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ISBN 13 :
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Book Synopsis NTP Technical Report on the Toxicity Studies of Select Ionic Liquids (1-Ethyl-3-Methylimidazolium Chloride, 1-Butyl-3-Methylimidazolium Chloride, 1-Butyl-1-Methylpyrrolidinium Chloride, and N-Butylpyridinium Chloride) Administered in Drinking Water to Sprague Dawley (Hsd:Sprague Dawley(r) SD(r)) Rats and B6C3F1/N Mice by :
Download or read book NTP Technical Report on the Toxicity Studies of Select Ionic Liquids (1-Ethyl-3-Methylimidazolium Chloride, 1-Butyl-3-Methylimidazolium Chloride, 1-Butyl-1-Methylpyrrolidinium Chloride, and N-Butylpyridinium Chloride) Administered in Drinking Water to Sprague Dawley (Hsd:Sprague Dawley(r) SD(r)) Rats and B6C3F1/N Mice written by and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ionic liquids (ILs) are synthetic solvents with applications in a variety of industrial and chemical industries. Human exposure to this diverse chemical class is primarily through dermal or oral routes. Research suggests toxicity may be associated with IL structural characteristics, including the type of cation base or alkyl chain substitutions associated with the cation. To further investigate this hypothesis, the National Toxicology Program (NTP) conducted 3-month toxicity studies in male and female Sprague Dawley (Hsd:Sprague Dawley(r) SD(r)) rats and B6C3F1/N mice (n\s=\s10/sex/exposure group; 3\sexposure concentrations per IL) to compare the relative toxicities of four ILs administered via drinking water--1-ethyl-3-methylimidazolium chloride (Emim-Cl),1-butyl-3-methylimidazolium chloride (Bmim-Cl), 1-butyl-1-methylpyrrolidinium chloride (Bmpy-Cl), and n-butylpyridinium chloride (NBuPy-Cl). To select exposure concentrations for the 3-month studies, 2-week drinking water studies in rats and mice were conducted to assess palatability and toxicity of each IL. Informed by the literature and preliminary palatability studies, exposure concentrations in the 2-week studies ranged from 0\sto 100\smg/mL. Clinical observations (e.g., thinness and ruffled fur), lower water consumption, and lower mean body weights were associated with higher IL exposure concentrations. At the end of the 2-week exposure period, a range of organ weight changes and histological lesions was observed in rats and mice exposed to ILs. These observations were considered secondary to body weight changes and/or stress, rather than a direct toxic effect from 2-week IL exposure. Exposure concentrations (ranging from 0\sto 30\smg/mL) were selected for the 3-month studies because of the observed relative decreases in mean body weight (≤10%) and water consumption (
