Novel Agents Inhibiting Hepatitis C Virus

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Novel Agents Inhibiting Hepatitis C Virus

Author : Daire T. O'Shea
Publisher :
ISBN 13 :
Total Pages : 103 pages
Book Rating : 4.:/5 (871 download)

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Book Synopsis Novel Agents Inhibiting Hepatitis C Virus by : Daire T. O'Shea

Download or read book Novel Agents Inhibiting Hepatitis C Virus written by Daire T. O'Shea and published by . This book was released on 2013 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recurrent Hepatitis C virus infection drives inferior outcomes experienced by patients undergoing liver transplantation due to HCV-associated liver disease. Existing therapies exhibit increased toxicity, poor efficacy, and profound patient intolerability in the immediate transplantation period. Liver transplantation provides a window of opportunity to prevent re-infection of the allograft and drastically improve patients' post-transplant outcomes. The anti-HCV activity of novel monoclonal antibodies(AR4a) and herbal extracts (Epigallocatechin-gallate, Silibinin) were studied in-vitro using HCV cell culture system and in-vivo using a humanized liver mouse model capable of supporting HCV replication. Alone these agents exhibit reliable cross-genotype HCV inhibition in-vitro. Combination therapy can completely prevent HCV infection. In-vivo EGCG alone fails to reliably protect against HCV-genotype1a challenge. AR4a alone and combined with EGCG robustly protects against the establishment of HCV infection. In common these agents have low toxicity potential and are thus applicable for use in complex transplant cohorts to prophylax against HCV re-infection.

Hepatitis C Virus Treatment

Author : Kazuaki Chayama
Publisher : Springer
ISBN 13 : 9811024162
Total Pages : 80 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Hepatitis C Virus Treatment by : Kazuaki Chayama

Download or read book Hepatitis C Virus Treatment written by Kazuaki Chayama and published by Springer. This book was released on 2016-11-01 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces readers to Direct Acting Antiviral (DAAs) agents, newly developed drugs to treat chronic hepatitis C virus infection, which have an excellent anti-viral effect on virus replication. These drugs have been developed to enhance the effect of interferon and ribavirin, as the resistant strains against each drug have been described both in vitro and in vivo and the existences of naturally occurring variants have been reported. However, since the combination of different classes of DAAs is sufficient to completely eradicate the virus without the need for interferon or ribavirin, the current treatment regimen does not include interferon. Ribavirin is used in combination with sofosbuvir, a potent polymerase inhibitor, to enhance its antiviral effects. Hepatitis C Virus Treatment offers readers a comprehensive guide to hepatitis C; describing the resistance profiles against these drugs and shedding light on the difficulties involved in DAA therapy and the direction of future treatments, it will equip doctors to understand the essentials of treating the disease. It also describes in detail new and innovative DAA treatments, the effects of the agents, and the characteristics of resistance, providing cutting-edge information not only for hepatologists, but also for researchers, clinical residents, and medical students.

Antiviral Agents

Author : Erik De Clercq
Publisher : Academic Press
ISBN 13 : 0124055370
Total Pages : 384 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Antiviral Agents by : Erik De Clercq

Download or read book Antiviral Agents written by Erik De Clercq and published by Academic Press. This book was released on 2013-07-22 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Advances in Pharmacology explores the current state of antiviral agents. Chapters cover such topics as virus entry inhibitors, interferon-free drug combinations, and antiviral agents for HSV. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike. Explores the current state of anti-viral agents Chapters cover a variety of topics such as virus entry inhibitors, interferon-free drug combinations, and antiviral agents for HSV With the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike

Chronic Hepatitis C Virus

Author : Mitchell L. Shiffman
Publisher : Springer Science & Business Media
ISBN 13 : 1461411920
Total Pages : 333 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Chronic Hepatitis C Virus by : Mitchell L. Shiffman

Download or read book Chronic Hepatitis C Virus written by Mitchell L. Shiffman and published by Springer Science & Business Media. This book was released on 2011-11-17 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future documents the monumental advances that have been made in our understanding of chronic HCV during the past decade. The first section reviews the natural history of chronic HCV, how this virus can affect other organs in addition to the liver, and whether treating chronic HCV alters the natural history of this disease. Section 2 reviews the advances that have been made in the treatment of chronic HCV during the past decade with interferon based therapy. Separate chapters on response guided therapy and how to manage the adverse events associated with these medications provide the physician with the concepts required to more effectively treat chronic HCV now and in the future. As the genetics of virologic response have recently been elucidated, a chapter is devoted to helping the clinician understand how genes that modulate disease processes and their treatment are identified and utilized in clinical care. Section 3 deals with the future of HCV treatment and specific inhibitors of HCV. Specific chapters explain how targets for drugs are identified and how drugs are then developed and tested; how mutations of HCV develop and how anti-viral agents will affect this process; the most up to date data regarding the treatment of chronic HCV with peginterferon, ribavirin and anti-viral agents; and the potential to treat chronic HCV with just oral anti-viral agents and without peginterferon and ribavirin in the future. The final section of this book covers issues related to liver transplantation in patients with chronic HCV. Separate chapters review the natural history of chronic HCV in liver transplant recipients and the impact of utilizing HCV positive donors. The volume concludes with chapters that cover the treatment of chronic HCV both prior to and after liver transplantation with potent anti-viral agents. Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future is a valuable resource for all physicians caring for patients with chronic HCV.

Novel Inhibitors of the Hepatitis C Virus

Author : Daniel Cameron Talley
Publisher :
ISBN 13 :
Total Pages : 294 pages
Book Rating : 4.:/5 (971 download)

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Book Synopsis Novel Inhibitors of the Hepatitis C Virus by : Daniel Cameron Talley

Download or read book Novel Inhibitors of the Hepatitis C Virus written by Daniel Cameron Talley and published by . This book was released on 2016 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several analogs of the natural product UK-1 have been identified as potent inhibitors of hepatitis C virus (HCV) replication in a replicon assay. One set of inhibitors has been shown to inhibit the HCV non-structural protein 3 helicase (NS3h), while another acts via an unknown cellular target. Efforts have been focused on (1) identifying the inhibitor binding pocket within the NS3 helicase and (2) exploring the possible role zinc binding may play in the inhibitory mode of action of the latter.

Studies on Hepatitis Viruses

Author : Satya Prakash Gupta
Publisher : Academic Press
ISBN 13 : 0128133317
Total Pages : 244 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Studies on Hepatitis Viruses by : Satya Prakash Gupta

Download or read book Studies on Hepatitis Viruses written by Satya Prakash Gupta and published by Academic Press. This book was released on 2018-06-20 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies on Hepatitis Viruses: Life Cycle, Structure, Functions, and Inhibition presents the latest on this systemic infection that predominantly affects the liver with inflammation that can be acute or chronic. Hepatitis viruses have been the subject of intense study in the last twenty years, with a wealth of information related to their lifecycle, structure, functions and inhibition being presented. This book compiles the most important developments and research, giving users a very useful guide on this evolving area of virology and medicinal chemistry. Provides comprehensive, state-of-the-art coverage of hepatitis virus infections, the virus' lifecycle, and mechanisms of protease inhibition Analyzes structure-activity relationships of inhibitors of viral hepatitis Presents an in-depth view of the structure and function of viral hepatitis Discusses classification, epidemiology, pathogenesis, natural history, clinical manifestations, diagnosis, complications, associated disorders and animal models

Viral Proteases and Their Inhibitors

Author : Satya Prakash Gupta
Publisher : Academic Press
ISBN 13 : 0128096829
Total Pages : 518 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Viral Proteases and Their Inhibitors by : Satya Prakash Gupta

Download or read book Viral Proteases and Their Inhibitors written by Satya Prakash Gupta and published by Academic Press. This book was released on 2017-07-03 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents. Provides comprehensive, state-of-the-art coverage of virus infections, the virus lifecycle, and mechanisms of protease inhibition Analyzes structure-activity relationships of inhibitors of each viral protease Presents an in-depth view of the structure and function of viral proteases

Hepatitis Prevention and Treatment

Author : Joseph M. Colacino
Publisher : Birkhäuser
ISBN 13 : 3034879032
Total Pages : 250 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Hepatitis Prevention and Treatment by : Joseph M. Colacino

Download or read book Hepatitis Prevention and Treatment written by Joseph M. Colacino and published by Birkhäuser. This book was released on 2012-12-06 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic viral hepatitis has emerged as one of the most common causes of disease and death worldwide. Because of their unique modes of replication and intimate association with the host immune system, hepatitis B virus (HBV) and hepatitis C virus (HCV) pose challenging problems to scientists in basic and applied research as well as to clinicians engaged in disease management. Although approved antiviral therapy is available for chronic HBV, the emergence of viral resistance provides a rationale for the development of novel chemotherapeutic agents. The lack of a robust cell culture system for HCV replication and a readily accessible small-animal model of HCV infection have hampered the development of antiviral agents for HCV. Neverthe-less, new antiviral agents targeting HCV are now in preclinical and clinical development. This monograph, providing an up-to-date overview of the field of Hepatitis Prevention and Treatment, includes contributions from internationally recognized experts in the field of viral hepatitis, and covers the current state of knowledge and practice regarding the molecular biology, immunology, biochemistry, pharmacology and clinical aspects of chronic HBV and HCV infection. The volume includes salient topics such as: the history and epidemiology of HBV and HCV; recent insights into the molecular mechanisms of viral replication; the host immune response to infection and a discussion of the use (HBV) or potential development (HCV) of vaccines; the current standard of care for chronically-infected patients; and emerging therapies and issues associated with current antiviral treatments. The latest information to researchers and clinicians actively engaged in viral hepatitis research is provided, but also sufficient background and discussion of the literature to benefit the newcomer to the field.

Successful Strategies for the Discovery of Antiviral Drugs

Author : Manoj C. Desai
Publisher : Royal Society of Chemistry
ISBN 13 : 184973657X
Total Pages : 551 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Successful Strategies for the Discovery of Antiviral Drugs by : Manoj C. Desai

Download or read book Successful Strategies for the Discovery of Antiviral Drugs written by Manoj C. Desai and published by Royal Society of Chemistry. This book was released on 2013 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will be aimed at medicinal chemistry and emerging drug discovery scientists.

Novel Inhibitors of the Hepatitis C Virus NS3 Helicase and Mechanism of Action

Author : Craig A. Belon
Publisher :
ISBN 13 :
Total Pages : 299 pages
Book Rating : 4.:/5 (815 download)

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Book Synopsis Novel Inhibitors of the Hepatitis C Virus NS3 Helicase and Mechanism of Action by : Craig A. Belon

Download or read book Novel Inhibitors of the Hepatitis C Virus NS3 Helicase and Mechanism of Action written by Craig A. Belon and published by . This book was released on 2010 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advances in Treatment of Hepatitis C and B

Author : Naglaa Allam
Publisher : BoD – Books on Demand
ISBN 13 : 9535129937
Total Pages : 408 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Advances in Treatment of Hepatitis C and B by : Naglaa Allam

Download or read book Advances in Treatment of Hepatitis C and B written by Naglaa Allam and published by BoD – Books on Demand. This book was released on 2017-03-08 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: As in many areas of medicine, treatment of viral hepatitis has seen an acceleration of change driven by new therapies and evolving technology. Thanks to the direct-acting antiviral agents (DAAs), the era of HCV eradication and cure has begun. As regards to hepatitis B therapy, potent antiviral drugs for suppression of viral replication are available, new research activities to enhance eradication are visible, and these may influence clinical practice in the coming years. This book covers the latest advances in hepatitis C and hepatitis B therapeutics as well as the emerging and investigational treatment strategies. "Advances in Treatment of Hepatitis C and Hepatitis B" book is an up-to-date source of information for physicians, residents, and advanced medical students seeking a broader understanding of treatment of viral hepatitis. The authors of the chapters come from many eminent centers around the world and are experts in their respective fields.

Novel Therapies in Hepatitis C Virus, an Issue of Clinics in Liver Disease

Author : Paul J. Pockros
Publisher : Saunders
ISBN 13 : 9781437712360
Total Pages : 0 pages
Book Rating : 4.7/5 (123 download)

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Book Synopsis Novel Therapies in Hepatitis C Virus, an Issue of Clinics in Liver Disease by : Paul J. Pockros

Download or read book Novel Therapies in Hepatitis C Virus, an Issue of Clinics in Liver Disease written by Paul J. Pockros and published by Saunders. This book was released on 2009-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Guest Editor presents state-of-the-art articles devoted to therapies for treatment of HCV. The novel therapies addressed in this issue include interferons, viral kinetics and anti-viral resistence, anti-fibrotics, immunotherapeutics, hepatoprotectants and caspace inhibitors, and cyclosporine analogues, to name a few.

HCV: The Journey from Discovery to a Cure

Author : Michael J. Sofia
Publisher : Springer Nature
ISBN 13 : 3030282074
Total Pages : 457 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis HCV: The Journey from Discovery to a Cure by : Michael J. Sofia

Download or read book HCV: The Journey from Discovery to a Cure written by Michael J. Sofia and published by Springer Nature. This book was released on 2019-11-23 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatitis C is a liver disease caused by the hepatitis C virus (HCV) and infects approximately 75 million individuals worldwide. It is also one of the major causes of liver cancer and liver transplants. The elucidation of the HCV genome, and the development of a whole cell system to study the virus spurred the search for novel direct acting antiviral drugs to cure this disease. This global effort culminated in the development of direct acting antiviral drugs that led to cure rates approaching 100% in all patient populations after only 8-12 weeks of therapy. These efforts resulted in one of the greatest achievements in public health and provides the potential for eliminating HCV as a major disease worldwide. This volume is aimed at a broad audience of academic and industrial scientists interested in the discovery and development of drugs to treat viral diseases and those interested in reading about one of the most unique accomplishments in biomedical research. The volume will provide a one of a kind reference work that highlights the many efforts, from the discovery of the HCV virus, to the invention of breakthrough medicines and their use in the real world to cure patients. It is the companion book to the volume "HCV: The Journey from Discovery to a Cure - Volume II".

The Liver

Author : Irwin M. Arias
Publisher : John Wiley & Sons
ISBN 13 : 1119436826
Total Pages : 1156 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis The Liver by : Irwin M. Arias

Download or read book The Liver written by Irwin M. Arias and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.

Chronic Hepatitis C Virus

Author : Mitchell L. Shiffman
Publisher : Springer
ISBN 13 : 9781461411932
Total Pages : 332 pages
Book Rating : 4.4/5 (119 download)

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Book Synopsis Chronic Hepatitis C Virus by : Mitchell L. Shiffman

Download or read book Chronic Hepatitis C Virus written by Mitchell L. Shiffman and published by Springer. This book was released on 2012-02-10 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future documents the monumental advances that have been made in our understanding of chronic HCV during the past decade. The first section reviews the natural history of chronic HCV, how this virus can affect other organs in addition to the liver, and whether treating chronic HCV alters the natural history of this disease. Section 2 reviews the advances that have been made in the treatment of chronic HCV during the past decade with interferon based therapy. Separate chapters on response guided therapy and how to manage the adverse events associated with these medications provide the physician with the concepts required to more effectively treat chronic HCV now and in the future. As the genetics of virologic response have recently been elucidated, a chapter is devoted to helping the clinician understand how genes that modulate disease processes and their treatment are identified and utilized in clinical care. Section 3 deals with the future of HCV treatment and specific inhibitors of HCV. Specific chapters explain how targets for drugs are identified and how drugs are then developed and tested; how mutations of HCV develop and how anti-viral agents will affect this process; the most up to date data regarding the treatment of chronic HCV with peginterferon, ribavirin and anti-viral agents; and the potential to treat chronic HCV with just oral anti-viral agents and without peginterferon and ribavirin in the future. The final section of this book covers issues related to liver transplantation in patients with chronic HCV. Separate chapters review the natural history of chronic HCV in liver transplant recipients and the impact of utilizing HCV positive donors. The volume concludes with chapters that cover the treatment of chronic HCV both prior to and after liver transplantation with potent anti-viral agents. Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future is a valuable resource for all physicians caring for patients with chronic HCV.

New Drug Development for Known and Emerging Viruses

Author : Helga Rübsamen-Schaeff
Publisher : John Wiley & Sons
ISBN 13 : 3527810706
Total Pages : 530 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis New Drug Development for Known and Emerging Viruses by : Helga Rübsamen-Schaeff

Download or read book New Drug Development for Known and Emerging Viruses written by Helga Rübsamen-Schaeff and published by John Wiley & Sons. This book was released on 2021-11-30 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses how to fight Ebola, SARS Corona, and other known or emerging human viruses by building on the successes in antiviral therapy of the past decades Written by leading medicinal chemists from academia and industry, this book discusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antiviral drugs, targets, and viral disease mechanisms. It provides an outlook on emerging pathogens such as Ebola, Zika, West Nile, Lassa, and includes a chapter on SARS Coronoavirus-2 causing the present pandemic. New Drug Development for Known and Emerging Viruses describes the discovery and development process for antiviral agents for different classes of viruses and targets based on the experiences from the nine human viruses for which approved drugs are on the market (HIV, HCV, Influenza, RSV, HBV, HPV, HCMV, HSV, and VZV). It covers the properties and potential of 20 classes of currently approved antivirals, including combination drugs, and looks at novel antiviral strategies against emerging viruses. Covers the entire field of antiviral drug discovery and development Addresses the need for antiviral drugs to combat major health threats such as Ebola, Zika, West Nile, and SARS Coronavirus-2 Summarizes the successes of the past 15 years in developing ground-breaking medicines against 9 major human viruses, both from the medicinal chemistry and the pharmacological angle Discusses practical and strategic challenges in the drug discovery and development process, including screening technologies, latency, and toxicity issues New Developments in Antiviral Drugs is an important book for medicinal chemists, pharmaceutical chemists, virologists, and epidemiologists, and will be of great interest to those in the ;pharmaceutical industry and public health agencies.

Hepatitis C Virus: New Insights for the Healthcare Professional: 2012 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464970319
Total Pages : 293 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Hepatitis C Virus: New Insights for the Healthcare Professional: 2012 Edition by :

Download or read book Hepatitis C Virus: New Insights for the Healthcare Professional: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-10 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatitis C Virus: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Hepatitis C Virus. The editors have built Hepatitis C Virus: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Hepatitis C Virus in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Hepatitis C Virus: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.