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Molecular Mechanisms Of Aryl Hydrocarbon Receptor Transactivation And Crosstalk With Estrogen Receptor Alpha
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Book Synopsis Molecular Mechanisms of Aryl Hydrocarbon Receptor Transactivation and Crosstalk with Estrogen Receptor Alpha by : Shaimaa Ahmed
Download or read book Molecular Mechanisms of Aryl Hydrocarbon Receptor Transactivation and Crosstalk with Estrogen Receptor Alpha written by Shaimaa Ahmed and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Activation of Estrogen Receptor Alpha, Aryl Hydrocarbon Receptor, and Nuclear Factor Erythroid-2 Like 2 in Human Breast Cancer Cells by : Raymond Ho Fai Lo
Download or read book Activation of Estrogen Receptor Alpha, Aryl Hydrocarbon Receptor, and Nuclear Factor Erythroid-2 Like 2 in Human Breast Cancer Cells written by Raymond Ho Fai Lo and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Advances in Molecular Toxicology by : Jason Matthews
Download or read book Advances in Molecular Toxicology written by Jason Matthews and published by Elsevier Inc. Chapters. This book was released on 2013-08-12 with total page 43 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aryl hydrocarbon receptor (AHR) and estrogen receptors (ERs) are ligand-activated transcription factors and members of the basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) and nuclear receptor (NR) superfamilies, respectively. The bHLH-PAS and NRs regulate many vital physiological processes including metabolism, circadian rhythm, differentiation, development, and reproduction. However, both receptor families are also associated with numerous human diseases. Reciprocal crosstalk between AHR and ERs is proposed to both positively and negatively impact human health. ERs are the most important targets in the treatment of breast cancer. The AHR, which is activated by many environmental pollutants, natural/dietary compounds, and endogenous substances, is a negative regulator of ER function. The role of ERα in AHR signaling is less clear as it is known to exhibit cell-type and promoter-specific differences. In this chapter, we will highlight the current understanding of AHR and ER crosstalk and toxicity.
Book Synopsis Estrogen and Aryl Hydrocarbon Receptor Signaling by : Elin Swedenborg
Download or read book Estrogen and Aryl Hydrocarbon Receptor Signaling written by Elin Swedenborg and published by . This book was released on 2009 with total page 41 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mechanisms of Aryl Hydrocarbon Receptor and Estrogen Receptor Action in Breast Cancer Cells by : Jeong Eun Lee
Download or read book Mechanisms of Aryl Hydrocarbon Receptor and Estrogen Receptor Action in Breast Cancer Cells written by Jeong Eun Lee and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In MCF7 and T47D cells cotreated with 1 nM 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) plus 0.1-10 uM 3̕,4̕ -dimethoxy flavone (DMF), there was a concentration-dependent decrease in the TCDD-induced ethoxyresorufin O-deethylase (EROD) activity. Gel mobility shift assays showed that 3̕,4̕ -DMF inhibited TCDD-induced aryl hydrocarbon receptor (AhR) transformation in rat liver cytosol and blocked TCDD-induced formation of the nuclear AhR complex in MCF7 and T47D cells. The antiestrogenic activity of TCDD in estrogen-induced transactivation assays in MCF7 cells was reversed by 3̕,4̕ -DMF, confirming the AhR antagonist activity of this compound in breast cancer cells. Cotreatment of T47D and MCF7 cells with TCDD and 10 uM resveratrol inhibited induction of CYP1A1 mRNA and EROD activity. Resveratrol did not inhibit TCDD-induced AhR transformation and reporter gene activity. Actinomycin D chase experiments in T47D cells showed that the mechanism of inhibition of CYP1A1 mRNA and EROD activity is due to an increased rate of CYP1A1 mRNA degradation, suggesting that resveratrol inhibits CYP1A1 via an AhR-independent post-transcriptional pathway. Vitamin D receptor-interacting protein 150 (DRIP150) coactivated estrogen receptor [alpha] (ER [alpha])-mediated transactivation and the response was AF2-dependent in ZR75 breast cancer cells. C-and N-terminal NR-boxes (amino acids 1186-1182 and 73-69, respectively) were not necessary for coactivation of ER [alpha]. Analysis of DRIP150 deletion mutants identified a 23 amino acid sequence (811-789) required for coactivation. The 23 amino acid contained two regions at amino acids 789-794 and 795-804 which resembled [alpha] -helical motifs identified in Lanuguinosa lipase/histamine N-methyl transferase and hepatocyte nuclear factor 1, respectively. A squelching assay using specific point mutations within each [alpha] -helix showed that the NIFSEVRVYN (795-804) region was the critical sequence required for the coactivator activity of DRIP150.
Book Synopsis Aryl Hydrocarbon and Estrogen Receptor Alpha Crosstalk in Human Breast and Endometrial Cancer Cell Lines by : Mark Thomas Wormke
Download or read book Aryl Hydrocarbon and Estrogen Receptor Alpha Crosstalk in Human Breast and Endometrial Cancer Cell Lines written by Mark Thomas Wormke and published by . This book was released on 2002 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Advances in Molecular Toxicology by :
Download or read book Advances in Molecular Toxicology written by and published by Newnes. This book was released on 2013-08-12 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of progress on the molecular level and on advances in technological approaches employed. - Cutting-edge reviews by leading workers in the discipline - In-depth dissection of molecular aspects of interest to a broad range of scientists, physicians and any student in the allied disciplines - Leading edge applications of technological innovations in chemistry, biochemistry and molecular medicine
Download or read book Comprehensive Toxicology written by and published by Elsevier. This book was released on 2017-12-01 with total page 8639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts
Book Synopsis Fish Reproduction by : Maria J Rocha
Download or read book Fish Reproduction written by Maria J Rocha and published by CRC Press. This book was released on 2008-01-01 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the decline in world fish stocks, our knowledge of fish reproduction has become fundamental. Reproduction is an essential commitment to future generation. It is also a continuous development process throughout ontogeny, requiring energetic, ecological, physiological, anatomical, biochemical and endrocrinological adaptations. The first chapters highlight important issues affecting fish normal ways of reproductive development; details would focus on species living in opposite environments, such as tropical and polar fishes; far related, as teleosts and cartilaginous fishes; and finally, fish having different reproductive strategies. Thereafter, since many fishes live in detrimental environments, mainly induced by the continuous input of xenobiotic substances into waterways, the authors found it highly pertinent to include this topic. Herein, the authors fix their attention on the factors and mechanisms that may well affect reproductionrelated hormonal systems as also on known consequences for fish living i
Book Synopsis Encyclopedia of Signaling Molecules by : Sangdun Choi
Download or read book Encyclopedia of Signaling Molecules written by Sangdun Choi and published by Springer. This book was released on 2017-12-15 with total page 6330 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this encyclopedia presents over 400 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities.
Download or read book Xenobiotics in Fish written by D.J. Smith and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aquaculture is rapidly becoming a major source of fish protein used to meet the nutritional needs of humans. As the aquaculture industry grows, exposure of farmed fish to environmental contaminants, and the need for chemical therapeutic agents for fish, will increase. This book is designed to bring together authorities worldwide on the regulation of environmental contaminants and food chemicals and researchers investigating the metabolism and disposition of foreign chemicals (xenobiotics) in fish species.
Book Synopsis Current Trends in Cancer Management by : Liliana Streba
Download or read book Current Trends in Cancer Management written by Liliana Streba and published by BoD – Books on Demand. This book was released on 2019-09-25 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of cancer diagnosis, prognosis, and treatment is constantly advancing. From novel biomarkers to cutting-edge imaging solutions, changing chemotherapy protocols and novel immune-targeting agents, medical teams develop and test new ways to manage this ever-growing threat to the modern age. Imaging has been a reliable method for initial diagnosis and later surveillance of premalignant and cancerous lesions of the digestive tract. This book project aims to characterize the main diagnostic procedures and novel medical and surgical treatments, as well as provide an updated view on current guidelines, premalignant lesions management, and minimally invasive curative techniques.
Book Synopsis Endocrine Disruption and Human Health by : Philippa D. Darbre
Download or read book Endocrine Disruption and Human Health written by Philippa D. Darbre and published by Academic Press. This book was released on 2015-03-21 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students. - Provides readers with access to a range of information from the basic mechanisms and assays to cutting-edge research investigating concerns for human health - Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health - Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations
Book Synopsis Gene Regulation, Epigenetics and Hormone Signaling by : Subhrangsu S. Mandal
Download or read book Gene Regulation, Epigenetics and Hormone Signaling written by Subhrangsu S. Mandal and published by John Wiley & Sons. This book was released on 2017-10-23 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1993 with total page 1498 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Trends in Breast Cancer Prevention by : Jose Russo
Download or read book Trends in Breast Cancer Prevention written by Jose Russo and published by Springer. This book was released on 2016-07-14 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, with contributions from the most recognized experts in preventive strategies in breast cancer, presents the accepted as well as the novel ideas that have been introduced for the prevention of breast cancer. There is no single preventive agent that can stop the incidence of breast cancer—the malignant disease most frequently diagnosed in women of all races and nationalities. Furthermore, its incidence around the globe is increasing in industrialized countries. The worldwide incidence of breast cancer has increased 30-40% since the 1970s, reaching an excess of 1,390,000 new cases and a mortality of more than 460,000 cases in 2015. Therefore, what is needed is the development of rational strategies for the prevention of this fatal disease.
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 1930 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
