Viral Proteases And Their Inhibitors

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Viral Proteases and Their Inhibitors

Author : Satya Prakash Gupta
Publisher : Academic Press
ISBN 13 : 0128096829
Total Pages : 516 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Viral Proteases and Their Inhibitors by : Satya Prakash Gupta

Download or read book Viral Proteases and Their Inhibitors written by Satya Prakash Gupta and published by Academic Press. This book was released on 2017-07-03 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents. Provides comprehensive, state-of-the-art coverage of virus infections, the virus lifecycle, and mechanisms of protease inhibition Analyzes structure-activity relationships of inhibitors of each viral protease Presents an in-depth view of the structure and function of viral proteases

Retroviral Proteases

Author : Lawrence C. Kuo
Publisher : Gulf Professional Publishing
ISBN 13 : 9780121821425
Total Pages : 494 pages
Book Rating : 4.8/5 (214 download)

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Book Synopsis Retroviral Proteases by : Lawrence C. Kuo

Download or read book Retroviral Proteases written by Lawrence C. Kuo and published by Gulf Professional Publishing. This book was released on 1994-09-22 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods included in this volume apply to the expression and characterization of retroviral proteases and their inhibitor/substrate design.

Viral Proteases and Antiviral Protease Inhibitor Therapy

Author : Uwe Lendeckel
Publisher : Springer Science & Business Media
ISBN 13 : 9048123488
Total Pages : 139 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Viral Proteases and Antiviral Protease Inhibitor Therapy by : Uwe Lendeckel

Download or read book Viral Proteases and Antiviral Protease Inhibitor Therapy written by Uwe Lendeckel and published by Springer Science & Business Media. This book was released on 2009-06-19 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 8th volume in the Proteases in Biology and Disease series focuses on the role of proteases in virus function and their potential as anti-viral targets. Viral infections are still difficult to threat and some remained life-threatening diseases in spite of antiviral drug research over decades. Proteases are still regarded as an Achilles’ heel of the pathogens and, thus, protease inhibitors may help to handle the known and the emerging viral threads. The book discusses viral proteases of the most important pathogenic viruses, responsible for severe diseases: AIDS, SARS, Hepatitis, Cytomegalovirus, T-cell lymphotropic virus, Picornavirus. This book focuses specifically on the viral proteases, crucial prerequisites for viral entry into cells and viral replication. Viral proteases represent an important pharmaceutical target. The current stage of protease inhibitor development and therapy are summarised and discussed by experts in the field. This volume represents a timely and valuable continuation of the Proteases in Biology and Disease series. The reader will learn the potential for proteases as targets for effective anti-virals. This book will be a valuable source of information on viral proteases and provoke further research in this important field.

Viral Replication Enzymes and their Inhibitors Part A

Author :
Publisher : Academic Press
ISBN 13 : 0128234695
Total Pages : 370 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Viral Replication Enzymes and their Inhibitors Part A by :

Download or read book Viral Replication Enzymes and their Inhibitors Part A written by and published by Academic Press. This book was released on 2021-10-23 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viral Replication Enzymes and their Inhibitors Part A, Volume 49, the latest release in the Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of related topics. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in The Enzymes series

Encyclopedia of Molecular Pharmacology

Author : Stefan Offermanns
Publisher : Springer Science & Business Media
ISBN 13 : 3540389164
Total Pages : 1515 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Encyclopedia of Molecular Pharmacology by : Stefan Offermanns

Download or read book Encyclopedia of Molecular Pharmacology written by Stefan Offermanns and published by Springer Science & Business Media. This book was released on 2008-08-14 with total page 1515 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.

Antiviral Strategies

Author : Hans-Georg Kräusslich
Publisher : Springer Science & Business Media
ISBN 13 : 3540790861
Total Pages : 386 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Antiviral Strategies by : Hans-Georg Kräusslich

Download or read book Antiviral Strategies written by Hans-Georg Kräusslich and published by Springer Science & Business Media. This book was released on 2008-12-02 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: A crucial issue for antiviral therapy is the fact that all antiviral substances rapidly select for resistance; thus, monitoring and overcoming resistance has become a most important clinical paradigm of antiviral therapy. This calls for cautious use of antiviral drugs and implementation of combination therapies. In parallel, efforts in drug discovery have to be continued to develop compounds with novel mode-of-action and activity against resistant strains. This book reviews the current status of antiviral therapy, from the roads to development of new compounds to their clinical use and cost effectiveness. Individual chapters address in more detail all available drug classes and outline new approaches currently under development.

Activation of Viruses by Host Proteases

Author : Eva Böttcher-Friebertshäuser
Publisher : Springer
ISBN 13 : 9783319754734
Total Pages : 0 pages
Book Rating : 4.7/5 (547 download)

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Book Synopsis Activation of Viruses by Host Proteases by : Eva Böttcher-Friebertshäuser

Download or read book Activation of Viruses by Host Proteases written by Eva Böttcher-Friebertshäuser and published by Springer. This book was released on 2018-05-31 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will give an overview on viruses undergoing proteolytic activation through host proteases. The chapters will be organized in three themed parts, the first part describing respective viruses and their characteristics in detail. In the second part the molecular and cellular biology of the proteases involved as well as their physiological functions will be further explored. The third part will contain a chapter on protease inhibitors that are promising tools for antiviral therapy. This book will engage scholars in virology and medical microbiology as well as researchers with an interest in enzymology and protein structure and function relationship.

Viral Proteases and Antiviral Protease Inhibitor Therapy

Author : Uwe Lendeckel
Publisher : Springer
ISBN 13 : 9789048123759
Total Pages : 132 pages
Book Rating : 4.1/5 (237 download)

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Book Synopsis Viral Proteases and Antiviral Protease Inhibitor Therapy by : Uwe Lendeckel

Download or read book Viral Proteases and Antiviral Protease Inhibitor Therapy written by Uwe Lendeckel and published by Springer. This book was released on 2009-08-29 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 8th volume in the Proteases in Biology and Disease series focuses on the role of proteases in virus function and their potential as anti-viral targets. Viral infections are still difficult to threat and some remained life-threatening diseases in spite of antiviral drug research over decades. Proteases are still regarded as an Achilles’ heel of the pathogens and, thus, protease inhibitors may help to handle the known and the emerging viral threads. The book discusses viral proteases of the most important pathogenic viruses, responsible for severe diseases: AIDS, SARS, Hepatitis, Cytomegalovirus, T-cell lymphotropic virus, Picornavirus. This book focuses specifically on the viral proteases, crucial prerequisites for viral entry into cells and viral replication. Viral proteases represent an important pharmaceutical target. The current stage of protease inhibitor development and therapy are summarised and discussed by experts in the field. This volume represents a timely and valuable continuation of the Proteases in Biology and Disease series. The reader will learn the potential for proteases as targets for effective anti-virals. This book will be a valuable source of information on viral proteases and provoke further research in this important field.

Handbook of Antimicrobial Resistance

Author : Matthias Gotte
Publisher : Springer
ISBN 13 : 9781493906932
Total Pages : 0 pages
Book Rating : 4.9/5 (69 download)

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Book Synopsis Handbook of Antimicrobial Resistance by : Matthias Gotte

Download or read book Handbook of Antimicrobial Resistance written by Matthias Gotte and published by Springer. This book was released on 2018-02-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: While many volumes have been written about various aspects of antimicrobial resistance, this book is a comprehensive reference work. All manifestations of resistance are addressed: viral; bacterial, parasitical and fungal are given dedicated sections. The underlining molecular mechanisms, which depend not only on the microbe but on the specific drug (target), are highly diverse. This work discusses and compares the biological, biochemical and structural aspects of resistance and its evolution.

Mechanisms of Catalysis

Author :
Publisher : Academic Press
ISBN 13 : 9780080865966
Total Pages : 459 pages
Book Rating : 4.8/5 (659 download)

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Book Synopsis Mechanisms of Catalysis by :

Download or read book Mechanisms of Catalysis written by and published by Academic Press. This book was released on 1991-01-28 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: The remarkable expansion of information leading to a deeper understanding of enzymes on the molecular level necessitated the development of this volume which not only introduces new topics to The Enzymes series but presents new information on some covered in Volume I and II of this edition.

Cancer-Leading Proteases

Author : Satya Prakash Gupta
Publisher : Academic Press
ISBN 13 : 0128181680
Total Pages : 524 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Cancer-Leading Proteases by : Satya Prakash Gupta

Download or read book Cancer-Leading Proteases written by Satya Prakash Gupta and published by Academic Press. This book was released on 2020-02-03 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating to how these proteases can be exploited to find useful chemotherapeutics to fight cancers. In addition, the book encompasses the experimental and theoretical aspects of anticancer drug design based on proteases. It is a useful resource for pharmaceutical scientists, medicinal chemists, biochemists, microbiologists, and cancer researchers working on proteases. Explains the role of proteases in the biology of cancer Discusses how proteases can be used as potential drug targets or as diagnostic and prognostic biomarkers Covers a wide range of cancers and provides detailed discussions on protease examples

Proteases in Human Diseases

Author : Sajal Chakraborti
Publisher : Springer
ISBN 13 : 9811031622
Total Pages : 513 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Proteases in Human Diseases by : Sajal Chakraborti

Download or read book Proteases in Human Diseases written by Sajal Chakraborti and published by Springer. This book was released on 2017-07-13 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems in different diseases. Several established investigators have elucidated the crucial role of proteases in biological processes, including how proteolytic function and regulation can be combined to develop new strategies of therapeutic interventions. Proteases form one of the largest and most diverse families of enzymes known. It is now clear that proteases are involved in every aspect of life functions of an organism. Under physiological conditions, proteases are regulated by their endogenous inhibitors; however, when the activity of proteases is not regulated appropriately, disease processes can result in. So, there is absolute need for a stringent control of proteolytic activities in cells and tissues. Dysregulation of proteases may cause derangement of cellular signalling network resulting in different pathophysiological conditions such as vascular remodelling, atherosclerotic plaque progression, ulcer and rheumatoid arthritis, Alzheimer disease, cancer metastasis, tumor progression and inflammation. Additionally, many infective microorganisms require proteases for replication or use proteases as virulence factors, which have facilitated the development of protease-targeted therapies for a variety of parasitic diseases.

Human Herpesviruses

Author : Ann Arvin
Publisher : Cambridge University Press
ISBN 13 : 1139461648
Total Pages : 1325 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Human Herpesviruses by : Ann Arvin

Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Antimicrobial Drug Resistance

Author : Douglas L. Mayers
Publisher : Springer
ISBN 13 : 3319467182
Total Pages : 773 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Antimicrobial Drug Resistance by : Douglas L. Mayers

Download or read book Antimicrobial Drug Resistance written by Douglas L. Mayers and published by Springer. This book was released on 2017-06-19 with total page 773 pages. Available in PDF, EPUB and Kindle. Book excerpt: The two volumes included in Antimicrobial Drug Resistance, Second Edition is an updated, comprehensive and multidisciplinary reference covering the area of antimicrobial drug resistance in bacteria, fungi, viruses, and parasites from basic science, clinical, and epidemiological perspectives. This newly revised compendium reviews the most current research and development on drug resistance while still providing the information in the accessible format of the first edition. The first volume, Antimicrobial Drug Resistance: Mechanisms of Drug Resistance, is dedicated to the biological basis of drug resistance and effective avenues for drug development. With the emergence of more drug-resistant organisms, the approach to dealing with the drug resistance problem must include the research of different aspects of the mechanisms of bacterial resistance and the dissemination of resistance genes as well as research utilizing new genomic information. These approaches will permit the design of novel strategies to develop new antibiotics and preserve the effectiveness of those currently available. The second volume, Antimicrobial Drug Resistance: Clinical and Epidemiological Aspects, is devoted to the clinical aspects of drug resistance. Although there is evidence that restricted use of a specific antibiotic can be followed by a decrease in drug resistance to that agent, drug resistance control is not easily achieved. Thus, the infectious diseases physician requires input from the clinical microbiologist, antimicrobial stewardship personnel, and infection control specialist to make informed choices for the effective management of various strains of drug-resistant pathogens in individual patients. This 2-volume set is an important reference for students in microbiology, infectious diseases physicians, medical students, basic scientists, drug development researchers, microbiologists, epidemiologists, and public health practitioners.

Biological Functions of Proteases and Inhibitors

Author : Nobuhiko Katunuma
Publisher :
ISBN 13 :
Total Pages : 294 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Biological Functions of Proteases and Inhibitors by : Nobuhiko Katunuma

Download or read book Biological Functions of Proteases and Inhibitors written by Nobuhiko Katunuma and published by . This book was released on 1994 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Successful Strategies for the Discovery of Antiviral Drugs

Author : Manoj C. Desai
Publisher : Royal Society of Chemistry
ISBN 13 : 1849737819
Total Pages : 544 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Successful Strategies for the Discovery of Antiviral Drugs by : Manoj C. Desai

Download or read book Successful Strategies for the Discovery of Antiviral Drugs written by Manoj C. Desai and published by Royal Society of Chemistry. This book was released on 2013-06-17 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: The antiviral therapeutic area continues to rapidly generate meaningful new chemical entities; for example, for HIV alone more than 25 drugs have been approved, and in the next few years many individual drugs and single tablet regimens will be approved for the treatment of hepatitis C virus infection. The increasing success in the antiviral area could be due to targeting drugs at "non-self" genomes and to the patient population that is tolerant of manageable side effects and adaptable to inconvenient dosing. Aimed at medicinal chemists and emerging drug discovery scientists, the book is organized according to the various strategies deployed for the discovery and optimization of initial lead compounds. This book focuses on capturing tactical aspects of problem solving in antiviral drug design, an approach that holds special appeal for those engaged in antiviral drug development, but also appeals to the broader medicinal chemistry community based on its focus on tactical aspects of drug design.

Drug Design

Author : Gerhard Klebe
Publisher : Springer
ISBN 13 : 9783642179068
Total Pages : 0 pages
Book Rating : 4.1/5 (79 download)

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Book Synopsis Drug Design by : Gerhard Klebe

Download or read book Drug Design written by Gerhard Klebe and published by Springer. This book was released on 2013-07-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unique work on structure-based drug design, covering multiple aspects of drug discovery and development. Fully colored, many images, computer animations of 3D structures (these only in electronic form). Makes the spatial aspects of interacting molecules clear to the reader, covers multiple applications and methods in drug design. Structures by mode of action, no therapeutic areas. Of high relevance for academia and industrial research. Focus on gene technology in drug design, omics-technologies computational methods experimental techniques of structure determination multiple examples on mode of action of current drugs, ADME-tox properties in drug development, QSAR methods, combinatorial chemistry, biologicals, ribosome, targeting protein-protein interfaces.