Moments Of Truth In Genetic Medicine

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Moments of Truth in Genetic Medicine

Author : M. Susan Lindee
Publisher : JHU Press
ISBN 13 : 080189915X
Total Pages : 283 pages
Book Rating : 4.8/5 (18 download)

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Book Synopsis Moments of Truth in Genetic Medicine by : M. Susan Lindee

Download or read book Moments of Truth in Genetic Medicine written by M. Susan Lindee and published by JHU Press. This book was released on 2008-11-24 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic research increasingly dominates medical thought and practice in the United States and in many other industrialized nations. Susan Lindee's original study explores the institutions, disciplines, and ideas that initiated the reconfiguration of genetic medicine from a marginal field in the mid-1950s to a core research frontier of biomedicine. Tracing the work of geneticists and other experts in identifying and classifying disease during the explosive period between 1950 and 1980, Lindee identifies the individual "moments of truth" that moved the field away from its eugenic past to the center of a new world view in which nearly all disease is understood to be fundamentally genetic. She suggests that these moments of truth were experienced not only by scientists but also by those who had familial, intimate, emotional knowledge of hereditary disease: patients, family members, and research subjects. Focusing on benchmarks in the field—such as the rise of neonatal testing in the 1960s, genetic studies of unique human populations such as the Amish, the development of human cytogenetics and human behavioral genetics, and the efforts to find genes for rare diseases such as familial dysautonomia—she tracks the emergence of a biomedical consensus that nearly all disease is genetic disease. Using the success of this field as a point of entry, Lindee chronicles both the production of knowledge in biomedicine and changes in the cultural meaning of the body in the late twentieth century. She suggests that scientific knowledge is a community project that is shaped directly by people in many different social and professional locations. The power to experience and report scientific truth may be much more dispersed than it sometimes appears, because people know things about their own bodies, and their knowledge has often been incorporated into the technical infrastructure of genomic medicine. Lindee's pathbreaking study shows the interdependence of technical and social parameters in contemporary biomedicine.

Moments of Truth in Genetic Medicine

Author : M. Susan Lindee
Publisher : JHU Press
ISBN 13 : 0801891019
Total Pages : 283 pages
Book Rating : 4.8/5 (18 download)

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Book Synopsis Moments of Truth in Genetic Medicine by : M. Susan Lindee

Download or read book Moments of Truth in Genetic Medicine written by M. Susan Lindee and published by JHU Press. This book was released on 2008-10-15 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical genetics.

A Short History of Medical Genetics

Author : Peter S. Harper
Publisher : Oxford University Press
ISBN 13 : 0190208392
Total Pages : 576 pages
Book Rating : 4.1/5 (92 download)

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Book Synopsis A Short History of Medical Genetics by : Peter S. Harper

Download or read book A Short History of Medical Genetics written by Peter S. Harper and published by Oxford University Press. This book was released on 2008-10-24 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: An eminent geneticist, veteran author, OMMG Series Editor, and noted archivist, Peter Harper presents a lively account of how our ideas and knowledge about human genetics have developed over the past century from the perspective of someone inside the field with a deep interest in its historical aspects. Dr. Harper has researched the history of genetics and has had personal contact with a host of key figures whose memories and experiences extend back 50 years, and he has interviewed and recorded conversations with many of these important geneticists. Thus, rather than being a conventional history, this book transmits the essence of the ideas and the people involved and how they interacted in advancing- and sometimes retarding- the field. From the origins of human genetics; through the contributions of Darwin, Mendel, and other giants; the identification of the first human chromosome abnormalities; and up through the completion of the Human Genome project, this Short History is written in the author's characteristic clear and personal style, which appeals to geneticists and to all those interested in the story of human genetics.

Health Care in America

Author : John C. Burnham
Publisher : JHU Press
ISBN 13 : 1421416093
Total Pages : 429 pages
Book Rating : 4.4/5 (214 download)

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Book Synopsis Health Care in America by : John C. Burnham

Download or read book Health Care in America written by John C. Burnham and published by JHU Press. This book was released on 2015-05-15 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive history of sickness, health, and medicine in America from Colonial times to the present. In Health Care in America, historian John C. Burnham describes changes over four centuries of medicine and public health in America. Beginning with seventeenth-century concerns over personal and neighborhood illnesses, Burnham concludes with the arrival of a new epoch in American medicine and health care at the turn of the twenty-first century. From the 1600s through the 1990s, Americans turned to a variety of healers, practices, and institutions in their efforts to prevent and survive epidemics of smallpox, yellow fever, cholera, influenza, polio, and AIDS. Health care workers in all periods attended births and deaths and cared for people who had injuries, disabilities, and chronic diseases. Drawing on primary sources, classic scholarship, and a vast body of recent literature in the history of medicine and public health, Burnham finds that traditional healing, care, and medicine dominated the United States until the late nineteenth century, when antiseptic/aseptic surgery and germ theory initiated an intellectual, social, and technical transformation. He divides the age of modern medicine into several eras: physiological medicine (1910s–1930s), antibiotics (1930s–1950s), technology (1950s–1960s), environmental medicine (1970s–1980s), and, beginning around 1990, genetic medicine. The cumulating developments in each era led to today's radically altered doctor-patient relationship and the insistent questions that swirl around the financial cost of health care. Burnham's sweeping narrative makes sense of medical practice, medical research, and human frailties and foibles, opening the door to a new understanding of our current concerns.

Military Medicine to Win Hearts and Minds

Author : Robert J. Wilensky
Publisher : Texas Tech University Press
ISBN 13 : 9780896725324
Total Pages : 256 pages
Book Rating : 4.7/5 (253 download)

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Book Synopsis Military Medicine to Win Hearts and Minds by : Robert J. Wilensky

Download or read book Military Medicine to Win Hearts and Minds written by Robert J. Wilensky and published by Texas Tech University Press. This book was released on 2004 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Most important, there is no evidence that the good will built by U.S. doctors transferred to the South Vietnamese forces, and in fact the opposite may have been true: American programs may have emphasized the inability of the South Vietnamese government to provide basic health care to its own people. Furthermore, the programs may have demonstrated to Vietnamese civilians that foreign soldiers cared more for them than their own troops did. If that is the case, the programs actually did more harm than good in the attempt to win hearts and minds."--BOOK JACKET.

History and Philosophy of the Life Sciences

Author :
Publisher :
ISBN 13 :
Total Pages : 668 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis History and Philosophy of the Life Sciences by :

Download or read book History and Philosophy of the Life Sciences written by and published by . This book was released on 2006 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Rational Fog

Author : M. Susan Lindee
Publisher : Harvard University Press
ISBN 13 : 0674919181
Total Pages : 297 pages
Book Rating : 4.6/5 (749 download)

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Book Synopsis Rational Fog by : M. Susan Lindee

Download or read book Rational Fog written by M. Susan Lindee and published by Harvard University Press. This book was released on 2020-09-15 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: A thought-provoking examination of the intersections of knowledge and violence, and the quandaries and costs of modern, technoscientific warfare. Science and violence converge in modern warfare. While the finest minds of the twentieth century have improved human life, they have also produced human injury. They engineered radar, developed electronic computers, and helped mass produce penicillin all in the context of military mobilization. Scientists also developed chemical weapons, atomic bombs, and psychological warfare strategies. Rational Fog explores the quandary of scientific and technological productivity in an era of perpetual war. Science is, at its foundation, an international endeavor oriented toward advancing human welfare. At the same time, it has been nationalistic and militaristic in times of crisis and conflict. As our weapons have become more powerful, scientists have struggled to reconcile these tensions, engaging in heated debates over the problems inherent in exploiting science for military purposes. M. Susan Lindee examines this interplay between science and state violence and takes stock of researchers’ efforts to respond. Many scientists who wanted to distance their work from killing have found it difficult and have succumbed to the exigencies of war. Indeed, Lindee notes that scientists who otherwise oppose violence have sometimes been swept up in the spirit of militarism when war breaks out. From the first uses of the gun to the mass production of DDT and the twenty-first-century battlefield of the mind, the science of war has achieved remarkable things at great human cost. Rational Fog reminds us that, for scientists and for us all, moral costs sometimes mount alongside technological and scientific advances.

The PKU Paradox

Author : Diane B. Paul
Publisher : JHU Press
ISBN 13 : 1421411318
Total Pages : 316 pages
Book Rating : 4.4/5 (214 download)

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Book Synopsis The PKU Paradox by : Diane B. Paul

Download or read book The PKU Paradox written by Diane B. Paul and published by JHU Press. This book was released on 2013-12 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: How did a disease of marginal public health significance acquire paradigmatic status in public health and genetics? In a lifetime of practice, most physicians will never encounter a single case of PKU. Yet every physician in the industrialized world learns about the disease in medical school and, since the early 1960s, the newborn heel stick test for PKU has been mandatory in many countries. Diane B. Paul and Jeffrey P. Brosco’s beautifully written book explains this paradox. PKU (phenylketonuria) is a genetic disorder that causes severe cognitive impairment if it is not detected and treated with a strict and difficult diet. Programs to detect PKU and start treatment early are deservedly considered a public health success story. Some have traded on this success to urge expanded newborn screening, defend basic research in genetics, and confront proponents of genetic determinism. In this context, treatment for PKU is typically represented as a simple matter of adhering to a low-phenylalanine diet. In reality, the challenges of living with PKU are daunting. In this first general history of PKU, a historian and a pediatrician explore how a rare genetic disease became the object of an unprecedented system for routine testing. The PKU Paradox is informed by interviews with scientists, clinicians, policymakers, and individuals who live with the disease. The questions it raises touch on ongoing controversies about newborn screening and what happens to blood samples collected at birth.

Our Present Complaint

Author : Charles E. Rosenberg
Publisher : JHU Press
ISBN 13 : 9780801887154
Total Pages : 236 pages
Book Rating : 4.8/5 (871 download)

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Book Synopsis Our Present Complaint by : Charles E. Rosenberg

Download or read book Our Present Complaint written by Charles E. Rosenberg and published by JHU Press. This book was released on 2007-12-26 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: At a time when clinical care and biomedical research generate as much angst as they offer cures, this volume provides valuable insight into how the practice of medicine has evolved, where it is going, and how lessons from history can improve its prognosis.--Thomas S. Huddle, M.D., Ph.D. "Journal of the History of Medicine"

Life Histories of Genetic Disease

Author : Andrew J. Hogan
Publisher : Johns Hopkins University Press+ORM
ISBN 13 : 1421420759
Total Pages : 264 pages
Book Rating : 4.4/5 (214 download)

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Book Synopsis Life Histories of Genetic Disease by : Andrew J. Hogan

Download or read book Life Histories of Genetic Disease written by Andrew J. Hogan and published by Johns Hopkins University Press+ORM. This book was released on 2016-10-30 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: A richly detailed history that “uncovers the challenges and limitations of our increasing reliance on genetic data in medical decision making” (Shobita Parthasarathy, author of Building Genetic Medicine). Medical geneticists began mapping the chromosomal infrastructure piece by piece in the 1970s by focusing on what was known about individual genetic disorders. Five decades later, their infrastructure had become an edifice for prevention, allowing expectant parents to test prenatally for hundreds of disease-specific mutations using powerful genetic testing platforms. In this book, Andrew J. Hogan explores how various diseases were “made genetic” after 1960, with the long-term aim of treating and curing them using gene therapy. In the process, he explains, these disorders were located in the human genome and became targets for prenatal prevention, while the ongoing promise of gene therapy remained on the distant horizon. In narrating the history of research that contributed to diagnostic genetic medicine, Hogan describes the expanding scope of prenatal diagnosis and prevention. He draws on case studies of Prader-Willi, fragile X, DiGeorge, and velo-cardio-facial syndromes to illustrate that almost all testing in medical genetics is inseparable from the larger—and increasingly “big data”–oriented—aims of biomedical research. Hogan also reveals how contemporary genetic testing infrastructure reflects an intense collaboration among cytogeneticists, molecular biologists, and doctors specializing in human malformation. Hogan critiques the modern ideology of genetic prevention, which suggests all pregnancies are at risk for genetic disease and should be subject to extensive genomic screening. He examines the dilemmas and ethics of the use of prenatal diagnostic information in an era when medical geneticists and biotechnology companies offer whole genome prenatal screening—essentially searching for any disease-causing mutation. Hogan’s analysis is animated by ongoing scientific and scholarly debates about the extent to which the preventive focus in contemporary medical genetics resembles the aims of earlier eugenicists. Written for historians, sociologists, and anthropologists of science and medicine, as well as bioethics scholars, physicians, geneticists, and families affected by genetic conditions, Life Histories of Genetic Disease is a profound exploration of the scientific culture surrounding malformation and mutation.

The Immortal Life of Henrietta Lacks

Author : Rebecca Skloot
Publisher : Crown
ISBN 13 : 0307589382
Total Pages : 386 pages
Book Rating : 4.3/5 (75 download)

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Book Synopsis The Immortal Life of Henrietta Lacks by : Rebecca Skloot

Download or read book The Immortal Life of Henrietta Lacks written by Rebecca Skloot and published by Crown. This book was released on 2010-02-02 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: #1 NEW YORK TIMES BESTSELLER • “The story of modern medicine and bioethics—and, indeed, race relations—is refracted beautifully, and movingly.”—Entertainment Weekly NOW A MAJOR MOTION PICTURE FROM HBO® STARRING OPRAH WINFREY AND ROSE BYRNE • ONE OF THE “MOST INFLUENTIAL” (CNN), “DEFINING” (LITHUB), AND “BEST” (THE PHILADELPHIA INQUIRER) BOOKS OF THE DECADE • ONE OF ESSENCE’S 50 MOST IMPACTFUL BLACK BOOKS OF THE PAST 50 YEARS • WINNER OF THE CHICAGO TRIBUNE HEARTLAND PRIZE FOR NONFICTION NAMED ONE OF THE BEST BOOKS OF THE YEAR BY The New York Times Book Review • Entertainment Weekly • O: The Oprah Magazine • NPR • Financial Times • New York • Independent (U.K.) • Times (U.K.) • Publishers Weekly • Library Journal • Kirkus Reviews • Booklist • Globe and Mail Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor Southern tobacco farmer who worked the same land as her slave ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine: The first “immortal” human cells grown in culture, which are still alive today, though she has been dead for more than sixty years. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions. Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave. Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family—past and present—is inextricably connected to the dark history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of. Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah. Deborah was consumed with questions: Had scientists cloned her mother? Had they killed her to harvest her cells? And if her mother was so important to medicine, why couldn’t her children afford health insurance? Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

Disease-Proof

Author : David L. Katz, M.D.
Publisher : Penguin
ISBN 13 : 0698137116
Total Pages : 304 pages
Book Rating : 4.6/5 (981 download)

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Book Synopsis Disease-Proof by : David L. Katz, M.D.

Download or read book Disease-Proof written by David L. Katz, M.D. and published by Penguin. This book was released on 2013-09-26 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: “If you want to build better health and a better future, this book makes an excellent tool kit.”—David A. Kessler, MD, author of The End of Overeating and former commissioner of the FDA It sometimes seems as if everyone around us is being diagnosed with a chronic illness—and that we might soon join them. In Disease-Proof, leading specialist in preventive medicine Dr. David Katz draws upon the latest scientific evidence and decades of clinical experience to explain how we can slash our risk of every major chronic disease—heart disease, cancer, stroke, diabetes, dementia, and obesity—by an astounding 80%. Dr. Katz arms us with skillpower: a proven, user-friendly set of tools that helps us make simple behavioral changes that have a tremendous effect on our health and well-being. Inspiring, groundbreaking, and prescriptive, Disease-Proof proves making lasting lifestyle changes is easier than we think.

Telling Genes

Author : Alexandra Minna Stern
Publisher : JHU Press
ISBN 13 : 1421406675
Total Pages : 249 pages
Book Rating : 4.4/5 (214 download)

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Book Synopsis Telling Genes by : Alexandra Minna Stern

Download or read book Telling Genes written by Alexandra Minna Stern and published by JHU Press. This book was released on 2012-09-11 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: For sixty years genetic counselors have served as the messengers of important information about the risks, realities, and perceptions of genetic conditions. More than 2,500 certified genetic counselors in the United States work in clinics, community and teaching hospitals, public health departments, private biotech companies, and universities. Telling Genes considers the purpose of genetic counseling for twenty-first century families and society and places the field into its historical context. Genetic counselors educate physicians, scientific researchers, and prospective parents about the role of genetics in inherited disease. They are responsible for reliably translating test results and technical data for a diverse clientele, using scientific acumen and human empathy to help people make informed decisions about genomic medicine. Alexandra Minna Stern traces the development of genetic counseling from the eugenics movement of the early twentieth century to the current era of human genomics. Drawing from archival records, patient files, and oral histories, Stern presents the fascinating story of the growth of genetic counseling practices, principles, and professionals. -- Troy Duster, Chancellor'

Bulletin of the History of Medicine

Author :
Publisher :
ISBN 13 :
Total Pages : 1020 pages
Book Rating : 4.3/5 (555 download)

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Book Synopsis Bulletin of the History of Medicine by :

Download or read book Bulletin of the History of Medicine written by and published by . This book was released on 2007 with total page 1020 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes the Transactions of the 15th- annual meetings of the American Association of the History of Medicine, 1939-

The African American National Biography: Moore, Lenny-Romain

Author : Henry Louis Gates (Jr.)
Publisher :
ISBN 13 :
Total Pages : 706 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The African American National Biography: Moore, Lenny-Romain by : Henry Louis Gates (Jr.)

Download or read book The African American National Biography: Moore, Lenny-Romain written by Henry Louis Gates (Jr.) and published by . This book was released on 2008 with total page 706 pages. Available in PDF, EPUB and Kindle. Book excerpt: An 8-volume reference set containing over 4,000 entries written by distinguished scholars, 'The African American National Biography' is the most significant and expansive compilation of black lives in print today.

Cancer in the Twentieth Century

Author : David Cantor
Publisher :
ISBN 13 :
Total Pages : 372 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Cancer in the Twentieth Century by : David Cantor

Download or read book Cancer in the Twentieth Century written by David Cantor and published by . This book was released on 2008-05-26 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of essays explores efforts to control and prevent cancer in North America and Europe. On both sides of the Atlantic, control programs emerged in the early twentieth century, and most were focused on early detection and treatment. Yet, those initiatives took very different forms in different countries. Experts disagreed on how to persuade the public to go to their doctors, what should be the role of public education, how cancer services should be delivered, who should provide them, which forms of therapy were most appropriate to particular cancers, and where to draw the line between therapy and prevention. Focusing on the United States and Britain, this volume examines why these differences emerged, how they shaped national programs of control, and how control programs in the early twentieth century presaged and set the conditions for the emergence of prevention-oriented programs in the 1960s and 1970s. Featuring works by leading medical historians on subjects such as the portrayal of cancer in the movies, feminist surgeons, risk factors for breast cancer, and the emergence of clinical trials, Cancer in the Twentieth Century will engage historians of medicine and public health as well as health policy analysts, medical sociologists and anthropologists, and medical researchers and practitioners.

Breath from Salt

Author : Bijal P. Trivedi
Publisher : BenBella Books
ISBN 13 : 1948836629
Total Pages : 744 pages
Book Rating : 4.9/5 (488 download)

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Book Synopsis Breath from Salt by : Bijal P. Trivedi

Download or read book Breath from Salt written by Bijal P. Trivedi and published by BenBella Books. This book was released on 2020-09-08 with total page 744 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recommended by Bill Gates and included in GatesNotes "Elaborating on the science as well as the business behind the fight against cystic fibrosis, Trivedi captures the emotions of the families, doctors, and scientists involved in the clinical trials and their 'weeping with joy' as new drugs are approved, and shows how cystic fibrosis, once a 'death sentence,' became, for many, a manageable condition. This is a rewarding and challenging work." —Publishers Weekly Cystic fibrosis was once a mysterious disease that killed infants and children. Now it could be the key to healing millions with genetic diseases of every type—from Alzheimer's and Parkinson's to diabetes and sickle cell anemia. In 1974, Joey O'Donnell was born with strange symptoms. His insatiable appetite, incessant vomiting, and a relentless cough—which shook his tiny, fragile body and made it difficult to draw breath—confounded doctors and caused his parents agonizing, sleepless nights. After six sickly months, his salty skin provided the critical clue: he was one of thousands of Americans with cystic fibrosis, an inherited lung disorder that would most likely kill him before his first birthday. The gene and mutation responsible for CF were found in 1989—discoveries that promised to lead to a cure for kids like Joey. But treatments unexpectedly failed and CF was deemed incurable. It was only after the Cystic Fibrosis Foundation, a grassroots organization founded by parents, formed an unprecedented partnership with a fledgling biotech company that transformative leaps in drug development were harnessed to produce groundbreaking new treatments: pills that could fix the crippled protein at the root of this deadly disease. From science writer Bijal P. Trivedi, Breath from Salt chronicles the riveting saga of cystic fibrosis, from its ancient origins to its identification in the dank autopsy room of a hospital basement, and from the CF gene's celebrated status as one of the first human disease genes ever discovered to the groundbreaking targeted genetic therapies that now promise to cure it. Told from the perspectives of the patients, families, physicians, scientists, and philanthropists fighting on the front lines, Breath from Salt is a remarkable story of unlikely scientific and medical firsts, of setbacks and successes, and of people who refused to give up hope—and a fascinating peek into the future of genetics and medicine.