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Author : Davide Volpi
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (16 download)
Download or read book New Technologies for Fluorescence Image-guided Surgery written by Davide Volpi and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Takeaki Ishizawa
Publisher : Springer Nature
ISBN 13 : 9811973725
Total Pages : 254 pages
Book Rating : 4.8/5 (119 download)
Download or read book Fluorescence-Guided Surgery written by Takeaki Ishizawa and published by Springer Nature. This book was released on 2023-12-05 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a practical guide of theranostics using intraoperative fluorescence imaging technology, as an all-out effort by the Japanese Society for Fluorescence Guided Surgery. It describes the various approaches the technique is being used such as vascular imaging, identification of lymphatic vessels by intratissue injection, lymph node imaging, and imaging for identification of anatomical structures. The book is organized into three major parts and the first one delivers the basics, introducing the use of the technology in clinical settings and initial setups. Next comes the description of clinical applications where chapters illustrate perfusion assessment, cancer localization, anatomy visualization, and lymph nodes/ducts mapping. Each chapter is devoted to the specific surgical field and disease areas, presenting images and videos of case studies. The last part presents some upcoming techniques for treatments. The Editor and the authors wish the ideas presented here will be hints to bridge the knowledge between surgeons and basic researchers for further innovation and practicality. It is important to stay up-to-date since intraoperative fluorescence imaging has been applied to clinical settings in various surgical fields and at the same time, novel techniques improving the efficacy of the technology have also been developed actively. Fluorescence-Guided Surgery – From Lab to Operation Room is recommended for surgeons, operating nurses, medical experts, basic researchers and, industry engineers worldwide beyond boundaries of specialties. Edited and written by experts of The Japanese Society for Fluorescence-Guided Surgery, those who are the founders of the technology, it describes the accurate development history and cutting-edge techniques based on the knowledge accumulated over the years.
Author : Mark Preul
Publisher : Frontiers Media SA
ISBN 13 : 2889668568
Total Pages : 368 pages
Book Rating : 4.8/5 (896 download)
Download or read book Applications of Fluorescence in Surgery and Interventional Diagnostics written by Mark Preul and published by Frontiers Media SA. This book was released on 2021-06-04 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Fernando D. Dip
Publisher : Springer
ISBN 13 : 3319156780
Total Pages : 357 pages
Book Rating : 4.3/5 (191 download)
Download or read book Fluorescence Imaging for Surgeons written by Fernando D. Dip and published by Springer. This book was released on 2015-07-21 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text presents the experiences of leading researchers and surgeons with different fluorescence methods. Chapters range from basic science of fluorescence to current clinical applications and new horizons. The first few chapters describe the historical evolution and physical principles of fluorescence and provide the foundation for the reader to understand the current scope and limits of its use in surgery. The second section focuses on the clinical applications of intraoperative fluorescence imaging including subsections on fluorescence cholangiography, applications to hepatectomy, lymph node navigation, applications to GI tract and pelvic surgery and identification of cancer tissues. The third section focuses on new frontiers including fluorescence probes, imaging systems and applications to photodynamic therapy. Authored by leaders in the development of fluorescent methods worldwide, Fluorescence Imaging for Surgeons: Concepts and Applications will have an impact on numerous medical specialists including general surgeons, colorectal and minimally-invasive surgeons and surgical oncologists. Researchers will find the book to be an invaluable resource on the latest advances in the utilization of nanoparticles and fluorescent probes.
Author : Nova Szoka
Publisher : Springer Nature
ISBN 13 : 3031406850
Total Pages : 515 pages
Book Rating : 4.0/5 (314 download)
Download or read book The SAGES Manual of Fluorescence-Guided Surgery written by Nova Szoka and published by Springer Nature. This book was released on 2023-11-27 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorescence-guided surgery (FGS) is defined as a medical imaging technique that uses a fluorescent dye or a near-infrared emitting light source to identify anatomic structures during surgical procedures. In 2020 alone, over 1200 academic articles were published on the topic of fluorescence-guidance surgery, a sign that this modality is making significant inroads into surgical practice. The use of near-infrared imaging and FGS is a rapidly growing modality, allowing surgeons to see more intraoperatively, enhance surgical precision, and improve surgical decision-making and patient outcomes. This manual provides a comprehensive, state-of-the art review of this field and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in fluorescence-guided surgery, guiding patient management and stimulating investigative efforts. After initial chapters discussing the history of FGS and the current platforms and devices, it presents the most up-to-date data regarding the use of FGS in multiple surgical fields - colorectal, hepatic, endocrine, reconstructive, pediatric, among others - as well as in the treatment of specific conditions such as burns. Chapters are generously illustrated with full-color figures and intraoperative photographs, and selected chapters include video segments. Access to a comprehensive resource such as this is currently limited by the relatively new inroads that fluorescence-guided technology has made into surgery. The SAGES Manual of Fluorescence-Guided Surgery fills this gap in the literature.
Author : Essa M. Aleassa
Publisher : Springer Nature
ISBN 13 : 3030380920
Total Pages : 275 pages
Book Rating : 4.0/5 (33 download)
Download or read book Video Atlas of Intraoperative Applications of Near Infrared Fluorescence Imaging written by Essa M. Aleassa and published by Springer Nature. This book was released on 2020-03-24 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents a head-to-toe guide for clinicians who are interested in applying real-time near infrared (NIR) imaging for their patients. Expert surgeons from around the globe share their experience with NIR imaging, most commonly performed using indocyanine green (ICG) fluorescence. The chapters are structured to include a brief background, indications for use, followed by a technical description of the procedure. Each chapter is also accompanied by video examples and detailed information about necessary equipment, drug dosing, and alternative techniques. A pitfalls section serves as a “lessons learned” segment to bookend each chapter. Authors represent a comprehensive list of surgical subspecialties ranging from neurosurgery to plastic surgery. While it is not meant to serve as an exhaustive summary of ICG use in surgery, the goal is to highlight the successful use of this technology in a number of settings. As the technology and applications continue to expand, Video Atlas of Intraoperative Applications of Near Infrared Fluorescence Imaging serves as a foundation upon which to build.
Author : Suman Bikash Mondal
Publisher :
ISBN 13 :
Total Pages : 231 pages
Book Rating : 4.:/5 (954 download)
Download or read book Goggle Augmented Imaging and Navigation System for Fluorescence-guided Surgery written by Suman Bikash Mondal and published by . This book was released on 2016 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surgery remains the only curative option for most solid tumors. The standard-of-care usually involves tumor resection and sentinel lymph node biopsy for cancer staging. Surgeons rely on their vision and touch to distinguish healthy from cancer tissue during surgery, often leading to incomplete tumor resection that necessitates repeat surgery. Sentinel lymph node biopsy by conventional radioactive tracking exposes patients and caregivers to ionizing radiation, while blue dye tracking stains the tissue highlighting only superficial lymph nodes. Improper identification of sentinel lymph nodes may misdiagnose the stage of the cancer. Therefore there is a clinical need for accurate intraoperative tumor and sentinel lymph node visualization. Conventional imaging modalities such as x-ray computed tomography, positron emission tomography, magnetic resonance imaging, and ultrasound are excellent for preoperative cancer diagnosis and surgical planning. However, they are not suitable for intraoperative use, due to bulky complicated hardware, high cost, non-real-time imaging, severe restrictions to the surgical workflow and lack of sufficient resolution for tumor boundary assessment. This has propelled interest in fluorescence-guided surgery, due to availability of simple hardware that can achieve real-time, high resolution and sensitive imaging. Near-infrared fluorescence imaging is of particular interest due to low background absorbance by photoactive biomolecules, enabling thick tissue assessment. As a result several near-infrared fluorescence-guided surgery systems have been developed. However, they are limited by bulky hardware, disruptive information display and non-matched field of view to the user. To address these limitations we have developed a compact, light-weight and wearable goggle augmented imaging and navigation system (GAINS). It detects the near-infrared fluorescence from a tumor accumulated contrast agent, along with the normal color view and displays accurately aligned, color-fluorescence images via a head-mounted display worn by the surgeon, in real-time. GAINS is a platform technology and capable of very sensitive fluorescence detection. Image display options include both video see-through and optical see-through head-mounted displays for high-contrast image guidance as well as direct visual access to the surgical bed. Image capture options from large field of view camera as well high magnification handheld microscope, ensures macroscopic as well as microscopic assessment of the tumor bed. Aided by tumor targeted near-infrared contrast agents, GAINS guided complete tumor resection in subcutaneous, metastatic and spontaneous mouse models of cancer with high sensitivity and specificity, in real-time. Using a clinically-approved near-infrared contrast agent, GAINS provided real-time image guidance for accurate visualization of lymph nodes in a porcine model and sentinel lymph nodes in human breast cancer and melanoma patients with high sensitivity. This work has addressed issues that have limited clinical adoption of fluorescence-guided surgery and paved the way for research into developing this approach towards standard-of-care practice that can potentially improve surgical outcomes in cancer.
Author : N. Kokudo
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318022934
Total Pages : 134 pages
Book Rating : 4.3/5 (18 download)
Download or read book Fluorescent Imaging written by N. Kokudo and published by Karger Medical and Scientific Publishers. This book was released on 2013-09-10 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Indocyanine green (ICG) fluorescence has been used for imaging purposes for more than half a century; First employed by ophthalmologists for visualizing the retinal artery in the late 1960s, the application of ICG fluorescence imaging has since been continuously expanded. Recently, advances in imaging technologies have led to renewed attention regarding the use of ICG in the field of hepatobiliary surgery, as a new tool for visualizing the biliary tree and liver tumors.
Author : Nan Cui
Publisher :
ISBN 13 :
Total Pages : 101 pages
Book Rating : 4.:/5 (15 download)
Download or read book Bio-inspired Multi-spectral Image Sensor and Augmented Reality Display for Near-infrared Fluorescence Image-guided Surgery written by Nan Cui and published by . This book was released on 2018 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt: Background: Cancer remains a major public health problem worldwide and poses a huge economic burden. Near-infrared (NIR) fluorescence image-guided surgery (IGS) utilizes molecular markers and imaging instruments to identify and locate tumors during surgical resection. Unfortunately, current state-of-the-art NIR fluorescence imaging systems are bulky, costly, and lack both fluorescence sensitivity under surgical illumination and co-registration accuracy between multimodal images. Additionally, the monitor-based display units are disruptive to the surgical workflow and are suboptimal at indicating the 3-dimensional position of labeled tumors. These major obstacles have prevented the wide acceptance of NIR fluorescence imaging as the standard of care for cancer surgery. The goal of this dissertation is to enhance cancer treatment by developing novel image sensors and presenting the information using holographic augmented reality (AR) display to the physician in intraoperative settings.Method: By mimicking the visual system of the Morpho butterfly, several single-chip, color-NIR fluorescence image sensors and systems were developed with CMOS technologies and pixelated interference filters. Using a holographic AR goggle platform, an NIR fluorescence IGS display system was developed. Optoelectronic evaluation was performed on the prototypes to evaluate the performance of each component, and small animal models and large animal models were used to verify the overall effectiveness of the integrated systems at cancer detection.Result: The single-chip bio-inspired multispectral logarithmic image sensor I developed has better main performance indicators than the state-of-the-art NIR fluorescence imaging instruments. The image sensors achieve up to 140 dB dynamic range. The sensitivity under surgical illumination achieves 6 x 108 [mu]V/(mW/cm2), which is up to 25 times higher. The signal-to-noise ratio is up to 56 dB, which is 11 dB greater. These enable high sensitivity fluorescence imaging under surgical illumination. The pixelated interference filters enable temperature-independent co-registration accuracy between multimodal images. Pre-clinical trials with small animal model demonstrate that the sensor can achieve up to 95% sensitivity and 94% specificity with tumor-targeted NIR molecular probes. The holographic AR goggle provides the physician with a non-disruptive 3-dimensional display in the clinical setup. This is the first display system that co-registers a virtual image with human eyes and allows video rate image transmission. The imaging system is tested in the veterinary science operating room on canine patients with naturally occurring cancers. In addition, a time domain pulse-width-modulation address-event-representation multispectral image sensor and a handheld multispectral camera prototype are developed.Conclusion: The major problems of current state-of-the-art NIR fluorescence imaging systems are successfully solved. Due to enhanced performance and user experience, the bio-inspired sensors and augmented reality display system will give medical care providers much needed technology to enable more accurate value-based healthcare.
Author : Sylvain Gioux
Publisher :
ISBN 13 :
Total Pages : 526 pages
Book Rating : 4.:/5 (728 download)
Download or read book Image-guided Surgery Using Diffuse Near-infrared Light written by Sylvain Gioux and published by . This book was released on 2010 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Human surgery is often performed "blindly," without real-time assessment of diseased tissue that needs to be resected or normal tissue that needs to be avoided. However, recent progress in optical imaging suggests that image-guided surgery should be possible. Near-infrared (NIR) diffuse optical imaging takes advantage of deep photon penetration of NIR light into living tissue to provide fast, quantitative, relatively inexpensive imaging of endogenous and/or exogenous contrast at depth 1 cm. In this dissertation, we explore the key parameters necessary to efficiently translate wide-field (typically 5 cm in diameter) NIR optical imaging technologies to surgical environments. Initial work focused on the translation of qualitative imaging of continuous-wave NIR fluorescence. For this purpose, a novel modular LED light source was designed to achieve high fluence rates over a 15 cm diameter field of view. The light source was integrated into a new, clinically friendly imaging system termed FLARE(TM) (fluorescence-Assisted Resection and Exploration), which provided one color, and two NIR fluorescence imaging channels, in real-time. FLARE(TM) was successfully translated to the clinic where it was evaluated for sentinel lymph node mapping during breast cancer surgery and breast reconstruction after mastectomy. Motion artifacts are a considerable source of noise for both qualitative display of images and quantitative processing of image data. To solve this important problem, a novel, hardware-only gating device was developed. The device permits synchronized image acquisition from both non-periodic signals (e.g., involuntary motion) and periodic physiological signals (e.g., ECG, plethysmograph), with high timing precision. Finally, technologies have been advanced that benefit several quantitative, wide-field imaging techniques for image-guided surgery. In temporal frequency-domain imaging (TFDi), the use of high power LEDs was investigated for performing fluorescence lifetime imaging (FLi) using a custom-made LED module capable of DC to 35 MHz modulation. In collaboration with Dr. Tromberg's group at the University of California, Irvine, a profilometry-based correction method that compensates sample curvature was designed for optical imaging. This correction technique was applied to spatial frequency-domain imaging (SFDi), and it was demonstrated that tissue optical properties and oxygenation could be extracted with good accuracy, under clinically realistic conditions.
Author : Buhong Li
Publisher : John Wiley & Sons
ISBN 13 : 3527346562
Total Pages : 309 pages
Book Rating : 4.5/5 (273 download)
Download or read book Advances in Biomedical Photonics written by Buhong Li and published by John Wiley & Sons. This book was released on 2023-04-24 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: A state-of-the-art examination of biomedical photonic research, technologies, and applications In Biomedical Photonic Technologies, a team of distinguished researchers delivers a methodical inquiry and evaluation of the latest developments in the field of biomedical photonics, with a focus on novel technologies, including optical microscopy, optical coherence tomography, fluorescence imaging-guided surgery, photodynamic therapy dosimetry, and optical theranostic technologies. Each discussion of individual technologies includes examples of their contemporary application in areas like cancer therapy and drug delivery. Readers will discover the major research advancements in biomedical photonics from the last 20 years, ascertaining the basic principles of formation, development, and derivation of biomedical photonics phenomena at a variety of scales. Readers will also find: A thorough introduction to advanced wide-field fluorescent microscopy for biomedicine Comprehensive explorations of fluorescence resonance energy transfer and optical coherence tomography for structural and functional imaging Practical exploration of coherent Raman scattering microscopy and biomedical applications, as well as fluorescence image-guided surgery Complete analyses of enhanced photodynamic therapy, optogenetics, and optical theranostics employing gold nanoparticles Perfect for biophysicists and applied physicists, Biomedical Photonic Technologies will also benefit bioengineers and biotechnologists in academia and in industry.
Author : Shengkui Gao
Publisher :
ISBN 13 :
Total Pages : 142 pages
Book Rating : 4.:/5 (922 download)
Download or read book Bio-inspired Multi-spectral Imaging Sensors and Algorithms for Image Guided Surgery written by Shengkui Gao and published by . This book was released on 2015 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Image guided surgery (IGS) utilizes emerging imaging technologies to provide additional structural and functional information to the physician in clinical settings. This additional visual information can help physicians delineate cancerous tissue during resection as well as avoid damage to near-by healthy tissue. Near-infrared (NIR) fluorescence imaging (700 nm to 900 nm wavelengths) is a promising imaging modality for IGS, namely for the following reasons: First, tissue absorption and scattering in the NIR window is very low, which allows for deeper imaging and localization of tumor tissue in the range of several millimeters to a centimeter depending on the tissue surrounding the tumor. Second, spontaneous tissue fluorescence emission is minimal in the NIR region, allowing for high signal-to-background ratio imaging compared to visible spectrum fluorescence imaging. Third, decoupling the fluorescence signal from the visible spectrum allows for optimization of NIR fluorescence while attaining high quality color images. Fourth, there are two FDA approved fluorescent dyes in the NIR region--namely methylene blue (MB) and indocyanine green--which can help to identify tumor tissue due to passive accumulation in human subjects. The aforementioned advantages have led to the development of NIR fluorescence imaging systems for a variety of clinical applications, such as sentinel lymph node imaging, angiography, and tumor margin assessment. With these technological advances, secondary surgeries due to positive tumor margins or damage to healthy organs can be largely mitigated, reducing the emotional and financial toll on the patient. Currently, several NIR fluorescence imaging systems (NFIS) are available commercially or are undergoing clinical trials, such as FLARE, SPY, PDE, Fluobeam, and others. These systems capture multi-spectral images using complex optical equipment and are combined with real-time image processing to present an augmented view to the surgeon. The information is presented on a standard monitor above the operating bed, which requires the physician to stop the surgical procedure and look up at the monitor. The break in the surgical flow sometimes outweighs the benefits of fluorescence based IGS, especially in time-critical surgical situations. Furthermore, these instruments tend to be very bulky and have a large foot print, which significantly complicates their adoption in an already crowded operating room. In this document, I present the development of a compact and wearable goggle system capable of real-time sensing of both NIR fluorescence and color information. The imaging system is inspired by the ommatidia of the monarch butterfly, in which pixelated spectral filters are integrated with light sensitive elements. The pixelated spectral filters are fabricated via a carefully optimized nanofabrication procedure and integrated with a CMOS imaging array. The entire imaging system has been optimized for high signal-to-background fluorescence imaging using an analytical approach, and the efficacy of the system has been experimentally verified. The bio-inspired spectral imaging sensor is integrated with an FPGA for compact and real-time signal processing and a wearable goggle for easy integration in the operating room. The complete imaging system is undergoing clinical trials at Washington University in the St. Louis Medical School for imaging sentinel lymph nodes in both breast cancer patients and melanoma patients.
Author : Ferenc A. Jolesz
Publisher : Springer Science & Business Media
ISBN 13 : 1461476577
Total Pages : 870 pages
Book Rating : 4.4/5 (614 download)
Download or read book Intraoperative Imaging and Image-Guided Therapy written by Ferenc A. Jolesz and published by Springer Science & Business Media. This book was released on 2014-01-14 with total page 870 pages. Available in PDF, EPUB and Kindle. Book excerpt: Image-guided therapy (IGT) uses imaging to improve the localization and targeting of diseased tissue and to monitor and control treatments. During the past decade, image-guided surgeries and image-guided minimally invasive interventions have emerged as advances that can be used in place of traditional invasive approaches. Advanced imaging technologies such as magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET) entered into operating rooms and interventional suites to complement already-available routine imaging devices like X-ray and ultrasound. At the same time, navigational tools, computer-assisted surgery devices, and image-guided robots also became part of the revolution in interventional radiology suites and the operating room. Intraoperative Imaging and Image-Guided Therapy explores the fundamental, technical, and clinical aspects of state-of the-art image-guided therapies. It presents the basic concepts of image guidance, the technologies involved in therapy delivery, and the special requirements for the design and construction of image-guided operating rooms and interventional suites. It also covers future developments such as molecular imaging-guided surgeries and novel innovative therapies like MRI-guided focused ultrasound surgery. IGT is a multidisciplinary and multimodality field in which teams of physicians, physicists, engineers, and computer scientists collaborate in performing these interventions, an approach that is reflected in the organization of the book. Contributing authors include members of the National Center of Image-Guided Therapy program at Brigham and Women’s Hospital and international leaders in the field of IGT. The book includes coverage of these topics: - Imaging methods, guidance technologies, and the therapy delivery systems currently used or in development. - Clinical applications for IGT in various specialties such as neurosurgery, ear-nose-and-throat surgery, cardiovascular surgery, endoscopies, and orthopedic procedures. - Review and comparison of the clinical uses for IGT with conventional methods in terms of invasiveness, effectiveness, and outcome. - Requirements for the design and construction of image-guided operating rooms and interventional suites.
Author : Takeaki Ishizawa
Publisher : OAE Publishing Inc.
ISBN 13 :
Total Pages : 3 pages
Book Rating : 4./5 ( download)
Download or read book “Bon mariage” of artificial intelligence and intraoperative fluorescence imaging for safer surgery written by Takeaki Ishizawa and published by OAE Publishing Inc.. This book was released on 2023-08-16 with total page 3 pages. Available in PDF, EPUB and Kindle. Book excerpt: Partnering AI-based technologies with intraoperative fluorescence imaging can enhance the accuracy and reliability of fluorescence-guided surgery.
Author : Michael John Daly
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (133 download)
Download or read book An Image-Guided Computational Framework for Intraoperative Fluorescence Quantification written by Michael John Daly and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorescence-guided surgery uses molecular agents that target tumors, lymph nodes, or blood vessels. Optical devices measure fluorescence light emissions from these functional biomarkers to help surgeons differentiate diseased and healthy anatomy. Clinical indications for fluorescence guidance continue to expand, and are being spurred by the rapid development of new agents that improve biological targeting. To capitalize fully on these advances, there is a corresponding need to engineer high-resolution imaging systems that provide objective measurements of fluorescence. The key innovation in this thesis is the development of a computational framework for image-guided fluorescence quantification. The underlying principle is to directly incorporate spatial localization of patient anatomy and optical devices into multi-stage models of fluorescence light transport. This technique leverages technology for intraoperative cone-beam CT (CBCT) imaging and surgical navigation to account for tissue deformation and surgical excision. A novel calibration algorithm enables real-time compensation for fluorescence variations due to illumination inhomogeneities, tissue topography, and camera response. In endoscopic images of realistic oral cavity phantoms, navigated light transport modeling not only improved fluorescence quantification accuracy at the tissue surface, but also reduced tissue misclassification in a simulated model of surgical decision making (e.g., tumor vs. normal, perfused vs. necrotic) in comparison to an unguided approach. The image-guidance framework was also applied to a finite-element implementation of diffuse fluorescence tomography. Camera and laser tracking enabled adaptive, non-contact acquisition. Sub-surface spatial priors from CBCT imaging improved the depth-resolved spatial resolution and fluorescence quantification accuracy in liquid phantom experiments. These investigations elucidate the deleterious effects of view-dependent illumination inhomogeneities and depth-dependent diffuse tissue transport on fluorescence quantification accuracy. Moreover, the direct use of 3D data from a CBCT-guided surgical navigation system in computational light transport models improves fluorescence quantification and tissue classification accuracy in pre-clinical experiments. Future clinical translation of these fluorescence-guided surgery techniques is an essential next step to further assess the potential impact on intraoperative decision making and cancer patient care.
Author : Nimrod Missael Garcia Hernandez
Publisher :
ISBN 13 :
Total Pages : 151 pages
Book Rating : 4.:/5 (13 download)
Download or read book Bio-inspired Multi-spectral and Polarization Imaging Sensors for Image-guided Surgery written by Nimrod Missael Garcia Hernandez and published by . This book was released on 2017 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt: Image-guided surgery (IGS) can enhance cancer treatment by decreasing, and ideally eliminating, positive tumor margins and iatrogenic damage to healthy tissue. Current state-of-the-art near-infrared fluorescence imaging systems are bulky, costly, lack sensitivity under surgical illumination, and lack co-registration accuracy between multimodal images. As a result, an overwhelming majority of physicians still rely on their unaided eyes and palpation as the primary sensing modalities to distinguish cancerous from healthy tissue. In my thesis, I have addressed these challenges in IGC by mimicking the visual systems of several animals to construct low power, compact and highly sensitive multi-spectral and color-polarization sensors. I have realized single-chip multi-spectral imagers with 1000-fold higher sensitivity and 7-fold better spatial co-registration accuracy compared to clinical imaging systems in current use by monolithically integrating spectral tapetal and polarization filters with an array of vertically stacked photodetectors. These imaging sensors yield the unique capabilities of imaging simultaneously color, polarization, and multiple fluorophores for near-infrared fluorescence imaging. Preclinical and clinical data demonstrate seamless integration of this technologies in the surgical work flow while providing surgeons with real-time information on the location of cancerous tissue and sentinel lymph nodes, respectively. Due to its low cost, the bio-inspired sensors will provide resource-limited hospitals with much-needed technology to enable more accurate value-based health care.
Author : Zhe Liu
Publisher : Springer Nature
ISBN 13 : 9813299029
Total Pages : 196 pages
Book Rating : 4.8/5 (132 download)
Download or read book Visualized Medicine written by Zhe Liu and published by Springer Nature. This book was released on 2023-07-17 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the recent advancements for visualized medicine in terms of fundamental principles, rapidly emerging techniques and developing frontiers. Especially with the combination of artificial intelligence (AI), medical imaging agents and medical robots, smart medical technologies have been innovated and applied to the clinical uses to serve the fatal human diseases diagnosis, treatment, prognosis and data analysis. This philosophy comprehensively revolutionizes the treatment strategy of human healthcare, and will enable precision medicine and precision surgery further intuitively detectable, smartly analyzable and accurately operational. This book will discuss and conclude: 1) state-of-the-art definition of visualized medicine; 2) advanced techniques and clinical applications of visualized medicine in the past decade; 3) novel frontiers and brand-new technologies, e.g. artificial intelligence (AI), surgical robots, etc. 4) revolutionary impacts on disease diagnosis, treatments and prognosis; 5) future challenges and perspectives.
