Modelling Methodology For Physiology And Medicine

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Modelling Methodology for Physiology and Medicine

Author : Ewart Carson
Publisher : Newnes
ISBN 13 : 0124095259
Total Pages : 588 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Modelling Methodology for Physiology and Medicine by : Ewart Carson

Download or read book Modelling Methodology for Physiology and Medicine written by Ewart Carson and published by Newnes. This book was released on 2013-12-05 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modelling Methodology for Physiology and Medicine, Second Edition, offers a unique approach and an unprecedented range of coverage of the state-of-the-art, advanced modeling methodology that is widely applicable to physiology and medicine. The second edition, which is completely updated and expanded, opens with a clear and integrated treatment of advanced methodology for developing mathematical models of physiology and medical systems. Readers are then shown how to apply this methodology beneficially to real-world problems in physiology and medicine, such as circulation and respiration. The focus of Modelling Methodology for Physiology and Medicine, Second Edition, is the methodology that underpins good modeling practice. It builds upon the idea of an integrated methodology for the development and testing of mathematical models. It covers many specific areas of methodology in which important advances have taken place over recent years and illustrates the application of good methodological practice in key areas of physiology and medicine. It builds on work that the editors have carried out over the past 30 years, working in cooperation with leading practitioners in the field. Builds upon and enhances the reader's existing knowledge of modeling methodology and practice Editors are internationally renowned leaders in their respective fields Provides an understanding of modeling methodologies that can address real problems in physiology and medicine and achieve results that are beneficial either in advancing research or in providing solutions to clinical problems

Introduction to Modeling in Physiology and Medicine

Author : Claudio Cobelli
Publisher : Elsevier
ISBN 13 : 0080559980
Total Pages : 337 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Introduction to Modeling in Physiology and Medicine by : Claudio Cobelli

Download or read book Introduction to Modeling in Physiology and Medicine written by Claudio Cobelli and published by Elsevier. This book was released on 2008-02-06 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unified modeling textbook for students of biomedical engineering provides a complete course text on the foundations, theory and practice of modeling and simulation in physiology and medicine. It is dedicated to the needs of biomedical engineering and clinical students, supported by applied BME applications and examples. Developed for biomedical engineering and related courses: speaks to BME students at a level and in a language appropriate to their needs, with an interdisciplinary clinical/engineering approach, quantitative basis, and many applied examples to enhance learning Delivers a quantitative approach to modeling and also covers simulation: the perfect foundation text for studies across BME and medicine Extensive case studies and engineering applications from BME, plus end-of-chapter exercises

Introduction to Modeling in Physiology and Medicine

Author : Claudio Cobelli
Publisher : Academic Press
ISBN 13 : 0128158050
Total Pages : 384 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Introduction to Modeling in Physiology and Medicine by : Claudio Cobelli

Download or read book Introduction to Modeling in Physiology and Medicine written by Claudio Cobelli and published by Academic Press. This book was released on 2019-08-01 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Modeling in Physiology and Medicine, Second Edition, develops a clear understanding of the fundamental principles of good modeling methodology. Sections show how to create valid mathematical models that are fit for a range of purposes. These models are supported by detailed explanation, extensive case studies, examples and applications. This updated edition includes clearer guidance on the mathematical prerequisites needed to achieve the maximum benefit from the material, a greater detail regarding basic approaches to modeling, and discussions on non-linear and stochastic modeling. The range of case study material has been substantially extended, with examples drawn from recent research experience. Key examples include a cellular model of insulin secretion and its extension to the whole-body level, a model of insulin action during a meal/oral glucose tolerance test, a large-scale simulation model of type 1 diabetes and its use in in silico clinical trials and drug trials. Covers the underlying principles of good quantitative modeling methodology, with applied biomedical engineering and bioscience examples to ensure relevance to students, current research and clinical practice Includes modeling data, modeling systems, linear and non-linear systems, model identification, parametric and non-parametric models, and model validation Presents clear, step-by-step working plus examples and extensive case studies that relate concepts to real world applications Provides end-of-chapter exercises and assignments to reinforce learning

Nonlinear Dynamic Modeling of Physiological Systems

Author : Professor Vasilis Z. Marmarelis
Publisher : John Wiley & Sons
ISBN 13 : 9780471469605
Total Pages : 564 pages
Book Rating : 4.4/5 (696 download)

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Book Synopsis Nonlinear Dynamic Modeling of Physiological Systems by : Professor Vasilis Z. Marmarelis

Download or read book Nonlinear Dynamic Modeling of Physiological Systems written by Professor Vasilis Z. Marmarelis and published by John Wiley & Sons. This book was released on 2004-09-03 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of nonlinearities in physiology has been hindered by the lack of effective ways to obtain nonlinear dynamic models from stimulus-response data in a practical context. A considerable body of knowledge has accumulated over the last thirty years in this area of research. This book summarizes that progress, and details the most recent methodologies that offer practical solutions to this daunting problem. Implementation and application are discussed, and examples are provided using both synthetic and actual experimental data. This essential study of nonlinearities in physiology apprises researchers and students of the latest findings and techniques in the field.

Personalized Predictive Modeling in Type 1 Diabetes

Author : Eleni I. Georga
Publisher : Academic Press
ISBN 13 : 0128051469
Total Pages : 252 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Personalized Predictive Modeling in Type 1 Diabetes by : Eleni I. Georga

Download or read book Personalized Predictive Modeling in Type 1 Diabetes written by Eleni I. Georga and published by Academic Press. This book was released on 2017-12-11 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Personalized Predictive Modeling in Diabetes features state-of-the-art methodologies and algorithmic approaches which have been applied to predictive modeling of glucose concentration, ranging from simple autoregressive models of the CGM time series to multivariate nonlinear regression techniques of machine learning. Developments in the field have been analyzed with respect to: (i) feature set (univariate or multivariate), (ii) regression technique (linear or non-linear), (iii) learning mechanism (batch or sequential), (iv) development and testing procedure and (v) scaling properties. In addition, simulation models of meal-derived glucose absorption and insulin dynamics and kinetics are covered, as an integral part of glucose predictive models. This book will help engineers and clinicians to: select a regression technique which can capture both linear and non-linear dynamics in glucose metabolism in diabetes, and which exhibits good generalization performance under stationary and non-stationary conditions; ensure the scalability of the optimization algorithm (learning mechanism) with respect to the size of the dataset, provided that multiple days of patient monitoring are needed to obtain a reliable predictive model; select a features set which efficiently represents both spatial and temporal dependencies between the input variables and the glucose concentration; select simulation models of subcutaneous insulin absorption and meal absorption; identify an appropriate validation procedure, and identify realistic performance measures. Describes fundamentals of modeling techniques as applied to glucose control Covers model selection process and model validation Offers computer code on a companion website to show implementation of models and algorithms Features the latest developments in the field of diabetes predictive modeling

Models for Biomedical Research

Author :
Publisher : National Academies
ISBN 13 :
Total Pages : 196 pages
Book Rating : 4.1/5 (38 download)

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Book Synopsis Models for Biomedical Research by :

Download or read book Models for Biomedical Research written by and published by National Academies. This book was released on 1985-01-01 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Basic Science Methods for Clinical Researchers

Author : Morteza Jalali
Publisher : Academic Press
ISBN 13 : 012803078X
Total Pages : 382 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Basic Science Methods for Clinical Researchers by : Morteza Jalali

Download or read book Basic Science Methods for Clinical Researchers written by Morteza Jalali and published by Academic Press. This book was released on 2017-03-31 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Science Methods for Clinical Researchers addresses the specific challenges faced by clinicians without a conventional science background. The aim of the book is to introduce the reader to core experimental methods commonly used to answer questions in basic science research and to outline their relative strengths and limitations in generating conclusive data. This book will be a vital companion for clinicians undertaking laboratory-based science. It will support clinicians in the pursuit of their academic interests and in making an original contribution to their chosen field. In doing so, it will facilitate the development of tomorrow’s clinician scientists and future leaders in discovery science. Serves as a helpful guide for clinical researchers who lack a conventional science background Organized around research themes pertaining to key biological molecules, from genes, to proteins, cells, and model organisms Features protocols, techniques for troubleshooting common problems, and an explanation of the advantages and limitations of a technique in generating conclusive data Appendices provide resources for practical research methodology, including legal frameworks for using stem cells and animals in the laboratory, ethical considerations, and good laboratory practice (GLP)

Signals and Systems in Biomedical Engineering

Author : Suresh R. Devasahayam
Publisher : Springer Science & Business Media
ISBN 13 : 1461542995
Total Pages : 348 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Signals and Systems in Biomedical Engineering by : Suresh R. Devasahayam

Download or read book Signals and Systems in Biomedical Engineering written by Suresh R. Devasahayam and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past few years Biomedical Engineering has received a great deal of attention as one of the emerging technologies in the last decade and for years to come, as witnessed by the many books, conferences, and their proceedings. Media attention, due to the applications-oriented advances in Biomedical Engineering, has also increased. Much of the excitement comes from the fact that technology is rapidly changing and new technological adventures become available and feasible every day. For many years the physical sciences contributed to medicine in the form of expertise in radiology and slow but steady contributions to other more diverse fields, such as computers in surgery and diagnosis, neurology, cardiology, vision and visual prosthesis, audition and hearing aids, artificial limbs, biomechanics, and biomaterials. The list goes on. It is therefore hard for a person unfamiliar with a subject to separate the substance from the hype. Many of the applications of Biomedical Engineering are rather complex and difficult to understand even by the not so novice in the field. Much of the hardware and software tools available are either too simplistic to be useful or too complicated to be understood and applied. In addition, the lack of a common language between engineers and computer scientists and their counterparts in the medical profession, sometimes becomes a barrier to progress.

Physiologically Based Pharmacokinetic (PBPK) Modeling

Author : Jeffrey W. Fisher
Publisher : Academic Press
ISBN 13 : 0128196823
Total Pages : 348 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Physiologically Based Pharmacokinetic (PBPK) Modeling by : Jeffrey W. Fisher

Download or read book Physiologically Based Pharmacokinetic (PBPK) Modeling written by Jeffrey W. Fisher and published by Academic Press. This book was released on 2020-05-20 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment presents foundational principles, advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use of in vitro information, and in silico methods. With end-of-chapter exercises that allow readers to practice and learn the skills associated with PBPK modeling, dose-response, and its applications to safety and risk assessments, this book is a foundational resource that provides practical coverage of PBPK modeling for graduate students, academics, researchers, and more. Provides end-of-chapter exercises to teach hands-on computational tools used in toxicology Supplies computer code and explanations and includes examples of applied models used in regulatory toxicology and research Authored by expert editors and contributors who are among the best PBPK modelers in the world

Quantitative Physiology

Author : Shangbin Chen
Publisher : Springer Nature
ISBN 13 : 9813340339
Total Pages : 246 pages
Book Rating : 4.8/5 (133 download)

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Book Synopsis Quantitative Physiology by : Shangbin Chen

Download or read book Quantitative Physiology written by Shangbin Chen and published by Springer Nature. This book was released on 2021-02-09 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stephen Hawking says that the 21st century will be the century of complexity and indeed now systems biology or medicine means dealing with complexity. Both the genome and physiome have emerged in studying complex physiological systems. Computational and mathematical modeling has been regarded as an efficient tool to boost the understanding about living systems in normal or pathophysiological states. Covering applied methodology, basic case studies and complex applications, this volume provides researchers with an overview of modeling and computational studies of physiology (i.e. quantitative physiology), which is becoming an increasingly important branch of systems biology. This book aims to build multi-scale models to investigate functions in living systems and explain how biomolecules, cells, organs, organ systems and organisms carry out the chemical or physical functions. Some of the models addressed are related to gene expression, calcium signalling, neural activity, blood dynamics and bone mechanics. Combining theory and practice, with extensive use of MATLAB, this book is designed to establish a paradigm for quantitative physiology by integrating biology, mathematics, physics and informatics etc. To benefit from this book, the readers are expected to have a background in general physiology and mathematics

Prognosis Research in Healthcare

Author : Richard D. Riley
Publisher : Oxford University Press
ISBN 13 : 0192516655
Total Pages : 384 pages
Book Rating : 4.1/5 (925 download)

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Book Synopsis Prognosis Research in Healthcare by : Richard D. Riley

Download or read book Prognosis Research in Healthcare written by Richard D. Riley and published by Oxford University Press. This book was released on 2019-01-17 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: "What is going to happen to me?" Most patients ask this question during a clinical encounter with a health professional. As well as learning what problem they have (diagnosis) and what needs to be done about it (treatment), patients want to know about their future health and wellbeing (prognosis). Prognosis research can provide answers to this question and satisfy the need for individuals to understand the possible outcomes of their condition, with and without treatment. Central to modern medical practise, the topic of prognosis is the basis of decision making in healthcare and policy development. It translates basic and clinical science into practical care for patients and populations. Prognosis Research in Healthcare: Concepts, Methods and Impact provides a comprehensive overview of the field of prognosis and prognosis research and gives a global perspective on how prognosis research and prognostic information can improve the outcomes of healthcare. It details how to design, carry out, analyse and report prognosis studies, and how prognostic information can be the basis for tailored, personalised healthcare. In particular, the book discusses how information about the characteristics of people, their health, and environment can be used to predict an individual's future health. Prognosis Research in Healthcare: Concepts, Methods and Impact, addresses all types of prognosis research and provides a practical step-by-step guide to undertaking and interpreting prognosis research studies, ideal for medical students, health researchers, healthcare professionals and methodologists, as well as for guideline and policy makers in healthcare wishing to learn more about the field of prognosis.

Mathematical Physiology

Author : James Keener
Publisher : Springer Science & Business Media
ISBN 13 : 038775847X
Total Pages : 547 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Mathematical Physiology by : James Keener

Download or read book Mathematical Physiology written by James Keener and published by Springer Science & Business Media. This book was released on 2010-06-04 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Divided into two volumes, the book begins with a pedagogical presentation of some of the basic theory, with chapters on biochemical reactions, diffusion, excitability, wave propagation and cellular homeostasis. The second, more extensive part discusses particular physiological systems, with chapters on calcium dynamics, bursting oscillations and secretion, cardiac cells, muscles, intercellular communication, the circulatory system, the immune system, wound healing, the respiratory system, the visual system, hormone physiology, renal physiology, digestion, the visual system and hearing. New chapters on Calcium Dynamics, Neuroendocrine Cells and Regulation of Cell Function have been included. Reviews from first edition: Keener and Sneyd's Mathematical Physiology is the first comprehensive text of its kind that deals exclusively with the interplay between mathematics and physiology. Writing a book like this is an audacious act! -Society of Mathematical Biology Keener and Sneyd's is unique in that it attempts to present one of the most important subfields of biology and medicine, physiology, in terms of mathematical "language", rather than organizing materials around mathematical methodology. -SIAM review

The Medical Model in Mental Health

Author : Ahmed Samei Huda
Publisher : Oxford University Press
ISBN 13 : 0192534092
Total Pages : 384 pages
Book Rating : 4.1/5 (925 download)

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Book Synopsis The Medical Model in Mental Health by : Ahmed Samei Huda

Download or read book The Medical Model in Mental Health written by Ahmed Samei Huda and published by Oxford University Press. This book was released on 2019-05-16 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many published books that comment on the medical model have been written by doctors, who assume that readers have the same knowledge of medicine, or by those who have attempted to discredit and attack the medical practice. Both types of book have tended to present diagnostic categories in medicine as universally scientifically valid examples of clear-cut diseases easily distinguished from each other and from health; with a fixed prognosis; and with a well-understood aetiology leading to disease-reversing treatments. These are contrasted with psychiatric diagnoses and treatments, which are described as unclear and inadequate in comparison. The Medical Model in Mental Health: An Explanation and Evaluation explores the overlap between the usefulness of diagnostic constructs (which enable prognosis and treatment decisions) and the therapeutic effectiveness of psychiatry compared with general medicine. The book explains the medical model and how it applies in mental health, assuming little knowledge or experience of medicine, and defends psychiatry as a medical practice.

The Biopsychosocial Model of Health and Disease

Author : Derek Bolton
Publisher : Springer
ISBN 13 : 3030118991
Total Pages : 149 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis The Biopsychosocial Model of Health and Disease by : Derek Bolton

Download or read book The Biopsychosocial Model of Health and Disease written by Derek Bolton and published by Springer. This book was released on 2019-03-28 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book is a systematic update of the philosophical and scientific foundations of the biopsychosocial model of health, disease and healthcare. First proposed by George Engel 40 years ago, the Biopsychosocial Model is much cited in healthcare settings worldwide, but has been increasingly criticised for being vague, lacking in content, and in need of reworking in the light of recent developments. The book confronts the rapid changes to psychological science, neuroscience, healthcare, and philosophy that have occurred since the model was first proposed and addresses key issues such as the model’s scientific basis, clinical utility, and philosophical coherence. The authors conceptualise biology and the psychosocial as in the same ontological space, interlinked by systems of communication-based regulatory control which constitute a new kind of causation. These are distinguished from physical and chemical laws, most clearly because they can break down, thus providing the basis for difference between health and disease. This work offers an urgent update to the model’s scientific and philosophical foundations, providing a new and coherent account of causal interactions between the biological, the psychological and social.

Biomechanical Models for Soft Tissue Simulation

Author : Walter Maurel
Publisher : Springer Science & Business Media
ISBN 13 : 3662035898
Total Pages : 174 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Biomechanical Models for Soft Tissue Simulation by : Walter Maurel

Download or read book Biomechanical Models for Soft Tissue Simulation written by Walter Maurel and published by Springer Science & Business Media. This book was released on 2013-11-22 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of biomechanical modeling of human soft tissue using nonlinear theoretical mechanics and incremental finite element methods, useful for computer simulation of the human musculoskeletal system.

A Comprehensive Physically Based Approach to Modeling in Bioengineering and Life Sciences

Author : Riccardo Sacco
Publisher : Academic Press
ISBN 13 : 0128125195
Total Pages : 854 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis A Comprehensive Physically Based Approach to Modeling in Bioengineering and Life Sciences by : Riccardo Sacco

Download or read book A Comprehensive Physically Based Approach to Modeling in Bioengineering and Life Sciences written by Riccardo Sacco and published by Academic Press. This book was released on 2019-07-18 with total page 854 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Comprehensive Physically Based Approach to Modeling in Bioengineering and Life Sciences provides a systematic methodology to the formulation of problems in biomedical engineering and the life sciences through the adoption of mathematical models based on physical principles, such as the conservation of mass, electric charge, momentum, and energy. It then teaches how to translate the mathematical formulation into a numerical algorithm that is implementable on a computer. The book employs computational models as synthesized tools for the investigation, quantification, verification, and comparison of different conjectures or scenarios of the behavior of a given compartment of the human body under physiological and pathological conditions. Presents theoretical (modeling), biological (experimental), and computational (simulation) perspectives Features examples, exercises, and MATLAB codes for further reader involvement Covers basic and advanced functional and computational techniques throughout the book

Biomedical Models and Resources

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309060354
Total Pages : 85 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Biomedical Models and Resources by : National Research Council

Download or read book Biomedical Models and Resources written by National Research Council and published by National Academies Press. This book was released on 1998-02-16 with total page 85 pages. Available in PDF, EPUB and Kindle. Book excerpt: Printbegrænsninger: Der kan printes 10 sider ad gangen og max. 40 sider pr. session.