Novel Roles For Fragile X Protein In Neurogenesis

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Novel Roles for Fragile X Protein in Neurogenesis

Author : Matthew Aron Callan
Publisher :
ISBN 13 :
Total Pages : 214 pages
Book Rating : 4.:/5 (752 download)

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Book Synopsis Novel Roles for Fragile X Protein in Neurogenesis by : Matthew Aron Callan

Download or read book Novel Roles for Fragile X Protein in Neurogenesis written by Matthew Aron Callan and published by . This book was released on 2011 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fragile X Syndrome (FXS) is the most common form of inherited mental retardation, affecting approximately 1/4000 males and 1/6000 females worldwide. FXS is caused by loss of FMR1 gene expression, resulting in the lack of the protein product, Fragile X protein (FMRP). FMRP is an RNA-binding protein thought to regulate synaptic plasticity by controlling the localization and translation of specific mRNAs in neurons. To determine whether FMRP is also required in early brain development we examined the distribution of cell cycle markers in Drosophila FMR1 (dFmr1) mutant brains compared to wild-type brains. Our results indicate that the loss of dFmr1 leads to a significant increase in the number of mitotic neuroblasts and BrdU incorporation in the brain, consistent with the notion that FMRP controls proliferation in neural stem cells. To determine the role of FMRP in neuroblast division and differentiation, we used Mosaic Analysis with a Repressible Marker (MARCM) approaches in the developing larval brain and found that single dFmr1 neuroblasts generate significantly more neurons than controls. Developmental studies suggest that FMRP also inhibits neuroblast exit from quiescence, or reactivation, in early larval brains, as indicated by misexpression of the G1 to S phase transition marker Cyclin E. We have also identified a novel role for FMRP in the glia surrounding the neuroblasts, indicating that FMRP in these cells contributes to the regulation of neuroblast reactivation via signaling from the supporting glial cells. Our results demonstrate that FMRP is required during brain development to control the exit from quiescence and proliferative capacity of neuroblasts as well as neuron production, which may provide insights into Fragile X Syndrome and other Autism-Spectrum disorders.

Examining the Role of FXR1P in Adult Neurogenesis

Author : Natalie Patzlaff
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (124 download)

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Book Synopsis Examining the Role of FXR1P in Adult Neurogenesis by : Natalie Patzlaff

Download or read book Examining the Role of FXR1P in Adult Neurogenesis written by Natalie Patzlaff and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fragile X related protein 1 (FXR1P) is part of the fragile X family of RNA binding proteins (FXRs), which includes the fragile X mental retardation protein (FMRP) and fragile X related protein 2 (FXR2P). Both FMRP and FXR2P regulate adult neural stem cells (aNSCs) and neurogenesis, a process linked to neurological disorders, such as Fragile X syndrome. Although FXR1P has been implicated in diverse developmental processes and neurological diseases, its role in neurodevelopment is not well-understood. The goal of this study was to elucidate the function of FXR1P in aNSCs and hippocampal neurogenesis. We used a Tamoxifen-inducible triple transgenic mouse model to investigate how Fxr1 deletion affects aNSC proliferation and fate specification. Deletion of Fxr1 resulted in significantly decreased populations of radial glia-like cells, neuroblasts, immature neurons, neurons, and astrocytes. We hypothesized that this reduction in new cell numbers resulted from impaired proliferation, which was confirmed both in vivo and in vitro. We discovered that FXR1P-deficient aNSCs have altered expression of a select number of cell-cycle genes, and identified the mRNA of cyclin-dependent kinase inhibitor 1A (Cdkn1a, p21) as a direct target of FXR1P. Restoration of p21 mRNA to wildtype levels rescued the proliferation deficit in aNSCs lacking FXR1P, demonstrating that p21 is a mediator of FXR1P in aNSCs. Since Fxr1 deletion in aNSCs results in a reduction of new neurons, we also performed behavioral tests for locomotion, anxiety, and hippocampal learning and memory. Although these results are preliminary, it is likely that the loss of FXR1P in aNSCs results in impaired hippocampal-dependent learning and memory.

Fragile X Syndrome

Author : Sahar Javadi Novashnagh
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)

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Book Synopsis Fragile X Syndrome by : Sahar Javadi Novashnagh

Download or read book Fragile X Syndrome written by Sahar Javadi Novashnagh and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fragile X syndrome (FXS), the most prevalent inherited intellectual disability, is caused by a loss of the fragile X mental retardation protein (FMRP). FXS symptoms manifest early in life. FMRP plays a critical function in adult hippocampal neurogenesis. The development of the DG mainly occurs postnatally. However, the role of FMRP in hippocampal neurogenesis during postnatal development remains unknown. In this study, we used Fmr1-cTag::Nestin-Cre double transgenic mice to map FMRP expression patterns in neural stem progenitor cells (NSPCs) and neurons in the dentate gyrus (DG) during the juvenile and adolescent period. We found that the majority of Sox2 expressing NSPCs in the subgranular zone (SGZ) of the DG does not express GFP-tagged FMRP. On the other hand, post-mitotic NeuN expressing neurons in the DG showed a robust expression of GFP-tagged FMRP. Additionally, we used Fmr1 knockout (KO) mouse to investigate the function of FMRP in the proliferation and neuronal differentiation of hippocampal neural stem and progenitor cells (NSPCs) at different stages of postnatal development in mouse. We found that constitutive FMRP deficiency results in smaller hippocampal NSPC population size in early adolescence. This reduction may not be due to decreased proliferation of NSPCs in Fmr1 KO animals as cell division remained unchanged assessed using both Fmr1 KO and conditional KO (cKO). We showed that constitutive lack of FMRP has no effect on proliferation and neuronal differentiation of hippocampal NSPCs in the early postnatal week, early adolescence, and late adolescence. Therefore, our data FMRP regulates the size NSPCs pool in early adolesce. We have previously shown that impaired adult hippocampal neurogenesis and cognitive deficits in a FXS mouse model are rescued by Nutlin-3 treatment analyzed shortly after treatment. The second part of this study investigated whether the beneficial effect of Nutlin-3 is sustained after a transient administration. We treated 2-month-old young adult FMRP-deficient mice with Nutlin-3 for ten days and then assessed the persistent effect of Nutlin-3 on both cognitive functions and adult neurogenesis when mice were 6-month-old mature adults. We found that transient treatment with Nutlin-3 of 2-month-old young adult FMRP-deficient mice prevents the emergence of neurogenic and cognitive deficits in mature adult FXS mice at 6 months of age. In addition, we investigated the mechanisms underlying the persistent effects of Nutlin-3 by analyzing the proliferation and differentiation of NSPCs isolated from these mice and assessing the transcriptome of the hippocampal tissues of treated mice. We found no evidence of the long-lasting restoration of proliferation and neurogenesis in the isolated adult NSPCs. However, transcriptomic analysis of the hippocampal tissue revealed that transient Nutlin-3 treatment leads to significant expression changes in genes related to the extracellular matrix, secreted factors, and cell membrane proteins in the FMRP-deficient hippocampus. In summary, we report that brief Nutlin-3 treatment may prevent impairment of adult hippocampal neurogenesis-dependent cognitive functions induced by a lack of FMRP expression in FXS.

Patterning and Cell Type Specification in the Developing CNS and PNS

Author :
Publisher : Academic Press
ISBN 13 : 0123973481
Total Pages : 993 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Patterning and Cell Type Specification in the Developing CNS and PNS by :

Download or read book Patterning and Cell Type Specification in the Developing CNS and PNS written by and published by Academic Press. This book was released on 2013-05-06 with total page 993 pages. Available in PDF, EPUB and Kindle. Book excerpt: The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 1 offers 48 high level articles devoted mainly to patterning and cell type specification in the developing central and peripheral nervous systems. Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop Features leading experts in various subfields as Section Editors and article Authors All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship Volume 1 sections include coverage of mechanisms which: control regional specification, regulate proliferation of neuronal progenitors and control differentiation and survival of specific neuronal subtypes, and controlling development of non-neural cells

Fragile X Syndrome

Author : Rob Willemsen
Publisher : Academic Press
ISBN 13 : 0128045078
Total Pages : 500 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Fragile X Syndrome by : Rob Willemsen

Download or read book Fragile X Syndrome written by Rob Willemsen and published by Academic Press. This book was released on 2017-05-26 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fragile X Syndrome: From Genetics to Targeted Treatment provides a structured overview of the molecular and clinical background of the disorder as well as treatment options. The book discusses the detailed molecular information on each of the pathways involved with sufficient details for all whose research touches this pathway. It provides a state-of-the-art update on all clinical aspects associated with this syndrome, including phenotype, diagnostics and epidemiology. It also includes an overview of the lessons learned from the preclinical research and pioneering trials on the fragile X syndrome for the investigators involved in clinical trials of neurodevelopmental disorders. This book is written for academic researchers, pharmaceutical investigators, and clinicians in the field who work on the disorder, and for researchers involved in clinical trials of the fragile X syndrome or related disorders. “This fascinating book, edited by Rob Willemsen and Frank Kooy, summarizes the current knowledge of the molecular aspects of fragile X syndrome (FXS), andthe potential for therapies resulting from this knowledge...Particularly interesting is a review “fragile X research from a parental perspective,” which summarizes the results of an international survey of the attitudes of families with FXS relatives towards research...This book is also an essential reference book for genetic counselors...The book provides counselors with the necessary biological background for proper explanations to the relatives of FXS patients. Many parents acquire a substantial knowledge of the conditions afflicting their children. The book will be helpful for both families and counselors to manage the expectations of families participating in clinical trials...In conclusion, this book is essential for everyone who is involved in the diagnosis and treatment of FXS patients.” - European Journal of Human Genetics (September 2018) Provides a comprehensive overview of the molecular genetics, clinical trials, and treatment of Fragile X Syndrome Written for academic researchers, pharmaceutical investigators, and clinicians in the field Edited by international leaders in the field who have contributed greatly to the study of Fragile X Syndrome Directs the reader through complex issues surrounding FXS and draws the literature together for researchers and clinicians

Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309212219
Total Pages : 74 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System by : Institute of Medicine

Download or read book Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System written by Institute of Medicine and published by National Academies Press. This book was released on 2011-08-05 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.

Fragile-X Syndrome

Author : Dalit Ben-Yosef
Publisher : Humana Press
ISBN 13 : 9781493990795
Total Pages : 192 pages
Book Rating : 4.9/5 (97 download)

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Book Synopsis Fragile-X Syndrome by : Dalit Ben-Yosef

Download or read book Fragile-X Syndrome written by Dalit Ben-Yosef and published by Humana Press. This book was released on 2019-03-08 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume discusses the latest technologies used to study all aspects of Fragile-X Syndrome (FXS). The chapters in this book cover topics such as monitoring for epigenetic modifications at the FMR1 locus; modeling FXS with human pluripotent stem cells, mouse neural progenitors; mouse versus human-based models for FXS pre-clinical research; and Fragile-X associated with Tremor/Ataxia Syndrome (FXTAS). Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Fragile-X Syndrome: Methods and Protocols is a valuable tool to help scientists working towards one day developing a therapeutic solution to improve the symptoms of FXS. Chapter "Induced Neurons for the Study of Neurodegenerative and Neurodevelopmental Disorders" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Adult Neurogenesis in the Hippocampus

Author : Juan J. Canales
Publisher : Academic Press
ISBN 13 : 0128019921
Total Pages : 300 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Adult Neurogenesis in the Hippocampus by : Juan J. Canales

Download or read book Adult Neurogenesis in the Hippocampus written by Juan J. Canales and published by Academic Press. This book was released on 2016-03-23 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurogenesis in the adult brain has emerged as one of the most dynamic and rapidly moving fields in modern neuroscience research. The implications of adult neurogenesis for health and well-being are wide-ranging, with findings in this area having distinct relevance for treatment and rehabilitation in neurology and psychopathology. Adult Neurogenesis in the Hippocampus addresses these implications by providing an up-to-date account on how neurogenesis in the adult hippocampus contributes to critical psychological and physiological processes, such as learning and memory, and how it is modified by life experiences, such as aging, environmental enrichment, exercise, and dieting. The book also provides the most current reviews of how adult hippocampal neurogenesis influences the pathogenesis of mood disorders, addiction, and key neurological disorders. This book is the ideal resource for researchers and advanced graduates seeking focused knowledge on the role of adult neurogenesis in brain health and disease. Provides a unique overview of how adult hippocampal neurogenesis contributes to adaptive processes, brain psychopathology, and disease Includes state-of-the-art reviews by leading world experts in adult neurogenesis

Role of Biomarkers in Medicine

Author : Mu Wang
Publisher : BoD – Books on Demand
ISBN 13 : 9535125052
Total Pages : 262 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Role of Biomarkers in Medicine by : Mu Wang

Download or read book Role of Biomarkers in Medicine written by Mu Wang and published by BoD – Books on Demand. This book was released on 2016-08-17 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of biomarkers in basic and clinical research has become routine in many areas of medicine. They are accepted as molecular signatures that have been well characterized and repeatedly shown to be capable of predicting relevant disease states or clinical outcomes. In Role of Biomarkers in Medicine, expert researchers in their individual field have reviewed many biomarkers or potential biomarkers in various types of diseases. The topics address numerous aspects of medicine, demonstrating the current conceptual status of biomarkers as clinical tools and as surrogate endpoints in clinical research. This book highlights the current state of biomarkers and will aid scientists and clinicians to develop better and more specific biomarkers for disease management.

Epigenetics in Psychiatry

Author : Jacob Peedicayil
Publisher : Academic Press
ISBN 13 : 0128235780
Total Pages : 848 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Epigenetics in Psychiatry by : Jacob Peedicayil

Download or read book Epigenetics in Psychiatry written by Jacob Peedicayil and published by Academic Press. This book was released on 2021-08-21 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth. Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS) Features chapter contributions from international leaders in the field

Novel roles of non-coding brain RNAs in health and disease

Author : Hermona Soreq
Publisher : Frontiers E-books
ISBN 13 : 2889193098
Total Pages : 214 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Novel roles of non-coding brain RNAs in health and disease by : Hermona Soreq

Download or read book Novel roles of non-coding brain RNAs in health and disease written by Hermona Soreq and published by Frontiers E-books. This book was released on 2014-10-23 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-coding RNAs (ncRNAs), and in particular microRNAs are rapidly becoming the focus of research interest in numerous basic and translational fields, including brain research; and their importance for many aspects in brain functioning merits special discussion. The wide-scope, multi-targeted and highly efficient manner of ncRNA regulatory activities draws attention to this topic by many, but the available research and analysis tools and experimental protocols are still at their infancy, and calls for special discussion given their importance for many aspects in brain functioning. This eBook is correspondingly focused on the search for, identification and exploration of those non-coding RNAs whose activities modulate the multi-leveled functions of the eukaryotic brain. The different articles strive to cover novel approaches for identifying and establishing ncRNA-target relationships, provide state of the art reports of the affected neurotransmission pathways, describe inherited and acquired changes in ncRNA functioning and cover the use of ncRNA mimics and blockade tools for interference with their functions in health and disease of the brain. Non-coding RNAs are here to stay, and this exciting eBook provides a glimpse into their impact on our brain’s functioning at the physiology, cell biology, behavior and immune levels.

PI3K signalling

Author : Klaus Okkenhaug
Publisher : Frontiers Media SA
ISBN 13 : 2889194191
Total Pages : 140 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis PI3K signalling by : Klaus Okkenhaug

Download or read book PI3K signalling written by Klaus Okkenhaug and published by Frontiers Media SA. This book was released on 2015-03-05 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: The PI3Ks control many key functions in immune cells. PI3Ks phosphorylate PtdIns(4,5)P2 to yield PtdIns(3,4,5)P3. Initially, PI3K inhibitors such as Wortmannin, LY294002 and Rapamycin were used to establish a central role for Pi3K pathway in immune cells. Considerable progress in understanding the role of this pathway in cells of the immune system has been made in recent years, starting with analysis of various PI3K and Pten knockout mice and subsequently mTOR and Foxo knockout mice. Together, these experiments have revealed how PI3Ks control B cell and T cell development, T helper cell differentiation, regulatory T cell development and function, B cell and T cell trafficking, immunoglobulin class switching and much, much more. The PI3Kd inhibitor idelalisib has recently been approved for the treatment of B cell lymphoma. Clinical trials of other PI3K inhibitors in autoimmune and inflammatory diseases are also in progress. This is an opportune time to consider a Research Topic considering when what we have learned about the PI3K signalling module in lymphocyte biology and how this is making an impact on clinical immunology and haematology.

Towards Mechanism-based Treatments for Fragile X Syndrome

Author : Daman Kumari
Publisher : MDPI
ISBN 13 : 3039215051
Total Pages : 250 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Towards Mechanism-based Treatments for Fragile X Syndrome by : Daman Kumari

Download or read book Towards Mechanism-based Treatments for Fragile X Syndrome written by Daman Kumari and published by MDPI. This book was released on 2019-09-18 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been more than 25 years since the identification of the FMR1 gene and the demonstration of the causative role of CGG-repeat expansion in the disease pathology of fragile X syndrome (FXS), but the underlying mechanisms involved in the expansion mutation and the resulting gene silencing still remain elusive. Our understanding of the pathways impacted by the loss of FMRP function has grown tremendously, and has opened new avenues for targeted treatments for FXS. However, the failure of recent clinical trials that were based on successful preclinical studies using the Fmr1 knockout mouse model has forced the scientific community to revisit clinical trial design and identify objective outcome measures. There has also been a renewed interest in restoring FMR1 gene expression as a possible treatment approach for FXS. This special issue of Brain Sciences highlights the progress that has been made towards understanding the disease mechanisms and how this has informed the development of treatment strategies that are being explored for FXS.

Cognitive Plasticity in Neurologic Disorders

Author : Joseph I. Tracy
Publisher : Oxford University Press, USA
ISBN 13 : 0199965242
Total Pages : 433 pages
Book Rating : 4.1/5 (999 download)

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Book Synopsis Cognitive Plasticity in Neurologic Disorders by : Joseph I. Tracy

Download or read book Cognitive Plasticity in Neurologic Disorders written by Joseph I. Tracy and published by Oxford University Press, USA. This book was released on 2014-12-02 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume makes clear that the cognitive and behavioural symptoms of neurologic disorders and syndromes are dynamic and changing. Each chapter describes the neuroplastic processes at work in a particular condition, giving rise to these ongoing cognitive changes.

The Oxford Handbook of Neuronal Protein Synthesis

Author : Wayne S. Sossin
Publisher : Oxford University Press
ISBN 13 : 0190686324
Total Pages : 512 pages
Book Rating : 4.1/5 (96 download)

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Book Synopsis The Oxford Handbook of Neuronal Protein Synthesis by : Wayne S. Sossin

Download or read book The Oxford Handbook of Neuronal Protein Synthesis written by Wayne S. Sossin and published by Oxford University Press. This book was released on 2021-04-15 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational control in the nervous system is important. Many physiological processes in the nervous system depend on accurate control of the proteome that is mediated through protein synthetic mechanisms and thus, the nervous system is very sensitive to dysregulation of translational control. The Oxford Handbook of Neuronal Protein Synthesis reviews the mechanisms of translational control used by the nervous system, as well as how important nervous system functions, such as plasticity and homeostasis, depend on accurate translational control. The handbook extensively covers how dysregulation of protein synthesis can manifest itself in many distinct pathological processes including neurodevelopmental, neuropsychiatric, and neurodegenerative diseases. The handbook is comprehensive in its coverage of translational control mechanisms with particular focus on how these general control mechanisms are specifically utilized in the context of the cell biological constraints of the nervous system from both a mechanistic and systems perspective.

Jasper's Basic Mechanisms of the Epilepsies

Author : Jeffrey Noebels
Publisher : OUP USA
ISBN 13 : 0199746540
Total Pages : 1258 pages
Book Rating : 4.1/5 (997 download)

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Book Synopsis Jasper's Basic Mechanisms of the Epilepsies by : Jeffrey Noebels

Download or read book Jasper's Basic Mechanisms of the Epilepsies written by Jeffrey Noebels and published by OUP USA. This book was released on 2012-06-29 with total page 1258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.

Genome Editing in Neurosciences

Author : Rudolf Jaenisch
Publisher :
ISBN 13 : 9781013268564
Total Pages : 128 pages
Book Rating : 4.2/5 (685 download)

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Book Synopsis Genome Editing in Neurosciences by : Rudolf Jaenisch

Download or read book Genome Editing in Neurosciences written by Rudolf Jaenisch and published by . This book was released on 2020-10-08 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Innovations in molecular biology are allowing neuroscientists to study the brain with unprecedented resolution, from the level of single molecules to integrated gene circuits. Chief among these innovations is the CRISPR-Cas genome editing technology, which has the precision and scalability to tackle the complexity of the brain. This Colloque Médecine et Recherche has brought together experts from around the world that are applying genome editing to address important challenges in neuroscience, including basic biology in model organisms that has the power to reveal systems-level insight into how the nervous system develops and functions as well as research focused on understanding and treating human neurological disorders. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.