Nicotinic Receptors

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Nicotinic Receptors

Author : Robin A.J. Lester
Publisher : Springer
ISBN 13 : 1493911678
Total Pages : 461 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Nicotinic Receptors by : Robin A.J. Lester

Download or read book Nicotinic Receptors written by Robin A.J. Lester and published by Springer. This book was released on 2014-11-11 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive overview of nicotinic receptors that addresses their history from crystal structure to behavior as well as their implications in disease and potential as therapeutic targets. It includes background information on all subtypes of nicotinic receptors, the most recent information on the distribution throughout the nervous system and discussion of their implications in learning and memory, addiction and neurological and psychiatric disease such as Alzheimer's and Parkinson's. Takes advantage of several recent developments in the fields of optogenetics, viral expression and gene analysis to focus on current knowledge on the functional aspects of nicotinic receptors.

Nicotinic Receptors in the Nervous System

Author : Edward D. Levin
Publisher : CRC Press
ISBN 13 : 1420038524
Total Pages : 312 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Nicotinic Receptors in the Nervous System by : Edward D. Levin

Download or read book Nicotinic Receptors in the Nervous System written by Edward D. Levin and published by CRC Press. This book was released on 2001-08-29 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nicotine research has been conducted for the better part of a century, but with the discovery of the relationship of nicotinic systems to Alzheimer's disease, the differentiation of nicotinic receptor subtypes, and the development of novel nicotinic ligands, the field of nicotine research has exploded. This book will provide you reference to the latest research methods and findings concerning nicotinic neural systems. Featuring a unique approach, Nicotinic Receptors in the Nervous System provides integrated coverage of cutting-edge research concerning neuronal nicotinic systems relevant to smoking addiction and cognitive dysfunction. By bringing together molecular and neurochemical applications, this book provides the key to understanding function and dysfunction of nicotinic systems and how they are significant for disease, addiction, and the development of novel drug treatments. Within the next several years, it is very promising that clinical research will support the use of nicotinic treatments for addiction, pain, and cognitive and motor dysfunction. Nicotinic Receptors in the Nervous System provides you with the basic mechanistic background for these treatments as well as the functional assessment necessary to determine therapeutic effects.

Jasper's Basic Mechanisms of the Epilepsies

Author : Jeffrey L. Noebels
Publisher : OUP USA
ISBN 13 : 0199746540
Total Pages : 1258 pages
Book Rating : 4.1/5 (997 download)

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Book Synopsis Jasper's Basic Mechanisms of the Epilepsies by : Jeffrey L. Noebels

Download or read book Jasper's Basic Mechanisms of the Epilepsies written by Jeffrey L. Noebels and published by OUP USA. This book was released on 2012-06-29 with total page 1258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.

Nicotinoid Insecticides and the Nicotinic Acetylcholine Receptor

Author : I. Yamamoto
Publisher : Springer Science & Business Media
ISBN 13 : 4431679332
Total Pages : 300 pages
Book Rating : 4.4/5 (316 download)

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Book Synopsis Nicotinoid Insecticides and the Nicotinic Acetylcholine Receptor by : I. Yamamoto

Download or read book Nicotinoid Insecticides and the Nicotinic Acetylcholine Receptor written by I. Yamamoto and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nicotinoids are the most important new class of pesticides, joining the organophosphorus compounds, methylcarbamates, and pyrethroids as the major insecticides. Recently, imidacloprid and related nicotinoids have begun replacing organophosphorus and methylcarbamate compounds as insecticides to control insect pests on major crops. Nicotinoids act on the nicotinic acetylcholine receptor, as does naturally occurring nicotine, but with remarkable effectiveness against insects while being safe for mammals; they are quickly degraded and do not persist in the environment. This volume describes the relationship of nicotinoids to botanical insecticidal alkaloids, their discovery and development as insecticides, and the prospects for their expanded use and for the development of resistance. This book is the first to provide concise, comprehensive information on nicotinoids, their chemistry, mode of action, metabolism, and application in agriculture.

Neuroscience of Nicotine

Author : Victor R. Preedy
Publisher : Academic Press
ISBN 13 : 0128130369
Total Pages : 566 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Neuroscience of Nicotine by : Victor R. Preedy

Download or read book Neuroscience of Nicotine written by Victor R. Preedy and published by Academic Press. This book was released on 2019-03-20 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroscience of Nicotine: Mechanisms and Treatment presents the fundamental information necessary for a thorough understanding of the neurobiological underpinnings of nicotine addiction and its effects on the brain. Offering thorough coverage of all aspects of nicotine research, treatment, policy and prevention, and containing contributions from internationally recognized experts, the book provides students, early-career researchers, and investigators at all levels with a fundamental introduction to all aspects of nicotine misuse. With an estimated one billion individuals worldwide classified as tobacco users—and tobacco use often being synonymous with nicotine addiction—nicotine is one of the world’s most common addictive substances, and a frequent comorbidity of misuse of other common addictive substances. Nicotine alters a variety of neurological processes, from molecular biology, to cognition, and quitting is exceedingly difficult because of the number of withdrawal symptoms that accompany the process. Integrates cutting-edge research on the pharmacological, cellular and molecular aspects of nicotine use, along with its effects on neurobiological function Discusses nicotine use as a component of dual-use and poly addictions and outlines numerous screening and treatment strategies for misuse Covers both the physical and psychological effects of nicotine use and withdrawal to provide a fully-formed view of nicotine dependency and its effects

Nicotinic Acetylcholine Receptors in the Nervous System

Author : Francesco Clementi
Publisher : Springer Science & Business Media
ISBN 13 : 3642741673
Total Pages : 432 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Nicotinic Acetylcholine Receptors in the Nervous System by : Francesco Clementi

Download or read book Nicotinic Acetylcholine Receptors in the Nervous System written by Francesco Clementi and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The acetylcholine nicotinic receptor is an ionic channel whose aperture is directly controlled by acetylcholine. It is a key molecule in the chemical communication between nerve cells and between nerve cell and muscle. The structure and function of muscular nicotinic receptors have been unraveled in recent years and its beauty and mysteries were reviewed in the Santorini NATO ARW organized by Dr. Maelicke in 1986. The neat, linear structure of this molecule and its conservation throughout evolution, from bacteria to humans, have led to the suggestion that it has reached the optimal structure for performing its function. But when scientists began to look at the nicotinic receptor in the nervous system, they found several surprises. From the beginning, pharmacological and physiological experiments, have made it clear that the functional characteristics of neuronal nicotinic receptors are substantially different from those of muscle receptors. Furthermore, recent sophisticated techniques such as patch clamp and gene cloning have revealed that the nicotinic receptor in the nervous system is not a single molecule but (although there are some important exceptions) a large family of similar molecules, which have in common the property of binding nicotinic agonists or antagonists. Over the last few years, the physiological implications of nicotinic receptors have been reevaluated on the basis of more precise behavioural and pharmacological techniques. Moreover, the involvement of nicotinic receptors in degenerative pathologies of the eNS, such as Parkinson's and Alzheimer's disease, has also been discovered very recently.

Nicotine and Other Tobacco Compounds in Neurodegenerative and Psychiatric Diseases

Author : Emilija Veljkovic
Publisher : Academic Press
ISBN 13 : 0128129239
Total Pages : 164 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Nicotine and Other Tobacco Compounds in Neurodegenerative and Psychiatric Diseases by : Emilija Veljkovic

Download or read book Nicotine and Other Tobacco Compounds in Neurodegenerative and Psychiatric Diseases written by Emilija Veljkovic and published by Academic Press. This book was released on 2018-01-15 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nicotine and Other Tobacco Compounds in Neurodegenerative and Psychiatric Diseases: Epidemiological Data on Smoking and Preclinical and Clinical Data on Nicotine provides a comprehensive summary of the epidemiological data on smoking and several neurological disorders, including Alzheimer’s disease, Parkinson’s disease, Multiple Sclerosis, Tourette’s syndrome, schizophrenia, anxiety, depression and ADHD, as well as preclinical and clinical data on the effects of nicotine. Despite the obvious and undisputed harmful nature of smoking, evidence suggests that some tobacco and tobacco smoke-derived constituents may offer neuroprotective effects, possibly in combinations, rather than individually. This unprecedented book describes the complex relationships between smoking and neurological disease and the bioactive compounds found in tobacco. It provides a comprehensive review of nicotine and other compounds found in tobacco plant, with scientific evidence of neuroprotective and anti-inflammatory effects that may act in conjunction with nicotine to exert neuroprotective effects observed in smokers. By presenting findings beyond harmful cigarette smoke effects, attention can be drawn to individual compounds of tobacco that may serve as inspiration for further therapy development. Presents the first comprehensive, tabulated summary of literature on the epidemiological data on smoking and neurological disease Includes preclinical and clinical data on nicotine in neurological diseases and mechanisms of action of nicotine in neuroprotection Features a comprehensive summary of non-nicotine smoke constituents with potentially neuroprotective and anti-inflammatory properties Discusses Multiple Sclerosis, Alzheimer’s disease, Parkinson’s Disease, Schizophrenia, Depression, ADHD, Anxiety and Tourette’s Syndrome in the context of smoking and nicotine

Nicotinic Acetylcholine Receptors in Health and Disease

Author : R. Thomas Boyd
Publisher : Academic Press
ISBN 13 : 0128204184
Total Pages : 292 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Nicotinic Acetylcholine Receptors in Health and Disease by : R. Thomas Boyd

Download or read book Nicotinic Acetylcholine Receptors in Health and Disease written by R. Thomas Boyd and published by Academic Press. This book was released on 2023-03-14 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nicotinic Acetylcholine Receptors in Health and Disease provides the latest information Nicotinic acetylcholine receptors (nAChRs), which are involved in numerous diseases, including Alzheimer’s, Parkinson’s, and schizophrenia, and are important potential translational targets for treatment of these diseases, as well as therapy for addiction. This book focuses on the roles and function of nAChRs inside and outside of the nervous system, with an emphasis on translational implications and future prospects for the treatment of numerous disorders. This greater understanding of the basic neurobiology and clinical roles of nAChRs provides important insights for future clinical treatments of many major disorders. Describes the roles, expression and function of nicotinic receptors Includes receptor involvement, both inside and outside the nervous system Details nicotinic receptor involvement in Alzheimer’s, Parkinson’s, Cancer, Schizophrenia, and more Emphasizes future treatment prospects of disorders via modulation of nAChR signaling

Neuronal Nicotinic Receptors

Author : F. Clementi
Publisher : Springer Science & Business Media
ISBN 13 : 3642570798
Total Pages : 837 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Neuronal Nicotinic Receptors by : F. Clementi

Download or read book Neuronal Nicotinic Receptors written by F. Clementi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 837 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuronal nicotinic receptors are key molecules for signal transduction in a number of neuronal pathways. They are widely distributed in the brain and are known to be involved in cognitive tasks, including learning and memory, in smoking addiction and in several brain diseases, such as Alzheimer's and Parkinson's dementias, schizophrenia, and epilepsy. This book provides a comprehensive review of the field, starting with a historical perspective and dealing with the molecular structure of these receptors, their biophysical and pharmacological properties, their distribution in central and peripheral nervous systems, and their major involvement in brain functions. Particular emphasis is paid to drugs (both new and old) that are useful in the diagnosis and treatment of diseases involving neuronal nicotinic receptors. Finally, the relevance of these receptors in smoking addiction is carefully evaluated, together with future trends and the latest results.

Insect Nicotinic Acetylcholine Receptors

Author : Steeve Hervé Thany
Publisher : Springer Science & Business Media
ISBN 13 : 1441964452
Total Pages : 118 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Insect Nicotinic Acetylcholine Receptors by : Steeve Hervé Thany

Download or read book Insect Nicotinic Acetylcholine Receptors written by Steeve Hervé Thany and published by Springer Science & Business Media. This book was released on 2011-01-11 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to summarize our understanding on the insect nicotinic acetylcholine receptors. This area of research received great impetus from the identification of the first subunit sequences to be used as neonicotinoid insecticide target sites. Although a book of this nature can provide the details only of commonly published results, it is hoped that it may provide a useful guide to the newcomer to the field as well as to point out some of the future challenges. For example, we need to determine the precise subunit nomenclature of insect nicotinic receptors. This nomenclature varies amongst species and this led to some of the early confusion that persists. We need to be precise in identifying the subunit composition of native insect nicotinic receptor subtypes, their functional properties and physiological roles.

Nicotinic Acetylcholine Receptor

Author : Alfred Maelicke
Publisher : Springer Science & Business Media
ISBN 13 : 3642716490
Total Pages : 489 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Nicotinic Acetylcholine Receptor by : Alfred Maelicke

Download or read book Nicotinic Acetylcholine Receptor written by Alfred Maelicke and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the NATO Advanced Research Workshop on Mechanism of Action of the Nicotinic Acetylcholine Receptors held on the Island of Santorini, Greece, May 19-23, 1986

Genetics, Neurology, Behavior, and Diet in Dementia

Author : Colin R Martin
Publisher : Academic Press
ISBN 13 : 0128158697
Total Pages : 954 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Genetics, Neurology, Behavior, and Diet in Dementia by : Colin R Martin

Download or read book Genetics, Neurology, Behavior, and Diet in Dementia written by Colin R Martin and published by Academic Press. This book was released on 2020-08-11 with total page 954 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics, Neurology, Behavior, and Diet in Dementia: The Neuroscience of Dementia, Volume 2 consolidates different fields of dementia research into a single book, covering a range of subjects, including Alzheimer’s disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, and molecular biology. This foundational, comprehensive book assembles the latest understanding on all dementias and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. Offers comprehensive coverage of a broad range of topics related to dementia Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations Serves as a "one-stop" source for everything you need to know about dementia

Cellular and Molecular Neurophysiology

Author : Constance Hammond
Publisher : Academic Press
ISBN 13 : 0123973228
Total Pages : 444 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Cellular and Molecular Neurophysiology by : Constance Hammond

Download or read book Cellular and Molecular Neurophysiology written by Constance Hammond and published by Academic Press. This book was released on 2014-12-30 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular and Molecular Neurophysiology, Fourth Edition, is the only up-to-date textbook on the market that focuses on the molecular and cellular physiology of neurons and synapses. Hypothesis-driven rather than a dry presentation of the facts, the book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in a graduate-level course on the topic alike. This new edition explains the molecular properties and functions of excitable cells in detail and teaches students how to construct and conduct intelligent research experiments. The content is firmly based on numerous experiments performed by top experts in the field This book will be a useful resource for neurophysiologists, neurobiologists, neurologists, and students taking graduate-level courses on neurophysiology. 70% new or updated material in full color throughout, with more than 350 carefully selected and constructed illustrations Fifteen appendices describing neurobiological techniques are interspersed in the text

The Nicotinic Acetylcholine Receptor

Author : Francisco Jose Barrantes
Publisher : Springer
ISBN 13 : 3662402793
Total Pages : 233 pages
Book Rating : 4.6/5 (624 download)

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Book Synopsis The Nicotinic Acetylcholine Receptor by : Francisco Jose Barrantes

Download or read book The Nicotinic Acetylcholine Receptor written by Francisco Jose Barrantes and published by Springer. This book was released on 2013-12-17 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nicotinic Acetylcholine Receptors

Author : Jean-Pierre Changeux
Publisher : ODILE JACOB PUBLISHING CORP
ISBN 13 : 0976890801
Total Pages : 298 pages
Book Rating : 4.9/5 (768 download)

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Book Synopsis Nicotinic Acetylcholine Receptors by : Jean-Pierre Changeux

Download or read book Nicotinic Acetylcholine Receptors written by Jean-Pierre Changeux and published by ODILE JACOB PUBLISHING CORP. This book was released on 2005-09-08 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: The acetylcholine nicotinic receptor is among the most studied receptors in neuroscience. Involved in muscle contraction and a wide variety of other neurological functions, including the processing of nicotine, it was the first receptor to be isolated and observed at the molecular level, providing a major research pathway for scientists working in neuroscience, biochemistry, pharmacology, and behavioral science. This book describes four decades of scientific research that inform our current understanding of this receptor. Jean-Pierre Changeux and Stuart J. Edelstein played important roles in pioneering research on the acetylcholine nicotinic receptor and on allosteric proteins, and here they reveal the complete scientific trajectory of that research. They begin with a historical perspective, describing how several fields converged around a single receptor and then explain the initial receptor purification and characterization. Subsequent chapters trace the investigations into various aspects of receptor structure and function, including the chemical structure of the binding site, the identity and properties of the ion channel, and the mechanism of signal transmission. In the final portion of the book, Changeux and Edelstein discuss recent studies on the three-dimensional structure of the receptor molecule and share their novel understanding of inherited diseases such as congenital myasthenia and epilepsy. They also address the integration of the receptor into its synaptic membrane environment and its distribution, physiology, and regulation in brain functions and cognition. Richly illustrated and lucidly written, this book provides an exceptional opportunity for scientists and students to follow a historic advance in our knowledge of molecular mechanisms and the workings of the brain.

Computational Psychiatry

Author : Alan Anticevic
Publisher : Academic Press
ISBN 13 : 0128098260
Total Pages : 332 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Computational Psychiatry by : Alan Anticevic

Download or read book Computational Psychiatry written by Alan Anticevic and published by Academic Press. This book was released on 2017-09-19 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Psychiatry: Mathematical Modeling of Mental Illness is the first systematic effort to bring together leading scholars in the fields of psychiatry and computational neuroscience who have conducted the most impactful research and scholarship in this area. It includes an introduction outlining the challenges and opportunities facing the field of psychiatry that is followed by a detailed treatment of computational methods used in the service of understanding neuropsychiatric symptoms, improving diagnosis and guiding treatments. This book provides a vital resource for the clinical neuroscience community with an in-depth treatment of various computational neuroscience approaches geared towards understanding psychiatric phenomena. Its most valuable feature is a comprehensive survey of work from leaders in this field. Offers an in-depth overview of the rapidly evolving field of computational psychiatry Written for academics, researchers, advanced students and clinicians in the fields of computational neuroscience, clinical neuroscience, psychiatry, clinical psychology, neurology and cognitive neuroscience Provides a comprehensive survey of work from leaders in this field and a presentation of a range of computational psychiatry methods and approaches geared towards a broad array of psychiatric problems

The Biology of Nicotine Dependence

Author : Gregory Bock
Publisher : John Wiley & Sons
ISBN 13 :
Total Pages : 288 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Biology of Nicotine Dependence by : Gregory Bock

Download or read book The Biology of Nicotine Dependence written by Gregory Bock and published by John Wiley & Sons. This book was released on 1990-08-15 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nicotine is considered to be the main agent in the maintenance of the tobacco smoking habit and is largely responsible for the behavioral and physiological responses to the inhalation of tobacco smoke. This work presents advances made in the elucidation of the action of nicotine in the body--essential information for developing treatments to help people give up smoking. The book reviews the progress made in identifying nicotinic acetylcholine receptors in the brain, using the techniques of molecular biology to characterize receptors and investigate the functional differences between receptors composed of different types of subunits. Sex-specific differences in the response to nicotine, the effects of nicotine on locomotor activity, and its still-debated influence on cognitive performance are considered. The book also examines the habit-forming role of nicotine, the development of tolerance to nicotine, and the less clearly understood phenomenon of withdrawal. Also discusses some potential therapeutic strategies.