Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Molecular And Cellular Biology Of Platelet Formation
Download Molecular And Cellular Biology Of Platelet Formation full books in PDF, epub, and Kindle. Read online Molecular And Cellular Biology Of Platelet Formation ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Molecular and Cellular Biology of Platelet Formation by : Harald Schulze
Download or read book Molecular and Cellular Biology of Platelet Formation written by Harald Schulze and published by Springer. This book was released on 2017-02-07 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives a comprehensive insight into platelet biogenesis, platelet signal transduction, involvement of platelets in disease, the use of diverse animal models for platelet research and future perspectives in regard to platelet production and gene therapy. Being written by international experts, the book is a concise state-of-the art work in the field of platelet biogenesis, biology and research. It represents an indispensable tool for research scientists in biomedicine, vascular biology, hematopoiesis and hemostasis and specifically for scientists in platelet research, as well as for clinicians in the field of hematology and transfusion medicine.
Book Synopsis Thrombopoiesis and Thrombopoietins by : David Kuter
Download or read book Thrombopoiesis and Thrombopoietins written by David Kuter and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: David Kuter and a host of leading international researchers summarize in one volume all the knowledge of thrombopoietins (TPO) available today. The distinguished experts review the history of the search to discover TPO, describe the molecular and biological characteristics of this new molecule, and present the results of the preclinical animal experiments that will guide clinical use of this new hormone. Along the way they provide the most recent and comprehensive guide to the biology of megakaryocytes and platelets.
Book Synopsis Platelets and Megakaryocytes by : Jonathan M. Gibbins
Download or read book Platelets and Megakaryocytes written by Jonathan M. Gibbins and published by Humana Press. This book was released on 2004-08-13 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: 12 The average human body has on the order of 10 circulating platelets. They are crucial for hemostasis, and yet excessive platelet activation is a major cause of m- bidity and mortality in Western societies. It is therefore not surprising that platelets have become one of the most extensively investigated biological cell types. We are, however, far from understanding precisely how platelets become activated under physiological and pathophysiological conditions. In addition, there are large gaps in our knowledge of platelet production from their giant precursor cell, the megakar- cyte. Understanding megakaryocyte biology will be crucial for the development of platelet gene targeting. The aim of Platelets and Megakaryocytes is therefore to bring together established and recently developed techniques to provide a comprehensive guide to the study of both the platelet and the megakaryocyte. It consists of five s- tions split between two volumes. The more functional assays appear in Volume 1, whereas Volume 2 includes signaling techniques, postgenomic methods, and a n- ber of key perspectives chapters. Part I of Volume 1, Platelets and Megakaryocytes: Functional Assays, describes many well-established approaches to the study of platelet function, including aggregometry, secretion, arachidonic acid metabolism, procoagulant responses, pla- let adhesion under static or flow conditions, flow cytometry, and production of microparticles. Although one would ideally wish to perform experiments with human platelets, studies within the circulation using intravital microscopy require the use of animal models, which are described in Chapter 16, vol. 1.
Book Synopsis Platelets and Megakaryocytes by : Jonathan M. Gibbins
Download or read book Platelets and Megakaryocytes written by Jonathan M. Gibbins and published by . This book was released on 2018 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main aim of this fourth volume is to complement the first three volumes published in 2004 and 2012 by adding advanced methodologies and perspectives. Chapters guide readers through new techniques into the study of platelets and megakaryocytes, including new imaging approaches, new methods for platelet production in vitro, and systems biology approaches. Written in the highly successful Methods in Molecular Biology series format, methods chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and vital tips on troubleshooting or avoiding known pitfalls. Authoritative and up-to-date, Platelets and Megakaryocytes: Volume 4, Additional Protocols and Perspectives adds a wealth of new expertise for the labs of scientists working in this key biological area of study.
Book Synopsis Platelets and Megakaryocytes by : Jonathan M. Gibbins
Download or read book Platelets and Megakaryocytes written by Jonathan M. Gibbins and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: 12 The average human body has in the order of 10 circulating platelets. They are crucial for hemostasis, and yet excessive platelet activation is a major cause of m- bidity and mortality in western societies. It is therefore not surprising that platelets have become one of the most extensively investigated biological cell types. We are, however, far from understanding precisely how platelets become activated under physiological and pathophysiological conditions. In addition, there are large gaps in our knowledge of platelet production from their giant precursor cell, the megakar- cyte. Understanding megakaryocyte biology will be crucial for the development of platelet gene targeting. The aim of Platelets and Megakaryocytes is therefore to bring together established and recently developed techniques to provide a comprehensive guide to the study of both the platelet and the megakaryocyte. It consists of five s- tions split between two volumes. The more functional assays appear in Volume 1, whereas Volume 2 includes signaling techniques, postgenomic methods, and a n- ber of key perspectives chapters. Part I of Volume 1, Platelets and Megakaryocytes: Functional Assays, describes many well established approaches to the study of platelet function, including aggregometry, secretion, arachidonic acid metabolism, procoagulant responses, pla- let adhesion under static or flow conditions, flow cytometry, and production of microparticles. Although one would ideally wish to perform experiments with human platelets, studies within the circulation using intravital microscopy require the use of animal models, which are described in Chapter 16, vol. 1.
Book Synopsis Platelets and Megakaryocytes by : Jonathan M. Gibbins
Download or read book Platelets and Megakaryocytes written by Jonathan M. Gibbins and published by Springer Science & Business Media. This book was released on 2004-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: For both volumes: A comprehensive collection of cutting-edge methods for the molecular and cellular analysis of platelets and megakaryocytes. Volume 1 details basic and advanced techniques for analyzing platelet and megakaryocyte function. The approaches presented for platelet analysis include aggregometry, secretion, arachidonic acid metabolism, procoagulent response, platelet adhesion under static and flow conditions, flow cytometry, and production of microparticles. The techniques for study of megakaryocyte function allow the measurement of specialized structures for platelet production, the appearance of platelet-specific surface receptors, and the increase in ploidy. Volume 2 offers techniques for studying many aspects of signaling in platelets and megakaryocytes, as well as state-of-the-art commentaries on our understanding of these cells. The methods include ligand-binding assays, the study of protein and lipid kinases and phosphatases, the analysis of lipid rafts, and the measurement of intracellular calcium levels. There are also techniques for study of electrophysiological events, nitric oxide signaling, venom proteins, and for the internalization of proteins into platelets through permeabilization. This volume also describes the application of molecular and post-genomic methods for the study of platelets and megakaryocytes. All protocols follow the successful Methods in Molecular Biology⢠series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. The two volumes offer novice and experienced cell biologists, hematologists, and clinicians not only a benchmark survey of the field, but also a comprehensive library of proven techniques essential for productive research on platelets and megakaryocytes today.
Book Synopsis Platelets and Megakaryocytes by : Jonathan M. Gibbins
Download or read book Platelets and Megakaryocytes written by Jonathan M. Gibbins and published by Humana Press. This book was released on 2011-12-02 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: New techniques to study cell signaling and function can develop at a staggering pace; however, many approaches are as valid today as on the day they were established. Thus, the main aim of Platelets and Megakaryocytes: Volume 3, Additional Protocols and Perspectives is to complement the first two volumes published in 2004 by adding recently developed state of the art techniques. Conveniently divided into three sections, this detailed volume covers techniques to study platelet function, approaches to investigate megakaryocyte function, and perspectives on important overall concepts in the field of megakaryocyte and platelet biology. Written in the highly successful Methods in Molecular BiologyTM series format, methods chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and vital tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Platelets and Megakaryocytes: Volume 3, Additional Protocols and Perspectives adds a wealth of new expertise for the labs of scientists working in this key biological area of study.
Book Synopsis The Molecular and Cellular Biology of Wound Repair by : R.A.F. Clark
Download or read book The Molecular and Cellular Biology of Wound Repair written by R.A.F. Clark and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Provides comprehensive detail on the various aspects of particular molecules involved in the phases of injury and repair and the cellular movements and processes....This is an excellent reference book for libraries serving biology and health science clientele and for workers in this field of research.' -American Scientist, from a review of the First Edition All chapters of this second edition have been completely revised and expanded-especially the chapters on growth factors and extracellular matrix molecules. New chapters discuss provisional matrix proteins, extracellular matrix receptors, and scarring versus nonscarring wound healing.
Book Synopsis Homeostasis by : Fernanda Lasakosvitsch Castanho
Download or read book Homeostasis written by Fernanda Lasakosvitsch Castanho and published by BoD – Books on Demand. This book was released on 2019-01-30 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human body is composed of several systems and organs, consisting of millions of cells that need relatively stable conditions to function and contribute to the survival of the body as a whole. The maintenance of stable conditions for the cells against the variations of the external environment is an essential function of the body and is called homeostasis. As a consequence of the loss of homeostasis, a disease is manifested. This book aims to provide the reader with an up-to-date view of the self-regulatory mechanisms that are activated to achieve homeostasis, the pathways that are altered during the disease process, and how medicine can intervene to restore balance in critical patients.
Book Synopsis Molecular Biology of The Cell by : Bruce Alberts
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Molecular and Cellular Biology of Wound Repair by : Richard A. F. Clark
Download or read book The Molecular and Cellular Biology of Wound Repair written by Richard A. F. Clark and published by Springer Science & Business Media. This book was released on 1988 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: I. Inflammation.- 1 Overview and General Considerations of Wound Repair.- 2 Platelets and Response to Injury.- 3 Potential Functions of the Clotting System in Wound Repair.- 4 Endothelial Cell Regulation of Coagulation.- 5 Factors That Affect Vessel Reactivity and Leukocyte Emigration.- 6 Neutrophil Emigration, Activation, and Tissue Damage.- 7 Resolution of Inflammation.- 8 The Multiple Roles of Macrophages in Wound Healing.- II. Granulation Tissue Formation.- 9 The Role of Growth Factors in Tissue Repair I: Platelet-Derived Growth Factor.- 10 The Role of Growth Factors in Tissue Repair II: Epidermal Growth Factor.- 11 The Role of Growth Factors in Tissue Repair III: Fibroblast Growth Factor.- 12 The Role of Growth Factors in Tissue Repair IV: Type ?-Transforming Growth Factor and Stimulation of Fibrosis.- 13 Mechanisms of Parenchymal Cell Migration into Wounds.- 14 Re-epithelialization.- 15 Angiogenesis.- 16 The Role of Cell-Cell Interaction in the Regulation of Endothelial Cell Growth.- 17 The Biology of the Myofibroblast Relationship to Wound Contraction and Fibrocontractive Diseases.- III. Extracellular Matrix Production and Remodeling.- 18 Fibronectin: A Primitive Matrix.- 19 Proteoglycans and Wound Repair.- 20 Collagen in Dermal Wound Repair.- 21 Role of Degradative Enzymes in Wound Healing.- 22 Basement Membranes.- 23 Re-formation of the Epidermal-Dermal Junction during Wound Healing.
Download or read book The Platelet written by E.G. Lapetina and published by Elsevier Science. This book was released on 1997-04-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Platelets have been an important model system in which to study various aspects of signal transduction. In spite of the fact that platelets are anucleated cells, it has been possible to assess the relationship between receptors, transducers and effectors, and specific platelet physiological responses. As a consequence, discrete biochemical events can be related to shape change, aggregation, and secretion. In addition to undergoing these internal biochemical changes, activated platelets express glycoproteins receptors for adhesive proteins on their surfaces; these help consolidation of the initial platelet aggregate to stop bleeding and start repair. When this protective action of platelets is exaggerated, a pathological situation arises. Abnormal platelet function is associated with thrombosis, atherosclerosis, and bleeding disorders. This book deals with the most important aspects of platelet signal transduction that have been revealed in the past few years. Emphasis is given to knowledge gained in the area of glycoprotein receptors or integrins that bind adhesive proteins and play a crucial role in thrombosis. One of these integrins also serves as a collagen receptor on platelets. Collagen and thrombin are primary activators at sites of vascular injury. The main thrombin receptor recently was recognized as a seven trans-membrane domain receptor, and attention is now focused on the development of thrombin receptor antagonists that might prove to be useful in treatment of thrombosis and restenosis. The formation and release of thromboxane A2 n activated platelets help to recruit additional platelets to the injury site; the receptor for thromboxane A2 is a newly discovered seven trans-membrane domain receptor that is also covered in this book. The coupling of platelet receptors to the effectors or second-messenger-producting enzymes is mostly through heterotrimeric and low molecular weight GTP-binding proteins, which have an important role in the stimulation or inhibition of platelet effectors. Two chapters deal with the role of GTP-binding proteins in human platelets. Several chapters are devoted to the effectors, including phospholipases C, A2, D, and phosphatidylinositol 3-kinase; the mobilization of Ca2+; and the formation of cAMP, cGMP, nitric oxide, and the role of the NA+/K+ exchanger. This is integrated with information on the activation of important protein kinases - that is, protein kinase C, Ca2+ -calmodulin-dependent protein kinases, cAMP and cGMP-dependent kinases, and tyrosine kinases - and on how these activities lead to changes in platelet cytoskeleton to cause shape change, aggregation, and secretion.
Book Synopsis Platelets and Megakaryocytes by : Jonathan M. Gibbins
Download or read book Platelets and Megakaryocytes written by Jonathan M. Gibbins and published by Humana Press. This book was released on 2018-08-29 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main aim of this fourth volume is to complement the first three volumes published in 2004 and 2012 by adding advanced methodologies and perspectives. Chapters guide readers through new techniques into the study of platelets and megakaryocytes, including new imaging approaches, new methods for platelet production in vitro, and systems biology approaches. Written in the highly successful Methods in Molecular Biology series format, methods chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and vital tips on troubleshooting or avoiding known pitfalls. Authoritative and up-to-date, Platelets and Megakaryocytes: Volume 4, Additional Protocols and Perspectives adds a wealth of new expertise for the labs of scientists working in this key biological area of study.
Book Synopsis Platelets in Thrombotic and Non-Thrombotic Disorders by : Paolo Gresele
Download or read book Platelets in Thrombotic and Non-Thrombotic Disorders written by Paolo Gresele and published by Springer. This book was released on 2017-03-08 with total page 1445 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. More than a scientific resource, this is also an authoritative reference and guide to the diagnosis.
Book Synopsis Transfusion Medicine and Hemostasis by : Beth H. Shaz
Download or read book Transfusion Medicine and Hemostasis written by Beth H. Shaz and published by Newnes. This book was released on 2013-05-13 with total page 1014 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Transfusion Medicine and Hemostasis continues to be the only "pocket-size" quick reference for pathology residents and transfusion medicine fellows. It covers all topics in blood banking, transfusion medicine, and clinical and laboratory based coagulation. Short, focused chapters, organized by multiple hierarchical headings, are supplemented with up to 10 suggested reading citations. This single reference covers essentially all the topics required to meet the goals and objectives of a major program in transfusion medicine and clinical coagulation. New chapters in the coagulation testing section reflect the development of new tests available and their incorporation into clinical practice. Coverage includes essential updates on the importance of new cellular therapies, peripheral blood and bone marrow hematopoietic progenitor cells, as well as cord blood banking and regenerative medicine. The authors also examine advances in the understanding of molecular testing and pathogen reduction in two separate quality control chapters (one for blood centers and one for hospitals). Updated content covers new coagulation tests, cellular therapies, and quality control issues Easy to use, with focused, well-defined chapters in a standardized format throughout Offers quick "cross-reference" lists at the end of each chapter Includes lists of common abbreviations and indexes that cross reference diagnostic, clinical and therapeutic commonalities
Download or read book Platelets written by Alan D. Michelson and published by Elsevier. This book was released on 2011-08-29 with total page 1386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Platelets, Second Edition is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource. First edition won Best Book in Medical Science Award from the Association of American Publishers Contains fourteen new chapters on topics such as platelet genomics and proteomics, inhibition of platelet function by the endothelium, clinical tests of platelet function, real time in vivo imaging of platelets, and inherited thrombocytopenias A comprehensive full color reference comprising over 70 chapters, 1400 pages, and 16,000 references
Book Synopsis Mechanisms of Vascular Disease by : Robert Fitridge
Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
