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Author : Emanuel Rubin
Publisher :
ISBN 13 : 9780897666626
Total Pages : 848 pages
Book Rating : 4.6/5 (666 download)
Download or read book Molecular and Cellular Mechanisms of Alcohol and Anesthetics written by Emanuel Rubin and published by . This book was released on 1991 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Christer Alling
Publisher : Springer Science & Business Media
ISBN 13 : 1461524709
Total Pages : 320 pages
Book Rating : 4.4/5 (615 download)
Download or read book Alcohol, Cell Membranes, and Signal Transduction in Brain written by Christer Alling and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alcohol abuse and alcoholism are international problems whose costs economical ly, psychologically and medically have been well documented. Alcohol is a unique drug in that the effects of excessive use can have a deleterious effect on most if not all organs of the body. The brain is one of the organs most affected by excessive alcohol consumption. Effects on the brain can be seen in cognitive function, brain structure and neurochemistry. Over the past few years, there have been significant advances made in understanding how alcohol affects brain neurochemistry. This book examines four major areas, i. e. , membrane lipids, receptors and ion channels, second messengers, and gene expression, where significant advancements have been made. The book is divided into four sections based on the four major areas. In each section, data are examined that cover a range of approaches from in vitro to in vivo studies. The section on membrane lipids includes recent developments in how ethanol affects membrane cholesterol domains, polyunsaturated fatty acids, the cause and consequences of phosphatidylethanol formation, and the modulation of membrane protein function by lipid-protein interaction. The second section comprises chapters on NMDA and 5-HT3 receptors, including new aspects on alcohol neurotoxicity and the molecular heterogeneity that may underlie differences in alcohol sensitivity as well as chapters on GABA-gated chloride flux, and calcium channels.
Author : Emanuel Rubin
Publisher :
ISBN 13 :
Total Pages : 872 pages
Book Rating : 4.X/5 (1 download)
Download or read book Molecular and Cellular Mechanisms of Alcohol and Anesthetics written by Emanuel Rubin and published by . This book was released on 1991 with total page 872 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : M. Endo
Publisher : Springer Science & Business Media
ISBN 13 : 3642570836
Total Pages : 674 pages
Book Rating : 4.6/5 (425 download)
Download or read book Pharmacology of Ionic Channel Function: Activators and Inhibitors written by M. Endo and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cells maintain uneven distribution of Na, K and Ca ions across the cell membrane and membranes of intracellular organellae. Cells exert their functions by allowing for some ion to cross the membrane through ion channels which either produces an electrical effect across the membrane or switches on a series of chemical or physicochemical reactions. This is a comprehensive book about these vitally important ion channels with detailed description of the molecular structure and function and especially of activators and inhibitors. All chapters are written by renowned specialists in their field.
Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 968 pages
Book Rating : 4.:/5 (319 download)
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1991 with total page 968 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jürgen Schüttler
Publisher : Springer Science & Business Media
ISBN 13 : 3540748067
Total Pages : 497 pages
Book Rating : 4.5/5 (47 download)
Download or read book Modern Anesthetics written by Jürgen Schüttler and published by Springer Science & Business Media. This book was released on 2008-01-08 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some important constraints of anesthesia must be taken into consideration when the pharmacological properties of modern anesthetics are discussed. The most imp- tant of these could be that the target effect be achieved preferably within seconds, at most within a few minutes. Similarly, offset of drug action should be achieved within minutes rather hours. The target effects, such as unconsciousness, are pot- tially life-threatening, as are the side effects of modern anesthetics, such as respi- tory and cardiovascular depression. Finally, the patient’s purposeful responses are not available to guide drug dosage, because, either the patient is unconscious, or more problematically, the patient is aware but unable to communicate pain because of neuromuscular blockade. These constraints were already recognised 35 years ago, when in 1972 Volume XXX entitled “Modern Inhalation Anesthetics” appeared in this Handbook Series. The present volume is meant as a follow up and extension of that volume. At the beginning of the 1970’s anesthesia was commonly delivered by inhalation, with only very few exceptions. The clinical understanding of that time considered anesthesia as a unique state achieved by any of the inhalation anesthetics, in- pendent of their specific molecular structure. “The very mechanism of anesthetic action at the biophase” was discussed within the theoretical framework of the “u- tary theory of narcosis”.
Author : S.H. Roth
Publisher : Springer
ISBN 13 :
Total Pages : 520 pages
Book Rating : 4.3/5 (91 download)
Download or read book Molecular and Cellular Mechanisms of Anesthetics written by S.H. Roth and published by Springer. This book was released on 1986-03-31 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: B. Raymond Fink Sheldon Roth and Keith Miller have asked me to record that the Third Conference on Molecular and Cellular Mechanisms of Anesthesia was held in Calgary last May "in my honor. " Such was my dear friends' gracious way of continuing a series that began at the University of Washington, where I hosted two, four, or five previous ones, 1,3-6 depending 2 on how far back one wishes to count. At that, Seattle took up where Paris left off in 1951. These occasions create their own unforgettable memories. This book captures the fine, invigorating ambience of the University of Calgary and the exciting explorations and com panionship of a gathering in a frontier territory of neuroscience. So, floreant symposia. They have progressively refined the quarry, from pathway to synapse to lipoprotein membrane to receptor and single channel, in heuristic convergences of neuronal physiology, biochemistry, and pharmacology. Nevertheless, the anesthesiologist in me senses a certain disquiet, a certain claustrophobia provoked by the narrow confines of micropipettes. How much more tubular must tunnel vision become before the desired broad view emerges? At present, the advances in molecular neurobiology seem continually to increase the apparent complexity of the total problem and the conceptual distance between the reductionists in the laboratories and the holists in the operating rooms. Happily, what is also growing is the excitement in trying to bridge the gap. Perhaps it would be timely to regard general anesthesia not as a state but as a syndrome.
Author : Jochen Schulte am Esch
Publisher : Springer Science & Business Media
ISBN 13 : 3642784410
Total Pages : 343 pages
Book Rating : 4.6/5 (427 download)
Download or read book Central Nervous System Monitoring in Anesthesia and Intensive Care written by Jochen Schulte am Esch and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research in electrophysiologic monitoring in anesthesia and intensive care has focussed mostly on questions pertinent for patient care: First how to quantitate drug effects on brain electrical activity and the degree of anesthetic-induced suppression of the central nervous system. Second, how to monitor functional impairment following cerebral ischemia and hypoxia. And third, how to differ entiate between drug-induced effects on the central nervous system and deleteri ous events related to reductions in cerebral blood flow and/or oxygen delivery. Even though progress has been achieved over the last 10 years in this field and fascinating new techniques have been developed, it is still not clear which monitor parameter will provide adequate information on the depth of anes thesia and the analgesic level. Because the central nervous system has been one of the main research areas in our department over the last 10 years, we organized a workshop to summarize the latest developments in central nervous system monitoring. This book comprises the topics of this workshop and is intended to provide insight into the current status of central nervous system monitoring, elucidating possible indications and delineating its limitations.
Author : Ronald Ross Watson
Publisher : CRC Press
ISBN 13 : 9780849379369
Total Pages : 340 pages
Book Rating : 4.3/5 (793 download)
Download or read book Alcohol and Neurobiology written by Ronald Ross Watson and published by CRC Press. This book was released on 1992-06-24 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Public attention and research efforts are being driven by an ever- increasing understanding of the problems and magnitude of alcohol abuse, particularly its neurological consequences. Two out of three high school students report that they used alcohol during the previous month. This continuing source of potential abusers, plus 10 million alcohol-abusing adults, along with the several million abusers of other drugs, costs the people of the U.S. more than $200 billion in lost wages, health care, theft, and shortened life span. An intimate, detailed knowledge of the effects of alcohol on the biochemical reactions and neurological changes is critical in preventing or treating abuse. We must study the mechanisms of ethanol's effects on the neurological system at a cellular and systematic level to understand its actions. These include modifications of hormonal regulation and production with major functional consequences. The progress of research over the past decade is encouraging as we begin to summarize and evaluate in detail advances in understanding changes in the biochemistry and physiology caused by ethanol. This information will assist the researcher, clinician, and student in comprehending the complex changes caused by direct and indirect effects of single drugs at the cellular level.
Author : Jan Egebjerg
Publisher : CRC Press
ISBN 13 : 0203299388
Total Pages : 442 pages
Book Rating : 4.2/5 (32 download)
Download or read book Glutamate and GABA Receptors and Transporters written by Jan Egebjerg and published by CRC Press. This book was released on 2001-10-04 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ubiquitous presence of glutamate and GABA receptors in the nervous system makes these receptor systems pivotal to our understanding of neurotransmission. Cloning of the molecular components of these receptor systems has provided insights to the selectivity of many drugs and detailed characterisation at the molecular level is emerging. Moreover,
Author :
Publisher :
ISBN 13 :
Total Pages : 1320 pages
Book Rating : 4.3/5 (243 download)
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1991 with total page 1320 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Antonius M. VanDongen
Publisher : CRC Press
ISBN 13 : 142004415X
Total Pages : 368 pages
Book Rating : 4.4/5 (2 download)
Download or read book Biology of the NMDA Receptor written by Antonius M. VanDongen and published by CRC Press. This book was released on 2008-10-29 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written
Author : Joseph E. Antognini
Publisher : Springer Science & Business Media
ISBN 13 : 1592593224
Total Pages : 464 pages
Book Rating : 4.5/5 (925 download)
Download or read book Neural Mechanisms of Anesthesia written by Joseph E. Antognini and published by Springer Science & Business Media. This book was released on 2002-08-22 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading investigators critically evaluate the latest information on how anesthetics work at the molecular, cellular, organ, and whole animal level. These distinguished experts review anesthetic effects on memory, consciousness, and movement and spell out in detail both the anatomic structures and physiological processes that are their likely targets, as well as the cellular and molecular mechanisms by which they operate. Comprehensive and authoritative, Neural Mechanisms of Anesthesia draws together and critically reviews all the recent research on anesthetic mechanisms, highlighting the precise routes along which these substances operate, and how this deeper understanding will lead to the design of effective drugs free ofundesirable side effects.
Author : Michael J. Cousins
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1451178654
Total Pages : 1360 pages
Book Rating : 4.4/5 (511 download)
Download or read book Cousins and Bridenbaugh's Neural Blockade in Clinical Anesthesia and Pain Medicine written by Michael J. Cousins and published by Lippincott Williams & Wilkins. This book was released on 2012-03-29 with total page 1360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive, authoritative text presents the scientific foundations and clinical practice of neural blockade in both regional anesthesia and the management of pain. The descriptions and illustrations of pain mechanisms are considered classic examples. The Fourth Edition has been refined for clarity and flows logically from principles and pharmacology, to techniques for each anatomic region, to applications. This edition has two new co-editors and several new chapters on topics including neurologic complications, neural blockade for surgery, treatment of pain in older people, and complications in pain medicine. A companion Website will offer the fully searchable text and an image bank.
Author : Yuan Liu
Publisher : Springer Science & Business Media
ISBN 13 : 1461547393
Total Pages : 216 pages
Book Rating : 4.4/5 (615 download)
Download or read book The “Drunken” Synapse written by Yuan Liu and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past two years, the National Institute on Alcohol Abuse and Alcoholism (NIAAA) has begun a series of symposia to highlight the need for more integrative re search to understand how ethanol alters behavior. Much of the research to date has dealt either at the molecular level or has been whole animal studies. More studies are needed to build our base of knowledge between these two extremes by focusing more on cellular and network levels of organization. To begin this focus on the intermediate steps in this scheme, the NIAAA presented a satellite symposium entitled "Approaches for Studying Neural Circuits: Application to Al cohol Research" held at the Annual Meeting of the Society for Neuroscience in Washing ton, DC, on November 16, 1996. This symposium brought together a group of scientists who presented their work on techniques used to study neural circuits. The proceedings of that symposium were published (Y. Liu (Ed.) Approaches for Studying Neural Circuits: Application to Alcohol Research. Alcohol Clin Exp Res 1998 Feb; 22: 1--{j6).
Author : Thomas Lincoln Casey
Publisher :
ISBN 13 :
Total Pages : 616 pages
Book Rating : 4.:/5 (5 download)
Download or read book Annals of the New York Academy of Sciences written by Thomas Lincoln Casey and published by . This book was released on 1994 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : William Winlow
Publisher : Frontiers Media SA
ISBN 13 : 2889631451
Total Pages : 150 pages
Book Rating : 4.8/5 (896 download)
Download or read book Sentience, Pain, and Anesthesia in Advanced Invertebrates written by William Winlow and published by Frontiers Media SA. This book was released on 2019-11-04 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is an emerging view, supported by animal welfare legislation in a number of countries, that some advanced invertebrates are self-aware, sentient beings with the ability to feel pain. Sentience must encompass elements of time and neural complexity, including memory and learning, which leads us to ask: At what convergent point in the evolution of nervous systems does the subjective sensation of pain arise? Here we start to grapple with this issue, particularly with regard to arthropods and cephalopod molluscs, and to consider the most appropriate ways of anesthetizing them to minimize pain wherever possible. We also report on the development of cell culture techniques to understand the actions of the anesthetics being used. A better understanding of sentient creatures, other than ourselves, may eventually assist future development of artificial intelligence, particularly if we are able to perceive whatever common neural features underlie sentience in those animals that possess it.
