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Muscarinic Receptors
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Book Synopsis Muscarinic Receptors by : Allison D. Fryer
Download or read book Muscarinic Receptors written by Allison D. Fryer and published by Springer Science & Business Media. This book was released on 2012-01-06 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: Muscarinic acetylcholine receptors have played a key role in the advancement of knowledge of pharmacology and neurotransmission since the inception of studies in these fields, and the effects of naturally occurring drugs acting on muscarinic receptors were known and exploited for both therapeutic and non-therapeutic purposes for hundreds of years before the existence of the receptors themselves was recognized. This volume presents a broad yet detailed review of current knowledge of muscarinic receptors that will be valuable both to long-time muscarinic investigators and to those new to the field. It describes the detailed insights that have been obtained on the structure, function, and cell biology of muscarinic receptors. This volume also describes physiological analyses of muscarinic receptors and their roles in regulating the function of the brain and of a variety of peripheral tissues. This volume shows how the study of muscarinic receptors continues to provide new and surprising insights not just to the cholinergic system but to the broad areas of neurobiology, cell biology, pharmacology, and therapeutics.
Book Synopsis Muscarinic Receptors by : Allison D. Fryer
Download or read book Muscarinic Receptors written by Allison D. Fryer and published by Springer Science & Business Media. This book was released on 2012-01-07 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: Muscarinic acetylcholine receptors have played a key role in the advancement of knowledge of pharmacology and neurotransmission since the inception of studies in these fields, and the effects of naturally occurring drugs acting on muscarinic receptors were known and exploited for both therapeutic and non-therapeutic purposes for hundreds of years before the existence of the receptors themselves was recognized. This volume presents a broad yet detailed review of current knowledge of muscarinic receptors that will be valuable both to long-time muscarinic investigators and to those new to the field. It describes the detailed insights that have been obtained on the structure, function, and cell biology of muscarinic receptors. This volume also describes physiological analyses of muscarinic receptors and their roles in regulating the function of the brain and of a variety of peripheral tissues. This volume shows how the study of muscarinic receptors continues to provide new and surprising insights not just to the cholinergic system but to the broad areas of neurobiology, cell biology, pharmacology, and therapeutics.
Book Synopsis Muscarinic Receptors by : Allison D. Fryer
Download or read book Muscarinic Receptors written by Allison D. Fryer and published by Springer. This book was released on 2014-02-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Muscarinic acetylcholine receptors have played a key role in the advancement of knowledge of pharmacology and neurotransmission since the inception of studies in these fields, and the effects of naturally occurring drugs acting on muscarinic receptors were known and exploited for both therapeutic and non-therapeutic purposes for hundreds of years before the existence of the receptors themselves was recognized. This volume presents a broad yet detailed review of current knowledge of muscarinic receptors that will be valuable both to long-time muscarinic investigators and to those new to the field. It describes the detailed insights that have been obtained on the structure, function, and cell biology of muscarinic receptors. This volume also describes physiological analyses of muscarinic receptors and their roles in regulating the function of the brain and of a variety of peripheral tissues. This volume shows how the study of muscarinic receptors continues to provide new and surprising insights not just to the cholinergic system but to the broad areas of neurobiology, cell biology, pharmacology, and therapeutics.
Book Synopsis The Muscarinic Receptors by : Joan Heller Brown
Download or read book The Muscarinic Receptors written by Joan Heller Brown and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on muscarinic receptors is advancing at an extraordinary rate. Ten years ago, the existence of muscarinic receptor sub types was a logical assumption with only scattered experimen tal support. The discovery that pirenzepine recognized apparent heterogeneity in muscarinic binding sites infused new life into the problem of subclassifying muscarinic receptors. Simultaneous advances in molecular biology created a frenzy to clone cell sur face receptors. The muscarinic receptor succumbed surprisingly quickly, revealing its structure and that of at least four closely related gene products within a year. Our hope of obtaining clear evidence for muscarinic receptor subtypes was answered with a vengeance. Now a family of muscarinic receptors sits before us, asking to be understood. The bounty is as attractive to those who have not previously studied muscarinic receptors as to those who have dedicated their research careers to this subject. The goal of this book is to ensure that the new generation of research will profit from the wisdom of the past. The tools of molecular biology are well suited to the tasks of characteriz ing the pharmacology, function, and regulation of the distinct muscarinic receptor subtypes. However, efficient and intelligent use of these tools is not possible, unless one understands the properties of the receptor, the molecular mechanisms by which it couples to effectors, and the ways that it is regulated.
Book Synopsis Muscarinic Receptor Subtypes in Smooth Muscle by : Richard M. Eglen
Download or read book Muscarinic Receptor Subtypes in Smooth Muscle written by Richard M. Eglen and published by CRC Press. This book was released on 2020-10-08 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores several subtypes of muscarinic receptors that modulate smooth muscle activity. Main topics include a classification of muscarinic receptors, biochemical responses that occur in smooth muscle, the role of muscarinic receptors in the function of gastrointestinal and genitourinary smooth muscle, and prejunctional muscarinic receptors in smooth muscle. Discussions cover the current state of research and are intended to generate further research into the design of novel therapeutics for disorders of smooth muscle function.
Book Synopsis Animal Models of Cognitive Impairment by : Edward D. Levin
Download or read book Animal Models of Cognitive Impairment written by Edward D. Levin and published by CRC Press. This book was released on 2006-06-22 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: The costs associated with a drug’s clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairment examines some of the most popular and successful animal archetypes used in the context of drug discovery. It provides integrated coverage of the latest research concerning neuronal systems relevant to cognitive function and dysfunction, assimilating reviews of this research within the context of each chapter. This approach is unique in that it brings together molecular and neurochemical methodologies, behavioral applications in translational models, and clinical applications. The book comprehensively discusses a wide variety of animal models of cognitive impairment, including genetic, lesion, pharmacological, and aging related impairments. It also explores the significance of this research in regards to the treatment of various addictions and disorders such as stroke, autism, Alzheimer’s, schizophrenia, and ADHD. Edited by two renowned authorities in the field, Animal Models of Cognitive Impairment is a timely book that provides integrated coverage of cutting-edge research that concerns neuronal systems relevant to cognitive function and dysfunction.
Book Synopsis The Muscarinic Receptors by : Joan Heller Brown
Download or read book The Muscarinic Receptors written by Joan Heller Brown and published by Humana. This book was released on 2012-01-22 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on muscarinic receptors is advancing at an extraordinary rate. Ten years ago, the existence of muscarinic receptor sub types was a logical assumption with only scattered experimen tal support. The discovery that pirenzepine recognized apparent heterogeneity in muscarinic binding sites infused new life into the problem of subclassifying muscarinic receptors. Simultaneous advances in molecular biology created a frenzy to clone cell sur face receptors. The muscarinic receptor succumbed surprisingly quickly, revealing its structure and that of at least four closely related gene products within a year. Our hope of obtaining clear evidence for muscarinic receptor subtypes was answered with a vengeance. Now a family of muscarinic receptors sits before us, asking to be understood. The bounty is as attractive to those who have not previously studied muscarinic receptors as to those who have dedicated their research careers to this subject. The goal of this book is to ensure that the new generation of research will profit from the wisdom of the past. The tools of molecular biology are well suited to the tasks of characteriz ing the pharmacology, function, and regulation of the distinct muscarinic receptor subtypes. However, efficient and intelligent use of these tools is not possible, unless one understands the properties of the receptor, the molecular mechanisms by which it couples to effectors, and the ways that it is regulated.
Book Synopsis Muscarinic Receptor: From Structure to Animal Models by : Jaromir Myslivecek
Download or read book Muscarinic Receptor: From Structure to Animal Models written by Jaromir Myslivecek and published by Humana. This book was released on 2016-11-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides methods for characterization of muscarinic receptor in crystallography studies that advanced our understanding of structural properties and activation mechanism of muscarinic receptors and are cornerstone in molecular modeling and computer‐based approaches to study muscarinic receptors. Muscarinic Receptor: From Structure to Animal Models guides readers through binding techniques, protocols to investigate molecular properties of muscarinic receptors, protocols to study muscarinic receptors in the central nervous system using autoradiography and PET studies and protocols on animals with knock-out and knock-in muscarinic genes to study role of muscarinic receptors in physiology and behavior. Written in the popular Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory. Concise and easy-to-use, Muscarinic Receptor: From Structure to Animal Models aims to ensure successful results in the further study of this vital field.
Book Synopsis Muscarinic Receptor Subtypes in the GI Tract by : G. Lux
Download or read book Muscarinic Receptor Subtypes in the GI Tract written by G. Lux and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: The differentiation between the muscarinic and the nicotinic ef fects of acetylcholine led to the subdivision of the cholinergic ner vous system into two categories. Further studies showed that stimu lating and inhibiting muscarinic effects could be demonstrated in different organs. For instance, gastric secretion and gastrointestinal motility are stimulated, while heart rate and the vascular muscula ture are inhibited. For decades, it could not be determined whether the various ef fects were mediated by different subgroups of muscarinic receptors, but eventually, with the availability of agonists and antagonists to muscarinic receptors, and using various techniques, the existence of at least two such subgroups could be ascertained . . Mt receptors are defined by their high affinity for the antagonist pirenzipine in comparison to M2 receptors. This subdivision of muscarinic receptors has since been proved beyond doubt by experi ments in vivo and in vitro, by receptor binding studies, by histoauto radiography, and by electrophysiological studies. However, these different classes of muscarinic receptors have not been found to relate to different types of effects; instead both excit atory and inhibitory effects appear to be linked to each class. For ex ample, excitation of gut motility and inhibition of cardiac contrac tile activities both appear to be mediated by M2 receptors, while ex citation of some nerves in sympathetic ganglia and inhibition of some myenteric nerves may be mediated by M receptors.
Book Synopsis Muscarinic Receptors in Airways Diseases by : Johan Zaagsma
Download or read book Muscarinic Receptors in Airways Diseases written by Johan Zaagsma and published by Springer. This book was released on 2013-03-08 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: What are the different muscarinic acetylcholine receptor subtypes and how are they distributed in the airways and molecular signalling mechanisms? What is their function in neurogenic and non-neurogenic control of the airways and in inflammatory mechanisms? How is their gene expression regulated? The great importance of muscarinic acetylcholine receptors for the pathophysiology and treatment of chronic inflammatory obstructive airways diseases calls for a comprehensive and integrated overview of the current knowledge to address such questions, to discuss the role of these receptor subtypes in diseases such as asthma and COPD, and to present novel perspectives on antimuscarinic drug development. The present book is the worthy result of this need. It points out innovative insights into the hitherto poorly understood role of postjunctional muscarinic M2 receptors in airway smooth muscle contraction and sheds some light on the novel concepts of antimuscarinic drug development, with special reference to the l
Book Synopsis Post-Genomic Cardiology by : José Marín-García
Download or read book Post-Genomic Cardiology written by José Marín-García and published by Academic Press. This book was released on 2014-05-09 with total page 944 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the “epigenome,” comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach. This book, written by respected cardiologist José Marín-García, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA. Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approaches Analyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndrome Presents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs
Book Synopsis Neurotransmitters, Drugs and Brain Function by : Roy Webster
Download or read book Neurotransmitters, Drugs and Brain Function written by Roy Webster and published by John Wiley & Sons. This book was released on 2001-11-28 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurotransmitters, Drugs and Brain Function aims to link basic aspects of the activity of neurotransmitters at the receptor and synaptic level with their role in normal brain function, disease states, and drug action. Thus, the material considers to what extent our knowledge of the central synaptic action of certain drugs can explain their possible roles in the cause of diseases and in the modes of action of drugs effective in those conditions. It offers a working explanation of drug and neurotransmitter action in CNS function, with a clear, comprehensive, and challenging style of writing. The authors review the chemical basis for drugs and the conditions they treat. It also, includes numerous illustrations and schematic diagrams.
Book Synopsis Functional Neurobiology of Aging by : Patrick R. Hof
Download or read book Functional Neurobiology of Aging written by Patrick R. Hof and published by Academic Press. This book was released on 2001-01-11 with total page 960 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some well-known age-related neurological diseases include Parkinson's disease, Alzheimer's disease, deafness, and blindness. Even more common are the problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging continue to become more common, and conditions associated with aging need more attention by doctors and researchers. In 1991, patients over the age of 65 saw their doctors an average of eight times per year. Research funding is provided by the Neuroscience and Neuropsychology of Aging (NNA) Program, which is run by the National Institute on Aging. This book offers a comprehensive overview of all topics related to functional impairments which are related to the aging brain and nervous system. It is organized according to four general functions: movement, senses, memory, and neuroendocrine regulation. Written by the leading researchers in the field, this comprehensive work addresses both impairments associated with diseases and not associated with diseases, making it easier to understand the mechanisms involved. Functional Neurobiology of Aging is an important reference for professionals and students involved in aging research, as well as physicians who need to recognize and understand age-related impairments. Organized by function, making it easy to find and understand the material Addresses impairments both associated with diseases and not associated with diseases Written by leading researchers in the field Most comprehensive source of information on the neurobiology of aging
Book Synopsis Perspiration Research by : H. Yokozeki
Download or read book Perspiration Research written by H. Yokozeki and published by Karger Medical and Scientific Publishers. This book was released on 2016-09-01 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research into perspiration has developed dramatically during the last 15 years, continually improving our understanding of the pathogenesis of sweating disorders. It has become clear that, in addition to its temperature-regulating function, perspiration offers bactericidal protection as well. In this book, select authors further broaden our perspective on perspiration. Contributions cover a variety of new aspects, offering insight into the sweat glands' major role during the onset of disorders such as parapsoriasis, lichen planus, and lichen amyloidosis. They also highlight the importance of Malassezia - an allergen in sweat that exacerbates atopic dermatitis and cholinergic urticarial. Further roles of the sweat glands are discussed, including as storage of stem cells for replenishing epidermal cells in the case of thermal burns or as water retention sites for replenishing moisture in the stratum corneum. In addition, a novel analysis of the sweat glands' three-dimensional structures, using high-speed en-face optical coherence tomography (OCT), is introduced. Offering an in-depth overview of the latest knowledge in perspiration research, this book serves as an essential reference for all medical staff and researchers in the field.
Book Synopsis Receptors in the Human Nervous System by : F. A. O. Mendelsohn
Download or read book Receptors in the Human Nervous System written by F. A. O. Mendelsohn and published by Academic Press. This book was released on 2013-10-22 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Receptors in the Human Nervous System is a synthesis of the results of receptor mapping by leaders in the field. In addition to a comprehensive discussion of the distribution and possible interactions of the receptors of different neuroactive substances, this book also contains an abundance of pictorial representations of receptor distributions. High-quality photographs of one receptor are often juxtaposed with photographs of the distribution of a different receptor or receptor subtype for the consideration of possible interactions between different systems. The book surveys the distribution of receptor subtypes for the classical monoamine transmitters (acetylcholine, adrenaline, noradrenaline and serotonin) as well as the distribution of receptors for the excitatory and inhibitory amino acids, (glutamate, GABA and benzodiazepines) as well as the opioid peptides, angiotensen and other neuropeptides. The distribution of multiple types of serotonin receptors is given in detail, and the codistribution of receptors in the cortex is discussed. The book is directed toward researchers in the field of chemical neuroanatomy, as well as pharmacologists, neurophysiologists, and neuroscientists.
Book Synopsis Molecular Mechanisms of Muscarinic Acetylcholine Receptor Function by : Jürgen Wess
Download or read book Molecular Mechanisms of Muscarinic Acetylcholine Receptor Function written by Jürgen Wess and published by . This book was released on 1995-01-01 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the molecular mechanisms governing the function of muscarinic acetylcholine receptors. Detailed knowledge about these processes is essential to understand the complex roles that muscarinic receptors play under physiological and pathophysiological conditions. The volume is written by the leaders in the field and provides concise, up-to-date, comprehensive information.
Book Synopsis New Rapid-acting Antidepressants by : Kenji Hashimoto
Download or read book New Rapid-acting Antidepressants written by Kenji Hashimoto and published by Springer Nature. This book was released on 2021-10-22 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses new candidates for rapid-acting antidepressants, such as (R)-ketamine, (2R,6R)-hydroxynorketamine, scopolamine, mGluR2/3 antagonists and AMPA receptor agonists. There are serious limitations to currently available antidepressants, such as delayed onset and low rates of efficacy. The discovery that a single dose of ketamine, an NMDAR antagonist, can produce rapid antidepressant effects that are sustained has led to new research in this area. In this volume, a variety of novel pharmaceutical treatments are examined. This volume would be useful to both researchers and clinicians who work in the field of pharmacology, specifically CNS drug treatments.
