined using the latest in vivo and in vitro methods. Particular emphasis is placed on the physiological and pharmacological effects of opiate dependence and withdrawal, in addition to the mechanism of opiate reinforcement and molecular mechanisms of opiate regulation. Opiate actions on the developing brain and in the hypothalamo-pituitary-adrenal axis are also discussed. This comprehensive text provides readers with the latest results and challenges them with new directions for opiate research.
Book Synopsis Opiate Receptors and Antagonists by : Reginald Dean
Download or read book Opiate Receptors and Antagonists written by Reginald Dean and published by Springer Science & Business Media. This book was released on 2009-03-12 with total page 767 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive and authoritative, Opioid Receptors and Antagonists: From Bench to Clinic offers neuroscientists, pharmacologists and interested clinicians a unique survey of the extensive and diverse research efforts currently employed with opioid antagonists to develop novel innovative drug therapies. Summarizes the present understanding of the chemistry, pharmacology and molecular biology of opioid receptors and their subtypes Highlights differences and similarities between the opioid pharmacology of animals and human Describes current and potential therapeutic areas for opioid antagonists, including substance abuse, alcohol and ingestive behaviors, behavioral disorders and other medical indications, supported by nonclinical and clinical evidence Focuses on the development of exciting and innovative drug delivery approaches that are being used with opioid antagonists for the above medical indications
Download or read book Opioid Peptides written by Rao S. Rapaka and published by . This book was released on 1986 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Advances in Endogenous and Exogenous Opioids by : Hiroshi Takagi
Download or read book Advances in Endogenous and Exogenous Opioids written by Hiroshi Takagi and published by Elsevier. This book was released on 2013-10-22 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Endogenous and Exogenous Opioids contains the proceedings of the International Narcotic Research Conference (Satellite Symposium of the 8th International Congress of Pharmacology) held in Kyoto, Japan on July 26-30, 1981. The conference provided a forum for discussing advances that have been made in the understanding of endogenous and exogenous opioids and tackled a wide array of topics ranging from novel opiate binding sites selective for benzomorphan drugs to the purification of opioid receptors and sequellae of receptor binding. Comprised of 156 chapters, this book begins with an analysis of the interaction of opioid peptides and alkaloid opiates with mu-, delta-, and kappa-binding sites. The reader is then systematically introduced to biochemical evidence for kappa and sigma opiate receptors; the action of morphine and oxymorphone as partial agonists on the field-stimulated rat vas deferens; mechanisms of supersensitivity in the enkephalinergic system; and properties of the solubilized opiate receptor from human placenta. Subsequent chapters explore the biosynthesis of opioid peptides as well as their localization, release, and degradation; physiological and pharmacological actions of opioids; and the use of analgesia in acupuncture. Results of behavioral and clinical studies of endogenous and exogenous opioids are also presented, and the structure-activity relationships of opioids are examined. This monograph will be of interest to students, practitioners, and researchers in the fields of psychiatry and pharmacology.
Book Synopsis Alcohol and Opiates by : Kenneth Blum
Download or read book Alcohol and Opiates written by Kenneth Blum and published by Elsevier. This book was released on 2012-12-02 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alcohol and Opiates: Neurochemical and Behavioral Mechanisms contains the proceedings of the 1976 conference, ""The Neurochemical and Behavioral Mechanisms of Alcohol and Opiate Dependence"", held in New York. The papers focus on the commonalities and distinctions of alcohol and opiates in terms of neurochemical and behavioral mechanisms. It also highlights key research findings on alcohol and drug dependence as well as advances in the understanding of opiate neurochemistry and the nature of alcoholism. Organized into two sections comprised of 22 chapters, this compilation begins with an overview of the various techniques used to produce and to measure alcohol dependence using animal models. It then discusses the neurochemical components of ethanol dependence, the pharmacogenetics of alcoholism, and the effects of alcohol on behavioral performance. The remaining chapters examine the pharmacology of isoquinoline alkaloids and ethanol interactions, the neurochemical aspects of opiate dependence, the pharmocological heterogeneity of narcotic receptors, and the pharmacology of endogenous opiate-like peptides. The book also introduces the reinforcement of behavior by morphine injections and the metabolic stereospecificity of opiate agonist and antagonist drugs. It concludes with an assessment of future research directions concerning opioid peptides (endorphins). This book is a valuable source of information for those seeking to build clinical programs designed to alleviate the sociological and medical ills associated with alcohol and opiate abuse and drug dependency.
