Oecd Conceptual Framework For Testing And Assessment Of Endocrine Disrupters As A Basis For Regulation Of Substances With Endocrine Disrupting Properties

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OECD Conceptual Framework for Testing and Assessment of Endocrine Disrupters as a Basis for Regulation of Substances with Endocrine Disrupting Properties

Author : Nordic Council of Ministers
Publisher :
ISBN 13 : 9789289337076
Total Pages : pages
Book Rating : 4.3/5 (37 download)

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Book Synopsis OECD Conceptual Framework for Testing and Assessment of Endocrine Disrupters as a Basis for Regulation of Substances with Endocrine Disrupting Properties by : Nordic Council of Ministers

Download or read book OECD Conceptual Framework for Testing and Assessment of Endocrine Disrupters as a Basis for Regulation of Substances with Endocrine Disrupting Properties written by Nordic Council of Ministers and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The existing EU chemical legislation only covers some of the effects caused by endocrine disruption. In the proposal for the new REACH system, endocrine disrupters are covered by the authorisation procedure based on a case-by-case assessment, but no indication of criteria for the assessment is given. Several toxicological and ecotoxicological screening tests for predicting endocrine disrupting properties of a chemical are now under development and international validation within the OECD, but it will probably take several years before the full range of validated testing methods and criteria are developed. In the meantime there is a need for guidance on how to interpret test results from existing test methods and how to identify a substance as an endocrine disrupter. Regulatory instruments that can be used towards endocrine disrupters should also be considered in this interim period. The aim of this project has been to investigate if and how the OECD Conceptual Framework for Testing and Assessment of Endocrine Disrupters can be used as a basis for regulatory initiatives towards endocrine disrupters. The report includes an assessment of the tests in the OECD Conceptual Framework, including specification of the endpoint for the test and reliability and relevance for effects in humans. This report is expected to serve as a basis for the Nordic contribution to the discussions in EU on interpretation and use of test results indicating endocrine disruption for regulatory purposes and furthermore, how to integrate endocrine disrupters in the new EU chemicals regulation

OECD Conceptual Framework for Testing and Assessment of Endocrine Disrupters as a basis for regulation of substances with endocrine disrupting properties

Author : Ulla Hass
Publisher : Nordic Council of Ministers
ISBN 13 : 9289310731
Total Pages : 101 pages
Book Rating : 4.2/5 (893 download)

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Book Synopsis OECD Conceptual Framework for Testing and Assessment of Endocrine Disrupters as a basis for regulation of substances with endocrine disrupting properties by : Ulla Hass

Download or read book OECD Conceptual Framework for Testing and Assessment of Endocrine Disrupters as a basis for regulation of substances with endocrine disrupting properties written by Ulla Hass and published by Nordic Council of Ministers. This book was released on 2004 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt:

TemaNord

Author : Nordisk Ministerråd
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (873 download)

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Book Synopsis TemaNord by : Nordisk Ministerråd

Download or read book TemaNord written by Nordisk Ministerråd and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook of Laboratory Animal Science

Author : Jann Hau
Publisher : CRC Press
ISBN 13 : 0429801599
Total Pages : 1890 pages
Book Rating : 4.4/5 (298 download)

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Book Synopsis Handbook of Laboratory Animal Science by : Jann Hau

Download or read book Handbook of Laboratory Animal Science written by Jann Hau and published by CRC Press. This book was released on 2021-05-17 with total page 1890 pages. Available in PDF, EPUB and Kindle. Book excerpt: Building upon the success of previous editions of the bestselling Handbook of Laboratory Animal Science, first published in 1994, this latest revision combines all three volumes in one definitive guide. It covers the essential principles and practices of Laboratory Animal Science as well as selected animal models in scientific disciplines where much progress has been made in recent years. Each individual chapter focuses on an important subdiscipline of laboratory animal science, and the chapters can be read and used as stand-alone texts, with only limited necessity to consult other chapters for information. With new contributors at the forefront of their fields, the book reflects the scientific and technological advances of the past decade. It also responds to advances in our understanding of animal behavior, emphasizing the importance of implementing the three Rs: replacing live animals with alternative methods, reducing the number of animals used, and refining techniques to minimize animal discomfort. This fourth edition will be useful all over the world as a textbook for laboratory animal science courses for postgraduate and undergraduate students and as a handbook for scientists who work with animals in their research, for university veterinarians, and for other specialists in laboratory animal science.

Principles for Evaluating Health Risks in Children Associated with Exposure to Chemicals

Author : Germaine Buck Louis
Publisher : World Health Organization
ISBN 13 : 924157237X
Total Pages : 352 pages
Book Rating : 4.2/5 (415 download)

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Book Synopsis Principles for Evaluating Health Risks in Children Associated with Exposure to Chemicals by : Germaine Buck Louis

Download or read book Principles for Evaluating Health Risks in Children Associated with Exposure to Chemicals written by Germaine Buck Louis and published by World Health Organization. This book was released on 2006 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conclusions, and recommendations -- Introduction and background -- Unique biological characteristics of children -- Developmental stage-specific susceptibilities and outcomes in children -- Exposure assessment of children -- Methodologies to assess health outcomes in children -- Implications and strategies for risk assessment for children.

OECD Series on Testing and Assessment Detailed Review Paper on the State of the Science on Novel In Vitro and In Vivo Screening and Testing Methods and Endpoints for Evaluating Endocrine Disruptors

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Author : OECD
Publisher : OECD Publishing
ISBN 13 : 9264221352
Total Pages : 213 pages
Book Rating : 4.2/5 (642 download)

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Book Synopsis OECD Series on Testing and Assessment Detailed Review Paper on the State of the Science on Novel In Vitro and In Vivo Screening and Testing Methods and Endpoints for Evaluating Endocrine Disruptors by : OECD

Download or read book OECD Series on Testing and Assessment Detailed Review Paper on the State of the Science on Novel In Vitro and In Vivo Screening and Testing Methods and Endpoints for Evaluating Endocrine Disruptors written by OECD and published by OECD Publishing. This book was released on 2012-08-21 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: This paper provides methods for both the mechanistic evaluation of the action of Endocrine Disrupter Chemicals (EDCs).

Guidance Document on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption

Author : OECD
Publisher : OECD Publishing
ISBN 13 : 9264221417
Total Pages : 524 pages
Book Rating : 4.2/5 (642 download)

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Book Synopsis Guidance Document on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption by : OECD

Download or read book Guidance Document on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption written by OECD and published by OECD Publishing. This book was released on 2014-09-03 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: This document is a tool to support regulatory authorities’ decisions on the hazard of specific chemicals when they receive test results from a Test Guideline (TG) or draft TG for the screening/testing of chemicals for endocrine disrupting properties.

OECD Series on Testing and Assessment Detailed Review Paper on the Use of Metabolising Systems for In Vitro Testing of Endocrine Disruptors

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Author : OECD
Publisher : OECD Publishing
ISBN 13 : 9264085491
Total Pages : 95 pages
Book Rating : 4.2/5 (64 download)

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Book Synopsis OECD Series on Testing and Assessment Detailed Review Paper on the Use of Metabolising Systems for In Vitro Testing of Endocrine Disruptors by : OECD

Download or read book OECD Series on Testing and Assessment Detailed Review Paper on the Use of Metabolising Systems for In Vitro Testing of Endocrine Disruptors written by OECD and published by OECD Publishing. This book was released on 2014-09-03 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Detailed Review Paper describes some endocrine pathways that have been shown to be susceptible to environmental endocrine disruption and whose disruption could contribute to increasing incidents of some disorders in humans and wildlife populations.

Handbook of Laboratory Animal Science, Volume II

Author : Jann Hau
Publisher : CRC Press
ISBN 13 : 1420084585
Total Pages : 469 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Handbook of Laboratory Animal Science, Volume II by : Jann Hau

Download or read book Handbook of Laboratory Animal Science, Volume II written by Jann Hau and published by CRC Press. This book was released on 2011-04-22 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical research involving animals remains essential for the advancement of the medical, veterinary, agricultural, and biological sciences. Following in the footsteps of its predecessors, the Handbook of Laboratory Animal Science, Volume II, Third Edition: Animal Models explains in great detail the comparative considerations underlying the choic

OECD Series on Testing and Assessment Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption

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Author : OECD
Publisher : OECD Publishing
ISBN 13 : 9264304746
Total Pages : 692 pages
Book Rating : 4.2/5 (643 download)

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Book Synopsis OECD Series on Testing and Assessment Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption by : OECD

Download or read book OECD Series on Testing and Assessment Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption written by OECD and published by OECD Publishing. This book was released on 2018-09-03 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guidance document was originally published in 2012 and updated in 2018 to reflect new and updated OECD test guidelines, as well as reflect on scientific advances in the use of test methods and assessment of the endocrine activity of chemicals.

Endocrine Disrupters – Developing criteria

Author :
Publisher : Nordic Council of Ministers
ISBN 13 : 9289322373
Total Pages : 49 pages
Book Rating : 4.2/5 (893 download)

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Book Synopsis Endocrine Disrupters – Developing criteria by :

Download or read book Endocrine Disrupters – Developing criteria written by and published by Nordic Council of Ministers. This book was released on 2011 with total page 49 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Modern Methods in Crop Protection Research

Author : Peter Jeschke
Publisher : John Wiley & Sons
ISBN 13 : 3527655921
Total Pages : 429 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Modern Methods in Crop Protection Research by : Peter Jeschke

Download or read book Modern Methods in Crop Protection Research written by Peter Jeschke and published by John Wiley & Sons. This book was released on 2013-02-05 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook and ready reference highlights a couple of basic aspects of recently developed new methods in modern crop protection research, authored by renowned experts from major agrochemical companies. Organized into four major parts that trace the key phases of the compound development process, the first section addresses compound design, while the second covers newly developed methods for the identification of the mode of action of agrochemical compounds. The third part describes methods used in improving the bioavailability of compounds, and the final section looks at modern methods for risk assessment. As a result, the agrochemical developer will find here a valuable toolbox of advanced methods, complete with first-hand practical advice and copious examples from current industrial practice.

Temporal Aspects in the Testing of Chemicals for Endocrine Disrupting Effects (in Relation to Human Health and the Environment)

Author :
Publisher :
ISBN 13 :
Total Pages : 353 pages
Book Rating : 4.:/5 (16 download)

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Book Synopsis Temporal Aspects in the Testing of Chemicals for Endocrine Disrupting Effects (in Relation to Human Health and the Environment) by :

Download or read book Temporal Aspects in the Testing of Chemicals for Endocrine Disrupting Effects (in Relation to Human Health and the Environment) written by and published by . This book was released on 2017 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine disruptors are exogenous substances or mixtures that alter function(s) of the endocrine system and consequently cause adverse health effects in an intact organism, its progeny or (sub) populations. Exposure to endocrine disruptors is of particular concern in phases of critical developmental processes, where the endogenous hormonal systems are particularly vulnerable or sensitive to disturbances during certain developmental life stages (e.g. organogenesis), which may consequently lead to serious and irreversible health effects. The Organisation for Economic Co-operation and Development (OECD) is the responsible body for the development and validation of test guidelines for testing endocrine-disrupting properties. The OECD's "Conceptual Framework for Testing and Assessment of Endocrine Disrupters" (as revised in 2012) lists the OECD Test Guidelines (TGs) and standardised test methods available, under development or proposed that can be used to evaluate chemicals for endocrine disruption. However, there are currently gaps and limitations in the existing OECD TGs that hinder the identification of health effects from endocrine-disrupting chemicals (EDCs) such as insufficient coverage of examining the temporal aspects of EDC exposure and effects in the current TGs. Therefore, in order to identify these gaps and limitations of the existing OECD TGs regarding temporal aspects of chemical exposure and effects, a critical literature review on the existing scientific knowledge on this topic was conducted. Afterwards, a comparative analysis was performed between studies following OECD TGs and those using modified or non-OECD TG protocols, e.g. to identify what temporal aspects of EDC exposure and effects have been observed in the non-OECD TG studies but are not addressed in the TGs. This technical report presents the outcomes of the critical literature review and the comparative analysis.

OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Detailed Review Paper Appraisal of Test Methods for Sex Hormone Disrupting Chemicals

Download OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Detailed Review Paper Appraisal of Test Methods for Sex Hormone Disrupting Chemicals PDF Online Free

Author : OECD
Publisher : OECD Publishing
ISBN 13 : 926407838X
Total Pages : 313 pages
Book Rating : 4.2/5 (64 download)

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Book Synopsis OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Detailed Review Paper Appraisal of Test Methods for Sex Hormone Disrupting Chemicals by : OECD

Download or read book OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Detailed Review Paper Appraisal of Test Methods for Sex Hormone Disrupting Chemicals written by OECD and published by OECD Publishing. This book was released on 2002-05-10 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: This documents servies as the basis for the first step in the consideration and development of OECD Test Guidelines for the testing of chemicals for endocrine-disrupting effects.

IPCS Risk Assessment Terminology

Author : International Program on Chemical Safety
Publisher : World Health Organization
ISBN 13 : 9241562676
Total Pages : 126 pages
Book Rating : 4.2/5 (415 download)

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Book Synopsis IPCS Risk Assessment Terminology by : International Program on Chemical Safety

Download or read book IPCS Risk Assessment Terminology written by International Program on Chemical Safety and published by World Health Organization. This book was released on 2004 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: A joint project of IPCS/OECD. In two parts: Part 1: IPCS/OECD Key Generic Terms used in Chemical Hazard/Risk Assessment. Part 2: IPCS Glossary of Key Exposure Assessment Terminology. IPCS project on the Harmonization of Approaches to the Assessment of Risk from Exposure to Chemicals

Challenges in Endocrine Disruptor Toxicology and Risk Assessment

Author : Alexandra Fucic
Publisher : Royal Society of Chemistry
ISBN 13 : 1788017412
Total Pages : 539 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Challenges in Endocrine Disruptor Toxicology and Risk Assessment by : Alexandra Fucic

Download or read book Challenges in Endocrine Disruptor Toxicology and Risk Assessment written by Alexandra Fucic and published by Royal Society of Chemistry. This book was released on 2020-12-08 with total page 539 pages. Available in PDF, EPUB and Kindle. Book excerpt: Insight into the role of hormones, particularly estrogen and testosterone, in health and disease etiology - including interactions with other hormone pathways - has dramatically changed. Estrogen and androgen receptors, with their polymorphisms, are key molecules in all tissues and are involved in a number of homeostatic mechanisms but also pathological processes including carcinogenesis and the development of metabolic and neurological disorders such as diabetes and Alzheimer's disease. Endocrine disrupting chemicals (EDCs) can interfere with the endocrine (hormone) systems at certain dosages and play a key role in the pathology of disease. Most known EDCs are manmade and are therefore an increasing concern given the number commonly found in household products and the environment. This book will cover the mechanisms of EDC pathology across the spectrum of disease, as well as risk assessment and government and legal regulation to provide a holistic view of the current issues and cutting-edge research in the topic. With contributions from global leaders in the field, this book will be an ideal reference for toxicologists, endocrinologists and researchers interested in developmental biology, regulatory toxicology and the interface between environment and human health.

Mammalian Toxicology

Author : Mohamed Abou-Donia
Publisher : John Wiley & Sons
ISBN 13 : 1119940419
Total Pages : 716 pages
Book Rating : 4.1/5 (199 download)

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Book Synopsis Mammalian Toxicology by : Mohamed Abou-Donia

Download or read book Mammalian Toxicology written by Mohamed Abou-Donia and published by John Wiley & Sons. This book was released on 2015-05-04 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mammalian Toxicology surveys chemical agents and examines how such chemicals impact on human health, emphasizing the importance in minimizing environmental exposure to chemical and physical hazards in our homes, communities and workplaces through such media as contaminated water, soil and air. Starting with the basic principles on a wide range of toxic agents, this textbook describes how they enter the body, their mechanisms of action once inside, and strategies for diagnosis, prevention and treatment. Topics covered include: General principles of toxicology: pharmacological and toxicological principles underpinning the study of toxicology, risk assessments and mechanisms of cell death Disposition: routes of chemical exposures, entry into the body and various tissues, storage, metabolic biotransformation and elimination, with examples from various toxicants. Toxic agents: the occurrences, disposition in the body, health effects, toxic mechanisms, antidotes and treatments of a range of agents including pesticides, metals, solvents, gases, nanomaterials, food components and additives, pharmaceuticals, drugs of abuse, natural toxins, endocrine disruptors, radiation, and warfare weapons. Toxic effects: including neurotoxicity, developmental toxicity, immunotoxicity, teratogenecity, male and female reproductive toxicity, mutagenecity, carcinogenicity, pulmonary toxicity, cardiovascular toxicity, hepatotoxicity, gastrointestinal toxicity and cardiovascular toxicity Toxicology and society: epidemiological studies of chemical-induced diseases in human populations, and a vision for toxicology in the 21st century. Mammalian Toxicology is an essential primer for students of toxicology, biochemistry, biology, medicine and chemistry. It is also appropriate for professional toxicologists in research or regulatory affairs, and anyone who needs to understand the adverse effects of toxic agents on the human body.