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Modifications To Rna Polymerase Ii And Transcription Regulation In Herpes Simplex Virus Type 1 Infected Cells
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Book Synopsis Modifications to RNA Polymerase II and Transcription Regulation in Herpes Simplex Virus Type 1 Infected Cells by : Melissa Catherine Long
Download or read book Modifications to RNA Polymerase II and Transcription Regulation in Herpes Simplex Virus Type 1 Infected Cells written by Melissa Catherine Long and published by . This book was released on 1997 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modifications to RNA Polymerase II and Transcription Regulation in Herpes Simplex Virus Type 1 Infected Cells by :
Download or read book Modifications to RNA Polymerase II and Transcription Regulation in Herpes Simplex Virus Type 1 Infected Cells written by and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chromatin and Coactivators in Herpes Simplex Virus Type-1 Gene Regulation by : Sebla Bulent Kutluay
Download or read book Chromatin and Coactivators in Herpes Simplex Virus Type-1 Gene Regulation written by Sebla Bulent Kutluay and published by . This book was released on 2009 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Aberrant Phosphorylation of RNA Polymerase II During Herpes Simplex Type I Infection by : Kathryn Aileen Fraser
Download or read book The Aberrant Phosphorylation of RNA Polymerase II During Herpes Simplex Type I Infection written by Kathryn Aileen Fraser and published by . This book was released on 2007 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Book Synopsis Herpesvirus Transcription and Its Regulation by : Edward K. Wagner
Download or read book Herpesvirus Transcription and Its Regulation written by Edward K. Wagner and published by CRC Press. This book was released on 1991-01-03 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: The herpesviruses are arguably the most successful animal viruses, and nearly 100 distinct examples have been described. Currently, a number of active research groups throughout the world are making important contributions concerning the precise molecular nature of herpesvirus transcripts, the proteins they encode, and the viral and host factors responsible for the control of their expression. Herpesvirus Transcription and Its Regulation describes current programs in a number of leading laboratories and emphasizes the research regarding herpes simplex virus type 1, due primarily to its importance in herpesvirus research. However, several other well-characterized herpesviruses are also described. New research areas covered include molecular analyses of herpesvirus regulatory functions and herpes simplex virus latent phase gene expression. This volume is a timely guide for established research workers and advanced students currently engaged in research on animal virology, viral pathogenesis, and virus-host interactions.
Book Synopsis The Creation of an in Vitro Transcription System for Herpes Simplex Virus Type 1 by : Caroline N. Niederman
Download or read book The Creation of an in Vitro Transcription System for Herpes Simplex Virus Type 1 written by Caroline N. Niederman and published by . This book was released on 1982 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis In Vitro Transcription of Herpes Simplex Virus Genes by : Thomas W. Beck
Download or read book In Vitro Transcription of Herpes Simplex Virus Genes written by Thomas W. Beck and published by . This book was released on 1982 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Searching for Rnap Ii on the Compact Hsv-1 Genome by : Mark Ou
Download or read book Searching for Rnap Ii on the Compact Hsv-1 Genome written by Mark Ou and published by . This book was released on 2014 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt: Herpes Simplex Virus type-1 (HSV-1) is one of the eight human herpes viruses and it causes cold sores in infected individuals. HSV-1 infects epithelial cells, then travels to the trigeminal ganglion through retrograde transport in the peripheral neurons. During the initial lytic infection in the epithelial host cell, HSV-1 hijacks cellular RNA polymerase II (RNAP II) to sites of viral transcription for viral gene expression. Previous studies have found an intermediately phosphorylated form of RNAP II in HSV-1 infected cells starting approximately 5 hours post infection. This intermediately phosphorylated form of RNAP II appeared to be different from the usual hypo- and hyperphosphorylated forms of RNAP II normally found in uninfected cells. Subsequent studies had revealed that at late time in HSV-1 infection, elongating RNAP II, marked by phosphorylated serine 2 residues at the C-terminal domain (CTD), was degraded in infected cells, and this degradation could be prevented by inhibiting transcription. The loss of elongating RNAP II was in contrast to the high levels of viral transcription that occurs during late phase of HSV-1 replication cycle. We have previously proposed a collision model where the compact viral genome becomes overburdened by the high transcriptional activities at late time in HSV-1 infection, leading to arrested RNAP II complexes that then in turn, trigger a proteasome-mediated proteolysis of the polymerase to resolve stalled transcription. In this body of work, we first attempted to determine the if HSV-1 transcription is more similar to cellular transcription in that it requires phosphoserine-2 form of RNAP II and found that when we inhibited cdk9, the kinase responsible for phosphorylating serine 2 residues of the RNAP II CTD, viral transcription was also inhibited. Viral yield under cdk9 inhibition was also dramatically reduced, supporting the idea that like cellular transcription, HSV-1 transcription requires phosphoserine-2 form of RNAP II. We also attempted to substantiate our RNAP II collision model by assessing RNAP II occupancy on the HSV-1 genome using chromatin immunoprecipitation (ChIP) quantitative polymerase chain reaction (qPCR) analysis. In our ChIP qPCR analysis of an Early HSV-1 gene cluster, we found that though ChIP signals from one of the antibodies were consistent with known expression patterns of the genes, we were unable to validate the results with phosphoform-specific ChIP results due to the high noise levels of these phosphoform-specific antibodies. When analyzing a Late HSV-1 gene cluster, we were unable to achieve satisfactory signal-to-noise ratios regardless of the antibody used. Therefore we were unsuccessful to support or refute our collision model at this time. Lastly, we investigated a possible link between HSV-1 induced RNAP II degradation and the cellular transcription-coupled nucleotide excision repair (TC-NER) pathway by examining the role of a general transcription factor TFIIS, a factor known to stimulate transcription after RNAP II becomes stalled, in HSV-1 transcription. Our initial immunofluorescence studies had shown that one of the isoforms of TFIIS (TCEA2) appeared to re-localize to HSV-1 transcription replicative compartments in infected cells. Subsequent confocal microscopy co-location studies however, showed a rather inconsistent localization patterns among the isoforms of TFIIS. When attempting to perform functional knock-down experiments of each of the TFIIS isoforms, we found that the antibodies we were using exhibited cross-reactivity to unknown antigens in Western blot analysis. More importantly, these antibodies failed to recognize FLAG-tagged TFIIS transiently expressed in HeLa cells, thereby overturning our initial re-localization results. At this time, we do not have evidence that support a functional involvement of TFIIS in HSV-1 transcription. We believe that further experimentation would be required to support our colliding RNAP II model during HSV-1 lytic infection.
Book Synopsis The Regulation of Latent Transcription in Wild-type and Recombinant Herpes Simplex Viruses by : Anthony Thomas Dobson
Download or read book The Regulation of Latent Transcription in Wild-type and Recombinant Herpes Simplex Viruses written by Anthony Thomas Dobson and published by . This book was released on 1993 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Mechanism of Interferon Action on Herpes Simplex Virus Type 1 Replication by : Pasquale Raniero De Stasio
Download or read book The Mechanism of Interferon Action on Herpes Simplex Virus Type 1 Replication written by Pasquale Raniero De Stasio and published by . This book was released on 1989 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies on the Structure, Function, and Regulation of Expression of the Latency-associated Transcript of Herpes Simplex Virus Type 1 by : Michael James Farrell
Download or read book Studies on the Structure, Function, and Regulation of Expression of the Latency-associated Transcript of Herpes Simplex Virus Type 1 written by Michael James Farrell and published by . This book was released on 1993 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis A Purification Scheme for Isolating RNA Polymerase II from Rabbit Liver Tissue and Its Role in Studies of Transcriptional Control During Herpes Simplex Virus Type One Infections by : Margaret J. Schoeller
Download or read book A Purification Scheme for Isolating RNA Polymerase II from Rabbit Liver Tissue and Its Role in Studies of Transcriptional Control During Herpes Simplex Virus Type One Infections written by Margaret J. Schoeller and published by . This book was released on 1982 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Regulation and Export of ICP27 During Herpes Simplex Virus Type-1 Lytic Infection by : Anna Karin Strain
Download or read book Regulation and Export of ICP27 During Herpes Simplex Virus Type-1 Lytic Infection written by Anna Karin Strain and published by . This book was released on 2007 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Epstein-Barr Virus by : M. A. Epstein
Download or read book The Epstein-Barr Virus written by M. A. Epstein and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Epstein-Barr virus was discovered 15 years ago. Since that time an immense body of information has been accumu lated on this agent which has come to assume great signifi cance in many different fields of biological science. Thus, the virus has very special relevance in human medicine and oncology, in tumor virology, in immunology, and in mole cular virology, since it is the cause of infectious mononu cleosis and also the first human cancer virus, etiologically related to endemic Burkitt's lymphoma and probably to nasopharyngeal carcinoma. In addition, continuous human lymphoid cell lines initiated and maintained by the transform ing function of the virus genome provide a laboratory tool with wide and ever-growing applications. Innumerable papers on the Epstein-Barr virus have ap peared over recent years and reports of work with this agent now constitute a veritable flood. The present book provides the first and only comprehensive, authoritative over-view of all aspects of the virus by authors who have been the original and major contributors in their particular disciplines. A complete and up-to-date survey of this unique and important agent is thus provided which should be of great interest to experts, teachers, and students engaged in cancer research, virology, immunology, molecular biology, epide miology, and cell culture. Where topics have been dealt with from more than one of these viewpoints, some inevitable overlap and duplication has resulted; although this has been kept to a minimum, it has been retained in some places because of positive usefulness.
Book Synopsis Regulation of Translation During Herpes Simplex Virus 1 Infection by : Kevin Francis Bryant
Download or read book Regulation of Translation During Herpes Simplex Virus 1 Infection written by Kevin Francis Bryant and published by . This book was released on 2006 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: In an effort to better understand the regulation of viral and cellular gene expression during HSV-1 infection, I examined several mechanisms employed by the virus to regulate translation. I described an element in the 5' leader of the pol transcript that was necessary and sufficient to inhibit translation in vitro and in transfected cells. This inhibitory element was characterized by RNase structure mapping and mutagenic analyses. Deleting this element from HSV-1 resulted in an increase in the translation of Pol and also resulted in a replication defect relative to a control virus with wild type pol sequence, indicating the importance of this inhibitory element for viral replication.
Book Synopsis Fields Virology: Emerging Viruses by : Peter M. Howley
Download or read book Fields Virology: Emerging Viruses written by Peter M. Howley and published by Lippincott Williams & Wilkins. This book was released on 2020-02-11 with total page 2597 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in four convenient volumes, Field’s Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families. This volume of Field’s Virology: Emerging Viruses, 7th Edition covers recent changes in emerging viruses, providing new or extensively revised chapters that reflect these advances in this dynamic field.