Neuroprotective Signal Transduction

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Neuroprotective Signal Transduction

Author : Mark P. Mattson
Publisher : Springer Science & Business Media
ISBN 13 : 1592594751
Total Pages : 349 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Neuroprotective Signal Transduction by : Mark P. Mattson

Download or read book Neuroprotective Signal Transduction written by Mark P. Mattson and published by Springer Science & Business Media. This book was released on 1997-10-10 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Neuroprotective Signal Transduction prominent researchers and clinicians focus on how inter- and intracellular signaling mechanisms prevent the degeneration and death of neurons occurring in both acute and chronic neurodegenerative disorders. Authoritative contributions dissect the signaling pathways of an array of neuroprotective factors-ranging from neurotrophins (NGF, BDNF, NT-3, and NT-4/5), to growth factors (bFGF, IGF-1, GDNF), to cytokines (TNF, IL-1b, and TGFb), to secreted amyloid precursor proteins, to protease nexin-1. Also treated are cytoprotective signaling events that occur within injured neurons independently of intercellular signals. Neuroprotective Signal Transduction presents fundamental, cutting-edge treatment of the cellular and molecular signal transduction pathways found in human neurodegenerative conditions. The book's elucidation of the molecular cascades evolved by the nervous system to protect itself is now lead to effective strategies for preventing neuronal degeneration in such conditions as stroke, traumatic brain injury, Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis, and will form the basis for powerful new drug discovery and gene therapy strategies.

Neuroprotective Signal Transduction

Author : Mark P. Mattson
Publisher :
ISBN 13 : 9781475759679
Total Pages : 360 pages
Book Rating : 4.7/5 (596 download)

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Book Synopsis Neuroprotective Signal Transduction by : Mark P. Mattson

Download or read book Neuroprotective Signal Transduction written by Mark P. Mattson and published by . This book was released on 2014-01-15 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nicotinic Acetylcholine Receptor Signaling in Neuroprotection

Author : Akinori Akaike
Publisher : Springer
ISBN 13 : 9811084882
Total Pages : 191 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Nicotinic Acetylcholine Receptor Signaling in Neuroprotection by : Akinori Akaike

Download or read book Nicotinic Acetylcholine Receptor Signaling in Neuroprotection written by Akinori Akaike and published by Springer. This book was released on 2018-04-04 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book. In response to rapidly evolving areas in clinical and laboratory neuropharmacology and neurochemistry, this volume provides in-depth coverage of neuroprotection in basic research and future developments in the clinical application of effective neuroprotective strategies in neurodegenerative diseases. This work appeals to both basic and clinical researchers in several fields, such as neuroscience, neurology, and pharmacology.

Nicotinic Acetylcholine Receptor Signaling in Neuroprotection

Author : Shun Shimohama
Publisher :
ISBN 13 : 9781013269752
Total Pages : 196 pages
Book Rating : 4.2/5 (697 download)

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Book Synopsis Nicotinic Acetylcholine Receptor Signaling in Neuroprotection by : Shun Shimohama

Download or read book Nicotinic Acetylcholine Receptor Signaling in Neuroprotection written by Shun Shimohama and published by . This book was released on 2020-10-08 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book. In response to rapidly evolving areas in clinical and laboratory neuropharmacology and neurochemistry, this volume provides in-depth coverage of neuroprotection in basic research and future developments in the clinical application of effective neuroprotective strategies in neurodegenerative diseases. This work appeals to both basic and clinical researchers in several fields, such as neuroscience, neurology, and pharmacology. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

Neuroprotection Methods and Protocols

Author : Tiziana Borsello
Publisher : Springer Science & Business Media
ISBN 13 : 1588296660
Total Pages : 498 pages
Book Rating : 4.5/5 (882 download)

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Book Synopsis Neuroprotection Methods and Protocols by : Tiziana Borsello

Download or read book Neuroprotection Methods and Protocols written by Tiziana Borsello and published by Springer Science & Business Media. This book was released on 2007-08-08 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines current research into the role of neuronal death in cell signaling pathways, and its role in neurodegenerative diseases, such as Alzheimer's and Parkinson's. After introducing neurodegenerative, traumatic, and ishemic disorders, the authors cover in vitro and animal systems, and cellular and molecular mechanisms.

The Orexin System. Basic Science and Role in Sleep Pathology

Author : M.A. Steiner
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318068446
Total Pages : 165 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis The Orexin System. Basic Science and Role in Sleep Pathology by : M.A. Steiner

Download or read book The Orexin System. Basic Science and Role in Sleep Pathology written by M.A. Steiner and published by Karger Medical and Scientific Publishers. This book was released on 2021-05-28 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: The orexin system, discovered in 1998, has emerged as a crucial player in regulating the sleep and wake balance inside our brain. This discovery has sparked a burst of novel and dynamic research on the physiology and pathology of sleep. The Orexin System: Basic Science and Role in Sleep Pathology honors this research and the authors share their ideas and perspectives on the novel developments within the field. The book examines the intricate role of the orexin system in regulating sleep and wake, and its interaction with other wake-regulating systems. The orexin system is dissected at the cellular and molecular level to explore the diversity of the orexin-producing neurons, their projections, and their signaling pathways. Additionally, the book discusses the diseases which are associated with a dysfunctional orexin system, such as narcolepsy, insomnia, substance abuse, and Alzheimer’s disease, and explores the new potential therapeutic applications derived from the burst of research around this fascinating system. This publication is essential reading for neurobiologists, neurologists, psychopharmacologists, sleep researchers, and other researchers and clinical scientists interested in sleep, sleep research, insomnia, and medicine in general.

Phytochemicals, Signal Transduction, and Neurological Disorders

Author : Akhlaq A. Farooqui
Publisher : Springer Science & Business Media
ISBN 13 : 1461438047
Total Pages : 371 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Phytochemicals, Signal Transduction, and Neurological Disorders by : Akhlaq A. Farooqui

Download or read book Phytochemicals, Signal Transduction, and Neurological Disorders written by Akhlaq A. Farooqui and published by Springer Science & Business Media. This book was released on 2012-07-10 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phytochemicals Signal Transduction and Neurological Disorders Phytochemicals are heterogeneous group of bioactive compounds produced by plants, which are extensively researched by scientists for their health-promoting potentials in human diseases. Unlike vitamins and minerals, phytochemicals are not required for sustaining cell viability, but they play an important role in protecting tissues and cells from the harmful effects of oxidative stress and inflammation. Examples of phytochemicals include catechins, resveratrol, ginkgo biloba, curcumin, and sulfur compounds found in garlic. Although, the precise molecular mechanisms associated with beneficial effects of phytochemicals still remain the subject of intense investigations, but it is becoming increasingly evident that phytochemicals mediate their effects by counteracting, reducing, and repairing the damage caused by oxidative stress and neuroinflammation. In addition, phytochemicals also stimulate the synthesis of adaptive enzymes and proteins through the stimulation of a transcription factor called Nrf2 and induction of phase II detoxifying enzymes. Consumption of phytochemicals induces neurohormetic response that results in the expression of adaptive stress-resistance genes that are responsible for encoding antioxidant enzymes, protein chaperones, and neurotrophic factor (BDNF). Based on the stimulation of signal transduction network and adaptive stress-resistance genes, it is proposed that the use of phytochemicals from childhood to old age along with regular exercise is an important strategy for maintaining normal aging and delaying onset of age-related neurological disorders (stroke, Alzheimer disease, and Parkinson disease). Phytochemicals Signal Transduction and Neurological Disorders presents readers with cutting edge and comprehensive information not only on bioavailability, and mechanism of action of phytochemicals in the brain, but also provides the molecular mechanism associated with beneficial effects of phytochemicals in neurotraumatic (stroke, spinal cord trauma, and traumatic brain injury) and neurodegenerative (Alzheimers disease, Parkinson disease, Huntington disease, and amyotrophic lateral sclerosis) diseases.

Neuroinflammation, Resolution, and Neuroprotection in the Brain

Author : Akhlaq A. Farooqui
Publisher : Academic Press
ISBN 13 : 032388461X
Total Pages : 334 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Neuroinflammation, Resolution, and Neuroprotection in the Brain by : Akhlaq A. Farooqui

Download or read book Neuroinflammation, Resolution, and Neuroprotection in the Brain written by Akhlaq A. Farooqui and published by Academic Press. This book was released on 2021-09-15 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroinflammation, Resolution, and Neuroprotection in the Brain discusses the molecular aspects of neuroinflammation in neurological disorders. The book examines the effect of diet and exercise on neuroinflammatory diseases. Chapters focus on bioactive lipids, cytokines and chemokines, as well as the involvement of neuroinflammation, resolution and neuroprotection in neurotraumatic diseases, neurodegenerative diseases and neuropsychiatric diseases. The comprehensive information in this monograph will help readers understand molecular cross-talk among mediators of phospholipid, sphingolipid and cholesterol metabolism. The book's goal is to jumpstart more studies on molecular mechanisms and the therapeutic aspects of neurological disorders in human subjects. Discusses the molecular aspects of neuroinflammation, resolution and neuroprotection Examines the role of diet and exercise on neuroinflammatory diseases Provides cutting-edge research on signal transduction processes Explores the treatment of neurological disorders caused by neuroinflammation

Neuroprotective Effects of Phytochemicals in Neurological Disorders

Author : Tahira Farooqui
Publisher : John Wiley & Sons
ISBN 13 : 1119155142
Total Pages : 662 pages
Book Rating : 4.1/5 (191 download)

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Book Synopsis Neuroprotective Effects of Phytochemicals in Neurological Disorders by : Tahira Farooqui

Download or read book Neuroprotective Effects of Phytochemicals in Neurological Disorders written by Tahira Farooqui and published by John Wiley & Sons. This book was released on 2017-03-20 with total page 662 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phytochemicals are naturally occurring bioactive compounds found in edible fruits, plants, vegetables, and herbs. Unlike vitamins and minerals, phytochemicals are not needed for the maintenance of cell viability, but they play a vital role in protecting neural cells from inflammation and oxidative stress associated with normal aging and acute and chronic age-related brain diseases. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the advances in our understanding of the potential neuroprotective benefits that these naturally occurring chemicals contain. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the role that a number of plant-based chemical compounds play in a wide variety of neurological disorders. Chapters explore the impact of phytochemicals on neurotraumatic disorders, such as stroke and spinal cord injury, alongside neurodegenerative diseases such as Alzheimer's and Parkinson's Disease, as well as neuropsychiatric disorders such as depression and schizophrenia. The chapters and sections of this book provide the reader with a big picture view of this field of research. Neuroprotective Effects of Phytochemicals in Neurological Disorders aims to present readers with a comprehensive and cutting edge look at the effects of phytochemicals on the brain and neurological disorders in a manner useful to researchers, neuroscientists, clinical nutritionists, and physicians.

Neuroprotective Signaling Through Metabotropic Glutamate Receptor 1

Author : Andrew Clayton Emery
Publisher :
ISBN 13 : 9781124598307
Total Pages : 113 pages
Book Rating : 4.5/5 (983 download)

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Book Synopsis Neuroprotective Signaling Through Metabotropic Glutamate Receptor 1 by : Andrew Clayton Emery

Download or read book Neuroprotective Signaling Through Metabotropic Glutamate Receptor 1 written by Andrew Clayton Emery and published by . This book was released on 2011 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabotropic glutamate receptor 1 (mGlu1) is a G protein-coupled receptor which enhances the hydrolysis of membrane phosphoinositides (PI). Additionally, mGlu1 receptors have been shown to stimulate cytoprotective signaling in the presence of the endogenous ligand glutamate. This goal of the experiments in the following thesis was to (1) characterize the signal transduction pathway through which mGlu1 receptors protect cells expressing these receptors from toxicity. Instead of the classical G protein-mediated (PI) signaling, the following experiments indicate that mGlu1a receptors cause a sustained phosphorylation of ERK that is {beta}-arrestin-1 dependent. This G protein-independent signaling pathway was necessary for protective signaling and was stimulated by glutamate, but not quisqualate, demonstrating ligand bias at this receptor. (2) Therefore, pharmacological and mutational studies were carried out to investigate the molecular basis of this ligand bias. Together, these studies indicate the existence of 3 classes of mGlu1a receptor agonists: (a) unbiased agonists, such as glutamate, which stimulate both signal transduction pathways, (b) biased agonists, such as quisqualate, which only stimulate PI hydrolysis, and (c) agonists which are biased toward sustained ERK phosphorylation and protective signaling. In these studies, glutaric and succinic acid were identified as protection-biased mGlu1a receptor agonists. Further pharmacological studies indicate that quisqualate does not inhibit glutamate-induced protection and glutaric acid fails to inhibit glutamate-induced PI hydrolysis, suggesting the existence of two distinct, non-overlapping agonist binding sites on mGlu1a receptors.

Cerebral Signal Transduction

Author : Maarten E. A. Reith
Publisher : Springer Science & Business Media
ISBN 13 : 1592590195
Total Pages : 423 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Cerebral Signal Transduction by : Maarten E. A. Reith

Download or read book Cerebral Signal Transduction written by Maarten E. A. Reith and published by Springer Science & Business Media. This book was released on 2000-02-16 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the pioneering discovery of cyclic AMP four decades ago, a multitude of signaling pathways have been uncovered in which an extracellular signal (first messenger) impacts the cell surface, thereby triggering a cascade that ultimately acts on the cell nucleus. In each cascade the first messenger gives rise to the appearance of a second messenger such as cyclic AMP, cyclic GMP, or diacylglycerol, which in turn triggers a third messenger, a fourth messenger, and so forth. Many advances in elucidating such pathways have been made, including efforts to link messenger molecules to brain processes operative in health or disease. However, the latter type of information, relating signaling pathways to brain function, is scattered across a variety of publication media, which makes it difficult to integrate the multiple roles of different signaling cascades into our understanding of brain function in health and disease. The primary aim of Cerebral Signal Transduction: From First to Fourth Messengers, therefore, is to offer a comprehensive picture of the recent advances made in the signaling field as it relates to neuronal and cere bral function. The current state of progress provides an exciting opportunity for such a comprehensive focus because molecular tools have become available to selectively remove, reduce, or enhance spe cific components in the signaling pathways, e. g. , by interfering with the genes encoding key proteins. In addition, the increased awareness of crosstalk between different signaling cascades has revealed many possibilities for changes in gene expression underlying long-term changes in brain function.

Neuroprotection

Author : Matilde Otero-Losada
Publisher : BoD – Books on Demand
ISBN 13 : 1838804390
Total Pages : 350 pages
Book Rating : 4.8/5 (388 download)

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Book Synopsis Neuroprotection by : Matilde Otero-Losada

Download or read book Neuroprotection written by Matilde Otero-Losada and published by BoD – Books on Demand. This book was released on 2020-11-26 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurological disease affects nearly 25%–30% of the world’s population, exerting enormous financial strain on the healthcare system. Estimated current costs are around $800 annual billion, and this number is expected to increase exponentially as the global population ages. As such, new and alternative neuroprotective strategies are urgently needed. This book examines some of the most promising approaches in neuroprotection as well as discusses current goals and prospects. Organized into three sections, chapters cover such topics as the use of cannabinoids, medicinal plants, and essential oils in Alzheimer’s and Parkinson’s; protein misfolding and the neuroprotective potential of vitamin E in cerebral ischemia; and potential new neurological treatments and their mechanisms of action.

Recent Advances in Prolactin Research

Author : Maria Diakonova, PhD
Publisher : Springer
ISBN 13 : 3319121146
Total Pages : 286 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Recent Advances in Prolactin Research by : Maria Diakonova, PhD

Download or read book Recent Advances in Prolactin Research written by Maria Diakonova, PhD and published by Springer. This book was released on 2014-12-03 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Advances in Prolactin Research summarizes the current knowledge of prolactin (PRL), PRL receptor, PRL-dependent signaling pathways, the role of PRL in oncogenesis and PRL crosstalk with other oncogenic factors. The chapters are written by experts in these fields and focus on identifying and reviewing timely experimental findings that provide new insights into the expanding role of PRL in the pathophysiology associated with a variety of human conditions. Prolactin is a peptide hormone that is best known for its role in lactation. Prolactin also has an influence on hematopoiesis and angiogenesis, and is involved in the regulation of blood clotting through several pathways. Although PRL was discovered more than 80 years ago, the understanding of PRL signaling and its relationship to various pathologies is still very incomplete. PRL is not only a pituitary hormone with an important role in reproduction, but PRL also acts as a cytokine, modulating a wide variety of physiological processes. For example, data gathered during the last decade have demonstrated that locally produced PRL acts as the autocrine/paracrine factor and plays a contributory role during breast oncogenesis. In fact, the scientific and clinical communities have suggested that the manipulation of the PRL axis may lead to the successful treatment of breast cancer. However, recent work has demonstrated that the role of the PRL axis is much more complex than first envisaged.

Signal Transduction in the Retina

Author : Steven J. Fliesler
Publisher : CRC Press
ISBN 13 : 1420007165
Total Pages : 410 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Signal Transduction in the Retina by : Steven J. Fliesler

Download or read book Signal Transduction in the Retina written by Steven J. Fliesler and published by CRC Press. This book was released on 2007-12-26 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the twenty-first century, we are just beginning to understand more clearly the enormous diversity and complexity of signaling processes in the retina. Integrating advances in the biochemistry, cell biology, physiology, and physics of phototransduction, Signal Transduction in the Retina presents the methodologies and experimental approache

P38 Signaling Pathway

Author : Ana Cuenda
Publisher : MDPI
ISBN 13 : 3036508589
Total Pages : 194 pages
Book Rating : 4.0/5 (365 download)

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Book Synopsis P38 Signaling Pathway by : Ana Cuenda

Download or read book P38 Signaling Pathway written by Ana Cuenda and published by MDPI. This book was released on 2021-09-02 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: p38 Mitogen activated protein kinases (p38MAPK) are a group of evolutionary conserved protein kinases which are central for cell adaptation to environmental changes as well as for immune response, inflammation, tissue regeneration and tumour formation. The interest in this group of protein kinases has grown continually since their discovery. Recent studies using new genetic and pharmacological tools are providing helpful information on the function of these stress-activated protein kinases and show that they have an acute impact on the development of prevalent diseases related to inflammation, diabetes, neurodegeneration, and cancer. In this Special Issue we present novel advances and review the knowledge on the identification of p38MAPK substrates, functions, and regulation; mechanisms underlying the role of p38MAPK in malignant transformation and other pathologies; and therapeutic opportunities associated with regulation of p38MAPK activity.

Molecular Aspects of Neurodegeneration and Neuroprotection

Author : Akhlaq A. Farooqui
Publisher : Bentham Science Publishers
ISBN 13 : 1608050920
Total Pages : 156 pages
Book Rating : 4.6/5 (8 download)

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Book Synopsis Molecular Aspects of Neurodegeneration and Neuroprotection by : Akhlaq A. Farooqui

Download or read book Molecular Aspects of Neurodegeneration and Neuroprotection written by Akhlaq A. Farooqui and published by Bentham Science Publishers. This book was released on 2011-01-26 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Neurodegenerative diseases are a complex heterogeneous group of diseases associated with site-specific premature and slow death of certain neuronal populations in brain and spinal cord tissues. For example, in Alzheimer disease, neuronal degeneration occu"

Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis

Author : Achille G. Gravanis
Publisher : John Wiley & Sons
ISBN 13 : 3527633979
Total Pages : 381 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis by : Achille G. Gravanis

Download or read book Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis written by Achille G. Gravanis and published by John Wiley & Sons. This book was released on 2011-06-24 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: As life expectancy increases and population ages, the already enormous impact of neurodegeneration on society will become even larger without better prevention and treatment. Developing strategies to prevent degeneration of neurons and to promote a healthy nervous system is, thus, critical. The development of pharmacological agents that would increase production of new neurons was recently facilitated by the identification of the hormonal regulators of various steps of adult neurogenesis. The proposed book is writen by a group of top world experts involved in the study of the mechanisms of hormonal control of brain damage and repair. The effects of thyroid and steroid hormones (estrogens, androgens, progestins, gluco-mineralo-corticoids, various neurosteroids) or polypeptide hormones (CRF, urocortins, somatostastin, GH/IGF, leptin, prolactin, PACAP, erythropoetin) on neuronal survival and neurogenesis in various neurodegenerative conditions and in brain aging will be discussed in detail. The proposed book is unique because it gives a comprehensive account of the neuroprotective and neurogenic effects of steroid and polypeptide hormones. Furthermore, new pharmacological approaches for treatment of neurodegenerative conditions are presented, based on the neuroprotective and neurogenic properties of natural and synthetic hormones.