Author : Laura de Miguel Martínez de Aragón
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (863 download)
Book Synopsis Nanoparticules Multifonctionnelles de PBLG Destinées Au Ciblage Et À la Délivrance D'anticancéreux Aux Tissus Osseux by : Laura de Miguel Martínez de Aragón
Download or read book Nanoparticules Multifonctionnelles de PBLG Destinées Au Ciblage Et À la Délivrance D'anticancéreux Aux Tissus Osseux written by Laura de Miguel Martínez de Aragón and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multifunctional bone targeted polymeric nanoparticles prepared by self-assembly of several poly(gamma-benzyl-L-glutamate) (PBLG) derivates have been developed. Their bone binding properties were provided by two different osteotropic moieties, alendronate or/and poly(glutamic acid) exposed on the nanoparticle surface. Their affinity for bone tissues has been evaluated in vitro, ex vivo and in vivo, including their detailed distribution in bone tissues structures. Further, in view of bone cancer therapeutics, nanoparticles were provided with anticancer properties thanks to the complexation of cisplatin, which leaded to very well controlled release properties. Finally, cytotoxicity were studied. Therefore, this strategy constitute a promising approach for the improvement of bone cancer therapeutics.
