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Author : Bertrand Kaeffer
Publisher : Frontiers Media SA
ISBN 13 : 2832510361
Total Pages : 203 pages
Book Rating : 4.8/5 (325 download)
Download or read book Non-coding RNA in immunotherapies and immune regulation written by Bertrand Kaeffer and published by Frontiers Media SA. This book was released on 2023-01-02 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Adam Williams
Publisher : Frontiers Media SA
ISBN 13 : 2889669173
Total Pages : 68 pages
Book Rating : 4.8/5 (896 download)
Download or read book Long Non-Coding RNAs and Immunity written by Adam Williams and published by Frontiers Media SA. This book was released on 2021-06-29 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt: We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.
Author : Yanyan Tang
Publisher : Frontiers Media SA
ISBN 13 : 2889769577
Total Pages : 446 pages
Book Rating : 4.8/5 (897 download)
Download or read book The Role of ncRNAs (non-coding RNAs) in Regulating Tumor Immune Microenvironment written by Yanyan Tang and published by Frontiers Media SA. This book was released on 2022-09-14 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Shuai Jiang
Publisher : Academic Press
ISBN 13 : 9780323855044
Total Pages : 316 pages
Book Rating : 4.8/5 (55 download)
Download or read book Advances in Non-coding RNAs in Cancer-Biology and Immunology written by Shuai Jiang and published by Academic Press. This book was released on 2022-05-15 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Non-coding RNAs in Cancer-Biology and Immunology is a resource for three major types of non-coding RNAs including microRNA, LnRNA and piRNA. It covers machinery of non-coding RNAs, including microRNA, LnRNA and piRNA, and the identification of targets of these non-coding RNAs, and the identification of physiological and pathological roles of miRNAs, LnRNAs and piRNAs in immunology and cancer biology. The aberrant expressions of these non-coding RNAs within the cells cause various abnormalities and diseases including cancer and immune system-associated diseases. Manipulating their aberrant expression or function can serve as potential novel diagnostic/prognostic biomarkers and bring in new therapeutic strategies for multiple human diseases. This can be further translated from bench-side to clinic for improving human health. Advances in Non-coding RNAs in Cancer-Biology and Immunology introduces basic ideas of miRNAs, LnRNAs and piRNAs, along with their detailed bio-processing steps, critical functions in the development of tumorigenesis and controlling immune cell responses, which benefits for identifying different classes of non-coding RNAs and their targets, identifying new members of these non-coding RNAs and predicting the possible functions of these molecules. It captures the essence of the pioneering work of some of the world's leading researchers showcasing the scientific excitements surrounding the evolving regulatory roles of miRNAs, LnRNAs, piRNAs highlighting their potential towards the diagnosis and therapeutics of various diseases. Provides a unified cutting-edge resource for non-coding RNAs including miRNAs LnRNAs, and piRNAs, their physiological and pathological roles and potential applications Showcases high-throughput technologies and other approaches for discovery of these non-coding RNAs and their downstream targets Unveils the diverse molecular mechanisms by which miRNAs, LnRNAs and piRNAs regulate gene expression in animal cells Showcases recent discoveries on involvement of these non-coding RNAs in different biological processes and diseases as well as their possible use in diagnosis Reports breakthroughs in the use of these non-coding RNAs for diagnosis and personalized therapy
Author : Joanna Sztuba-Solinska
Publisher : Elsevier
ISBN 13 : 0323907008
Total Pages : 450 pages
Book Rating : 4.3/5 (239 download)
Download or read book Navigating Non-coding RNA written by Joanna Sztuba-Solinska and published by Elsevier. This book was released on 2023-06-17 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Navigating Non-coding RNA: From Biogenesis to Therapeutic Application provides a concise overview of the field of non-coding RNA (ncRNA). Chapters cover the history of discoveries that have occurred in the area of ncRNA, specific types of ncRNA, housekeeping ncRNAs such as ribosomal RNA, transfer RNA, small nuclear RNA and telomerase RNA, regulatory ncRNAs such as microRNA, small interfering RNA, long non-coding RNA and Y RNA. Biogenesis, structure, function, and regulation of each of these are also explored in addition to traditional and cutting-edge methods for the identification, functional characterization and structural characterization of ncRNA. The book also focuses on the different types of epitranscriptomic modifications and their involvement in regulating ncRNA structure, stability and intermolecular interactions in addition to the role of ncRNAs in a range of diseases and potential therapeutic applications. - Covers a wide range of non-coding RNAs, including ribosomal RNA, transfer RNA, telomerase RNA, microRNA, small interfering RNA and circular RNA - Features both traditional and novel methodologies for investigating ncRNA, from microarray and conventional chemical probing to CAGE-seq and computational methods - Includes chapters on ncRNAs in a range of diseases, including cancers, neurological disorders, cardiovascular conditions and infectious illnesses - Discusses novel therapeutic strategies for targeting ncRNAs, including CRISP/Ca9 applications and RNAi-based strategies - Explores the molecular mechanisms and intermolecular interactions of ncRNA
Author : Nicholas Delihas
Publisher : MDPI
ISBN 13 : 3038420050
Total Pages : 837 pages
Book Rating : 4.0/5 (384 download)
Download or read book Regulation by non-coding RNAs Volume 1 written by Nicholas Delihas and published by MDPI. This book was released on 2018-10-09 with total page 837 pages. Available in PDF, EPUB and Kindle. Book excerpt: Printed Edition of the Special Issue Published in IJMS
Author : Jonathan J. Kotzin
Publisher :
ISBN 13 :
Total Pages : 262 pages
Book Rating : 4.:/5 (123 download)
Download or read book Long Non-coding RNA Regulation of Immune Homeostasis written by Jonathan J. Kotzin and published by . This book was released on 2017 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: The immune system is comprised of diverse cell types that work together to protect the host from infection and maintain tissue homeostasis. To achieve this complex balance, extracellular cues determine highly specific epigenetic landscapes and transcriptional profiles of each immune cell subtype. New evidence indicates that long non-coding RNAs (lncRNAs) play critical roles in epigenetic and transcriptional regulation in mammals. Here we identify the lncRNA Morrbid, and examine its role in immune function. In Chapter 2, we assess the function of Morrbid at homeostasis and describe its role in finely tuning the lifespan of short-lived myeloid cells. In Chapter 3, we examine Morrbid under inflammatory conditions and illustrate its role in restraining CD8 T cell responses following viral infection. These data demonstrate that lncRNAs can function as highly cell-type specific effectors of extracellular cues to control immunological processes that require rapid and strict regulation.
Author : Lütfi Tutar
Publisher : BoD – Books on Demand
ISBN 13 : 1789856558
Total Pages : 150 pages
Book Rating : 4.7/5 (898 download)
Download or read book Non-Coding RNAs written by Lütfi Tutar and published by BoD – Books on Demand. This book was released on 2020-03-04 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Noncoding RNAs (ncRNAs) are an attractive research field in the RNA world. ncRNAs play important roles in regulating gene expression in animals, plants, and various human diseases. It is clear that current and further research on ncRNAs will change our knowledge of the nature of genome composition by editing previous dogmas. This book provides an overview of current knowledge on ncRNA research by dealing with miRNA and ncRNA-related human diseases, plant miRNA markers, and the roles of lncRNAs in cancer and epigenetics.
Author : Kevin V. Morris
Publisher : Springer
ISBN 13 : 3319239074
Total Pages : 267 pages
Book Rating : 4.3/5 (192 download)
Download or read book Long Non-coding RNAs in Human Disease written by Kevin V. Morris and published by Springer. This book was released on 2016-04-13 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the development of personalized therapeutics. It offers an appealing and insightful resource for scientists and clinicians alike.
Author : Catherine M. Greene
Publisher : Springer
ISBN 13 : 3319136895
Total Pages : 242 pages
Book Rating : 4.3/5 (191 download)
Download or read book MicroRNAs and Other Non-Coding RNAs in Inflammation written by Catherine M. Greene and published by Springer. This book was released on 2015-02-06 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book serves as a comprehensive resource for scientists and clinicians studying the role of non-coding RNAs in inflammation (viral infections, wound inflammation), human inflammatory diseases (i.e. rheumatoid arthritis, Crohn’s disease, diabetes) and innate immunity. It provides a universal reference work comprising both basic and specialized information. Given that ncRNAs represent new therapeutic targets, this volume will also be of interest to industrial biomedical researchers and those involved in drug development.
Author : Junjie Yang
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (115 download)
Download or read book The Role of H19, a Long Non-coding RNA in the Immune System written by Junjie Yang and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic imprinting, a unique epigenetic regulation resulting in a parent-of-origin specificgene expression, is essential for normal mammalian development and growth. H19 is amaternally expressed long non-coding RNA that is a central regulator of the imprinting gene network controlling development and growth. H19 is expressed throughout embryonic development in multiple tissues including all hematopoietic cells. The role of H19 during embryonic development has only been documented for the placenta where it controls growthand the role of H19 in lymphopoiesis has not been investigated. The laboratory has previouslyfound H19 as the major differentially expressed transcript in two microarrays comparing fetalliver (FL) and bone marrow (BM) derived pro-B cells, as well as between early and latethymic settling progenitors. However, a role for imprinting gene H19 in B cell development,or even in immune system remains elusive. Here we sought to analyze mice where a large segment of the H19 locus has been deleted. In our work, we found that loss of H19 have specific impact on the FL B cell development byproducing increased numbers of BP1+ proB cell. Although BP1+ proB cells from H19-/- FLshowed impaired Ig heavy chain V-D-J rearrangement, that increase resulted in a net enlarged B cell compartment in the adult periphery of H19 mutant. In adult mice, although H19 is notexpressed in B lymphocytes after birth, B cells from H19-/- mice exhibited altered B cellsurface phenotype, represented by an upregulated B220 expression on all B cell subsets. After immunization with different T cell dependent antigens, H19-/- exhibits reduced GC B cells, and impaired specific IgM titer in the serum, indicating a defected B cell response in H19-/-mice. Competitive reconstitution analysis showed a B cell autonomous impairment in the Bcell response. Consistently we found a reduced BCR responsiveness of H19-/- naïve B cells that together with less efficient upregulation of MHCII and CD40 expression after immunization might be responsible for the impaired immune response in H19-/- mice. Genome-wide transcription analysis revealed differential expression of genes involved inregulating the intensity of B cell receptor signaling. This work brings new insights on the regulation role of long non-coding RNA H19 in the early B cell development and immune system.
Author : Sujit Nair
Publisher : Frontiers Media SA
ISBN 13 : 2832541852
Total Pages : 180 pages
Book Rating : 4.8/5 (325 download)
Download or read book Noncoding RNA in Disease: Diagnosis, Etiology, Progression, Prognosis and Treatment. written by Sujit Nair and published by Frontiers Media SA. This book was released on 2024-01-10 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: An exciting class of regulatory small noncoding RNAs (ncRNAs) has emerged in recent years that play key role(s) in the etiology/pathogenesis and diagnosis/prognosis of various human diseases including various hematologic and solid cancers, cardiovascular diseases including stroke/atherosclerosis, diabetes, obesity, and metabolic disorders, neuropathies, neurodegeneration including Alzheimer’s Disease, Parkinson’s Disease or Multiple Sclerosis, neurological disorders including epilepsy and muscular dystrophies, liver diseases, pulmonary fibrosis, immune-mediated inflammatory disorders and inflammatory bowel disease, gastritis, autoimmune disorders including arthritis, acromegaly, chronic kidney disease, allergic rhinitis, vitiligo, osteoporosis, obstructive sleep apnea, ocular disease, periodontitis, skeletal muscle atrophy, and parasitic diseases including leishmaniasis, amongst others. These ncRNAs include primarily microRNAs (miRNAs), long noncoding RNAs (lncRNAs), circular RNAs (circRNAs), piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), small interfering RNAs (siRNAs) or exosomal RNAs (exRNAs), etc. that modulate the expression of target genes thus potentially regulating protein expression in normal versus diseased individuals. This Research Topic recognizes the importance of and seeks to explore, ncRNAs in the diagnosis, etiology, progression, prognosis, and treatment of human disease as well as novel biomarker discovery by multi-omics technologies and other methodologies. Indeed, high-throughput technologies employing deep sequencing, proteogenomic, microarrays, and quantitative real-time PCR have begun to shed new light on the architecture of ncRNA landscapes in various diseases and key signal transduction cascades modulated by these ncRNAs in disease pathology. Epigenetic control of gene expression mediated via miRNAs, for instance, has expanded our understanding of transcriptional and post-transcriptional regulation of gene expression by critical ncRNAs in the cellular milieu. Network biology approaches including the construction of relevant ncRNA networks, ncRNA-mRNA networks, and bioinformatics for mining of ncRNAs, are gaining greater relevance in the search for ‘target hubs’ or novel biomarker(s) of disease. Delineation of ncRNA signatures by transcriptomic profiling or RNA-seq, for example, is an important milestone in furthering our knowledge of the repertoire of specific ncRNAs implicated in various diseases. Further, elucidation of the specific steps of the signaling cascades where ncRNAs exert their regulatory actions will augment our understanding of diseases. This will lead to the development of (i) a novel biomarker, or biomarker signature panel, for disease; (ii) ncRNA-based companion diagnostics for diagnosis of disease; (iii) point-of-care testing devices based on ncRNAs; (iv) newer therapeutic agents that target novel biomarkers with specificity, thereby reducing toxicity; (v) ncRNA-based prophylactic approaches of the future; and, (vi) ncRNA-based prognosis of disease.
Author : Gordon G. Carmichael
Publisher :
ISBN 13 : 9781493913695
Total Pages : 181 pages
Book Rating : 4.9/5 (136 download)
Download or read book Regulatory Non-Coding RNAs written by Gordon G. Carmichael and published by . This book was released on 2014 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulatory Non-Coding RNAs: Methods and Protocols offers a collection of methods for those interested in the discovery, localization, and functional analysis of these non-coding transcripts that have the potential and ability to orchestrate and control gene expression. After a review of the field, this detailed volume continues with methods useful for the study of siRNAs, microRNAs and their targets, techniques concerned with long non-coding RNAs, as well as studies of the critical parameters of functional non-coding RNA protein-RNA interactions and the environment in which they act. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips for troubleshooting and avoiding known pitfalls.Dependable and easy to use, Regulatory Non-Coding RNAs: Methods and Protocols provides a current, state-of-the-art collection of methods and approaches that will be of value to researchers in this expanding and fascinating field.
Author : Yujing Li
Publisher : Frontiers Media SA
ISBN 13 : 2889638324
Total Pages : 346 pages
Book Rating : 4.8/5 (896 download)
Download or read book Non-Coding RNAs and Human Diseases written by Yujing Li and published by Frontiers Media SA. This book was released on 2020-07-08 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Subash Gupta
Publisher : Elsevier
ISBN 13 : 0128245506
Total Pages : 478 pages
Book Rating : 4.1/5 (282 download)
Download or read book Clinical Applications of Noncoding RNAs in Cancer written by Subash Gupta and published by Elsevier. This book was released on 2022-01-24 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Applications of Noncoding RNAs in Cancer summarizes the existing strategies, advances, and future opportunities on the role of noncoding RNAs in cancer patients. Established clinicians and researchers from all around the world share their views and expertise and provide readers with invaluable knowledge on the subject. This book provides a comprehensive collection of information on the utility of noncoding RNAs in the diagnosis, prognosis, and therapy of cancer. It also discusses the evolutionary significance of noncoding RNAs and how the molecular tools such as RNA-seq, RNA-FISH, ic-SHAPE, and quantitative real-time PCR help in the detection and elucidation of the functions of noncoding RNAs. Additionally, the challenges associated with noncoding RNA approaches and future developments are discussed. It is a valuable resource for cancer researchers, oncologists, clinicians, and other biomedical field members who want to learn more about noninvasive ways to diagnose and efficiently treat diverse cancer types. Presents a beginning chapter summary to help readers understand the content thoroughly Encompasses detailed description of information from clinical studies on noncoding RNAs in cancer therapy Discusses one cancer type per chapter making the content easy to reference
Author : Nicholas Delihas
Publisher : MDPI
ISBN 13 : 3038420069
Total Pages : 1 pages
Book Rating : 4.0/5 (384 download)
Download or read book Regulation by non-coding RNAs Volume 2 written by Nicholas Delihas and published by MDPI. This book was released on 2018-10-09 with total page 1 pages. Available in PDF, EPUB and Kindle. Book excerpt: Printed Edition of the Special Issue Published in IJMS
Author : Alfons Navarro
Publisher : Humana
ISBN 13 : 9781071615836
Total Pages : 0 pages
Book Rating : 4.6/5 (158 download)
Download or read book Long Non-Coding RNAs in Cancer written by Alfons Navarro and published by Humana. This book was released on 2022-06-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents techniques needed for the study of long non-coding RNAs (lncRNAs) in cancer from their identification to functional characterization. Chapters guide readers through identification of lncRNA expression signatures in cancer tissue or liquid biopsies by RNAseq, single Cell RNAseq, Phospho RNAseq or Nanopore Sequencing techniques; validation of lncRNA signatures by Real time PCR, digital PCR or in situ hybridization; and functional analysis by siRNA or CRISPR based methods for lncRNA silencing or overexpression. Lipid based nanoparticles for delivery of siRNAs in vivo, lncRNA-protein interactions, viral lncRNAs and circRNAs are also treated in this volume. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Long Non-Coding RNAs in Cancer aims to provide a collection of laboratory protocols, bioinformatic pipelines, and review chapters to further research in this vital field.
