Neurobiology Of Cytokines

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The Neuroimmunological Basis of Behavior and Mental Disorders

Author : Allan Siegel
Publisher : Springer Science & Business Media
ISBN 13 : 0387848517
Total Pages : 437 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis The Neuroimmunological Basis of Behavior and Mental Disorders by : Allan Siegel

Download or read book The Neuroimmunological Basis of Behavior and Mental Disorders written by Allan Siegel and published by Springer Science & Business Media. This book was released on 2008-11-09 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: For many years, the immune and central nervous systems were thought to function independently with little or no interaction between the two. This view has und- gone dramatic changes over the past three decades. Indeed, we now know that there exists various feedback loops between the brain and immune systems that impact signi cantly upon different behavioral processes, including normal behavior and mental disorders. Pioneering efforts in generating this change were initiated by a number of early investigators. Included were those whose efforts were directed at establishing neuroimmune connections as well as others whose research focused upon the relationship between immunity, cytokines, and behavior. This book brings together outstanding scientists and clinicians who have made major contributions to the rapidly developing eld investigating the relationship between immunity and behavior. The book is divided into three parts. The rst part describes pathways by which the brain and immune systems communicate and int- act with each other. In the chapter “Cytokines and the Blood–Brain Barrier” p- vides insight into interactions between the blood–brain barrier and cytokines. Such interactions underlie basic communication between the immune system and brain that are present in normal as well as in disease conditions. In the chapter “Neu- chemical and Endocrine Responses to Immune Activation: The Role of Cytokines,” the neurochemical and endocrine consequences of immune challenge and cytokine administration on central neurotransmitter activity are discussed.

Cytokines, Stress, and Depression

Author : Robert Dantzer
Publisher : Springer Science & Business Media
ISBN 13 : 058537970X
Total Pages : 335 pages
Book Rating : 4.5/5 (853 download)

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Book Synopsis Cytokines, Stress, and Depression by : Robert Dantzer

Download or read book Cytokines, Stress, and Depression written by Robert Dantzer and published by Springer Science & Business Media. This book was released on 2007-11-23 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytokines had been characterized in the early eighties as communication mole cules between immune cells, and between immunocytes and other peripheral cells, such as fibroblasts and endothelial cells. They play a key role in the regulation of the immune response and the coordination of the host response to infection. Based on these biological properties, nobody would have predicted that one decade later cytokines would burst upon neurosciences and permeate into several avenues of current research. In neurology, the connection between cytokines and inflammation, and the demonstration of a pivotal role of some of these molecules in cell death by apoptosis, prompted the investigation of their involvement in several neurological diseases involving an inflammatory component, including multiple sclerosis, brain trauma, stroke, and Alzheimer's disease. This movement started in the late eighties, and the corresponding field of research, known as neuroimmunology, is presently booming. In psychiatry, however, the relationship between cytokines and mental disorders was much less evident and took longer to materialize. The first indication that cytokines might be involved in psychopathology came from cancerology and internal medicine.

Neurobiology of Cytokines

Author : Errol B. De Souza
Publisher : Academic Press
ISBN 13 : 1483217558
Total Pages : 369 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Neurobiology of Cytokines by : Errol B. De Souza

Download or read book Neurobiology of Cytokines written by Errol B. De Souza and published by Academic Press. This book was released on 2013-10-22 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurobiology of Cytokines, Part A provides an overview of the effects of cytokines in the brain and in the endocrine system. The book discusses the general aspects of cytokines, including the endogenous agonists and antagonists, their receptors, their second messengers, and transport mechanisms for cytokines across the blood-brain barrier. The text also describes the anatomical localization of cytokines, cytokine receptors, and their respective mRNA in brain and in endocrine tissues. The methods for evaluating the in vivo as well as in vitro actions of cytokines on hormone secretion are also considered. The book further tackles the synthesis and release of cytokines and their central nervous system actions; and the methodology for studying the role of cytokines in human neuropathological conditions.

Neuroscience in the 21st Century

Author : Donald W. Pfaff
Publisher : Springer
ISBN 13 : 9781493934737
Total Pages : 0 pages
Book Rating : 4.9/5 (347 download)

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Book Synopsis Neuroscience in the 21st Century by : Donald W. Pfaff

Download or read book Neuroscience in the 21st Century written by Donald W. Pfaff and published by Springer. This book was released on 2016-10-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer’s and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States’ Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century in its second edition serves as a comprehensive resource to students and researchers alike.

The Dentate Gyrus: A Comprehensive Guide to Structure, Function, and Clinical Implications

Author : Helen E. Scharfman
Publisher : Elsevier
ISBN 13 : 0080551750
Total Pages : 841 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis The Dentate Gyrus: A Comprehensive Guide to Structure, Function, and Clinical Implications by : Helen E. Scharfman

Download or read book The Dentate Gyrus: A Comprehensive Guide to Structure, Function, and Clinical Implications written by Helen E. Scharfman and published by Elsevier. This book was released on 2011-09-22 with total page 841 pages. Available in PDF, EPUB and Kindle. Book excerpt: The dentate gyrus is a part of the brain that has been a topic of intense interest since the beginning of neuroscience, and pioneering studies from the distant and recent past attest to this. One of the reasons for such interest is that this structure provides some of the most remarkable examples of plasticity within the nervous system. In addition, it is critical to normal cognitive function, although exactly how and when is still a question that eludes answers. Furthermore, abnormalities within the dentate gyrus appear to play a role in diverse clinical conditions, from depression to epilepsy and traumatic brain injury. The primary goal of this book is to provide a context, or background, upon which the detailed knowledge of the current era can be appreciated. A series of overviews are provided to clarify essentials related to structural organization and development, cellular components, neurotransmitters and neuromodulators, plasticity, and clinical relevance. * Covers the topic comprehensively from anatomy to cellular and systems perspectives* Includes basic research and addresses translational implications, so it will be useful to both researchers in the laboratory and clinicians who conduct experiments in humans* Chapters provide fundamentals, but also details and ample references for further review of the topic

Neural Plasticity and Memory

Author : Federico Bermudez-Rattoni
Publisher : CRC Press
ISBN 13 : 1420008412
Total Pages : 368 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Neural Plasticity and Memory by : Federico Bermudez-Rattoni

Download or read book Neural Plasticity and Memory written by Federico Bermudez-Rattoni and published by CRC Press. This book was released on 2007-04-17 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniq

Cytokines in the Nervous System

Author : Nancy J. Rothwell
Publisher : Springer Science & Business Media
ISBN 13 : 1461596955
Total Pages : 216 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Cytokines in the Nervous System by : Nancy J. Rothwell

Download or read book Cytokines in the Nervous System written by Nancy J. Rothwell and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Neurobiology of Cytokines, Part B

Author : Errol B. DeSouza
Publisher : Academic Press
ISBN 13 : 1483288315
Total Pages : 310 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Neurobiology of Cytokines, Part B by : Errol B. DeSouza

Download or read book Neurobiology of Cytokines, Part B written by Errol B. DeSouza and published by Academic Press. This book was released on 2013-10-22 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent data suggest a critical role for cytokines in the regulation of brain and endocrine function under normal physiological conditions. The aim of this volume and its companion Volume 16 is to provide an overview of the effects of cytokines in the brain and in the endocrine system. - Methods presented for easy adaptation to new systems - Comprehensive protocols included for: The synthesis and release of cytokines; The study of their central nervous system actions; Studying the role of cytokines in human neuropathological conditions

The Autoimmune Brain

Author : David S. Younger
Publisher : Rowman & Littlefield
ISBN 13 : 1538117711
Total Pages : 289 pages
Book Rating : 4.5/5 (381 download)

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Book Synopsis The Autoimmune Brain by : David S. Younger

Download or read book The Autoimmune Brain written by David S. Younger and published by Rowman & Littlefield. This book was released on 2019-11-10 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are millions of people who experience issues related to brain health—depression, attention issues, anxiety, forgetfulness, fatigue, and even chronic pain—yet can’t figure out what’s causing their problems and can’t find any relief. They may have seen a myriad of doctors, many of whom do not take their complaints seriously, or worse, turn to the easy, often inappropriate fix of antidepressants or anti-anxiety medications. Traditional medications, supplements, or other therapies haven’t worked. No matter what their age—from children to teens or seniors—people and their loved ones are frustrated, scared, and confused by their continued poor health. Countless others display severe psychiatric symptoms that seem to come out of nowhere, ranging from tics, obsessive-compulsive behaviors and anxiety, to depression, bipolar-like mood swings, and even borderline personality disorder and suicidal ideas. Sometimes, the people affected are the only ones that notices a change to the way they think or feel, and they suffer in silence. Or, they reach out to try to get help, and are all too frequently misdiagnosed. David Younger, a world-renowned physician, provides relief to these patients and their families. His diagnostic techniques and treatment protocols will help readers identify the true cause of their symptoms and put them on a clear path to healing so they no longer feel unbalanced, out of control, forgetful, and exhausted. The Autoimmune Brain connects common brain health symptoms to the changes in the immune system, and particularly bacterial, viral, and parasitic infections. Younger explains his groundbreaking research and adds a new component: how traumatic stress (whether physical or emotional) and genetics affects this same triad as inextricable factors in initiating disease and brain health symptoms. In fact, a change in personality, behavior, coping style, and one’s emotional state may be the first clue that there is a health problem brewing somewhere else in the body. Readers will find new answers to troubling conditions, including: Alzheimer’s disease; Anxiety; Arthritis; Autism; Autonomic disturbances; Bacterial and viral infections; Bipolar Disorder; Cancer; Celiac disease and gluten intolerances; Chronic Fatigue Syndrome (now referred to as Systemic Exertion Intolerance Disease); Chronic Pain; Dementia; Depression; Endocrine Disorders; Immune modulatory therapy using IVIg; Lyme disease and co-infections; Mast cell activation syndrome; Medical cannabis; Obsessive Compulsive Disorder; Orthostatic hypotension; Peripheral Neuropathy; Porphyria; Post-Traumatic Stress Disorder; and Postural orthostatic tachycardia.

Itch

Author : E. Carstens
Publisher : CRC Press
ISBN 13 : 1466505435
Total Pages : 482 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Itch by : E. Carstens

Download or read book Itch written by E. Carstens and published by CRC Press. This book was released on 2014-02-25 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.

Neurobiology of Hyperthermia

Author : Hari Shanker Sharma
Publisher : Elsevier
ISBN 13 : 0080549993
Total Pages : 611 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Neurobiology of Hyperthermia by : Hari Shanker Sharma

Download or read book Neurobiology of Hyperthermia written by Hari Shanker Sharma and published by Elsevier. This book was released on 2011-09-22 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: The effects of global warming on human health factors with special regards to our brain function are still not well understood. There is an urgent need to expand our knowledge on the effects of hot environment on our brain functions in healthy and in diseased populations. It is still unclear whether infectious events, traumatic injuries, metabolic diseases, carcinogenic events, cardiovascular and respiratory functions will be adversely affected by the rise in global temperature or whether environmental pollutants, such as nanoparticles entered into our body system will produce more damage at high ambient temperatures. This book aims to answer these questions based on recent research carried out by top experts in the field from the USA (11 chapters), Europe (8) chapters), the Middle East (3 chapters), Asia (2 chapters) and Canada (1). These chapters are written in review style and embedded with the author’s new and original data in relation to the current knowledge in the field. The book is highly interesting to the first time readers, beginners and students alike as well as provides in-depth knowledge to the professionals. In addition, prospects for future research and recommendations are clearly indicated in each chapter for future growth of the subject in this highly emerging new discipline. Describes the importance of brain temperature and hyperthermia in disease processes Presents research on the first observations on Nanoparticles that worsen the outcome of hyperthermia Discusses the effects of hyperthermia on the blood-brain and blood-cerebrospinal fluid barriers

Handbook of Neurochemistry

Author : Abel Lajtha
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (82 download)

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Book Synopsis Handbook of Neurochemistry by : Abel Lajtha

Download or read book Handbook of Neurochemistry written by Abel Lajtha and published by . This book was released on 1982 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mechanisms of Neuroinflammation

Author : Gonzalo Emiliano Aranda Abreu
Publisher : BoD – Books on Demand
ISBN 13 : 9535134515
Total Pages : 320 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Mechanisms of Neuroinflammation by : Gonzalo Emiliano Aranda Abreu

Download or read book Mechanisms of Neuroinflammation written by Gonzalo Emiliano Aranda Abreu and published by BoD – Books on Demand. This book was released on 2017-08-23 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Mechanisms of Neuroinflammation" book explains how the neuronal cells become swollen at the moment of the blood-brain barrier disruption and how they lose their immunological isolation. A cascade of cytokines and immune cells from the bloodstream enters the nervous system, inflaming neurons and activating the glia. This produces a neuroinflammatory process that can generate different neurodegenerative diseases. Better understanding of mechanisms that are activated at the time when the damage to the brain occurs could lead to the development of suitable therapies that revert the neuronal inflammation and thus prevent further damage to the nervous system.

Inflammatory Disorders of the Nervous System

Author : Alireza Minagar
Publisher : Humana Press
ISBN 13 : 331951220X
Total Pages : 283 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Inflammatory Disorders of the Nervous System by : Alireza Minagar

Download or read book Inflammatory Disorders of the Nervous System written by Alireza Minagar and published by Humana Press. This book was released on 2017-03-20 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thoroughly updated edition covers all clinical aspects of neuroinflammation. The latest developments in pathogenesis and advances in treatment are provided, along with an understanding of the immune system's role and interactions between the activated immune cells, cerebral endothelial cells, and other main components of the immune cascade. Cutting-edge and authoritative, this volume offers practitioners a valuable resource for research and clinical practice.

Inflammation-Associated Depression: Evidence, Mechanisms and Implications

Author : Robert Dantzer
Publisher : Springer
ISBN 13 : 3319511521
Total Pages : 357 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Inflammation-Associated Depression: Evidence, Mechanisms and Implications by : Robert Dantzer

Download or read book Inflammation-Associated Depression: Evidence, Mechanisms and Implications written by Robert Dantzer and published by Springer. This book was released on 2016-12-28 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammation has invaded the field of psychiatry. The finding that cytokines are elevated in various affective and psychotic disorders brings to the forefront the necessity of identifying the precise research domain criteria (RDoCs) that inflammation is responsible for. This task is certainly the most advanced in major depressive disorders. The reason is that a dearth of clinical and preclinical studies has demonstrated that inflammation can cause symptoms of depression and conversely, cytokine antagonists can attenuate symptoms of depression in medical and psychiatric patients with chronic low grade inflammation. Important knowledge has been gained on the symptom dimensions that inflammation is driving and the mechanisms of action of cytokines in the brain, providing new targets for drug research and development. The aim of the book “Inflammation-Associated Depression” is to present this field of research and its implications in a didactic and comprehensive manner to basic and clinical scientists, psychiatrists, physicians, and students at the graduate level.

Advances in Research on Neurodegeneration

Author : Y. Mizuno
Publisher : Springer Science & Business Media
ISBN 13 : 9783211834855
Total Pages : 228 pages
Book Rating : 4.8/5 (348 download)

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Book Synopsis Advances in Research on Neurodegeneration by : Y. Mizuno

Download or read book Advances in Research on Neurodegeneration written by Y. Mizuno and published by Springer Science & Business Media. This book was released on 2000-11-06 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: 7th International Winter Conference on Neurodegeneration

Neurobiology of Depression

Author : Francisco Lopez-Munoz
Publisher : CRC Press
ISBN 13 : 143983850X
Total Pages : 521 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Neurobiology of Depression by : Francisco Lopez-Munoz

Download or read book Neurobiology of Depression written by Francisco Lopez-Munoz and published by CRC Press. This book was released on 2011-09-09 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: Major depressive disorders have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways hold promise as new therapeutics for depression. With the collaboration of the most prestigious international specialists in biochemistry, mol