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Myocardial Preservation Preconditioning And Adaptation
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Book Synopsis Myocardial Preservation, Preconditioning, and Adaptation by : Dipak Kumar Das
Download or read book Myocardial Preservation, Preconditioning, and Adaptation written by Dipak Kumar Das and published by . This book was released on 1996 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this volume, basic scientists, cardiologists and cardiac surgeons discuss all that is known about preconditioning/adaptation and how this state-of-the-art technique compares with conventional techniques of myocardial preservation, unveiling its mechanism of protection and potential clinical application.
Book Synopsis Myocardial Preservation and Cellular Adaptation by : D.K. Das
Download or read book Myocardial Preservation and Cellular Adaptation written by D.K. Das and published by Elsevier. This book was released on 1998-12-18 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Living organisms exhibit specific responses when confronted with sudden changes in their environmental conditions. The ability of the cells to acclimate to their new environment is the integral driving force for adaptive modification of the cells. Such adaptation involves a number of cellular and biochemical alteration including metabolic homeostasis and reprogramming of gene expression. Changes in metabolic pathways are generally short-lived and reversible, while the consequences of gene expression are a long-term process and may lead to permanent alternation in the pattern of adaptive responses. The heart possesses remarkable ability to adapt itself against any stressful situation by increasing resistance to the adverse consequences. Stress composes the foundation of many degenerative heart diseases including atherosclerosis, spasm, thrombosis, cardiomyopathy, and congestive heart failure. Based on the concept that excessive stress may play a crucial role in the pathogenesis of ischemic heart disease, attempts were made to design methods for preventing of myocardial injury. Creation of stress reactions by repeated ischemia and reperfusion or subjecting the hearts to heat or oxidative stress enables them to meet the future stress challenge. Repeated stress exposures adapt the heart to withstand more severe stress reactions probably by upregulating the cellular defense and direct accumulation of intracellular mediators, which presumably constitute the material basis of increased adaptation to stress. Thus, the powerful cardioprotective effect of adaptation is likely to originate at the cellular and molecular levels that compose fundamental processes in the prophylaxis of such diseases. Volume six of the Advances in Organ Biology series contains state-of-the-art reviews on myocardial preservation and cellular adaptation from the leading authorities in this subject.
Book Synopsis Myocardial Preservation, Preconditioning, and Adaptation by : Dipak Kumar Das
Download or read book Myocardial Preservation, Preconditioning, and Adaptation written by Dipak Kumar Das and published by . This book was released on 1996 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this volume, basic scientists, cardiologists and cardiac surgeons discuss all that is known about preconditioning/adaptation and how this state-of-the-art technique compares with conventional techniques of myocardial preservation, unveiling its mechanism of protection and potential clinical application.
Book Synopsis Myocardial Protection by : Tomas A. Salerno
Download or read book Myocardial Protection written by Tomas A. Salerno and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myocardial protection is regarded as one of the most important, yet also most controversial aspects of cardiac surgery. There has been considerable improvement in myocardial protection strategies over recent years, utilising a variety of new approaches to treat cardiac diseases, and this text is intended to embrace the state of the art in this field. The book summarises the state of knowledge on all aspects of myocardial protection, including the latest in the treatment of cardiac diseases, robotics, pediatric surgery and the treatment of cardiac failure. Robotic surgery, valvular surgery, pediatric surgery and coronary surgery are all covered by renowned experts, producing a comprehensive, forward-looking view of the field of myocardial protection. This book should function to update physicians and surgeons interested in the field of cardiac surgery on the current state of knowledge on myocardial protection.
Book Synopsis Cardiac Ischemia: From Injury to Protection by : Bohuslav Ost'ádal
Download or read book Cardiac Ischemia: From Injury to Protection written by Bohuslav Ost'ádal and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac Ischemia: From Injury to Protection has been divided into six parts. The first part describes the differences between hypoxia and ischemia, animal models, the effects of ischemia on myocardial function and metabolism, and the electrophysiological consequences of ischemia. The second part deals with the mechanisms of cardiomyocyte death in ischemia, structural aspects of irreversible ischemic injury, necrosis and apoptosis of cardiac cells, the role of calcium, and the concept of calcium antagonism. The third chapter is a brief description of reperfusion injury, its clinical relevance, and possible prevention. The fourth part summarizes changes in myocardial vasculature during ischemia and reperfusion. The fifth part is the survey of two main possibilities for increasing cardiac resistance to ischemia and hypoxia, i.e. long-lasting adaptation to chronic hypoxia and short-lasting preconditioning. The last part of the book deals with comparative and ontogenetic aspects of cardiac sensitivity to oxygen deprivation; this chapter also summarizes the ontogenetic differences and limitations in endogenous and exogenous protection of the ischemic/hypoxic heart.
Book Synopsis Cardiac Adaptation and Failure by : Masatsugu Hori
Download or read book Cardiac Adaptation and Failure written by Masatsugu Hori and published by Springer Science & Business Media. This book was released on 2013-11-27 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in cellular physiology and molecular biology have now disclosed the metabolic changes and adaptational responses of the heart to various kinds of stresses. Topics covered in this volume include the regulation of myocardial proteins in mechanical overload, the alteration of adrenoceptors in the stressed heart, metabolic adaptation in cardiac hypertrophy, intracellular calcium metabolism in the ischemia-reperfused myocardium, calcium overload as a cause of myocardial stunning, acquisition of ischemic tolerance by ischemic preconditioning, factors that accelerate myocardial injury, and ventricular remodeling in the ischemic heart. As an update of the latest findings in basic cardiology, this book will benefit both researchers and clinical practitioners.
Book Synopsis Delayed Preconditioning and Adaptive Cardioprotection by : G.F. Baxter
Download or read book Delayed Preconditioning and Adaptive Cardioprotection written by G.F. Baxter and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in the ability of myocardium to adapt to ischaemic stress has continued to grow since the discovery of ischaemic preconditioning in 1986. In 1993, two reports heralded the recognition of a delayed preconditioning response in the heart, now commonly known as the `second window' of protection. Since then, a number of studies have described the ability of delayed preconditioning and related adaptive phenomena to protect against a variety of pathologies in the ischaemic and reperfused myocardium. Our understanding of the cellular mechanisms of sub-acute adaptive cardioprotection has advanced considerably during this period. This compilation of state-of-the-art reviews by those who have made significant contributions to this field provides detailed and critical analysis of this research, from molecular basis to potential clinical relevance. The book aims to provide an authoritative, comprehensive and thoroughly up-to-date overview for scientists and clinicians engaged in, or observing, this rapidly-developing area of heart research. It will also be of interest to those engaged in research on other tissues where ischaemia-reperfusion pathology is of major concern.
Book Synopsis Coronary Circulation and Myocardial Ischemia by : Michael R. Pinsky
Download or read book Coronary Circulation and Myocardial Ischemia written by Michael R. Pinsky and published by Springer Science & Business Media. This book was released on 2002-01-21 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: The coronary circulation is central to sustaining myocardial viability. Unlike the cir culations of most other organs, if the coronary circulation becomes insufficient to sustain myocardial contractile function, overall quality of life rapidly declines and life can abruptly end. In partnership with the cerebral circulation, the coronary circula tion plays a central role in sustaining life. However, unlike the cerebral circulation, whose function is self-sufficient to define life, the coronary circulation determines global blood flow and thus the initial state for the remainder of the body. This unique condition, together with the reality that coronary artery disease primarily affects peo ple in their productive years of life, has allowed physicians and scientists who study the heart to enjoy a privileged position in the field of medical research and clinical practice. Thus, it comes as little surprise that many new and exciting research developments involving the coronary circulation have recently come to the forefront of medical thinking. This reality, coupled with the large number of clinical trials of agents specif ically designed to sustain or improve coronary flow in many disease states, makes the timing of this monograph relevant. The book features papers presented at a recent international symposium, the fourth in a series of meetings on Applied Physiology of the Peripheral Circulation. The papers selected by the editors review the most impor tant advances in the fields of cardiology and the coronary circulation.
Book Synopsis Cardiac Development by : Bohuslav Ost'ádal
Download or read book Cardiac Development written by Bohuslav Ost'ádal and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: The importance of the developmental approach for experimental and clinical cardiology is indisputable. Clinical-epidemiological studies have clearly shown that the risk factors of serious cardiovascular diseases, such as atherosclerosis and ischemic heart disease, are already present during the early phases of ontogenetic development. Furthermore, congenital cardiovascular malformations remain the single largest cause of infant mortality from congenital defects in industrial countries. It is therefore not surprising that the interest of theoretical and clinical cardiologists in the developmental approach keeps increasing. Advances in molecular biology accelerated this trend substantially. This book is based on contributions presented at the international symposium The Developing Heart in Prague in May 2000. It is our contention that the biological, electrophysiological, morphological, functional, biochemical and functional approaches employed by distinguished scientists worldwide will provide the reader with a global picture for changes characterizing the developing heart. It should stimulate the curiosity of cardiovascular scientists in gaining insight into the mechanisms of normal and pathological development.
Book Synopsis Heat Shock Proteins in Myocardial Protection by : Rakesh C. Kukreja
Download or read book Heat Shock Proteins in Myocardial Protection written by Rakesh C. Kukreja and published by CRC Press. This book was released on 2000-08-01 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myocardial ischemic syndromes pose a major medical problem and a significant economic health care concern. Reperfusion, although used in the clinical arena as essential to the survival of acutely ischemic heart muscle carries with it the risk of reperfusion injury. Therefore the salvage of additional myocardium is highly desirable.
Book Synopsis Resveratrol in Health and Disease by : Bharat B. Aggarwal
Download or read book Resveratrol in Health and Disease written by Bharat B. Aggarwal and published by CRC Press. This book was released on 2005-11-01 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practicing evidenced-based medicine some 25 centuries ago, Hippocrates proclaimed "Let food be thy medicine and medicine be thy food." This advice parallels the common American saying, "You are what you eat," and is supported by a National Institute of Health recommendation to consume as many as eight servings of fruits and vegetables daily to prev
Book Synopsis Cardiac Adaptations by : Bohuslav Ostadal
Download or read book Cardiac Adaptations written by Bohuslav Ostadal and published by Springer Science & Business Media. This book was released on 2012-10-12 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes present knowledge of different mechanisms involved in the development of positive and negative consequences of cardiac adaptation. Particular attention is paid to the still underestimated adaptive cardiac responses during development, to adaptation to the frequently occurring pressure and volume overload as well as to cardiac changes, induced by enduring exercise and chronic hypoxia. Cardiac Adaptations will be of great value to cardiovascular investigators, who will find this book highly useful in their cardiovascular studies for finding solutions in diverse pathological conditions; it will also appeal to students, fellows, scientists, and clinicians interested in cardiovascular abnormalities.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1993 with total page 1356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Myocardial Preservation by : Dennis V. Cokkinos
Download or read book Myocardial Preservation written by Dennis V. Cokkinos and published by Springer. This book was released on 2019-01-28 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely book reveals an integrated approach to myocardial preservation focusing on translational research and clinical applications. Chapters cover both the mechanisms of heart failure in addition to therapeutic considerations, including forms of cardiac cell death, cardiac remodelling and cardiac regeneration. Potential future research directions are also proposed, enabling the reader to gain a broad in-depth understanding of the topic. Myocardial Preservation: Translational Research and Clinical Application presents a thorough review of myocardial preservation. Its comprehensive approach provides a valuable reference for cardiology researchers and practising and trainee cardiologists seeking new insight to the topic.
Book Synopsis Pharmacology and Therapeutics in the New Millennium by : S.K. Gupta
Download or read book Pharmacology and Therapeutics in the New Millennium written by S.K. Gupta and published by Springer Science & Business Media. This book was released on 2001-09-30 with total page 772 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past several years tremendous advancements have been made in the field of pharmacology and therapeutics. While new therapeutic strategies are coming up, old ones are being improved by modifications, or being replaced with newer ones. The major topics covered in this book include: endothelins, current topics in cardiovascular research, molecular pharmacology, recent developments in cancer research, antioxidants, oxidants and human disease, herbal drugs, developments in neuropharmacology, myelin biology and demyelinating disease, pharmacovigilance, role of cytokines in health and disease, ocular pharmacology, detoxification of xenobiotics-biotransformation and transport, and several other topics of current interest. The aim of this book is to fulfill the needs of the basic and clinical researchers as well as the students, particularly related to areas of current interest in pharmacology and therapeutics.
Book Synopsis Acute Coronary Syndromes: A Companion to Braunwald's Heart Disease E-Book by : Pierre Theroux
Download or read book Acute Coronary Syndromes: A Companion to Braunwald's Heart Disease E-Book written by Pierre Theroux and published by Elsevier Health Sciences. This book was released on 2010-09-24 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acute Coronary Syndromes—a Companion to Braunwald’s Heart Disease—covers the state-of-the-art scientific and clinical information you need to rapidly evaluate and manage acute coronary syndromes. Dr. Pierre Theroux and his team of expert contributors present advances in diagnostic and imaging techniques such as biomarkers, nuclear cardiology, echocardiography, and multislice CT; secondary prevention; and new antiplatelet, anti-ischemic, and gene therapies. Tap into the most definitive knowledge available from one of the leading experts in the field and a stellar cast of contributors. Understand the special considerations for the care of acute coronary syndromes in the emergency department and the coronary care unit. Effectively handle the treatment of special populations and chronic patients thanks to coverage of these challenges See techniques and procedures in greater detail and clarity through the all-new full-color design. Approach treatment with a global perspective from the new section on Population-Based Perspective that discusses the INTERHEART study, insights from the REACH registry, lessons learned from European registries, and ACS in North America. Gain a comprehensive understanding of ACS through coverage of pathophysiology, molecular mechanisms, the role of the immune system, and brand-new chapters on cell necrosis and cell regeneration and pharmacogenetics in the section on Disease-Based Perspectives. Integrate the latest testing and treatment techniques into your practice thanks to new chapters on biomarkers in acute ischemic heart disease; the role of noninvasive testing in prognostic risk stratification; the culprit lesions and patient at risk; non-responsiveness to antiplatelet therapy; bleeding in the acute coronary syndromes; and the refractory patient.
Book Synopsis Cardiovascular Development and Congenital Malformations by : Michael Artman
Download or read book Cardiovascular Development and Congenital Malformations written by Michael Artman and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Congenital cardiovascular malformations are the single most common form of birth defect. Therefore a better understanding of the mechanisms involved in both normal cardiac development and the formation of cardiovascular structural defects is of tremendous importance. This book brings together the leading scientists from around the world who are actively engaged in studies of the etiology, morphogenesis and physiology of congenital cardiovascular diseases. A broad variety of approaches, techniques, experimental models and studies of human genetics combine to make this a truly outstanding and unique treatise on this pressing topic. Cardiovascular Development and Congenital Malformations is divided into distinct categories, each focusing on a particular aspect of cardiovascular development. Sections are accompanied by editorial overviews which integrate new findings and place the information into a broader context.