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Author : Roeland van Driel
Publisher :
ISBN 13 : 9781383028089
Total Pages : 0 pages
Book Rating : 4.0/5 (28 download)
Download or read book Nuclear Organization, Chromatin Structure, and Gene Expression written by Roeland van Driel and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sarah C. R. Elgin
Publisher : Frontiers in Molecular Biology
ISBN 13 : 9780199638901
Total Pages : 372 pages
Book Rating : 4.6/5 (389 download)
Download or read book Chromatin Structure and Gene Expression written by Sarah C. R. Elgin and published by Frontiers in Molecular Biology. This book was released on 2000 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since publication of the first edition in 1995, there have been significant advances and understanding of chromatin structure and its relation to gene expression. These include a high-resolution structure of the nucleosome core, discovery of the enzymes and complexes that mediate histone acetylation and deacetylation, discovery of novel ATP-dependent chromatin remodeling complexes, new insights into nuclear organization and epigenetic silencing mechanisms. In light of these advances, Chromatin Structure and Gene Expression (2ed.) includes updated chapters and additional material that introduce new concepts in the process of gene regulation in chromatin.
Author : R. Curtis Bird
Publisher : Elsevier
ISBN 13 : 9780080537818
Total Pages : 304 pages
Book Rating : 4.5/5 (378 download)
Download or read book Nuclear Structure and Gene Expression written by R. Curtis Bird and published by Elsevier. This book was released on 1996-11-28 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear Structure and Gene Expression assimilates the contributions of genome organization and of the components of the nuclear matrix to the control of DNA and RNA synthesis. Nuclear domains which accommodate DNA replication and gene expression are considered in relation to short-term developmental and homeostatic requirements as well as to long-term commitments to phenotypic gene expression in differentiated cells. Consideration is given to the involvement of nuclear structure in gene localization as well as to the targeting and concentration of transcription factors. Aberrations in nuclear architecture associated with and potentially functionally related to pathologies are evaluated. Tumor cells are described from the perspective of the striking modifications in both the composition and organization of nuclear components. Nuclear Structure and Gene Expression presents concepts as well as experimental approaches, which define functionality of nuclear morphology. * Mechanisms of interaction between nuclear structure and genes * Gene expression regulation by elements of the nuclear matrix * How nuclear structure exerts a regulatory effect on other aspects of cell function/physiology
Author : Derek J. Chadwick
Publisher : John Wiley & Sons
ISBN 13 : 0470093749
Total Pages : 300 pages
Book Rating : 4.4/5 (7 download)
Download or read book Nuclear Organization in Development and Disease written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2006-02-08 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book draws together contributions from cell and developmental biologists, structural biologists, geneticists and clinical scientists aimed at a better understanding of the cellular and molecular basis of these diseases. Topics include: How nuclear structure and location within a nucleus affect gene expression Chromatin organization and cell differentiation The nature of the interactions between the nuclear envelope and the cytoskeleton The extent to which the cytoskeleton mediates communication between the cell membrane and nucleus in regulating gene expression and whether disruption of such communication might underlie the disease processes It is hoped that a better understanding of the mechanisms leading to disease pathogenesis may ultimately lead to more rational and appropriate treatments.
Author : Alan P. Wolffe
Publisher : Academic Press
ISBN 13 : 0080926606
Total Pages : 462 pages
Book Rating : 4.0/5 (89 download)
Download or read book Chromatin written by Alan P. Wolffe and published by Academic Press. This book was released on 2012-12-02 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the remarkable progress in chromatin research over the past three years. It has been extensively rewritten to cover new material on chromatin remodeling, histone modification, nuclear compartmentalization, DNA methylation, and transcriptional co-activators and co-repressors. The book is written in a clear and concise fashion, with 60 new illustrations. Chromatin: Structure and Function provides the reader with a concise and coherent account of the nature, structure, and assembly of chromatin and its active involvement in the processes of DNA transcription, replication and repair. This book consistently interrelates the structure of eukaryotic DNA with the nuclear processes it undergoes, and will be essential reading for students and molecular biologists who want to really understand how DNA works. Written in a clear and concise fashion Includes 60 new illustrations Extensively rewritten Brings the reader up-to-date with the remarkable progress in chromatin research over the past three years.
Author : Esteban Ballestar
Publisher : Springer
ISBN 13 : 9781441982179
Total Pages : 182 pages
Book Rating : 4.9/5 (821 download)
Download or read book Epigenetic Contributions in Autoimmune Disease written by Esteban Ballestar and published by Springer. This book was released on 2011-08-23 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the relevance of epigenetic mechanisms in autoimmune disease. It provides new directions for future research in autoimmune disease.
Author : Maximiliano D’Angelo
Publisher : Springer
ISBN 13 : 331971614X
Total Pages : 240 pages
Book Rating : 4.3/5 (197 download)
Download or read book Nuclear Pore Complexes in Genome Organization, Function and Maintenance written by Maximiliano D’Angelo and published by Springer. This book was released on 2018-02-02 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: The three-dimensional organization of the DNA inside the eukaryotic cell nucleus has emerged a critical regulator of genome integrity and function. Increasing evidence indicates that nuclear pore complexes (NPCs), the large protein channels that connect the nucleus to the cytoplasm, play a critical role in the establishment and maintenance of chromatin organization and in the regulation of gene activity. These findings, which oppose the traditional view of NPCs as channels with only one: the facilitation of nucleocytoplasmic molecule exchange, have completely transformed our understanding of these structures. This book describes our current knowledge of the role of NPCs in genome organization and gene expression regulation. It starts by providing an overview of the different compartments and structures of the nucleus and how they contribute to organizing the genome, then moves to examine the direct roles of NPCs and their components in gene expression regulation in different organisms, and ends by describing the function of nuclear pores in the infection and genome integration of HIV, in DNA repair and telomere maintenance, and in the regulation of chromosome segregation and mitosis. This book provides an intellectual backdrop for anyone interested in understanding how the gatekeepers of the nucleus contribute to safeguarding the integrity and function of the eukaryotic genome.
Author : Jerry L. Workman
Publisher : Springer Science & Business Media
ISBN 13 : 1461486246
Total Pages : 594 pages
Book Rating : 4.4/5 (614 download)
Download or read book Fundamentals of Chromatin written by Jerry L. Workman and published by Springer Science & Business Media. This book was released on 2013-12-04 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: While there has been an increasing number of books on various aspects of epigenetics, there has been a gap over the years in books that provide a comprehensive understanding of the fundamentals of chromatin. Chromatin is the combination of DNA and proteins that make up the genetic material of chromosomes. Its primary function is to package DNA to fit into the cell, to strengthen the DNA to prevent damage, to allow mitosis and meiosis, and to control the expression of genes and DNA replication. The audience for this book is mainly newly established scientists and graduate students. Rather than going into the more specific areas of recent research on chromatin the chapters in this book give a strong, updated groundwork about the topic. Some the fundamentals that this book will cover include the structure of chromatin and biochemistry and the enzyme complexes that manage it.
Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John C. Lucchesi
Publisher : Oxford University Press
ISBN 13 : 0192567160
Total Pages : 240 pages
Book Rating : 4.1/5 (925 download)
Download or read book Epigenetics, Nuclear Organization & Gene Function written by John C. Lucchesi and published by Oxford University Press. This book was released on 2018-12-19 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. These changes, consisting principally of DNA methylation, histone modifications, and non-coding RNAs, maintain or modulate the initial impact of regulatory factors that recognize and associate with particular genomic sequences. Epigenetic modifications are manifest in all aspects of normal cellular differentiation and function, but they can also have damaging effects that result in pathologies such as cancer. Research is continuously uncovering the role of epigenetics in a variety of human disorders, providing new avenues for therapeutic interventions and advances in regenerative medicine. This book's primary goal is to establish a framework that can be used to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. A further aim is to highlight the role played by the three-dimensional organization of the genetic material itself (the complex of DNA, histones and non-histone proteins referred to as chromatin), and its distribution within a functionally compartmentalized nucleus. This architectural organization of the genome plays a major role in the subsequent retrieval, interpretation, and execution of both genetic and epigenetic information.
Author : Renato Paro
Publisher : Springer Nature
ISBN 13 : 3030686701
Total Pages : 215 pages
Book Rating : 4.0/5 (36 download)
Download or read book Introduction to Epigenetics written by Renato Paro and published by Springer Nature. This book was released on 2021-03-23 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease
Author : David Evans
Publisher : John Wiley & Sons
ISBN 13 : 1118472489
Total Pages : 346 pages
Book Rating : 4.1/5 (184 download)
Download or read book Annual Plant Reviews, Plant Nuclear Structure, Genome Architecture and Gene Regulation written by David Evans and published by John Wiley & Sons. This book was released on 2013-03-27 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely volume brings together expert reviews of the recent significant advances in our knowledge and understanding of the organisation of the higher plant nucleus, and in particular in the relationship between nuclear organisation and the regulation of gene expression. Rapid progress has been made in a number of key areas over the last five years, including description and characterization of proteins of the nuclear envelope and nuclear pore complex, novel insights into nucleoskeletal structures, as well as developments related to chromatin organization, function and gene expression. These advances open the way for new research into areas such as stress tolerance, plant-pathogen interactions and ultimately crop improvement and food security. Continued research into plant nuclear structure, genome architecture and gene regulation also enriches our understanding of the origin and evolution of the nucleus and its envelope. Edited by world-class researchers in plant cell biology, and comprising contributions from internationally-renowned academics, this latest volume in the prestigious Annual Plant Reviews series brings together a wealth of knowledge in the burgeoning field of plant nuclear structure and genetics. Annual Plant Reviews, Volume 46: Plant Nuclear Structure, Genome Architecture and Gene Regulation is a vital resource for advanced students, researchers and professionals in plant science and related disciplines. Libraries in all research establishments where plant science, biochemistry, molecular biology, genetics and genomics and agricultural science are taught and studied will find this excellent volume an essential addition to their shelf.
Author : Christophe Lavelle
Publisher : Academic Press
ISBN 13 : 012803503X
Total Pages : 618 pages
Book Rating : 4.1/5 (28 download)
Download or read book Nuclear Architecture and Dynamics written by Christophe Lavelle and published by Academic Press. This book was released on 2017-10-27 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear Architecture and Dynamics provides a definitive resource for (bio)physicists and molecular and cellular biologists whose research involves an understanding of the organization of the genome and the mechanisms of its proper reading, maintenance, and replication by the cell. This book brings together the biochemical and physical characteristics of genome organization, providing a relevant framework in which to interpret the control of gene expression and cell differentiation. It includes work from a group of international experts, including biologists, physicists, mathematicians, and bioinformaticians who have come together for a comprehensive presentation of the current developments in the nuclear dynamics and architecture field. The book provides the uninitiated with an entry point to a highly dynamic, but complex issue, and the expert with an opportunity to have a fresh look at the viewpoints advocated by researchers from different disciplines. Highlights the link between the (bio)chemistry and the (bio)physics of chromatin Deciphers the complex interplay between numerous biochemical factors at task in the nucleus and the physical state of chromatin Provides a collective view of the field by a large, diverse group of authors with both physics and biology backgrounds
Author : Karsten Rippe
Publisher : John Wiley & Sons
ISBN 13 : 3527640002
Total Pages : 597 pages
Book Rating : 4.5/5 (276 download)
Download or read book Genome Organization And Function In The Cell Nucleus written by Karsten Rippe and published by John Wiley & Sons. This book was released on 2012-01-09 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: By way of its clear and logical structure, as well as abundant highresolution illustrations, this is a systematic survey of the players and pathways that control genome function in the mammalian cell nucleus. As such, this handbook and reference ties together recently gained knowledge from a variety of scientific disciplines and approaches, dissecting all major genomic events: transcription, replication, repair, recombination and chromosome segregation. A special emphasis is put on transcriptional control, including genome-wide interactions and non-coding RNAs, chromatin structure, epigenetics and nuclear organization. With its focus on fundamental mechanisms and the associated biomolecules, this will remain essential reading for years to come.
Author : Anita Göndör
Publisher : Academic Press
ISBN 13 : 0128034025
Total Pages : 496 pages
Book Rating : 4.1/5 (28 download)
Download or read book Chromatin Regulation and Dynamics written by Anita Göndör and published by Academic Press. This book was released on 2016-10-25 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes. The final chapters discuss the many ways chromatin dynamics can synergize to fundamentally contribute to the development of complex diseases. Chromatin dynamics, which is strategically positioned at the gene-environment interface, is at the core of disease development. As such, Chromatin Regulation and Dynamics, part of the Translational Epigenetics series, facilitates the flow of information between research areas such as chromatin regulation, developmental biology, and epidemiology by focusing on recent findings of the fast-moving field of chromatin regulation. Presents and discusses novel principles of chromatin regulation and dynamics with a cross-disciplinary perspective Promotes crosstalk between basic sciences and their applications in medicine Provides a framework for future studies on complex diseases by integrating various aspects of chromatin biology with cellular metabolic states, with an emphasis on the dynamic nature of chromatin and stochastic principles Integrates knowledge on the dynamic regulation of primary chromatin fiber with 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes
Author : Alexey V. Pindyurin
Publisher : Frontiers Media SA
ISBN 13 : 2832505295
Total Pages : 248 pages
Book Rating : 4.8/5 (325 download)
Download or read book The Role of High-Order Chromatin Organization in Gene Regulation written by Alexey V. Pindyurin and published by Frontiers Media SA. This book was released on 2022-11-11 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sue Shackleton
Publisher : Methods in Molecular Biology
ISBN 13 : 9781493980680
Total Pages : 540 pages
Book Rating : 4.9/5 (86 download)
Download or read book The Nuclear Envelope: Methods and Protocols written by Sue Shackleton and published by Methods in Molecular Biology. This book was released on 2018-05-19 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a wide range of protocols used in studying the nuclear envelope, with special attention to the experimental adjustments that may be required to successfully investigate this complex organelle in cells from various organisms. The Nuclear Envelope: Methods and Protocols is divided into five sections: Part I - Nuclear Envelope Isolation; Part II - Nuclear Envelope Protein Interactions, Localization, and Dynamics; Part III - Nuclear Envelope Interactions with the Cytoskeleton; Part IV - Nuclear Envelope-Chromatin Interactions; and Part V - Nucleo-Cytoplasmic Transport. Many of the modifications discussed in this book have only been circulated within laboratories that have conducted research in this field for many years. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and thorough, The Nuclear Envelope: Methods and Protocols is a timely resource for researchers who have joined this dynamic and rapidly growing field.
