New Mechanisms And Therapeutics In Neurodevelopmental Disorders

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New mechanisms and therapeutics in neurodevelopmental disorders

Author : Daniela Tropea
Publisher : Frontiers E-books
ISBN 13 : 2889190676
Total Pages : 109 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis New mechanisms and therapeutics in neurodevelopmental disorders by : Daniela Tropea

Download or read book New mechanisms and therapeutics in neurodevelopmental disorders written by Daniela Tropea and published by Frontiers E-books. This book was released on with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodevelopmental disorders (NDDs) are severe, heritable conditions characterized by impaired brain development and disability in cognition, social interaction and behavior. Genetic predisposition appears to interact with environmental factors to produce the onset of the disease. In the last decade genomic analysis on NDDs advanced the knowledge of the genetic causes of these disorders: most of the genes identified were not predicted from known biology, and almost all of them engage in neurodevelopmental processes. However, the same studies revealed an unexpected outcome regarding the molecular etiology: many of the same susceptibility genes as well as molecular pathways are emerging across hitherto unrelated disorders- such as autism and schizophrenia- challenging how we conceptualize these conditions. These new discoveries call for the establishment of additional criteria for the classification of the genes and related phenotypes. Beyond the classical distinction according to diagnostic criteria, new parameters should be taken into account: the genetics, the neurobiology of the gene products and the molecular mechanisms that they control. Our broad understanding of NDDs, requires a combination of approaches, including human studies, animal models and theoretical computation. Indeed, progress in technology and the generation of accurate models are advancing the field, and the research is rapidly growing. This Research Topic presents recent advances in neurodevelopmental disorders from genes to systems, in single conditions and across different phenotypes, and report the newest treatments in use. Recognized experts in the field discuss recent findings in molecular studies, in vivo imaging, neuropsychology, neuropharmacology and computational neuroscience. This multidisciplinary approach enriches our understanding of the mechanisms involved in the onset and progression of NDDs with the perspective of revealing the biological signs of the disorders and identifying new therapeutics.

Treatment of Neurodevelopmental Disorders

Author : Randi Jenssen Hagerman
Publisher : Oxford University Press, USA
ISBN 13 : 019993780X
Total Pages : 401 pages
Book Rating : 4.1/5 (999 download)

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Book Synopsis Treatment of Neurodevelopmental Disorders by : Randi Jenssen Hagerman

Download or read book Treatment of Neurodevelopmental Disorders written by Randi Jenssen Hagerman and published by Oxford University Press, USA. This book was released on 2014 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: This cutting-edge book brings advances in genetics, neurobiology, and psychopharmacology to the clinic to enhance treatment for neurodevelopmental disorders. Significant progress has been made in identifying the neurobiological mechanisms of several disorders and targeted treatments are modifying the outcome of these disorders. However, the ability to utilize this knowledge has not been summarized in one place for the practicing clinician. This book will fill that gap by providing the theoretical underpinnings and the latest advances in targeted treatments. Several neurodevelopmental disorders are reviewed in detail including clinical features and behavioral phenotypes, standard treatments and new targeted treatments based on the latest advances in neurobiology and the animal model studies that have lead to new treatments. The disorders covered include psychiatric disorders: schizophrenia, depression, autism and ADHD; single gene disorders including Tuberous Sclerosis, Fragile X Syndrome and fragile X- associated disorders, Angelman Syndrome, PKU, and Muscular Dystrophies; and complex genetic disorders such as Down syndrome. This book also highlights the commonalities across disorders and new genetic and molecular concepts in an easy to read format. This is a very exciting time for new targeted treatments and this volume is a landmark treatise on this new age of treatment.

Biomarkers to Enable Therapeutics Development in Neurodevelopmental Disorders

Author : Mustafa Sahin
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)

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Book Synopsis Biomarkers to Enable Therapeutics Development in Neurodevelopmental Disorders by : Mustafa Sahin

Download or read book Biomarkers to Enable Therapeutics Development in Neurodevelopmental Disorders written by Mustafa Sahin and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Biomarkers to Enable Therapeutics Development in Neurodevelopmental Disorders

Author : Mustafa Sahin
Publisher : Frontiers Media SA
ISBN 13 : 2889663388
Total Pages : 251 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Biomarkers to Enable Therapeutics Development in Neurodevelopmental Disorders by : Mustafa Sahin

Download or read book Biomarkers to Enable Therapeutics Development in Neurodevelopmental Disorders written by Mustafa Sahin and published by Frontiers Media SA. This book was released on 2020-12-31 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Targeted Therapies for Neurodevelopmental Disorders

Author : Ethan M. Goldberg
Publisher :
ISBN 13 : 9783318069600
Total Pages : pages
Book Rating : 4.0/5 (696 download)

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Book Synopsis Targeted Therapies for Neurodevelopmental Disorders by : Ethan M. Goldberg

Download or read book Targeted Therapies for Neurodevelopmental Disorders written by Ethan M. Goldberg and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Treatments of Neurodevelopmental Disorders

Author : Randi Jenssen Hagerman
Publisher :
ISBN 13 : 9780199380138
Total Pages : 376 pages
Book Rating : 4.3/5 (81 download)

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Book Synopsis Treatments of Neurodevelopmental Disorders by : Randi Jenssen Hagerman

Download or read book Treatments of Neurodevelopmental Disorders written by Randi Jenssen Hagerman and published by . This book was released on 2014 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This cutting-edge book brings advances in genetics, neurobiology, and psychopharmacology to the clinic to enhance treatment for neurodevelopmental disorders. Significant progress has been made in identifying the neurobiological mechanisms of several disorders and targeted treatments are modifying the outcome of these disorders. However, the ability to utilize this knowledge has not been summarized in one place for the practicing clinician. This book will fill that gap by providing the theoretical underpinnings and the latest advances in targeted treatments. Several neurodevelopmental disorders.

Neurodevelopmental Disorders

Author : Bin Chen
Publisher : Academic Press
ISBN 13 : 0128144106
Total Pages : 428 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Neurodevelopmental Disorders by : Bin Chen

Download or read book Neurodevelopmental Disorders written by Bin Chen and published by Academic Press. This book was released on 2020-05-24 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodevelopmental Disorders, the latest release in the Comprehensive Developmental Neuroscience series, presents the most thorough coverage available, addressing all aspects on how the nervous system and its components develop. This book brings together the latest research in this rapidly evolving field, with section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on neurodevelopmental disorders in humans and experimental organisms. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. - Features leading experts in various subfields as section editors and article authors - Presents articles that have been peer reviewed to ensure accuracy, thoroughness and scholarship - Covers disorders of the nervous system that arise through defects in neural development

Neurocognitive Development: Disorders and Disabilities

Author :
Publisher : Elsevier
ISBN 13 : 0444641491
Total Pages : 428 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Neurocognitive Development: Disorders and Disabilities by :

Download or read book Neurocognitive Development: Disorders and Disabilities written by and published by Elsevier. This book was released on 2020-09-25 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is one volume of a two-volume work on neurocognitive development, focusing separately on normative and non-normative development. The disorders and disabilities volume focuses on disorders of intellectual abilities, language, learning memory as well as psychiatric developmental disorders. The developmental aspects of neurological diseases in children is also covered. Chapters discuss when and how these disorders develop, the genetics and neurophysiology of their operation, and their evaluation and assessment in clinical practice. Assessment, treatment, and long-term outcome are provided as well as advances in methods and tools for assessment. This book will serve as a comprehensive reference to researchers in cognitive development in neuroscience, psychology, and medicine, as well as to clinicians and allied health professionals focused on developmental disabilities (child neurologists, pediatric neuropsychologists, child psychiatrists, speech and language therapists, and occupational therapists.) - Summarizes research on neurocognitive developmental disorders and disabilities - Includes disorders of intellectual abilities, language, learning, memory, and more - Separately covers developmental aspects of neurological diseases in children - Features advances in methods and tools of assessment - Reviews patient care, rehabilitation, and long-term outcomes - Provides interdisciplinary information of use to both researchers and clinicians

Autism Spectrum Disorders

Author : Andreas M. Grabrucker
Publisher :
ISBN 13 :
Total Pages : 117 pages
Book Rating : 4.:/5 (128 download)

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Book Synopsis Autism Spectrum Disorders by : Andreas M. Grabrucker

Download or read book Autism Spectrum Disorders written by Andreas M. Grabrucker and published by . This book was released on 2021 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism spectrum disorders are developmental disorders. Individuals with autism spectrum disorders develop differently. These differences are usually present in social interaction, communication, and sensory processing, and become visible through a wide variety of behavioral responses that differ from individuals without autism spectrum disorders. Despite significant research efforts, the exact causes of autism spectrum disorders remain poorly understood; however, researchers have gained extensive insights into possible pathomechanisms, even at the molecular level of cells. Many diagnostic criteria have been developed, adapted, and improved. The eight chapters in this book highlight the current state-of-the-art in many areas of autism spectrum disorders. Chapter 1 provides an overview of the epidemiology of autism spectrum disorders and the current knowledge of the underlying pathogenic mechanisms. Chapter 2 summarizes the diagnostic criteria and procedures and highlights present and upcoming therapeutic strategies. Chapter 3 reviews the adverse events and trauma in people with autism spectrum disorders. Chapters 4 and 5 focus on atypical sensory processing, and Chapter 6 discusses the genetic overlap of autism spectrum disorders with other neuropsychiatric disorders such as attention deficit hyperactivity disorder (ADHD), depression, and schizophrenia. Chapter 7 focuses on the contribution of abnormalities in mitochondria, and chapter 8 discusses gut-brain interactions and a potential role for microbiota in autism spectrum disorders. This book is aimed primarily at clinicians and scientists, but many areas will also be of interest to the layperson.

Emerging Trends in the Diagnosis and Intervention of Neurodevelopmental Disorders

Author : Gupta, Sanjeev Kumar
Publisher : IGI Global
ISBN 13 : 1522570055
Total Pages : 420 pages
Book Rating : 4.5/5 (225 download)

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Book Synopsis Emerging Trends in the Diagnosis and Intervention of Neurodevelopmental Disorders by : Gupta, Sanjeev Kumar

Download or read book Emerging Trends in the Diagnosis and Intervention of Neurodevelopmental Disorders written by Gupta, Sanjeev Kumar and published by IGI Global. This book was released on 2018-10-26 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodevelopmental disorders encompass a group of conditions that can typically manifest during early childhood. These include intellectual disabilities, communication disorders, autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), specific learning disorder (SLD), and motor disorders. Early identification and assessment can be a valuable tool in determining diagnosis, prognosis, functional abilities, and formulating clinical intervention for both children and adults with neurodevelopmental disorders. Emerging Trends in the Diagnosis and Intervention of Neurodevelopmental Disorders is an essential reference source that discusses and disseminates contributions covering recent trends in diagnosis, assessment, and intervention techniques. Featuring research on topics such as clinical linguistics, neural connectivity, and animal-assisted therapy, this book is ideally designed for speech pathologists, social workers, occupational therapists, psychologists, psychiatrists, neurologists, pediatricians, researchers, clinicians, and academicians seeking coverage on neural and developmental disorder identification and strategies for clinician support and therapies.

Gene Therapy in the CNS – Progress and Prospects for Novel Therapies

Author : Casper René Gøtzsche
Publisher : Frontiers Media SA
ISBN 13 : 2889718522
Total Pages : 188 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Gene Therapy in the CNS – Progress and Prospects for Novel Therapies by : Casper René Gøtzsche

Download or read book Gene Therapy in the CNS – Progress and Prospects for Novel Therapies written by Casper René Gøtzsche and published by Frontiers Media SA. This book was released on 2021-12-21 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Neurobiologically Informed Trauma Therapy with Children and Adol

Author : Linda Chapman
Publisher : W. W. Norton & Company
ISBN 13 : 0393707881
Total Pages : 268 pages
Book Rating : 4.3/5 (937 download)

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Book Synopsis Neurobiologically Informed Trauma Therapy with Children and Adol by : Linda Chapman

Download or read book Neurobiologically Informed Trauma Therapy with Children and Adol written by Linda Chapman and published by W. W. Norton & Company. This book was released on 2014-01-20 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nonverbal interactions are applied to trauma treatment for more effective results. The model of treatment developed here is grounded in the physical, psychological, and cognitive reactions children have to traumatic experiences and the consequences of those experiences. The approach to treatment utilizes the integrative capacity of the brain to create a self, foster insight, and produce change. Treatment strategies are based on cutting-edge understanding of neurobiology, the development of the brain, and the storage and retrieval of traumatic memory. Case vignettes illustrate specific examples of the reactions of children, families, and teens to acute and repeated exposure to traumatic events. Also presented is the most recent knowledge of the role of the right hemisphere (RH) in development and therapy. Right brain communication, and how to recognize the non-verbal symbolic and unconscious, affective processes will be explained, along with examples of how the therapist can utilize art making, media, tools, and self to engage in a two-person biology.

Neurodevelopmental Disorders

Author : Randi Jenssen Hagerman
Publisher : Oxford University Press
ISBN 13 : 0198028695
Total Pages : 425 pages
Book Rating : 4.1/5 (98 download)

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Book Synopsis Neurodevelopmental Disorders by : Randi Jenssen Hagerman

Download or read book Neurodevelopmental Disorders written by Randi Jenssen Hagerman and published by Oxford University Press. This book was released on 1999-09-16 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodevelopmental Disorders: Diagnosis and Treatment summarizes a vast body of literature concerning diagnosis and treatment for a variety of neurodevelopmental disorders, including both common and rare conditions. Throughout the book, Dr. Hagerman synthesizes treatment information for many disciplines that work together to provide multi-modality intervention. Psychopharmacological information and recommendations as well as the latest knowledge regarding genetic and diagnostic aspects of each disorder are explained in detail. And all chapters have one or more case studies to model the treatment recommendations, which are enhanced by extensive appendices reviewing educational programs, computer software, and supplementary reading. In addition, a detailed resource list of organizations, educational materials, and internet connections accompanies each chapter. This book not only integrates but also advances our knowledge of treatment, which is of prime importance for clinicians, therapists, educators, and parents.

Environmental Epigenetics

Author : L. Joseph Su
Publisher : Springer
ISBN 13 : 1447166787
Total Pages : 327 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Environmental Epigenetics by : L. Joseph Su

Download or read book Environmental Epigenetics written by L. Joseph Su and published by Springer. This book was released on 2015-05-18 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Jasper's Basic Mechanisms of the Epilepsies

Author : Jeffrey Noebels
Publisher : OUP USA
ISBN 13 : 0199746540
Total Pages : 1258 pages
Book Rating : 4.1/5 (997 download)

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Book Synopsis Jasper's Basic Mechanisms of the Epilepsies by : Jeffrey Noebels

Download or read book Jasper's Basic Mechanisms of the Epilepsies written by Jeffrey Noebels and published by OUP USA. This book was released on 2012-06-29 with total page 1258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.

Homeostatic Control of Brain Function

Author : Detlev Boison
Publisher : Oxford University Press
ISBN 13 : 0199322295
Total Pages : 657 pages
Book Rating : 4.1/5 (993 download)

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Book Synopsis Homeostatic Control of Brain Function by : Detlev Boison

Download or read book Homeostatic Control of Brain Function written by Detlev Boison and published by Oxford University Press. This book was released on 2016 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders. Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer's or Parkinson's are ever present, the incorporation of homeostatic techniques could successfully promote better overall brain health. Key Features include · A focus on the homeostatic controls that significantly depend on the way one lives, eats, and drinks. · Highlights from emerging research in non-pharmaceutical therapies including botanical medications, meditation, diet, and exercise. · Incorporation of homeostatic therapies into existing basic and clinical research paradigms. · Extensive scientific basic and clinical research ranging from molecules to disorders. · Emerging practical information for improving homeostasis. · Examples of homeostatic therapies in preventing and delaying dysfunction. Both editors, Detlev Boison and Susan Masino, bring their unique expertise in homeostatic research to the overall scope of this work. This book is accessible to all with an interest in brain health; scientist, clinician, student, and lay reader alike.

Neuropsychopharmacology

Author : Kenneth L. Davis
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781728379
Total Pages : 1964 pages
Book Rating : 4.7/5 (283 download)

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Book Synopsis Neuropsychopharmacology by : Kenneth L. Davis

Download or read book Neuropsychopharmacology written by Kenneth L. Davis and published by Lippincott Williams & Wilkins. This book was released on 2002 with total page 1964 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly updated and completely reorganized for a sharper clinical focus, the Fifth Edition of this world-renowned classic synthesizes the latest advances in basic neurobiology, biological psychiatry, and clinical neuropsychopharmacology. The book establishes a critical bridge connecting new discoveries in molecular and cellular biology, genetics, and neuroimaging with the etiology, diagnosis, and treatment of all neuropsychiatric disorders. Nine sections focus on specific groups of disorders, covering clinical course, genetics, neurobiology, neuroimaging, and current and emerging therapeutics. Four sections cover neurotransmitter and signal transduction, emerging methods in molecular biology and genetics, emerging imaging technologies and their psychiatric applications, and drug discovery and evaluation. Compatibility: BlackBerry(R) OS 4.1 or Higher / iPhone/iPod Touch 2.0 or Higher /Palm OS 3.5 or higher / Palm Pre Classic / Symbian S60, 3rd edition (Nokia) / Windows Mobile(TM) Pocket PC (all versions) / Windows Mobile Smartphone / Windows 98SE/2000/ME/XP/Vista/Tablet PC