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Multiple Sclerosis As A Neuronal Disease
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Book Synopsis Multiple Sclerosis As A Neuronal Disease by : Stephen Waxman
Download or read book Multiple Sclerosis As A Neuronal Disease written by Stephen Waxman and published by Elsevier. This book was released on 2005-05-27 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the role of neurons in multiple sclerosis (MS) and the changes that occur in neurons as a result of MS. It places MS in a new and important perspective that not only explains the basis for symptom production, remission, and progress in MS, but also promises to open up new therapeutic possibilities. * Brings together the latest information from clinical, pathological, imaging, molecular, and pharmacological realms to explore the neurobiology of Multiple Sclerosis * Places MS in a new and important perspective that promises to open up new therapeutic avenues * Superbly illustrated and referenced
Book Synopsis Multiple Sclerosis by : Institute of Medicine
Download or read book Multiple Sclerosis written by Institute of Medicine and published by National Academies Press. This book was released on 2001-08-10 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis is a chronic and often disabling disease of the nervous system, affecting about 1 million people worldwide. Even though it has been known for over a hundred years, no cause or cure has yet been discovered-but now there is hope. New therapies have been shown to slow the disease progress in some patients, and the pace of discoveries about the cellular machinery of the brain and spinal cord has accelerated. This book presents a comprehensive overview of multiple sclerosis today, as researchers seek to understand its processes, develop therapies that will slow or halt the disease and perhaps repair damage, offer relief for specific symptoms, and improve the abilities of MS patients to function in their daily lives. The panel reviews existing knowledge and identifies key research questions, focusing on: Research strategies that have the greatest potential to understand the biological mechanisms of recovery and to translate findings into specific strategies for therapy. How people adapt to MS and the research needed to improve the lives of people with MS. Management of disease symptoms (cognitive impairment, depression, spasticity, vision problems, and others). The committee also discusses ways to build and financially support the MS research enterprise, including a look at challenges inherent in designing clinical trials. This book will be important to MS researchers, research funders, health care advocates for MS research and treatment, and interested patients and their families.
Book Synopsis The Neurobiology of Multiple Sclerosis by :
Download or read book The Neurobiology of Multiple Sclerosis written by and published by Academic Press. This book was released on 2007-06-07 with total page 760 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis (MS) is an immune-mediated neurodegenerative disorder of the human central nervous system (CNS) which usually affects young adults with certain genetic backgrounds who are then exposed to certain precipitating environmental antigen(s). Despite major advances of the past two decades in understanding the pathophysiology of MS, and in spite of the introduction of new immunomodulatory and immuno-suppressive agents which may slow down disease progression and delay the onset of disability, the “cause and the “cure for MS remain elusive. This volume of International Review of Neurobiology focuses on MS and related disorders. The volume can be divided into various sections with the main emphasis on MS pathogenesis, clinical features and epidemiology, neuroimaging, and treatment. The ultimate goal of this book is to encourage further research into the pathogenesis of this elusive disease.
Book Synopsis Immune Rebalancing by : Diana Boraschi
Download or read book Immune Rebalancing written by Diana Boraschi and published by Academic Press. This book was released on 2016-01-25 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immune Rebalancing: The Future of Immunosuppression summarizes the most promising perspectives of immunopharmacology, in particular in the area of immunosuppression by considering molecular pathways, personalized medicine, microbiome and nanomedicine. Modulation of immune responses for therapeutic purposes is a particularly relevant area, given the central role of anomalous immunity in diseases. These diseases vary from the most typically immune-related syndromes (autoimmune diseases, allergy and asthma, immunodeficiencies) to those in which altered immunity and inflammation define the pathological outcomes (chronic infections, tumours, chronic inflammatory and degenerative diseases, metabolic disorders, etc. Visits immunosuppression from a modern point of view of signalling mechanisms at the light of the current knowledge of signalling mechanisms and regulatory networks allows the reader to formulate new ideas and concepts on how to use immunosuppression the therapeutic purposes Encourages researchers to engage into exploring the field of pharmacological modulation of immune responses in depth, and with the new knowledge and tools available, designs more effective therapeutic strategies to autoimmune and inflammatory diseases, cancer, degenerative diseases and infections Examines the link between molecular pathways associated to immune-suppression and the new immunopharmacology approaches Provides information on the new strategies for drug development in this field Considers the role of microbes in the development of the mammalian immune system and immune responses, which will widen the reader’s strategy for addressing therapeutic immune modulations
Book Synopsis Diseases of the Brain, Head and Neck, Spine 2020–2023 by : Juerg Hodler
Download or read book Diseases of the Brain, Head and Neck, Spine 2020–2023 written by Juerg Hodler and published by Springer Nature. This book was released on 2020-02-14 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book offers an essential overview of brain, head and neck, and spine imaging. Over the last few years, there have been considerable advances in this area, driven by both clinical and technological developments. Written by leading international experts and teachers, the chapters are disease-oriented and cover all relevant imaging modalities, with a focus on magnetic resonance imaging and computed tomography. The book also includes a synopsis of pediatric imaging. IDKD books are rewritten (not merely updated) every four years, which means they offer a comprehensive review of the state-of-the-art in imaging. The book is clearly structured and features learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers navigate the text. It will particularly appeal to general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic expertise, as well as clinicians from other specialties who are interested in imaging for their patient care.
Book Synopsis The Molecular and Clinical Pathology of Neurodegenerative Disease by : Patrick A. Lewis
Download or read book The Molecular and Clinical Pathology of Neurodegenerative Disease written by Patrick A. Lewis and published by Academic Press. This book was released on 2018-11-16 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a unique perspective in relating clinical experiences with the molecular understanding needed to examine these diseases and is a must-read for anyone who wants to learn more about neurodegeneration. Provides an up-to-date summary of neurodegeneration at a molecular, cellular, and tissue level for the most common human disorders Describes the clinical background and underlying molecular processes for Alzheimer’s disease, Parkinson’s, Prion, Motor Neuron, Huntington’s, and Multiple Sclerosis Highlights the state-of-the-art treatment options for each disorder Details examples of relevant cutting edge experimental systems, including genome editing and human pluripotent stem cell-derived neuronal models
Book Synopsis White Matter Diseases by : Massimo Filippi
Download or read book White Matter Diseases written by Massimo Filippi and published by Springer Nature. This book was released on 2020-02-13 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides cutting-edge information on the epidemiology, etiopathogenesis, clinical manifestations, diagnostic procedures and treatment approaches for the main white matter (WM) disorders of the central nervous system (CNS). WM lesions are associated with many neurological conditions, and with aging. The diagnostic work-up of neurological diseases characterized by the presence of these lesions has changed dramatically over the past few years. This is mainly due on the one hand to the discovery of specific pathogenetic factors in some of these conditions, and on the order to the optimized use of diagnostic tools. All of this has resulted in new diagnostic algorithms, and in the identification of new neurological conditions. The book offers neurologists essential guidance in the diagnosis and treatment of the most frequent WM conditions, promoting their correct and cost-saving diagnosis and management. By integrating neurological, laboratory and imaging concepts with the demands of accurate diagnosis, this reference guide provides a state-of-the-art overview of the current state of knowledge on these conditions, as well as practical guidelines for their diagnosis and treatment.
Book Synopsis Multiple Sclerosis by : Ian S. Zagon
Download or read book Multiple Sclerosis written by Ian S. Zagon and published by . This book was released on 2017 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neurodegeneration in Multiple Sclerosis by : M. Filippi
Download or read book Neurodegeneration in Multiple Sclerosis written by M. Filippi and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it is an indispensable tool for all those working in this field. The context in which this book exists is that there is an increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information.
Book Synopsis Neuroimmune Diseases by : Hiroshi Mitoma
Download or read book Neuroimmune Diseases written by Hiroshi Mitoma and published by Springer. This book was released on 2019-08-13 with total page 822 pages. Available in PDF, EPUB and Kindle. Book excerpt: A translational overview of neuroimmune diseases for neuroscientists and clinicians that clarifies the pathological mechanisms underlying neuroimmune diseases and builds a comprehensive bridge between the latest research findings and their clinical implications in daily practice. The material is presented in two steps. The first section comprises a review of the pathogenic actions of immune cells in brain diseases. Here the authors discuss the mechanisms through which immune cells disrupt the functions of nerve cells. The second section explores the ways in which the brain becomes dysfunctional due to impaired nerve cell function. Based on pathogenesis, diagnostic and therapeutic strategies are discussed for each clinical category. The book will be invaluable for use in clinical practice of neuroimmune diseases
Book Synopsis Neuroimmune Pharmacology by : Tsuneya Ikezu
Download or read book Neuroimmune Pharmacology written by Tsuneya Ikezu and published by Springer Science & Business Media. This book was released on 2008-03-21 with total page 828 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroimmune pharmacology seeks to harness the immune system to provide pharmacological intervention to combat neurodegenerative diseases. This book provides a comprehensive overview of topics that embrace the link between the immune system and the pathogenesis of neurodegenerative disorders. Results from recent studies strongly suggest that a major part of the process in diseases including Alzheimer’s and Parkinson’s as well as Prion diseases, comes from changes in the innate and adaptive arms of the brain and peripheral immune systems. Thus, the book provides an in-depth study of numerous fields including immunology, pharmacology, neuroscience and neurovirology. It is accompanied by a CD-ROM that includes access to lectures, slide presentations, and question and answers on neuroimmune pharmacology.
Book Synopsis Neurological Disorders by : World Health Organization
Download or read book Neurological Disorders written by World Health Organization and published by World Health Organization. This book was released on 2006 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although there are several gaps in understanding the many issues related to neurological disorders, we know enough to be able to shape effective policy responses to some of the most common. This book describes and discusses the increasing public health impact of common neurological disorders such as dementia, epilepsy, headache disorders, multiple sclerosis, neuroinfections, neurological disorders associated with malnutrition, pain associated with neurological disorders, Parkinson's disease, stroke and traumatic brain injuries. It provides information and advice on public health interventions that may reduce their occurrence and consequences, and offers health professionals and planners the opportunity to assess the burden caused by these disorders. The clear message that emerges is that unless immediate action is taken globally, the neurological burden is likely to become an increasingly serious and unmanageable.
Book Synopsis Multiple Sclerosis by : Erwin Scholz
Download or read book Multiple Sclerosis written by Erwin Scholz and published by Nova Biomedical Books. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis is a chronic inflammatory disease of the central nervous system which leads to neuronal demyelination. As the disease progresses, oligodendrocytes and axons are destroyed, resulting in sclerotic plaques or lesion formation. Although treatment is available which can alleviate some of the symptoms, no cure is available. This book presents current research in the study of the causes, diagnosis and management of multiple sclerosis. Topics discussed include the reactivity profile of B cells and autoantibodies in MS; the role of fatty acids in neurodegenerative diseases; the possible mechanisms that the Epstein-Barr virus is exploiting to trigger MS and immunoglobulin free light chains in the diagnosis of multiple sclerosis.
Book Synopsis Fatigue in Multiple Sclerosis by : Christian Dettmers
Download or read book Fatigue in Multiple Sclerosis written by Christian Dettmers and published by Frontiers Media SA. This book was released on 2016-02-03 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dear Readers, If you are engaged in the treatment of patients with MS (pwMS), this e-book’s aim is to offer novel insights to improve on an understanding of one of the major problems of pwMS: fatigue. Although there is increasing research into fatigue and its impact on MS, this collection of ten articles supports a better understanding of fatigue in MS patients. It explores pathophysiological concepts, provoking mechanisms, objective measurements, personality interactions, pharmacological and non-pharmacological interventions and summarizes clinical management. It is written by neurologists, psychologists, scientists and therapists and addresses this group of people, who deal with pwMS in private, clinical, rehabilitation or scientific settings. Its aim is to communicate high-quality information, knowledge and experience on MS to healthcare professionals, while providing global support for the international MS community.
Book Synopsis The Biology of Multiple Sclerosis by : Gregory Atkins
Download or read book The Biology of Multiple Sclerosis written by Gregory Atkins and published by Cambridge University Press. This book was released on 2012-11-08 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis is the most common debilitating neurological disease in people under the age of forty in the developed world. Many publications cover medical and clinical approaches to the disease; however, The Biology of Multiple Sclerosis provides a clear and concise up-to-date overview of the scientific literature on the various theories of MS pathogenesis. Covering the main elements of scientific research into multiple sclerosis, the book contains chapters on the neuropathology of the disease as well as an account of the most extensively used animal model experimental autoimmune encephalomyelitis. The book contains chapters regarding the role of viruses in the development of multiple sclerosis. Viruses have long been implicated and chapters on animal models based on virus infection, as well as their possible role in the etiology of MS, are included. Of interest to MS researchers, the book is written to also be of value to postgraduate and medical students.
Book Synopsis Neuropathology of Neurodegenerative Diseases by : Gabor G. Kovacs
Download or read book Neuropathology of Neurodegenerative Diseases written by Gabor G. Kovacs and published by Cambridge University Press. This book was released on 2017-12-13 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical guide to the diagnosis of neurodegenerative diseases discusses modern molecular techniques, morphological classification, fundamentals of clinical symptomology, diagnostic pitfalls and immunostaining protocols. It is based on the proteinopathy concept of neurodegenerative disease, which has influenced classification and provides new strategies for therapy. Numerous high-quality images, including histopathology photomicrographs and neuroradiology scans, accompany the description of morphologic alterations and interpretation of immunoreactivities. Diagnostic methods and criteria are placed within recent developments in neuropathology, including the now widespread application of immunohistochemistry. To aid daily practice, the guide includes diagnostic algorithms and offers personal insights from experienced experts in the field. Special focus is given to the way brain tissue should be handled during diagnosis. This is a must-have reference for medical specialists and specialist medical trainees in the fields of pathology, neuropathology and neurology working with neuropathologic features of neurodegenerative diseases.
Book Synopsis Multiple Sclerosis by : Alireza Minagar
Download or read book Multiple Sclerosis written by Alireza Minagar and published by Biota Publishing. This book was released on 2014-09-01 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis [MS] is one of the most common auto-immune-mediated diseases of the human central nervous system [CNS] which affects young adults and usually causes significant neurological disability. Currently, the causes of MS are still unclear, a cure for MS remains elusive and the effectiveness of treatment varies significantly among individuals. Clinical features and neurological deficits stemming from this progressive neurological disease are diverse since MS potentially affects human CNS at all levels from brain to the end of spinal cord. The triggering event for development of MS remains unknown. Immunopathogenesis of MS involves a number of steps which include activation of peripheral leukocytes against putative CNS antigen(s), interactions of the activated leukocytes with inflamed cerebral endothelial cells, transendothelial migration of activated lymphocytes and macrophages to the CNS milieu, and further propagation of the massive immune response within the CNS. Such massive immune activation leads to loss of myelin-oligodendrocyte complex. Several immune cell types and mediators of the immune-inflammatory response actively contribute to pathogenesis of MS. Genetic factors are also believed to play a central role in the development of most forms of MS. Another important but much unrecognized and under-researched feature of MS immunopathology is “neurodegeneration.” Neuronal loss and axonal degeneration are the core components of irreversible and permanent CNS atrophy and disability in MS. What we call MS in reality is a heterogeneous group of diseases and at least four distinct immunopathological subtypes of MS with dissimilar responses to therapy with immunomodulatory agents exist. MS is a clinical diagnosis, however, its diagnostic process is much facilitated by utilization of laboratory and neuroimaging studies. Present therapies of MS are either immunomodulatory agents or immunosuppressive and mainly target the peripheral immune system with the intention to ameliorate the severity of acute relapses, decrease annual relapse rate, and improve MRI lesions. Currently, much research activity is being conducted to better understand the fundamental disease mechanisms of MS and find more effective and safer treatments for this incurable disease. This book presents an overview of MS as a disease with neuroinflammatory and neurodegenerative features and the authors discuss the most recent findings about MS and its treatment. Table of Contents: Introduction / Clinical Features of Multiple Sclerosis / Pathophysiology of Multiple Sclerosis / Neuroimaging of Multiple Sclerosis / Diagnosis of Multiple Sclerosis / Treatment of Multiple Sclerosis / Prognosis of Multiple Sclerosis / Concluding Remarks . References
