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Molecular Machines Supported On Mesoporous Silica Nanoparticles For Drug Delivery Applications
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Book Synopsis Molecular Machines Supported on Mesoporous Silica Nanoparticles for Drug Delivery Applications by : Sarah Ann Angelos
Download or read book Molecular Machines Supported on Mesoporous Silica Nanoparticles for Drug Delivery Applications written by Sarah Ann Angelos and published by . This book was released on 2009 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Design, Synthesis, Multifunctionalization and Biomedical Applications of Multifunctional Mesoporous Silica-Based Drug Delivery Nanosystems by : Yu Chen
Download or read book Design, Synthesis, Multifunctionalization and Biomedical Applications of Multifunctional Mesoporous Silica-Based Drug Delivery Nanosystems written by Yu Chen and published by Springer. This book was released on 2015-10-14 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis reports on essential advances in the design, synthesis and biomedical applications of multifunctional Mesoporous Silica Nanoparticles (MSNs). It provides several examples of multifunctional MSN-based drug delivery nanosystems and demonstrates successful synergistic cancer therapies combining MSNs and high-intensity focused ultrasound. The book will especially be of interest to researchers and graduate students in the fields of biomaterials, biology, chemistry, medicine and the life sciences who are working to develop new methods and technologies to combat cancer.
Book Synopsis Mesoporous Materials for Drug Delivery and Theranostics by : Valentina Cauda
Download or read book Mesoporous Materials for Drug Delivery and Theranostics written by Valentina Cauda and published by MDPI. This book was released on 2020-12-17 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesoporous materials are capturing great interest thanks to their exceptional surface area, uniform and tunable pore size, ease surface functionalization, thus enabling broad series of intervention in the field of nanomedicine. Since many years, these aspects foster a deep investigation on mesoporous nanoparticles, to design and fabricate biocompatible, smart and stimuli-responsive nanotools for controlled drug- or gene-delivery, theranostics applications, in particular for cancer therapy, and tissue engineering. This Book is thus dedicated to the most recent advances in the field, collecting research papers and reviews. It spans from the synthesis and characterization of the mesoporous material, especially those made of silica, silicon and bioactive glasses, to their functionalization with smart gate-keepers, reporter molecules or targeting ligands, up to their in-vitro applications in the nanomedicine field.
Book Synopsis Multiple Methods of Activation of Molecular Machines on Mesoporous Silica Nanoparticles by : Travis Anthony Pecorelli
Download or read book Multiple Methods of Activation of Molecular Machines on Mesoporous Silica Nanoparticles written by Travis Anthony Pecorelli and published by . This book was released on 2011 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mesoporous Silica Nanoparticles by : Sachin Namdeo Kothawade
Download or read book Mesoporous Silica Nanoparticles written by Sachin Namdeo Kothawade and published by . This book was released on 2024-11-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesoporous silica comprehensively covers the importance and applications of mesoporous silica nanoparticles in the field of nanoscience and nanotechnology. The book delves into the synthesis and characterization of mesoporous silica nanoparticles, discussing various synthesis methods and characterization techniques employed in their production. It explores the properties and structure of mesoporous silica nanoparticles, including their porosity, surface area, structural features, and tunability. It discusses mechanical, thermal, and optical properties. The applications of mesoporous silica nanoparticles in drug delivery are covered in detail, focusing on controlled release systems, targeted drug delivery, and theranostic applications.The catalytic applications of mesoporous silica nanoparticles are examined, including the use of these nanoparticles as supported catalysts in catalytic reactions, with discussions on reaction mechanisms. The book also explores the sensing and biosensing applications of mesoporous silica nanoparticles, including optical and electrochemical sensing, bioanalytical applications, and detection of biomolecules and environmental pollutants. Surface functionalization techniques for mesoporous silica nanoparticles are discussed, highlighting the importance of tailoring their properties for specific applications. Biocompatibility and toxicity considerations are addressed, providing insights into the assessment of biocompatibility, toxicity evaluation, mitigation strategies, and regulatory considerations. The future directions and emerging trends in mesoporous silica nanoparticle research are explored, along with interdisciplinary approaches, challenges, and opportunities in the field. The book concludes by summarizing the key findings and discussing the overall significance of mesoporous silica nanoparticles in nanoscience and nanotechnology. The references section provides a comprehensive list of sources used throughout the book for further exploration. The book serves as an essential resource for researchers, professionals, and students interested in understanding the synthesis, characterization, properties, and diverse applications of mesoporous silica nanoparticles in the realm of nanoscience and nanotechnology.
Book Synopsis Multifunctional Mesoporous Silica Nanoparticles for Drug and Large Molecule Delivery by : Ruining Wang
Download or read book Multifunctional Mesoporous Silica Nanoparticles for Drug and Large Molecule Delivery written by Ruining Wang and published by . This book was released on 2020 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis involves synthesis, derivatization and biomedical applications of mesoporous silica nanoparticles (MSNs) based delivery systems. Chapter 1 introduces the background of MSNs including the advantages of MSNs, modification on MSNs for multifunctionality; formation mechanism, a typical synthesis condition for MCM-41 and following characterizaitons. In chapter 2 & 3, the synthesis and application of target moiety functionalized MSNs for gene therapy in vitro and in vivo are introduced. Chapters 4, & 5 introduce the relevant studies of utilizing MSN based delivery system for the treatment of infectious disease, from a pharmacokinetic study of moxifloxacin delivered by MSNs via different routes, to the enhanced efficacy of MSN based treatment by materials optimizations via inhalation administration route. Chapter 6 discusses the study of a general synthesis method for pore enlargement in various types of MSNs. In Chapter 7, the design and preparation of a thin film consist of ultra large pore-sized mesoporous silica spheres and polymer template macropores is illustrated. Overall, these chapters demonstrate the successful engineering of mesoporous silica nanoparticles and materials optimization and their enhanced performance in biological applications from in vivo tumor shrinkage by gene delivery to antibiotics delivery for enhanced bacterial killing efficacy in mouse model.
Book Synopsis Stimuli-responsive Drug Delivery Systems by : Amit Singh
Download or read book Stimuli-responsive Drug Delivery Systems written by Amit Singh and published by Royal Society of Chemistry. This book was released on 2018-07-09 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: The increased understanding of molecular aspects associated with chronic diseases, such as cancer and the role of tumor microenvironment, has led to the identification of endogenous and exogenous stimuli that can be exploited to devise “stimuli-responsive” materials for site-specific drug delivery applications. This book provides a comprehensive account on the design, materials chemistry, and application aspects behind these novel stimuli-responsive materials. Setting the scene, the editors open with a chapter addressing the need for smart materials in delivery applications for therapy, imaging and disease diagnosis. The following chapter describes the key physical and chemical aspects of smart materials, from lipids to polymers to hybrid materials, providing the reader with a springboard to delve into the more application oriented chapters that follow. With in-depth coverage of key drug delivery systems such as pH-responsive, temperature responsive, enzyme-responsive and light responsive systems, this book provides a rigorous foundation to the field. A perfect resource for graduate students and newcomers, the closing chapter on regulatory and commercialization challenges also makes the book ideal for those wanting to take the next step towards clinical translation.
Book Synopsis Design and Synthesis of Multifunctional Mesoporous Silica Nanoparticles for Drug Delivery and Bioimaging Applications by : Wei Chen
Download or read book Design and Synthesis of Multifunctional Mesoporous Silica Nanoparticles for Drug Delivery and Bioimaging Applications written by Wei Chen and published by . This book was released on 2019 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multifunctional mesoporous silica nanoparticles (MSNs) have aroused much attention during the past decades for drug delivery and bioimaging applications because of their intrinsic properties including extremely high surface area, large pore volume, tunable pore diameter, easy surface modification, and high biocompatibility. Even though MSNs have these preeminent properties, rendering this unique nanostructure a promising nanocarrier for biomedical applications, several hurdles still challenge the fields of drug delivery and bioimaging when using MSNs as the nanocarries: (i) high loading and high release amounts of water-insoluble drugs delivered to the site of diseases; (ii) precise control of the dosage of drugs delivered to the site of diseases using non-invasive external stimuli; and (iii) construction of MSNs-based shortwave infrared optical imaging contrast agents as an innovative tool for bioimaging and cancer diagnostics. Therefore, this dissertation primarily focuses on the development of innovative strategies that solve these unmet needs and that advance the research in the field of biomedical applications using MSNs as the nanocarriers. In this dissertation, first of all, we review the research work, which mainly focuses on the design and synthesis of multifunctional MSNs and nanomachines for biomedical applications in Accounts of Chemical Research. A wide variety of nanomachines responsive to the different stimuli (pH, redox, enzyme, heat, light, and/or magnetic field) are discussed in this Account. Additionally, we develop a facile strategy for MSNs delivery and release of the water-insoluble drug clofazimine (CFZ), which is used to treat multidrug-resistant tuberculosis. The strategy employs a companion molecule as a chaperone to improve both the loading of CFZ into the pores of MSNs and its subsequent release, thus enabling both high loading and high release of this water-insoluble drug by MSNs. In vitro treatment of macrophages infected with Mycobacterium tuberculosis with the optimized CFZ-loaded MSNs killed the bacteria in the cells in a dose-dependent manner. These studies demonstrate a highly efficient method for loading nanoparticles with water-insoluble drug molecules and the efficacy of the nanoparticles in delivering drugs into eukaryotic cells in aqueous media. Additionally, we used a noninvasive alternating magnetic field (AMF) to stimulate and control the dosage of drug release from MSNs. Noninvasive stimuli-responsive drug delivery using AMF in conjunction with superparamagnetic nanoparticles also offers the potential for the spatial and temporal control of drug release. In vitro studies showed that the death of pancreatic cancer cells treated by drug-loaded nanoparticles was controlled by different lengths of AMF exposure time due to different amounts of drug released from the carriers. Finally, to develop a new shortwave infrared (SWIR) optical imaging contrast agent which has a higher tissue penetration depth, we demonstrate that J-aggregates of near infrared (NIR) fluorophore IR-140 can be prepared inside hollow mesoporous silica nanoparticles (HMSNs) to result in nanomaterials that absorb and emit SWIR light. The use of J-aggregates stabilized in HMSNs as SWIR imaging agents has the potential to overcome the stability, toxicity, and brightness challenges of contrast agents for this compelling region of the electromagnetic spectrum. Collectively, in this dissertation, we explore and develop innovative strategies to load and deliver high amounts of water-insoluble drugs; control the dosage of anticancer drugs released from MSNs triggered by an AMF; and establish a new SWIR optical imaging contrast agent based on the superior carriers - MSNs.
Book Synopsis Mesoporous Silica Nanoparticles and Films for Cargo Delivery by : Tania Maria Guardado Alvarez
Download or read book Mesoporous Silica Nanoparticles and Films for Cargo Delivery written by Tania Maria Guardado Alvarez and published by . This book was released on 2014 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesoporous silica materials are well known materials that can range from films to nanoparticles. Mesoporous silica nanoparticles (MSNs) and mesoporous silica films have been of increasing interest among the scientific community for its use in cargo delivery. Silica provides ease of functionalization, a robust support and biocompatibility. Several methods have been used in order to give the mesoporous silica nanomaterials different qualities that render them a useful material with different characteristics. Among these methods is surface modification by taking advantage of the OH groups on the surface. When a molecule attached to the surface can act as a molecular machine it transforms the nanomaterial to act as delivery system that can be activated upon command. The work covered in this thesis focuses on the development and synthesis of different mesoporous silica materials for the purpose of trapping and releasing cargo molecules. Chapter 2 focuses in the photoactivation of "snap-top" stoppers over the pore openings of mesoporous silica nanoparticles that releases intact cargo molecules from the pores. The on-command release can be stimulated by either one UV photon or two coherent near-IR photons. Two-photon activation is particularly desirable for use in biological systems because it enables good tissue penetration and precise spatial control. Chapter 3 focuses on the design and synthesis of a nano-container consisting of mesoporous silica nanoparticles with the pore openings covered by "snap-top" caps that are opened by near-IR light. A photo transducer molecule that is a reducing agent in an excited electronic state is covalently attached to the system. Near IR two-photon excitation causes intermolecular electron transfer that reduces a disulfide bond holding the cap in place, thus allowing the cargo molecules to escape. The operation of the "snap-top" release mechanism by both one- and two photon is described. This system presents a proof of concept of a near-IR photoredox-induced nanoparticle delivery system that may lead to a new type of photodynamic drug release therapy. Chapter 4 focuses on the attachment of a photoacid molecule on the surface of silica nanoparticles. Upon light irradiation the pKa of the photoacid molecules decreases causing the dissociation of the proton and the acidification of the nanoparticle surface. The local nanoparticle surface acidification was probed using a pH sensitive nanovalve that was attached to MSNs next to a photoacid. The particles were loaded with a fluorescent dye that was contained by the naovalve and released upon acidification of the surrounding environment. The amount of the dye release was measure continuously by detecting its fluorescence. Chapter 5 focuses on the synthesis of materials that utilize the micropatterned structure of a mesoporous silica film to successfully load and release cargo using a thermal sensitive polymer. Films with pore sizes of ~2 and ~5 nm aligned in the pulling direction were synthesized using evaporation induced self-assembly techniques. The pores are exposed using a new method of stamping micropatterns without the use hydrofluoric acid. A well-studied temperature dependent polymer [poly(N-isopropylacrylamide-co-acrylamide)] was grafted onto the surface of these films to act as a temperature activated gatekeeper. Below the lower critical solution temperature (LCST) the polymer is erect and can block the pore openings, trapping cargo inside the pores. When the temperature is above the LCST the polymer collapses and unblocks the pores, allowing cargo to escape. The loading capacities as well as the reusability of these films were studied.
Book Synopsis Engineering Nanomaterials to Use in Biomedical Applications and in Examining Toxicology by : Courtney Rebecca Thomas
Download or read book Engineering Nanomaterials to Use in Biomedical Applications and in Examining Toxicology written by Courtney Rebecca Thomas and published by . This book was released on 2012 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesoporous silica nanoparticles (MSNs) have been shown to be useful in numerous applications, because the surface can be easily modified with various functional groups. MSNs can also be modified with respect to the interior or exterior of the particles: materials can be condensed within the silica framework, attached along the pore walls, or bound to the outer surface of the nanoparticles. Surface modifications with molecular machines can act to contain cargo molecules within the porous structure for stimulated release of the cargo. Additionally, materials have been developed that contain small metal oxide nanocrystals (d = 10-20 nm) encapsulated within a single MSN. These core-shell mesoporous materials can be used to examine toxicological properties of dissolved ions apart from their cell-surface interactions, since the porous shell allows for diffusion of ions through the porous channels, while also physically isolating the nanocrystal surface from direct contact with the biological material. Additionally, the outer surface of these core-shell MSNs can be modified with molecular machines for cargo storage and release. When iron oxide nanocrystals are encapsulated within MSNs that are equipped with nanovalves and exposed to high-frequency magnetic fields, the valves open and release cargo molecules from the nanoparticles. This property is used to deliver drug molecules in vitro. Furthermore, molecules can be covalently attached to the surface to direct the nanoparticles into certain cells. Cancer cells overexpressing transferrin receptors show enhanced uptake toward MSNs functionalized with surface-attached transferrin. When examined in vitro, these particles show increased uptake of MSNs compared to MSNs without surface-attached transferrin. This dissertation will include research on these two major research aims using MSNs: biological aims of specific drug delivery into target cells; and examining the environmental toxicity of engineered nanomaterials.
Book Synopsis Mesoporous Silica-based Nanomaterials and Biomedical Applications - by :
Download or read book Mesoporous Silica-based Nanomaterials and Biomedical Applications - written by and published by Academic Press. This book was released on 2018-10-22 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Therapy and Diagnosis, Part B, Volume 44 in The Enzymes series highlights new advances in the field, with this new volume presenting interesting chapters on Mesoporous silica nanoparticle synthesis, Periodic mesoporous organosilica, Nanovalves and other nanomachine-equipped nanoparticles and controlled release, Two-photon light control and photodynamic therapy, Biodegradable PMO nanoparticles, Cationic mesoporous silica and protein delivery, Drug loading, stimuli-responsive delivery and cancer treatment, Animal models and cancer therapy, siRNA delivery and TWIST shutdown for ovarian cancer treatment, and TBC (mesoporous silica nanoparticles and cancer therapy or biodistribution of MSN). Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in The Enzymes series Updated release includes the latest information on Cancer Therapy and Diagnosis
Book Synopsis Silk-based Drug Delivery Systems by : Elia Bari
Download or read book Silk-based Drug Delivery Systems written by Elia Bari and published by Royal Society of Chemistry. This book was released on 2020-10-07 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering spider silk and silk worm cocoons, the editors elucidate the extraction, structure and properties of silk sericin and silk fibroin.
Book Synopsis Handbook of Nanomaterials for Industrial Applications by : Chaudhery Mustansar Hussain
Download or read book Handbook of Nanomaterials for Industrial Applications written by Chaudhery Mustansar Hussain and published by Elsevier. This book was released on 2018-07-19 with total page 1143 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Nanomaterials for Industrial Applications explores the use of novel nanomaterials in the industrial arena. The book covers nanomaterials and the techniques that can play vital roles in many industrial procedures, such as increasing sensitivity, magnifying precision and improving production limits. In addition, the book stresses that these approaches tend to provide green, sustainable solutions for industrial developments. Finally, the legal, economical and toxicity aspects of nanomaterials are covered in detail, making this is a comprehensive, important resource for anyone wanting to learn more about how nanomaterials are changing the way we create products in modern industry. Demonstrates how cutting-edge developments in nanomaterials translate into real-world innovations in a range of industry sectors Explores how using nanomaterials can help engineers to create innovative consumer products Discusses the legal, economical and toxicity issues arising from the industrial applications of nanomaterials
Book Synopsis Mesoporous Silica Nanoparticles for Applications in Drug Delivery and Catalysis by : Xiaoxing Sun
Download or read book Mesoporous Silica Nanoparticles for Applications in Drug Delivery and Catalysis written by Xiaoxing Sun and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Polymer Modified Mesoporous Silica Nanoparticles for Controlled Drug and Protein Delivery by : Erick Yu
Download or read book Polymer Modified Mesoporous Silica Nanoparticles for Controlled Drug and Protein Delivery written by Erick Yu and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug delivery by nanoparticles has been an important, emergent field in the past decade with mesoporous silica at the forefront. With a high surface area and wide variety of modifications possible, mesoporous silica nanoparticles (MSNs) are a robust platform to load, transport and deliver molecular species, including tracer compounds, macromolecules, and anti-cancer agents. A wide variety of MSN crystalline structures were first synthesized in the 1990s and early 2000s. In the following years, advances in silane, inorganic, and organic chemistry led to “smart” drug delivery, a revolutionary method wherein contained species could be released at a desired rate. In combination with stimuli or target responsive functional groups, MSNs in recent years have shown particular promise for the therapeutic delivery of peptides, proteins, and small genetic material. To fully realize the potential for these applications, the porous structure of MSNs needs to be enlarged to accommodate larger species without compromising the overall nanoparticle structure. Additionally, due to the sensitive nature of these proteins and genetic matter, stability and prevention of structural deformation is important for their delivery into biological environments. Combining expanded pore MSNs with stimuli-responsive functional groups is currently a major focus for drug delivery. In this dissertation I report on modification of MSNs through inorganic and polymeric constituents. Using a pore-expansion process to synthesize MSNs capable of delivering proteins, specifically lysozyme (ca. 3.9 nm diameter) and bovine hemoglobin (c.a. 5.5 nm diameter), I further modified the MSNs using triblock polyethylene oxide-polypropylene-polyethylene oxide (PEO-PPO-PEO), poly(n-isopropylacrylamide) (PNIPAM), and polyethylene glycol (PEG). I show a well-controlled release of drugs and proteins with these nanoparticles. Triblock PEO-PPO-PEO copolymers function as weak surfactants, which allow them to potentially increase drug permeability through lipid bilayers that coat MSNs. The release behavior of lipid-MSNs can then be linearly fine-tuned with both the composition of the triblock copolymer and its concentration. Among the stimuli-sensitive functional groups used to modify MSNs, PNIPAM in particular has been developed significantly in the past decade as a gating molecule for both nanoparticles and porous membranes. As a thermoresponsive polymer, which changes both its surface hydrophilic/hydrophobic nature in addition to its morphology at 32 °C, PNIPAM can be applied to the MSN surface to provide a triggered release when temperatures are elevated to physiological temperatures. PNIPAM was investigated under in situ liquid atomic force microscopy at sub 80 nm grafting lengths in order to better understand and characterize its collapse behavior around nanostructured surfaces, comparable to the surface of mesoporous silica nanoparticles. Here I demonstrate that the collapse behavior occurs even at grafted lengths of 10-20 nm. However, under these conditions, the gating effect is minimal around nanostructured edges, as of those of nanopores. I further show that when PNIPAM is combined with the step-wise, template functionality of MSNs and further modified with PEG (notable for its ability to minimize non-specific binding and interactions between proteins and glass substrates), improved release delivery of loaded proteins is realized. With therapeutic peptide delivery in mind, these MSNs were tested with lysozyme and bovine hemoglobin to show their potential for delivery of both proteins and genetic material.
Book Synopsis Mechanized Mesoporous Inorganic Nanoparticles for Drug Delivery Applications by : Min Xue
Download or read book Mechanized Mesoporous Inorganic Nanoparticles for Drug Delivery Applications written by Min Xue and published by . This book was released on 2013 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: The research covered in this dissertation is described in six chapters. The first two chapters focus on the design of supramolecular nanovalves on mesoporous silica and silicon materials to form drug delivery systems. These systems are capable of autonomously releasing drug molecules in vitro. The third chapter describes size-selective nanovalves that are able to control the release of both large and small molecules. These nanovalves are constructed on mesoporous silica materials with 6.5 nm pores. The fourth chapter demonstrates two experimental methods, dynamic fluorescence anisotropy and rigidochromism spectroscopy, for probing the properties of the microenvironment inside the mesopores of mesoporous silica nanoparticles. In the fifth chapter of this dissertation, the design and operation of a chemical amplifier based on enzyme-encapsulated mesoporous silica are shown. This system employs a pH-responsive nanogate assembly to control the access to the encapsulated enzyme. It is the first example of a chemical amplifier that is activated by and also amplifies the same type of reaction. The last chapter describes the spectroscopic consequences of the excited state mixed valence in a binuclear copper complex using a neighboring orbital model. The copper complex represents a new class of excited state mixed valence compounds, where the coupling of two equivalent charge-baring units is mediated through a copper-iodine cluster. The result from the simple neighboring orbital approach is supported by resonance Raman spectroscopy and Gaussian calculations.
Book Synopsis Mesoporous Silica and Magnetic Nanoparticle Based Controlled Release by : Giri Supratim
Download or read book Mesoporous Silica and Magnetic Nanoparticle Based Controlled Release written by Giri Supratim and published by LAP Lambert Academic Publishing. This book was released on 2014-01 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology is one of the key technologies of twenty first century. It involves engineering with materials that have size dimension in nanometer range. As important biological entities like virus, pores of biological membranes, proteins, etc also share their sizes in the nanometer ranges; there has been an extensive application of nanotechnology in biology and biomedicine. Nanomaterial based drug delivery offers one of the most useful techniques to administer therapeutics in living cells and tissues. Mesoporous silica nanomaterials act as excellent hosts to store and deliver guest molecules. In this book, research topics on the development of mesoporous silica nanomaterials as a stimuli responsive and controlled release delivery agents have been discussed. Magnetic nanoparticles were utilized for targeting the drug delivery assembly to a site of interest and induce stimuli responsive drug release in 'proof of principle' studies. The work described in this book is expected to provide a rational approach towards designing targeted and stimuli responsive smart drug delivery systems.
