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Author : Henrik Cordes
Publisher :
ISBN 13 : 9783863597153
Total Pages : pages
Book Rating : 4.5/5 (971 download)
Download or read book Multi-scale Modeling in Human Systems Pharmacology & Physiology written by Henrik Cordes and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Masood Khaksar Toroghi
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (133 download)
Download or read book A Multi-scale Metabolic Model of the Whole-Human Body written by Masood Khaksar Toroghi and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Model-based design (MBD) is a well-known approach in the biomedical and health sciences research community. It has a significant impact for answering important questions related to human metabolism, systems pharmacology, precision medicine, epidemiology and public health. Multi-scale modelling is one of the MBD approaches to analyze and study complex biological systems like the human body. However, there are some challenges associated with this approach. For instance, a lack of systematic integration methods, a lack of efficient computational algorithms, and difficulty for model validation. This thesis aims to meet these challenges. First, I present a multi-scale modelling framework that was developed using a dynamic parsimonious flux balance analysis technique. The mechanistic model integrates the metabolomic and genomic data with human physiology. Simulations are performed to demonstrate the computational efficiency of integration algorithm. Then, I use the proposed model to identify biomarkers for inborn errors of metabolism. I explore how the developed model can be used to predict blood alcohol concentrations. Here, in vivo data are integrated with the metabolic model to validate the prediction results. In the next section of the thesis, I develop a mathematical model for low-density lipoprotein cholesterol (LDL-C) regulation in the body. The proposed model integrates the metabolic pathway for cholesterol synthesis, hepatic LDL receptor (LDLRs) signaling pathway, and proprotein convertase subtilisin/kexin type 9 (PCSK9) mechanism to degrade LDLRs at the surface of the hepatocyte cells. Circulating PCSK9 increases endosomal and lysosomal degradation of hepatic LDL receptors, resulting in the decreased ability to clear LDL-C from the circulation. Experimental evidence and previous studies are used to obtain the parameters of the model. The LDL-C model is employed to predict the effect of anti-PCSK9 and statin drugs on LDL-C levels in a certain populations with hypercholesterolemia. In the next part of the research, I develop an algorithm to estimate drug dosage for individual patients with hyperuricemia. The proposed computational algorithm uses the multi-scale modelling framework to create individual disease models. An in silico study shows the potential of proposed modelling framework in precision medicine. Finally, aligned with the research objective, I develop a new modelling framework to capture multiple functions of the liver cells simultaneously. The simulation results show that the developed model has promise with respect to computational efficiency, convergence and robustness. The proposed multi-scale metabolic modelling framework integrating genomic and metabolomic data presented in this thesis should aid biomedical engineers and clinicians to address different health-related problems such as obesity, diabetes, cardiovascular, and genetic diseases.
Author : Davide Manca
Publisher : Elsevier
ISBN 13 : 0444639675
Total Pages : 418 pages
Book Rating : 4.4/5 (446 download)
Download or read book Quantitative Systems Pharmacology written by Davide Manca and published by Elsevier. This book was released on 2018-07-18 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative Systems Pharmacology: Models and Model-Based Systems with Applications, Volume 42, provides a quantitative approach to problem-solving that is targeted to engineers. The book gathers the contributions of doctors, pharmacists, biologists, and chemists who give key information on the elements needed to model a complex machine like the human body. It presents information on diagnoses, administration and release of therapeutics, distribution metabolism and excretion of drugs, compartmental pharmacokinetics, physiologically-based pharmacokinetics, pharmacodynamics, identifiability of models, numerical methods for models identification, design of experiments, in vitro and in vivo models, and more. As the pharma community is progressively acknowledging that a quantitative and systematic approach to drug administration, release, pharmacokinetics and pharmacodynamics is highly recommended to understand the mechanisms and effects of drugs, this book is a timely resource. Outlines a model-based approach (based on Process Systems Engineering-OSE and Computer Aided Process Engineering-CAPE) in quantitative pharmacology Explains how therapeutics work in the human body and how anatomy and physiology influences drug efficacy Discusses how drugs are driven to specific targets using nanoparticles Offers insight into how in vitro and in vivo experiments help understand the drug mechanism of action and optimize their performance Includes case studies showing the positive outcome of these methods in personalized therapies, therapeutic drug monitoring, clinical trials analysis and drug formulation
Author : Glen L. Niebur
Publisher : Elsevier
ISBN 13 : 0128179325
Total Pages : 256 pages
Book Rating : 4.1/5 (281 download)
Download or read book Mechanobiology written by Glen L. Niebur and published by Elsevier. This book was released on 2019-12-01 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanobiology: From Molecular Sensing to Disease will provide a review of the current state of understanding of mechanobiology and its role in health and disease. It covers: Current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli, A review of diseases that with known or purported mechanobiological underpinnings; The role of mechanobiology in tissue engineering and regenerative medicine; Experimental methods to capture mechanobiological phenomena; Computational models in mechanobiology. Presents our current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli Provides a review of diseases with known or purported mechanobiological underpinnings Includes the role of mechanobiology in tissue engineering and regenerative medicine Covers experimental methods to capture mechanobiological phenomena
Author : Donald E. Mager
Publisher : Springer
ISBN 13 : 3319445340
Total Pages : 512 pages
Book Rating : 4.3/5 (194 download)
Download or read book Systems Pharmacology and Pharmacodynamics written by Donald E. Mager and published by Springer. This book was released on 2016-11-29 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and refined further to show practical applications in drug development. There is a growing awareness that pharmaceutical companies should reduce the high attrition in the pipeline due to insufficient efficacy or toxicity found in proof-of-concept and/or Phase II studies. Systems Pharmacology and Pharmacodynamics discusses the framework for integrating information obtained from understanding physiological/pathological pathways (normal body function system vs. perturbed system due to disease) and pharmacological targets in order to predict clinical efficacy and adverse events through iterations between mathematical modeling and experimentation.
Author : Ewart Carson
Publisher : Newnes
ISBN 13 : 0124095259
Total Pages : 589 pages
Book Rating : 4.1/5 (24 download)
Download or read book Modelling Methodology for Physiology and Medicine written by Ewart Carson and published by Newnes. This book was released on 2013-12-05 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modelling Methodology for Physiology and Medicine, Second Edition, offers a unique approach and an unprecedented range of coverage of the state-of-the-art, advanced modeling methodology that is widely applicable to physiology and medicine. The second edition, which is completely updated and expanded, opens with a clear and integrated treatment of advanced methodology for developing mathematical models of physiology and medical systems. Readers are then shown how to apply this methodology beneficially to real-world problems in physiology and medicine, such as circulation and respiration. The focus of Modelling Methodology for Physiology and Medicine, Second Edition, is the methodology that underpins good modeling practice. It builds upon the idea of an integrated methodology for the development and testing of mathematical models. It covers many specific areas of methodology in which important advances have taken place over recent years and illustrates the application of good methodological practice in key areas of physiology and medicine. It builds on work that the editors have carried out over the past 30 years, working in cooperation with leading practitioners in the field. Builds upon and enhances the reader's existing knowledge of modeling methodology and practice Editors are internationally renowned leaders in their respective fields Provides an understanding of modeling methodologies that can address real problems in physiology and medicine and achieve results that are beneficial either in advancing research or in providing solutions to clinical problems
Author : Sheila Annie Peters
Publisher : John Wiley & Sons
ISBN 13 : 111949768X
Total Pages : 644 pages
Book Rating : 4.1/5 (194 download)
Download or read book Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations written by Sheila Annie Peters and published by John Wiley & Sons. This book was released on 2021-10-12 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations The first book dedicated to the emerging field of physiologically based pharmacokinetic modeling (PBPK) Now in its second edition, Physiologically Based Pharmacokinetic (PBPK) Modelling and Simulations: Principles, Methods, and Applications in the Pharma Industry remains the premier reference book throughout the rapidly growing PBPK user community. Using clear and concise language, author Sheila Annie Peters connects theory with practice as she explores the vast potential of PBPK modeling for improving drug discovery and development. This fully updated new edition covers key developments in the field of PBPK modelling and simulations that have emerged in recent years. A brand-new section provides case studies in different application areas of PBPK modelling, including drug-drug interaction, genetic polymorphism, renal impairment, and pediatric extrapolation. Additional chapters address topics such as model-informed drug development (MIDD) and expose readers to a wide range of current applications in the field. Throughout the book, substantially revised chapters simplify complex topics and offer a balanced view of both the opportunities and challenges of PBPK modelling. Providing timely and comprehensive coverage of one of the most exciting new areas of pharmaceutical science, this book: Describes the principles behind physiological modeling of pharmacokinetic processes, inter-individual variability, and drug interactions for small molecule drugs and biologics Features a wealth of new figures and case studies of the applications of PBPK modelling along the value chain in drug discovery and development Reflects the latest regulatory guidelines on the reporting of PBPK modelling analysis Includes access to a new companion website containing code, datasets, explanations of case examples in the text, and discussion of key developments in the field Contains a brief overview of the field, end-of-chapter keywords for easy reference, and an extensive bibliography Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations: Principles, Methods, and Applications in the Pharmaceutical Industry, Second Edition is an indispensable single-volume resource for beginning and intermediate practitioners across the pharmaceutical sciences in both industry and academia.
Author : Pavel Gurevich
Publisher : Springer
ISBN 13 : 3319641735
Total Pages : 411 pages
Book Rating : 4.3/5 (196 download)
Download or read book Patterns of Dynamics written by Pavel Gurevich and published by Springer. This book was released on 2018-02-07 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: Theoretical advances in dynamical-systems theory and their applications to pattern-forming processes in the sciences and engineering are discussed in this volume that resulted from the conference Patterns in Dynamics held in honor of Bernold Fiedler, in Berlin, July 25-29, 2016.The contributions build and develop mathematical techniques, and use mathematical approaches for prediction and control of complex systems. The underlying mathematical theories help extract structures from experimental observations and, conversely, shed light on the formation, dynamics, and control of spatio-temporal patterns in applications. Theoretical areas covered include geometric analysis, spatial dynamics, spectral theory, traveling-wave theory, and topological data analysis; also discussed are their applications to chemotaxis, self-organization at interfaces, neuroscience, and transport processes.
Author : Panos Macheras
Publisher : Springer
ISBN 13 : 9783319801810
Total Pages : 483 pages
Book Rating : 4.8/5 (18 download)
Download or read book Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics written by Panos Macheras and published by Springer. This book was released on 2018-04-22 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this new second edition book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with epirical, compartmental, and stochastic pharmacokinetic models, with two new chapters, one on fractional pharmacokinetics and one on bioequivalence; and the fourth mainly with classical and nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. This second edition has new information on reaction limited models of dissolution, non binary biopharmaceutic classification system, time varying models, and interface models. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods. This book will appeal to graduate students and researchers in pharmacology, pharmaceutical sciences, bioengineering, and physiology. Reviews of the first edition: "This book presents a novel modelling approach to biopharmaceutics, pharmacokinetics and pharmacodynamic phenomena. This state-of-the-art volume will be helpful to students and researchers in pharmacology, bioengineering, and physiology. This book is a must for pharmaceutical researchers to keep up with recent developments in this field." (P. R. Parthasarathy, Zentralblatt MATH, Vol. 1103 (5), 2007) "These authors are the unique (or sole) contributors in this area that are working on these questions and bring a special expertise to the field that is now being recognized as essential to understanding biological system and kinetic/dynamic characteristics in drug development...This text is an essential primer for those who would envision the incorporation of heterogeneous approaches to systems where homogeneous approaches are not sufficient to describe the system." (Robert R. Bies, Journal of Clinical Pharmacology, Vol. 46, 2006)
Author : Johan Gabrielsson
Publisher : CRC Press
ISBN 13 : 9789186274924
Total Pages : 926 pages
Book Rating : 4.2/5 (749 download)
Download or read book Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition written by Johan Gabrielsson and published by CRC Press. This book was released on 2001-11-30 with total page 926 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a revised and very expanded version of the previous second edition of the book. "Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between relevant theory and the actual application of the theory to real life situations. The book is divided into two parts; the first introduces fundamental principles of PK and PD concepts, and principles of mathematical modeling, while the second provides case studies obtained from drug industry and academia. Topics included in the first part include a discussion of the statistical principles of model fitting, including how to assess the adequacy of the fit of a model, as well as strategies for selection of time points to be included in the design of a study. The first part also introduces basic pharmacokinetic and pharmacodynamic concepts, including an excellent discussion of effect compartment (link) models as well as indirect response models. The second part of the text includes over 70 modeling case studies. These include a discussion of the selection of the model, derivation of initial parameter estimates and interpretation of the corresponding output. Finally, the authors discuss a number of pharmacodynamic modeling situations including receptor binding models, synergy, and tolerance models (feedback and precursor models). This book will be of interest to researchers, to graduate students and advanced undergraduate students in the PK/PD area who wish to learn how to analyze biological data and build models and to become familiar with new areas of application. In addition, the text will be of interest to toxicologists interested in learning about determinants of exposure and performing toxicokinetic modeling. The inclusion of the numerous exercises and models makes it an excellent primary or adjutant text for traditional PK courses taught in pharmacy and medical schools. A diskette is included with the text that includes all of the exercises and solutions using WinNonlin.
Author : Claudio Carini
Publisher : CRC Press
ISBN 13 : 0429576730
Total Pages : 631 pages
Book Rating : 4.4/5 (295 download)
Download or read book Handbook of Biomarkers and Precision Medicine written by Claudio Carini and published by CRC Press. This book was released on 2019-04-16 with total page 631 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.
Author : Ales Prokop
Publisher : Springer Science & Business Media
ISBN 13 : 9400728484
Total Pages : 137 pages
Book Rating : 4.4/5 (7 download)
Download or read book Systems Biology in Biotech & Pharma written by Ales Prokop and published by Springer Science & Business Media. This book was released on 2012-01-05 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: The US is currently well ahead of the rest of the world in the development and application of SB and its principles especially as they pertain to basic medical research and development. This lead is largely due to its earlier start in the academic arena. However, there is evidence of rapid development in both the UK/EU and Japan, and the gap is narrowing, particularly in the UK. From an industrial point of view, the Pharmaceutical Industry based in the US and UK can capitalize on these opportunities and gain the benefits of this technology. Many educational institutions (particularly their medical divisions) at present are heavily business-oriented, realize that in this particular industrial environment, that every dollar counts.
Author : Johnny T. Ottesen
Publisher : SIAM
ISBN 13 : 9780898718287
Total Pages : 311 pages
Book Rating : 4.7/5 (182 download)
Download or read book Applied Mathematical Models in Human Physiology written by Johnny T. Ottesen and published by SIAM. This book was released on 2004-01-01 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces mathematicians to real applications from physiology. Using mathematics to analyze physiological systems, the authors focus on models reflecting current research in cardiovascular and pulmonary physiology. In particular, they present models describing blood flow in the heart and the cardiovascular system, as well as the transport of oxygen and carbon dioxide through the respiratory system and a model for baroreceptor regulation.
Author : Panos Macheras
Publisher : Springer Science & Business Media
ISBN 13 : 0387319107
Total Pages : 446 pages
Book Rating : 4.3/5 (873 download)
Download or read book Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics written by Panos Macheras and published by Springer Science & Business Media. This book was released on 2006-04-26 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a novel modeling approach to biopharamceutics, pharmacokinetics and pharmacodynamic phenomena. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. Throughout, many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods.
Author : Loewe, Axel
Publisher : KIT Scientific Publishing
ISBN 13 : 3731505282
Total Pages : 342 pages
Book Rating : 4.7/5 (315 download)
Download or read book Modeling Human Atrial Patho-Electrophysiology from Ion Channels to ECG - Substrates, Pharmacology, Vulnerability, and P-Waves written by Loewe, Axel and published by KIT Scientific Publishing. This book was released on 2016-08-03 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Half of the patients suffering from atrial fibrillation (AF) cannot be treated adequately, today. This book presents multi-scale computational methods to advance our understanding of patho-mechanisms, to improve the diagnosis of patients harboring an arrhythmogenic substrate, and to tailor therapy. The modeling pipeline ranges from ion channels on the subcellular level up to the ECG on the body surface. The tailored therapeutic approaches carry the potential to reduce the burden of AF.
Author : Dimitrios I. Fotiadis
Publisher : John Wiley & Sons
ISBN 13 : 1119517346
Total Pages : 404 pages
Book Rating : 4.1/5 (195 download)
Download or read book Multiscale Modelling in Biomedical Engineering written by Dimitrios I. Fotiadis and published by John Wiley & Sons. This book was released on 2023-06-07 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiscale Modelling in Biomedical Engineering Discover how multiscale modeling can enhance patient treatment and outcomes In Multiscale Modelling in Biomedical Engineering, an accomplished team of biomedical professionals delivers a robust treatment of the foundation and background of a general computational methodology for multi-scale modeling. The authors demonstrate how this methodology can be applied to various fields of biomedicine, with a particular focus on orthopedics and cardiovascular medicine. The book begins with a description of the relationship between multiscale modeling and systems biology before moving on to proceed systematically upwards in hierarchical levels from the molecular to the cellular, tissue, and organ level. It then examines multiscale modeling applications in specific functional areas, like mechanotransduction, musculoskeletal, and cardiovascular systems. Multiscale Modelling in Biomedical Engineering offers readers experiments and exercises to illustrate and implement the concepts contained within. Readers will also benefit from the inclusion of: A thorough introduction to systems biology and multi-scale modeling, including a survey of various multi-scale methods and approaches and analyses of their application in systems biology Comprehensive explorations of biomedical imaging and nanoscale modeling at the molecular, cell, tissue, and organ levels Practical discussions of the mechanotransduction perspective, including recent progress and likely future challenges In-depth examinations of risk prediction in patients using big data analytics and data mining Perfect for undergraduate and graduate students of bioengineering, biomechanics, biomedical engineering, and medicine, Multiscale Modelling in Biomedical Engineering will also earn a place in the libraries of industry professional and researchers seeking a one-stop reference to the basic engineering principles of biological systems.
Author :
Publisher : Academic Press
ISBN 13 : 0123947960
Total Pages : 2972 pages
Book Rating : 4.1/5 (239 download)
Download or read book Encyclopedia of Cell Biology written by and published by Academic Press. This book was released on 2015-08-07 with total page 2972 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Cell Biology, Four Volume Set offers a broad overview of cell biology, offering reputable, foundational content for researchers and students across the biological and medical sciences. This important work includes 285 articles from domain experts covering every aspect of cell biology, with fully annotated figures, abundant illustrations, videos, and references for further reading. Each entry is built with a layered approach to the content, providing basic information for those new to the area and more detailed material for the more experienced researcher. With authored contributions by experts in the field, the Encyclopedia of Cell Biology provides a fully cross-referenced, one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences. Fully annotated color images and videos for full comprehension of concepts, with layered content for readers from different levels of experience Includes information on cytokinesis, cell biology, cell mechanics, cytoskeleton dynamics, stem cells, prokaryotic cell biology, RNA biology, aging, cell growth, cell Injury, and more In-depth linking to Academic Press/Elsevier content and additional links to outside websites and resources for further reading A one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences
