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Misbehaving Proteins
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Book Synopsis Misbehaving Proteins by : Regina Murphy
Download or read book Misbehaving Proteins written by Regina Murphy and published by Springer Science & Business Media. This book was released on 2007-10-12 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides an up-to-date collection of theoretical and experimental studies into protein folding, misfolding, aggregation, and stability. Additionally, issues faced during the development of protein products are illustrated. It contains an introductory chapter for readers new to the protein folding field. The book provides a thorough and clear discussion of computational approaches to understanding and modeling protein aggregation.
Book Synopsis Aggregation of Therapeutic Proteins by : Wei Wang
Download or read book Aggregation of Therapeutic Proteins written by Wei Wang and published by John Wiley & Sons. This book was released on 2010-12-28 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives pharmaceutical scientists an up-to-date resource on protein aggregation and its consequences, and available methods to control or slow down the aggregation process. While significant progress has been made in the past decade, the current understanding of protein aggregation and its consequences is still immature. Prevention or even moderate inhibition of protein aggregation has been mostly experimental. The knowledge in this book can greatly help pharmaceutical scientists in the development of therapeutic proteins, and also instigate further scientific investigations in this area. This book fills such a need by providing an overview on the causes, consequences, characterization, and control of the aggregation of therapeutic proteins.
Book Synopsis Proteins in Solution and at Interfaces by : Juan M. Ruso
Download or read book Proteins in Solution and at Interfaces written by Juan M. Ruso and published by John Wiley & Sons. This book was released on 2013-01-31 with total page 823 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explores new applications emerging from our latest understanding of proteins in solution and at interfaces Proteins in solution and at interfaces increasingly serve as the starting point for exciting new applications, from biomimetic materials to nanoparticle patterning. This book surveys the state of the science in the field, offering investigators a current understanding of the characteristics of proteins in solution and at interfaces as well as the techniques used to study these characteristics. Moreover, the authors explore many of the new and emerging applications that have resulted from the most recent studies. Topics include protein and protein aggregate structure; computational and experimental techniques to study protein structure, aggregation, and adsorption; proteins in non-standard conditions; and applications in biotechnology. Proteins in Solution and at Interfaces is divided into two parts: Part One introduces concepts as well as theoretical and experimental techniques that are used to study protein systems, including X-ray crystallography, nuclear magnetic resonance, small angle scattering, and spectroscopic methods Part Two examines current and emerging applications, including nanomaterials, natural fibrous proteins, and biomolecular thermodynamics The book's twenty-three chapters have been contributed by leading experts in the field. These contributions are based on a thorough review of the latest peer-reviewed findings as well as the authors' own research experience. Chapters begin with a discussion of core concepts and then gradually build in complexity, concluding with a forecast of future developments. Readers will not only gain a current understanding of proteins in solution and at interfaces, but also will discover how theoretical and technical developments in the field can be translated into new applications in material design, genetic engineering, personalized medicine, drug delivery, biosensors, and biotechnology.
Book Synopsis Protein Chaperones and Protection from Neurodegenerative Diseases by : Stephan N. Witt
Download or read book Protein Chaperones and Protection from Neurodegenerative Diseases written by Stephan N. Witt and published by John Wiley & Sons. This book was released on 2011-09-09 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: How protein chaperones protect cells from neurodegenerative diseases Including contributions from leading experts, Protein Chaperones and Protection from Neurodegenerative Diseases provides an in-depth exploration of how protein chaperones are involved in shielding cells from toxic aggregated or misfolded protein states that cause ALS, Parkinson's, and related diseases. Examining how different protein chaperones ameliorate the toxicity of proteins that are known to cause neurodegenerative damage, the book addresses both research and clinical perspectives on chaperone and anti-chaperone properties. The intersection of molecular chaperones and neurodegeneration is an intensely studied area, partly because of the potential for manipulating the expression of molecular chaperones to thwart the progression of debilitating diseases, and partly because of the ever-aging global population. Discussing the potential to harness the power of protein chaperones, and future directions for research, discovery, and therapeutics, this book is essential reading for scientists working in the fields of biochemistry, molecular medicine, pharmacology and drug discovery, biotechnology and pharmaceutical companies, advanced students, and anyone interested in this cutting-edge topic.
Book Synopsis Analysis of Aggregates and Particles in Protein Pharmaceuticals by : Hanns-Christian Mahler
Download or read book Analysis of Aggregates and Particles in Protein Pharmaceuticals written by Hanns-Christian Mahler and published by John Wiley & Sons. This book was released on 2012-01-24 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes how to address the analysis of aggregates and particles in protein pharmaceuticals, provides a comprehensive overview of current methods and integrated approaches used to quantify and characterize aggregates and particles, and discusses regulatory requirements. Analytical methods covered in the book include separation, light scattering, microscopy, and spectroscopy.
Book Synopsis Protein Misfolding Diseases by : Marina Ramirez-Alvarado
Download or read book Protein Misfolding Diseases written by Marina Ramirez-Alvarado and published by John Wiley & Sons. This book was released on 2010-12-01 with total page 1311 pages. Available in PDF, EPUB and Kindle. Book excerpt: An increasingly aging population will add to the number of individuals suffering from amyloid. Protein Misfolding Diseases provides a systematic overview of the current and emerging therapies for these types of protein misfolding diseases, including Alzheimer's, Parkinson's, and Mad Cow. The book emphasizes therapeutics in an amyloid disease context to help students, faculty, scientific researchers, and doctors working with protein misfolding diseases bridge the gap between basic science and pharmaceutical applications to protein misfolding disease.
Book Synopsis Biophysics for Therapeutic Protein Development by : Linda O. Narhi
Download or read book Biophysics for Therapeutic Protein Development written by Linda O. Narhi and published by Springer Science & Business Media. This book was released on 2013-02-26 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book can be used to provide insight into this important application of biophysics for those who are planning a career in protein therapeutic development, and for those outside this area who are interested in understanding it better. The initial chapters describe the underlying theory, and strengths and weaknesses of the different techniques commonly used during therapeutic development. The majority of the chapters discuss the applications of these techniques, including case studies, across the product lifecycle from early discovery, where the focus is on identifying targets, and screening for potential drug product candidates, through expression and purification, large scale production, formulation development, lot-to-lot comparability studies, and commercial support including investigations.
Book Synopsis Parkinson's Disease by : Richard Nass
Download or read book Parkinson's Disease written by Richard Nass and published by Elsevier. This book was released on 2011-04-28 with total page 687 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson’s disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of research, the origin of the pathogenesis and the molecular determinants involved in the disorder has remained elusive. Confounding this issue is the lack of experimental models that completely recapitulate the disease state. The identification of a number of genes thought to play a role in the cell death, and development of both toxin and genetic models to explore the function of the genes both in unaffected and diseased cells are now providing new insights into the molecular basis of the neurodegeneration, as well as therapeutic approaches. In this reference, we will describe the advances and the advantages that various invertebrates, cell culture, rodents, and mammals provide in the identification of the molecular components and mechanisms involved in the cell death, and outline the opportunities that these systems provide in drug discovery. Comprehensive and critical assessment of the utility of various model systems to identify the molecular components and pathways involved in Parkinson’s disease Describes the power of toxin and genetic models to identify novel therapeutic targets and compounds that can be used in PD Current overviews of current status of PD research and discovery from bench-to-bedside Provides novel insights and views on where the future of PD research may lead Provides a powerful teaching tool and template to explore the utility of model systems to identify molecular pathways, molecular targets, and therapeutics that are applicable to a variety of neurological diseases
Book Synopsis Protein Transport into the Endoplasmic Reticulum by : Richard Zimmermann
Download or read book Protein Transport into the Endoplasmic Reticulum written by Richard Zimmermann and published by CRC Press. This book was released on 2009-08-31 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein transport into the endoplasmic reticulum (ER) is just one aspect of the general cell biology topic of intracellular protein sorting. This larger picture also includes protein transport into other organelles of the eukaryotic cell (chloroplasts, mitochondria, nucleus, peroxisomes), protein export from bacteria, vesicular transport that deliv
Book Synopsis Proteomics in Foods by : Fidel Toldrá
Download or read book Proteomics in Foods written by Fidel Toldrá and published by Springer Science & Business Media. This book was released on 2012-12-16 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: Food proteomics is one of the most dynamic and fast-developing areas in food science. The goal of this book is to be a reference guide on the principles and the current and future potential applications of proteomics in food science and technology. More specifically, the book will discuss recent developments and the expected trends of the near future in food proteomics. The book will be divided into two parts. The first part (7 chapters) will focus on the basic principles for proteomics, e.g., sample preparation, such as extraction and separation techniques, analytical instrumentation currently in use, and available databases for peptide and protein identification. The second part of the book (26 chapters) will focus on applications in foods. It will deal with quality issues related to post-mortem processes in animal foods and quality traits for all foods in general, as well as the identification of bioactive peptides and proteins, which are very important from the nutritional point of view. Furthermore, consumers are now extremely susceptible to food safety issues, and proteomics can provide reassurance with different safety aspects, such as food authenticity, detection of animal species in the food, and identification of food allergens. All of these issues will be covered in this book. It is also worth noting that both editors are internationally recognized experts in the field of food science, and both have edited numerous food science books and handbooks.
Book Synopsis Biodrug Delivery Systems by : Mariko Morishita
Download or read book Biodrug Delivery Systems written by Mariko Morishita and published by CRC Press. This book was released on 2016-04-19 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development presents the work of an international group of leading experts in drug development and biopharmaceutical science who discuss the latest advances in biodrug delivery systems and associated techniques. The book discusses components of successful formulation, delivery, and p
Book Synopsis Textbook of Pathology by : V. Krishna
Download or read book Textbook of Pathology written by V. Krishna and published by Orient Blackswan. This book was released on 2004-10 with total page 1346 pages. Available in PDF, EPUB and Kindle. Book excerpt: " This Book Explains The Basis Of Disease In Very Simple Terms, Using Many Comparisons From Real Life That Make It Easier To Understand The Disease Process. " Clinical Aspects Are Highlighted In Blue Screen Box. " Morphologic Aspects Are Highlighted The Form Of Blue Text." The Book Has Questions And Summaries That Make The Book Examination Oriented. " The Introduction To Systemic Pathology Section Is Special Since It Reduces The Need For The Student To Learn Things By Rote. The Logical Explanations Make It Easy For The Student To Understand And Approach The Subject. It Also Lists Out All The Necessary Definitions" It Has 56 Colour Pages Showing Colour Slides Of Various Disease Presentations." The Book Is Illustrated With Simple Line Drawings And Half Tones. " Real Clinical Case-Histories Are Presented" Clinico-Pathologic Algorithms Are Also Provided.
Book Synopsis Essential Biochemistry by : Charlotte W. Pratt
Download or read book Essential Biochemistry written by Charlotte W. Pratt and published by John Wiley & Sons. This book was released on 2023-08-25 with total page 755 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential Biochemistry, 5th Edition is comprised of biology, pre-med and allied health topics and presents a broad, but not overwhelming, base of biochemical coverage that focuses on the chemistry behind the biology. This revised edition relates the chemical concepts that scaffold the biology of biochemistry, providing practical knowledge as well as many problem-solving opportunities to hone skills. Key Concepts and Concept Review features help students to identify and review important takeaways in each section.
Download or read book Brain Storms written by Jon Palfreman and published by Macmillan + ORM. This book was released on 2015-09-15 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Top 10 Science Book of Fall 2015 - Publishers Weekly A star science journalist with Parkinson's reveals the inner workings of this perplexing disease Seven million people worldwide suffer from Parkinson's, and doctors, researchers, and patients continue to hunt for a cure. In Brain Storms, the award-winning journalist Jon Palfreman tells their story, a story that became his own when he was diagnosed with the debilitating illness. Palfreman chronicles how scientists have worked to crack the mystery of what was once called the shaking palsy, from the earliest clinical descriptions of tremors, gait freezing, and micrographia to the cutting edge of neuroscience, and charts the victories and setbacks of a massive international effort to best the disease. He takes us back to the late 1950s and the discovery of L-dopa. He delves into a number of other therapeutic approaches to this perplexing condition, from partial lobotomies and deep brain stimulation to neural grafting. And he shares inspiring stories of brave individuals living with Parkinson's, from a former professional ballet dancer who tricks her body to move freely again to a patient who cannot walk but astounds doctors when he is able to ride a bicycle with no trouble at all. With the baby boom generation beginning to retire and the population steadily aging, the race is on to discover a means to stop or reverse neurodegenerative conditions like Parkinson's and Alzheimer's. Brain Storms is the long-overdue, riveting, and deeply personal story of that race, and a passionate, insightful, and urgent look into the lives of those affected.
Book Synopsis Fragile Brain by : Scientific American Editors
Download or read book Fragile Brain written by Scientific American Editors and published by Scientific American. This book was released on 2017-04-24 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain disease such as Alzheimer’s and Parkinson’s affect an estimated one in six Americans and are increasing in incidence as the population ages. In this eBook, Fragile Brain: Neurodegenerative Diseases, we examine these and other conditions involving the damage and loss of neurons, including other forms of dementia, amyotrophic lateral sclerosis (ALS), chronic traumatic encephalopathy (CTE) and multiple sclerosis (MS). In “The Seeds of Dementia,” the authors discuss evidence of prions and protein misfolding as a universal culprit in Alzheimer’s and other conditions. Later, two articles by Gary Stix report on ongoing research into a cluster of Columbian families that experience early onset symptoms of Alzheimer’s. Researchers studying the genes and progression of disease in these families hope that results will reveal clues about its course and possible future remedies. In “New Movement in Parkinson’s,” the authors outline abnormal cell behavior and genetic mutations that may be behind the disease. In the study of ALS, Amy Yee examines research into why eye muscles tend to last longer than other motor neurons and what this may mean for treatment. Other pieces look at new lines of inquiry in MS, including why researchers are turning to gray matter, as opposed to white matter, as the starting point for the disease. We wrap up this collection with current preventative measures and treatments that target not only disease pathology, but also lifestyle changes as well. In “A Rare Success against Alzheimer’s,” the results of a large-scale Finnish study provide evidence that choices such as diet and exercise can help prevent cognitive decline. Although this news is far from a cure, forward movement against Alzheimer’s – and neurodegenerative disease in general – is reason for optimism. As research and evidence accumulates, we get ever closer to curative therapies that can halt the debilitation and death of neurons.
Book Synopsis Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals by : Feroz Jameel
Download or read book Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals written by Feroz Jameel and published by John Wiley & Sons. This book was released on 2010-07-13 with total page 986 pages. Available in PDF, EPUB and Kindle. Book excerpt: A real-world guide to the production and manufacturing of biopharmaceuticals While much has been written about the science of biopharmaceuticals, there is a need for practical, up-to-date information on key issues at all stages of developing and manufacturing commercially viable biopharmaceutical drug products. This book helps fill the gap in the field, examining all areas of biopharmaceuticals manufacturing, from development and formulation to production and packaging. Written by a group of experts from industry and academia, the book focuses on real-world methods for maintaining product integrity throughout the commercialization process, clearly explaining the fundamentals and essential pathways for all development stages. Coverage includes: Research and early development phase appropriate approaches for ensuring product stability Development of commercially viable formulations for liquid and lyophilized dosage forms Optimal storage, packaging, and shipping methods Case studies relating to therapeutic monoclonal antibodies, recombinant proteins, and plasma fractions Useful analysis of successful and failed products Formulation and Process Development Strategies for Manufacturing Biopharma-ceuticals is an essential resource for scientists and engineers in the pharmaceutical and biotech industries, for government and regulatory agencies, and for anyone with an interest in the latest developments in the field.
Book Synopsis Enzyme Biocatalysis by : Andrés Illanes
Download or read book Enzyme Biocatalysis written by Andrés Illanes and published by Springer Science & Business Media. This book was released on 2008-06-19 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book was written with the purpose of providing a sound basis for the design of enzymatic reactions based on kinetic principles, but also to give an updated vision of the potentials and limitations of biocatalysis, especially with respect to recent app- cations in processes of organic synthesis. The ?rst ?ve chapters are structured in the form of a textbook, going from the basic principles of enzyme structure and fu- tion to reactor design for homogeneous systems with soluble enzymes and hete- geneous systems with immobilized enzymes. The last chapter of the book is divided into six sections that represent illustrative case studies of biocatalytic processes of industrial relevance or potential, written by experts in the respective ?elds. We sincerely hope that this book will represent an element in the toolbox of gr- uate students in applied biology and chemical and biochemical engineering and also of undergraduate students with formal training in organic chemistry, biochemistry, thermodynamics and chemical reaction kinetics. Beyond that, the book pretends also to illustrate the potential of biocatalytic processes with case studies in the ?eld of organic synthesis, which we hope will be of interest for the academia and prof- sionals involved in R&D&I. If some of our young readers are encouraged to engage or persevere in their work in biocatalysis this will certainly be our more precious reward.
