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Nanoparticle Aided Radiotherapy
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Book Synopsis Nanoparticle-Aided Radiotherapy by : Erno Prof. Sajo
Download or read book Nanoparticle-Aided Radiotherapy written by Erno Prof. Sajo and published by Iop Expanding Physics. This book was released on 2020-11-12 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Improved targeting of abnormal cells and tissue in the radiotherapy of cancer has been a long-standing goal of researchers. The central purpose of nanoparticle-enhanced radiotherapy (NPRT) is to more precisely control where the radiation dose is delivered, desirably with subcellular precision, provided we can find a method to bring the nanoparticles to target as well as control their concentration and size distribution. The contents within this book will cover the rationale and fundamental principles of NPRT, optimal nanoparticle sizes, concentrations, design and fabrication, effective nanoparticle delivery methods, emerging clinical applications of NRT modalities, treatment planning and quality assurance and the potential of NPRT in global health. This volume will serve as a resource for researchers, educators and industry, and as a practical guide or comprehensive reference for students, research trainees and others working in cancer nanomedicine. Key Features Covers the most important advances in nanoparticle-aided radiation therapy over the last few decades Features contributions from leaders in the field Focuses first on the fundamentals of radiosensitization, then it continues with imaging methods and concludes with various clinical applications
Book Synopsis NANOPARTICLE-AIDED RADIATION THERAPY. by : WILFRED F. NGWA
Download or read book NANOPARTICLE-AIDED RADIATION THERAPY. written by WILFRED F. NGWA and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Nanoparticle-aided Radiation Therapy: Micro-dosimetry and Evaluation of the Mediators Producing Biological Damage by : Nava R. Paudel
Download or read book Nanoparticle-aided Radiation Therapy: Micro-dosimetry and Evaluation of the Mediators Producing Biological Damage written by Nava R. Paudel and published by . This book was released on 2014 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiation therapy has been established as a standard technique for cancer treatment. Advances in nanotechnology have enabled the application of many new approaches in the diagnosis and treatment of cancer. Achievement of selective enhancement in radiation dose deposition within a targeted tumor, while sparing surrounding normal structures, remains a challenge and one of the major objectives of cancer-related research. This objective can be realized by the insertion of high atomic number (Z) materials in the tumor site. Due to their high atomic number (Z=79) and favorable biological compatibility, gold nanoparticles (AuNPs) have been found very promising in this respect. Another candidate material, platinum (Z=78), offering very similar radiation interaction properties to gold and exhibiting additional cytotoxic effects, has been exploited in chemotherapeutic agents for a long time. A number of studies evaluating dose enhancement on the basis of an approximation of a uniform distribution of individual gold atoms rather than nanoparticles neglect the effects near the gold-tissue interface. Those studies have demonstrated high dose enhancement at low kiloelectronvolt (keV) energies, relevant only to certain brachytherapy nuclides, but have not shown a significant enhancement in clinical megavoltage (MV) radiation beams. However, recent experiments with biological systems have brought mixed results, few of them demonstrating promising cell kill effects exceeding the predictions based on pure dose deposition under MV beams. It has been a general observation in physics that many new phenomena originate from interfaces and hence it is important to closely examine the interface effects between high-Z materials, such as gold or platinum, and low-Z tissues. The small physical dimension of the radiation dose enhancement region, ~ 1 mm or less, and the very high dose gradient pose a great challenge in the investigation of the effects. Nonetheless, the interface effects have been largely overlooked in nanoparticle-aided radiation therapy studies. We explore the radiation effects near the interface of gold and platinum with tissue under a wide range of energies with Monte Carlo (MC) simulations. Our studies show that AuNPs and PtNPs (platinum nanoparticles) can offer a useful dose enhancement effect even in high energy radiotherapy beams, which can be important when critical structures are located close to the tumor. Our MC calculated dose enhancement increase of about 50% due to the removal of the flattening filter from the path of the photon beam of Varian TrueBeam accelerator suggests that flattening-filter-free beams are better suited for nanoparticle-aided radiation therapy. Also, the increase in dose enhancement with the tumor depth suggests that nanopartcle-aided radiation therapy can yield a better outcome while treating deep-seated tumors. Experimental microdosimetry is a non-trivial task, demanding detectors with small sensitive volumes to achieve a high spatial resolution. We have developed a microdosimetry technique utilizing an inexpensive in-house-built photodetector for the measurement of dose in a narrow high dose gradient region next to the interface between gold and tissue. Verification of the experimental results against MC simulations provides a foundation for the application of this technique to biological systems such as cell cultures. Recent studies demonstrating higher cancer cell killing than the predictions based on MC-modeled dose deposition due to AuNPs under radiation beams suggest the action of biochemical effects. Since free radicals are responsible for ~ 2/3 of cell killing in radiotherapy photon beams, we explore the role of gold and platinum in generating free radicals with the electron paramagnetic resonance (EPR) technique. Our results demonstrating higher free radical generation enhancement than the MC modeled enhancement in dose deposition due to thin gold or platinum wires under irradiation suggest that the high-Z material surfaces act as catalysts for free radical generation. The higher surface area to volume ratio and the size quantization effect should make this phenomenon even more pronounced with nanoparticles, thus augmenting the cell killing effect. Our results also show that platinum is as effective as gold in enhancing dose deposition as well as in generating free radicals in aqueous media under radiation beam.
Book Synopsis Development of Dosimetry and Imaging Techniques for Pre-clinical Studies of Gold Nanoparticle-aided Radiation Therapy by : Bernard Lee Jones
Download or read book Development of Dosimetry and Imaging Techniques for Pre-clinical Studies of Gold Nanoparticle-aided Radiation Therapy written by Bernard Lee Jones and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is one of the leading causes of death worldwide, and affects roughly 1.5 million new people in the United States every year. One of the leading tools in the detection and treatment of cancer is radiation. Tumors can be detected and identified using CT or PET scans, and can then be treated with external beam radiotherapy or brachytherapy. By taking advantage of the physical properties of gold and the biological properties of nanoparticles, gold nanoparticles (GNPs) can be used to improve both cancer radiotherapy and imaging. By infusing a tumor with GNPs, either using passive extravasation of nanoparticles by the tumor vasculature or active targeting of an antibody-conjugated nanoparticle to a specific tumor marker, the higher photon cross-section of gold will cause more radiation dose to be deposited in the tumor during photon-based radiotherapy. In principle, this would allow escalation of dose to the tumor while not increasing the dose to normal healthy tissue. Additionally, if a tumor infused with GNPs was irradiated by an external kilo-voltage source, the fluorescence emitted by the gold atoms would allow one to localize and quantify the GNP concentration. This work has two main aims: to quantify the GNP-mediated dose enhancement during GNRT on a nanometer scale, and to develop a refined imaging modality capable of quantifying GNP location and concentration within a small-animal-sized object. In order to quantify the GNP-mediated dose enhancement on a nanometer scale, a computational model was developed. This model combines both large-scale and small-scale calculations in order to accurately determine the heterogeneous dose distribution of GNPs. The secondary electron spectra were calculated using condensed history Monte Carlo, which is able to accurately take into account changes in beam quality throughout the tumor and calculate the average energy spectrum of the secondary charged particles created. Then, the dose distributions of these electron spectra were calculated on a nanometer scale using event-by-event Monte Carlo. The second aim is to develop an imaging system capable of reconstructing a tomographic image of GNP location and concentration in a small animal-sized object by capturing gold fluorescence photons emitted during irradiation of the object by an external beam. This would not only allow for localization of GNPs during gold nanoparticle-aided radiation therapy (GNRT), but also facilitate the use of GNPs as imaging agents for drug-delivery or other similar studies. The purpose of this study is to develop a cone-beam implementation of XFCT that meets realistic constrains on image resolution, detection limit, scan time, and dose. A Monte Carlo model of this imaging geometry was developed and used to test the methods of data acquisition and image reconstruction. The results of this study were then used to drive the production of a functioning benchtop, polychromatic cone-beam XFCT system.
Book Synopsis Monte Carlo Calculations of Microscopic Dose Enhancement for Gold Nanoparticle-aided Radiation Therapy by : Bernard Jones
Download or read book Monte Carlo Calculations of Microscopic Dose Enhancement for Gold Nanoparticle-aided Radiation Therapy written by Bernard Jones and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Gold Nanoparticle-Aided Radiation Therapy (GNRT) is a new paradigm in radiation therapy which seeks to make a tumor more susceptible to radiation damage by modifying its photon interaction properties with an infusion of a high-atomic-number substance. The purpose of this study was to quantify the energy deposition due to secondary electrons from gold nanoparticles on a micrometer scale and to calculate the corresponding microscopic dose enhancement factor during GNRT. The Monte Carlo code EGSnrc was modified to obtain the spectra of secondary electrons from atoms of gold and molecules of water under photon irradiation of a tumor infused with 0.7 wt. % gold. Six different photon sources were used: 125I, 103Pd, 169Yb, 192Ir, 50kVp, and 6MV x-rays. Treating the scored electron spectra as point sources within an infinite medium of water, the event-by-event Monte Carlo code NOREC was used to quantify the radial dose distribution, giving rise to gold and water electron dose point kernels. These kernels were applied to a scanning electron microscope (SEM) image of a gold nanoparticle distribution in tissue. The dose at each point was then calculated, enabling the determination of the microscopic dose enhancement at each point. For the lower energy sources 125I, 103Pd, 169Yb, and 50 kVp, the secondary electron fluence was increased by as much as two orders of magnitude, leading to a one-to-two order of magnitude increase in the electron dose point kernel over radial distances up to 50 um. The dose was enhanced by 100% within 5 um of the nanoparticles, and by 5% as far away as 30 um. This study demonstrates a remarkable microscopic dose enhancement due to gold nanoparticles and low energy photon sources. Given that the dose enhancement exceeds 100% within very short distances from the nanoparticles, the maximum radiobiological benefit may be derived from active targeting strategies that concentrate nanoparticles in close proximity to the cancer cell and/or its nucleus.
Book Synopsis Nanoparticle Enhanced Radiation Therapy by : Erno Sajo
Download or read book Nanoparticle Enhanced Radiation Therapy written by Erno Sajo and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Improved targeting of abnormal cells and tissue in the radiotherapy of cancer has been a long-standing goal of researchers. The central purpose in Nanoparticle-Enhanced Radiotherapy (NPRT) is to more precisely control where the radiation dose is delivered, desirably with subcellular precision, provided we can find a method to bring the nanoparticles to target and control their concentration and size distribution. The contents within this book will cover the rationale and fundamental principles of NPRT, optimal nanoparticle sizes, concentrations, design and fabrication, effective nanoparticle delivery methods, emerging clinical applications of NRT modalities, treatment planning and quality assurance and the potential of NPRT in global health. This volume will serve as a resource for researchers, educators and industry, and as a practical guide or comprehensive reference for students, research trainees and others working in cancer nanomedicine. Part of IOP Series in Global Health and Radiation Oncology.
Book Synopsis Nanoparticle Enhanced Radiation Therapy by : Erno Sajo
Download or read book Nanoparticle Enhanced Radiation Therapy written by Erno Sajo and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Improved targeting of abnormal cells and tissue in the radiotherapy of cancer has been a long-standing goal of researchers. The central purpose in Nanoparticle-Enhanced Radiotherapy (NPRT) is to more precisely control where the radiation dose is delivered, desirably with subcellular precision, provided we can find a method to bring the nanoparticles to target and control their concentration and size distribution. The contents within this book will cover the rationale and fundamental principles of NPRT, optimal nanoparticle sizes, concentrations, design and fabrication, effective nanoparticle delivery methods, emerging clinical applications of NRT modalities, treatment planning and quality assurance and the potential of NPRT in global health. This volume will serve as a resource for researchers, educators and industry, and as a practical guide or comprehensive reference for students, research trainees and others working in cancer nanomedicine. Part of IOP Series in Global Health and Radiation Oncology." -- Prové de l'editor.
Book Synopsis Nanoparticle Enhanced Radiation Therapy by : Erno Sajo
Download or read book Nanoparticle Enhanced Radiation Therapy written by Erno Sajo and published by Myprint. This book was released on 2020-11-19 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Improved targeting of abnormal cells and tissue in the radiotherapy of cancer has been a long-standing goal of researchers. The central purpose of nanoparticle-enhanced radiotherapy (NPRT) is to more precisely control where the radiation dose is delivered, desirably with subcellular precision, provided we can find a method to bring the nanoparticles to target as well as control their concentration and size distribution. The contents within this book will cover the rationale and fundamental principles of NPRT, optimal nanoparticle sizes, concentrations, design and fabrication, effective nanoparticle delivery methods, emerging clinical applications of NRT modalities, treatment planning and quality assurance and the potential of NPRT in global health. This volume will serve as a resource for researchers, educators and industry, and as a practical guide or comprehensive reference for students, research trainees and others working in cancer nanomedicine. Key Features Covers the most important advances in nanoparticle-aided radiation therapy over the last few decades Features contributions from leaders in the field Focuses first on the fundamentals of radiosensitization, then it continues with imaging methods and concludes with various clinical applications
Book Synopsis Cancer Nanotechnology by : Sang Hyun Cho
Download or read book Cancer Nanotechnology written by Sang Hyun Cho and published by Taylor & Francis. This book was released on 2016-04-19 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapid advances in nanotechnology have enabled the fabrication of nanoparticles from various materials with different shapes, sizes, and properties, and efforts are ongoing to exploit these materials for practical clinical applications. Nanotechnology is particularly relevant in the field of oncology, as the leaky and chaotic vasculature of tumors-a
Book Synopsis X-ray Radiation Enabled Cancer Detection and Treatment with Nanoparticles by : Mainul Hossain
Download or read book X-ray Radiation Enabled Cancer Detection and Treatment with Nanoparticles written by Mainul Hossain and published by . This book was released on 2012 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite significant improvements in medical sciences over the last decade, cancer still continues to be a major cause of death in humans throughout the world. Parallel to the efforts of understanding the intricacies of cancer biology, researchers are continuously striving to develop effective cancer detection and treatment strategies. Use of nanotechnology in the modern era opens up a wide range of possibilities for diagnostics, therapies and preventive measures for cancer management. Although, existing strategies of cancer detection and treatment, using nanoparticles, have been proven successful in case of cancer imaging and targeted drug deliveries, they are often limited by poor sensitivity, lack of specificity, complex sample preparation efforts and inherent toxicities associated with the nanoparticles, especially in case of in-vivo applications. Moreover, the detection of cancer is not necessarily integrated with treatment. X-rays have long been used in radiation therapy to kill cancer cells and also for imaging tumors inside the body using nanoparticles as contrast agents. However, X-rays, in combination with nanoparticles, can also be used for cancer diagnosis by detecting cancer biomarkers and circulating tumor cells. Moreover, the use of nanoparticles can also enhance the efficacy of X-ray radiation therapy for cancer treatment. This dissertation describes a novel in vitro technique for cancer detection and treatment using X-ray radiation and nanoparticles. Surfaces of synthesized metallic nanoparticles have been modified with appropriate ligands to specifically target cancer cells and biomarkers in vitro. Characteristic X-ray fluorescence signals from the X-ray irradiated nanoparticles are then used for detecting the presence of cancer. The method enables simultaneous detection of multiple cancer biomarkers allowing accurate diagnosis and early detection of cancer. Circulating tumor cells, which are the primary indicators of cancer metastasis, have also been detected where the use of magnetic nanoparticles allows enrichment of rare cancer cells prior to detection. The approach is unique in that it integrates cancer detection and treatment under one platform, since, X-rays have been shown to effectively kill cancer cells through radiation induced DNA damage. Due to high penetrating power of X-rays, the method has potential applications for in vivo detection and treatment of deeply buried cancers in humans. The effect of nanoparticle toxicity on multiple cell types has been investigated using conventional cytotoxicity assays for both unmodified nanoparticles as well as nanoparticles modified with a variety of surface coatings. Appropriate surface modifications have significantly reduced inherent toxicity of nanoparticles, providing possibilities for future clinical applications. To investigate cellular damages caused by X-ray radiation, an on-chip biodosimeter has been fabricated based on three dimensional microtissues which allows direct monitoring of responses to X-ray exposure for multiple mammalian cell types. Damage to tumor cells caused by X-rays is known to be significantly higher in presence of nanoparticles which act as radiosensitizers and enhance localized radiation doses. An analytical approach is used to investigate the various parameters that affect the radiosensitizing properties of the nanoparticles. The results can be used to increase the efficacy of nanoparticle aided X-ray radiation therapy for cancer treatment by appropriate choice of X-ray beam energy, nanoparticle size, material composition and location of nanoparticle with respect to the tumor cell nucleus.
Book Synopsis Nanoparticle Enhanced Radiotherapy by : Reem Hussain Ali Ahmad
Download or read book Nanoparticle Enhanced Radiotherapy written by Reem Hussain Ali Ahmad and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Theory and Applications of Heat Transfer in Humans, 2 Volume Set by : Devashish Shrivastava
Download or read book Theory and Applications of Heat Transfer in Humans, 2 Volume Set written by Devashish Shrivastava and published by John Wiley & Sons. This book was released on 2018-07-02 with total page 897 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative guide to theory and applications of heat transfer in humans Theory and Applications of Heat Transfer in Humans 2V Set offers a reference to the field of heating and cooling of tissue, and associated damage. The author—a noted expert in the field—presents, in this book, the fundamental physics and physiology related to the field, along with some of the recent applications, all in one place, in such a way as to enable and enrich both beginner and advanced readers. The book provides a basic framework that can be used to obtain ‘decent’ estimates of tissue temperatures for various applications involving tissue heating and/or cooling, and also presents ways to further develop more complex methods, if needed, to obtain more accurate results. The book is arranged in three sections: The first section, named ‘Physics’, presents fundamental mathematical frameworks that can be used as is or combined together forming more complex tools to determine tissue temperatures; the second section, named ‘Physiology’, presents ideas and data that provide the basis for the physiological assumptions needed to develop successful mathematical tools; and finally, the third section, named ‘Applications’, presents examples of how the marriage of the first two sections are used to solve problems of today and tomorrow. This important text is the vital resource that: Offers a reference book in the field of heating and cooling of tissue, and associated damage. Provides a comprehensive theoretical and experimental basis with biomedical applications Shows how to develop and implement both, simple and complex mathematical models to predict tissue temperatures Includes simple examples and results so readers can use those results directly or adapt them for their applications Designed for students, engineers, and other professionals, a comprehensive text to the field of heating and cooling of tissue that includes proven theories with applications. The author reveals how to develop simple and complex mathematical models, to predict tissue heating and/or cooling, and associated damage.
Book Synopsis Adverse Effects of Cancer Chemotherapy: Anything New to Improve Tolerance and Reduce Sequelae? by : Kulmira Nurgali
Download or read book Adverse Effects of Cancer Chemotherapy: Anything New to Improve Tolerance and Reduce Sequelae? written by Kulmira Nurgali and published by Frontiers Media SA. This book was released on 2018-06-12 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in anti-cancer chemotherapy over recent years have led to improved efficacy in curing or controlling many cancers. Some chemotherapy-related side-effects are well recognized and include: nausea, vomiting, bone marrow suppression, peripheral neuropathy, cardiac and skeletal muscle dysfunction and renal impairment. However, it is becoming clearer that some chemotherapy-related adverse effects may persist even in long term cancer survivors. Problems such as cognitive, cardiovascular and gastrointestinal dysfunction, and neuropathy may lead to substantial long term morbidity. Despite improvements in treatments to counteract acute chemotherapy-induced adverse effects, they are often incompletely effective. Furthermore, counter-measures for some acute side-effects and many potential longer term sequelae of anti-cancer chemotherapy have not been developed. Thus, new insights into prevalence and mechanisms of cancer chemotherapy-related side effects are needed and new approaches to improving tolerance and reduce sequelae of cancer chemotherapy are urgently needed. The present Research Topic focuses on adverse effects and sequelae of chemotherapy and strategies to counteract them.
Book Synopsis Advancing Nuclear Medicine Through Innovation by : National Research Council
Download or read book Advancing Nuclear Medicine Through Innovation written by National Research Council and published by National Academies Press. This book was released on 2007-09-11 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nearly 20 million nuclear medicine procedures are carried out each year in the United States alone to diagnose and treat cancers, cardiovascular disease, and certain neurological disorders. Many of the advancements in nuclear medicine have been the result of research investments made during the past 50 years where these procedures are now a routine part of clinical care. Although nuclear medicine plays an important role in biomedical research and disease management, its promise is only beginning to be realized. Advancing Nuclear Medicine Through Innovation highlights the exciting emerging opportunities in nuclear medicine, which include assessing the efficacy of new drugs in development, individualizing treatment to the patient, and understanding the biology of human diseases. Health care and pharmaceutical professionals will be most interested in this book's examination of the challenges the field faces and its recommendations for ways to reduce these impediments.
Book Synopsis Nanopharmaceuticals: Principles and Applications Vol. 3 by : Vinod Kumar Yata
Download or read book Nanopharmaceuticals: Principles and Applications Vol. 3 written by Vinod Kumar Yata and published by Springer Nature. This book was released on 2020-08-19 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the third volume on this subject and focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.
Book Synopsis Textbook of Radiation Oncology by : Steven A. Leibel
Download or read book Textbook of Radiation Oncology written by Steven A. Leibel and published by . This book was released on 2004 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly revised and updated, the 2nd Edition presents all of the latest advances in the field, including the most recent technologies and techniques. For each tumor site discussed, readers will find unparalleled coverage of multiple treatment plans, histology and biology of the tumor, its anatomic location and routes of spread, and utilization of specialized techniques. This convenient source also reviews all of the basic principles that underlie the selection and application of radiation as a treatment modality, including radiobiology, radiation physics, immobilization and simulation, high dose rate, intraoperative irradation, and more. Comprehensively reviews each topic, with a distinct clinical orientation throughout. Serves as a foundation for the basic principles that underlie the selection and application of radiation as a treatment modality, including radiobiology, radiation physics, immobilization and simulation, high dose rate, intraoperative irradation, and more. Guides readers through all stages of treatment application with step-by-step techniques for the assessment and implementation of radiotherapeutic options. Presents latest information on brachytherapy * 3-dimensional conformal treatment planning * sterotactic radiosurgery * and radiolabeled antibodies. Discusses the recent use of radiotherapy in the treatment of primary lymphoma, leukemia, multiple myeloma, and cancers of the prostate and central nervous system. Includes the latest AJCC staging system guidelines. Offers the latest advances in techniques, allowing you to deliver doses precisely to areas affected by malignancy and spare healthy tissue. Presents new chapters on the hottest topics including Three Dimensional Conformal Radiotherapy * Intensity Modulated Radiotherapy * Breathing Synchronized Radiotherapy * Plasma Cell Tumors: Multiple Myeloma and Solitary Plasmacytoma * Extracranial Stereotactic Radioablation * and [Imaging of the] Head and Neck * Thorax * Abdomen * and Pelvis.
Book Synopsis Nanoparticle-Based Drug Delivery in Cancer Treatment by : Loutfy H. Madkour
Download or read book Nanoparticle-Based Drug Delivery in Cancer Treatment written by Loutfy H. Madkour and published by CRC Press. This book was released on 2022-02-27 with total page 559 pages. Available in PDF, EPUB and Kindle. Book excerpt: The careful choice of nanoparticles as targets and in drug delivery routes enhances therapeutic efficacy in cancer. Nanoparticle-Based Drug Delivery in Cancer Treatment discusses nanotechnological developments of interfering RNA-based nanoparticles, delivery vehicles, and validated therapeutic RNAi–molecular target interactions and explains the results of clinical and preclinical trials. The book also gives strategies for universal methods of constructing hybrid organic–inorganic nanomaterials that can be widely applied in the biomedical field. Key Features: Reviews recent advances of nanoparticle-mediated siRNA delivery systems and their application in clinical trials for cancer therapy Focuses on material platforms that establish NPs and both localized and controlled gene silencing Emphasizes the most promising systems for clinical application Surveys progress in nanoparticle-based nanomedicine in cancer treatment Describes the most advanced of the nonviral nanocarriers for delivery of oligonucleotides to malignant blood cancer cells This book is a valuable resource for researchers, professors, and students researching drug delivery, gene carriers, cancer therapy, nanotechnology, and nanomaterials.
