Molecular Insights Into The Structure And Function Of The Telomerase Holoenzyme In Tetrahymena Thermophila

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Telomeres and Telomerase in Cancer

Author : Keiko Hiyama
Publisher : Springer Science & Business Media
ISBN 13 : 1603278796
Total Pages : 375 pages
Book Rating : 4.6/5 (32 download)

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Book Synopsis Telomeres and Telomerase in Cancer by : Keiko Hiyama

Download or read book Telomeres and Telomerase in Cancer written by Keiko Hiyama and published by Springer Science & Business Media. This book was released on 2009-03-18 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in “cancer stem cells” has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.

Non-Protein Coding RNAs

Author : Nils Walter
Publisher : Springer Science & Business Media
ISBN 13 : 3540708405
Total Pages : 400 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Non-Protein Coding RNAs by : Nils Walter

Download or read book Non-Protein Coding RNAs written by Nils Walter and published by Springer Science & Business Media. This book was released on 2008-11-18 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 2006 Nobel Prize in Physiology or Medicine was awarded to the discoverers of RNA interference, Andrew Fire and Craig Mello. This prize, which follows “RNA” Nobels for splicing and RNA catalysis, highlights just one class of recently discovered non-protein coding RNAs. Remarkably, non-coding RNAs are thought to outnumber protein coding genes in mammals by perhaps as much as four-fold. In fact, it appears that the complexity of an organism correlates with the fraction of its genome devoted to non-protein coding RNAs. Essential biological processes as diverse as cell differentiation, suppression of infecting viruses and parasitic tra- posons, higher-level organization of eukaryotic chromosomes, and gene expression are found to be largely directed by non-protein coding RNAs. Currently, bioinformatic, high-throughput sequencing, and biochemical approaches are identifying an increasing number of these RNAs. Unfortunately, our ability to characterize the molecular details of these RNAs is significantly lacking. The biophysical study of these RNAs is an emergent field that is unraveling the molecular underpinnings of how RNA fulfills its multitude of roles in sustaining cellular life. The resulting understanding of the physical and chemical processes at the molecular level is critical to our ability to harness RNA for use in biotechnology and human therapy, a prospect that has recently spawned a multi-billion dollar industry.

Fundamental Molecular Biology

Author : Lizabeth A. Allison
Publisher : Wiley
ISBN 13 : 9781118312599
Total Pages : 0 pages
Book Rating : 4.3/5 (125 download)

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Book Synopsis Fundamental Molecular Biology by : Lizabeth A. Allison

Download or read book Fundamental Molecular Biology written by Lizabeth A. Allison and published by Wiley. This book was released on 2011-10-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unique in in its focus on eukaryotic molecular biology, this textbook provides a distillation of the essential concepts of molecular biology, supported by current examples, experimental evidence, and boxes that address related diseases, methods, and techniques. End-of-chapter analytical questions are well designed and will enable students to apply the information they learned in the chapter. A supplementary website include self-tests for students, resources for instructors, as well as figures and animations for classroom use.

Soft Matter Physics

Author : Masao Doi
Publisher : Oxford University Press, USA
ISBN 13 : 0199652953
Total Pages : 271 pages
Book Rating : 4.1/5 (996 download)

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Book Synopsis Soft Matter Physics by : Masao Doi

Download or read book Soft Matter Physics written by Masao Doi and published by Oxford University Press, USA. This book was released on 2013-07-04 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Soft matter (polymers, colloids, surfactants, liquid crystals) are an important class of materials for modern and future technologies. They are complex materials that behave neither like a fluid nor a solid. This book describes the characteristics of such materials and how we can understand such characteristics in the language of physics.

Genome Plasticity in Health and Disease

Author :
Publisher : Academic Press
ISBN 13 : 0128178205
Total Pages : 290 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Genome Plasticity in Health and Disease by :

Download or read book Genome Plasticity in Health and Disease written by and published by Academic Press. This book was released on 2020-04-08 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors, non-coding RNAs, telomere dynamics and RNA editing. Later chapters explore disease relevance for cancer, as well as cardiovascular, neuropsychiatric, inflammatory, and endocrine disease, and associated pathways for drug discovery. - Examines the role of genome plasticity across a range of disease types, from cardiovascular disease, to cancer and neuropsychiatric disorders - Adopts an interdisciplinary approach, with expert contributions across the spectrum of basic science and disease relevance to drug discovery

Human Genome Structure, Function and Clinical Considerations

Author : Luciana Amaral Haddad
Publisher : Springer Nature
ISBN 13 : 3030731510
Total Pages : 367 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Human Genome Structure, Function and Clinical Considerations by : Luciana Amaral Haddad

Download or read book Human Genome Structure, Function and Clinical Considerations written by Luciana Amaral Haddad and published by Springer Nature. This book was released on 2021-06-07 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a detailed evidence-based overview of the latest developments in how the structure of the human genome is relevant to the health professional. It features comprehensive reviews of genome science including human chromosomal and mitochondrial DNA structure, protein-coding and noncoding genes, and the diverse classes of repeat elements of the human genome. These concepts are then built upon to provide context as to how they functionally relate to differences in phenotypic traits that can be observed in human populations. Guidance is also provided on how this information can be applied by the medical practitioner in day-to-day clinical practice. Human Genome Structure, Function and Clinical Considerations collates the latest developments in genome science and current methods for genome analysis that are relevant for the clinician, researcher and scientist who utilises precision medicine techniques and is an essential resource for any such practitioner.

RNA Infrastructure and Networks

Author : Lesley J. Collins
Publisher : Springer Science & Business Media
ISBN 13 : 1461403324
Total Pages : 297 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis RNA Infrastructure and Networks by : Lesley J. Collins

Download or read book RNA Infrastructure and Networks written by Lesley J. Collins and published by Springer Science & Business Media. This book was released on 2011-09-15 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNAs form complexes with proteins and other RNAs. The RNA‐infrastructure represents the spatiotemporal interaction of these proteins and RNAs in a cell‐wide network. RNA Infrastructure and Networks brings together these ideas to illustrate the scope of RNA‐based biology, and how connecting RNA mechanisms is a powerful tool to investigate regulatory pathways. This book is but a taste of the wide range of RNA‐based mechanisms that connect in the RNA infrastructure.

Recent Developments in Biomolecular NMR

Author : Marius Clore
Publisher : Royal Society of Chemistry
ISBN 13 : 1849731209
Total Pages : 362 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Recent Developments in Biomolecular NMR by : Marius Clore

Download or read book Recent Developments in Biomolecular NMR written by Marius Clore and published by Royal Society of Chemistry. This book was released on 2012 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text draws together experts in the field to discuss advances in nuclear magnetic resonance methods that have occurred or had an impact on the biomolecular field in the last few years.

Evolutionary Biology—A Transdisciplinary Approach

Author : Pierre Pontarotti
Publisher : Springer Nature
ISBN 13 : 3030572463
Total Pages : 389 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Evolutionary Biology—A Transdisciplinary Approach by : Pierre Pontarotti

Download or read book Evolutionary Biology—A Transdisciplinary Approach written by Pierre Pontarotti and published by Springer Nature. This book was released on 2020-10-29 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book includes 16 selected contributions presented at the 23rd Evolutionary Biology Meeting, which took place in Marseille in September 2019. The annual Evolutionary Biology Meetings in Marseille serve to gather leading evolutionary biologists and other scientists using evolutionary biology concepts, e.g. for medical research. The aim of these meetings is to promote the exchange of ideas to encourage interdisciplinary collaborations. Offering an up-to-date overview of recent findings in the field of evolutionary biology, this book is an invaluable source of information for scientists, teachers and advanced students.

A-Z of Quantitative PCR

Author : Stephen A. Bustin
Publisher :
ISBN 13 : 9780963681782
Total Pages : 0 pages
Book Rating : 4.6/5 (817 download)

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Book Synopsis A-Z of Quantitative PCR by : Stephen A. Bustin

Download or read book A-Z of Quantitative PCR written by Stephen A. Bustin and published by . This book was released on 2004 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive manual to allow both the novice researcher and the expert to set up and carry out quantitative PCR assays from scratch. However, this book also sets out to explain as many features of qPCR as possible, provide alternative viewpoints, methods, and aims to simulate the researchers into generating, interpreting, and publishing data that are reproducible, reliable, and biologically meaningful

Lewin's GENES XII

Author : Jocelyn E. Krebs
Publisher : Jones & Bartlett Learning
ISBN 13 : 1284104494
Total Pages : 864 pages
Book Rating : 4.2/5 (841 download)

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Book Synopsis Lewin's GENES XII by : Jocelyn E. Krebs

Download or read book Lewin's GENES XII written by Jocelyn E. Krebs and published by Jones & Bartlett Learning. This book was released on 2017-03-02 with total page 864 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its twelfth edition, Lewin's GENES continues to lead with new information and cutting-edge developments, covering gene structure, sequencing, organization, and expression. Leading scientists provide revisions and updates in their individual field of study offering readers current data and information on the rapidly changing subjects in molecular biology.

Genetics Essentials

Author : Benjamin Pierce
Publisher : WH Freeman
ISBN 13 : 9781319187972
Total Pages : 544 pages
Book Rating : 4.1/5 (879 download)

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Book Synopsis Genetics Essentials by : Benjamin Pierce

Download or read book Genetics Essentials written by Benjamin Pierce and published by WH Freeman. This book was released on 2018-02-23 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Derived from his popular and acclaimed Genetics: A Conceptual Approach, Ben Pierce’s streamlined text covers basic transmission, molecular, and population genetics in just 18 chapters, helping students uncover major concepts of genetics and make connections among those concepts as a way of gaining a richer understanding of the essentials of genetics. With the new edition, Ben Pierce again focuses on the most pervasive problems for students taking genetics—understanding how genetics concepts connect to each other and developing solid problem solving skills. And with this edition, Genetics Essentials is available as a fully integrated text/media resource with SaplingPlus, an online solution that combines an e-book of the text, Pierce’s powerful multimedia resources, and Sapling’s robust genetics problem library.

Photochemistry

Author : Stefano Crespi
Publisher : Royal Society of Chemistry
ISBN 13 : 183916526X
Total Pages : 507 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis Photochemistry by : Stefano Crespi

Download or read book Photochemistry written by Stefano Crespi and published by Royal Society of Chemistry. This book was released on 2021-09-20 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing critical analysis of emerging and well-established topics, this book is essential reading for anyone wanting to keep up to date with the literature on photochemistry and its applications. Volume 49 combines reviews on the latest advances in photochemical research with specific highlights in the field. The first section includes periodical reports of the recent literature on physical and inorganic aspects, including reviews of the molecules employed as dyes in art, light induced reactions in cryogenic matrices, photobiological systems studied by time-resolved infrared spectroscopy and photophysics, and photochemistry of transition metal complexes. This selection is completed by reviews of the literature on solar photocatalysis for water decontamination and disinfection and for water splitting/hydrogen production. Coverage continues in the second part with highlighted topics, from the use of aromatic carbonyls as photocatalysts and photoinitiators in synthesis, photoinduced and photocatalysed decarboxylation reactions, development of dye-sensitized solar cells, design of luminescent water-soluble systems, and applications of plasmonic nanoparticles. This volume also includes a third section entitled ‘SPR Lectures on Photochemistry’, where leading scientists in photochemistry provide examples to introduce a photochemical topic to academic readers, offering precious assistance to students in this field.

Translational Systems Medicine and Oral Disease

Author : Stephen T. Sonis
Publisher : Academic Press
ISBN 13 : 0128137630
Total Pages : 460 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Translational Systems Medicine and Oral Disease by : Stephen T. Sonis

Download or read book Translational Systems Medicine and Oral Disease written by Stephen T. Sonis and published by Academic Press. This book was released on 2019-09-14 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease specific chapters detail systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease, and autoimmune disease, among others. In addition, the book emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology and primary care. - Presents the work of leading international researchers and clinicians who speak on the clinical applications of genomics, proteomics, metabolomics, microbiomics, and epigenetics, as well as analytic methods and functional omics in oral medicine - Provides full-color, richly illustrated chapters that examine systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease and autoimmune diseases - Includes clinical case studies that illustrate examples of oral disease diagnostics and management, highlighting points of key importance for the reader - Emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers, and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology, and primary care

RNA Chaperones

Author : Tilman Heise
Publisher :
ISBN 13 : 9781071602317
Total Pages : 314 pages
Book Rating : 4.6/5 (23 download)

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Book Synopsis RNA Chaperones by : Tilman Heise

Download or read book RNA Chaperones written by Tilman Heise and published by . This book was released on 2020 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a wide spectrum of methods to study RNA chaperones in vitro, at the single molecule level, and protocols useful for cell-based assays. Beginning with a section on a number of bacterial proteins for study, the volume also explores proteins from eukaryotic cells and how to delve into the complex interactions between RNA chaperones and the folding and unfolding of proteins. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, RNA Chaperones: Methods and Protocols serves as an ideal guide for scientists and students interested in RNA biology and RNA chaperones. Chapter 3 is available Open Access under a CC-BY 4.0 license via link.springer.com.

RNA Folding

Author : Christina Waldsich
Publisher : Humana
ISBN 13 : 9781493960583
Total Pages : 0 pages
Book Rating : 4.9/5 (65 download)

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Book Synopsis RNA Folding by : Christina Waldsich

Download or read book RNA Folding written by Christina Waldsich and published by Humana. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on in vitro and intracellular RNA structure formation, RNA Folding: Methods and Protocols provides a comprehensive collection of experimental protocols which are suitable to dissect RNA folding pathways and to characterize the structure of RNA folding intermediates at nucleotide or even atomic resolution. The presented techniques include powerful tools with a long tradition in RNA research as well as more advanced, novel methods, thus the methods span multiple disciplines, including molecular biology, biochemistry, biophysics, and computational biology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and authoritative, RNA Folding: Methods and Protocols serves as a vital reference for researchers attempting to gain insights into the secrets of this astounding macromolecule.

Genes in Conflict

Author : Austin Burt
Publisher : Harvard University Press
ISBN 13 : 9780674017139
Total Pages : 650 pages
Book Rating : 4.0/5 (171 download)

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Book Synopsis Genes in Conflict by : Austin Burt

Download or read book Genes in Conflict written by Austin Burt and published by Harvard University Press. This book was released on 2006 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: In evolution, most genes survive and spread within populations because they increase the ability of their hosts (or their close relatives) to survive and reproduce. But some genes spread in spite of being harmful to the host organism—by distorting their own transmission to the next generation, or by changing how the host behaves toward relatives. As a consequence, different genes in a single organism can have diametrically opposed interests and adaptations.Covering all species from yeast to humans, Genes in Conflict is the first book to tell the story of selfish genetic elements, those continually appearing stretches of DNA that act narrowly to advance their own replication at the expense of the larger organism. As Austin Burt and Robert Trivers show, these selfish genes are a universal feature of life with pervasive effects, including numerous counter-adaptations. Their spread has created a whole world of socio-genetic interactions within individuals, usually completely hidden from sight.Genes in Conflict introduces the subject of selfish genetic elements in all its aspects, from molecular and genetic to behavioral and evolutionary. Burt and Trivers give us access for the first time to a crucial area of research—now developing at an explosive rate—that is cohering as a unitary whole, with its own logic and interconnected questions, a subject certain to be of enduring importance to our understanding of genetics and evolution.