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Microbial Proteomics Development In Technologies And Applications
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Book Synopsis Microbial Proteomics: Development in Technologies and Applications by : Divakar Sharma
Download or read book Microbial Proteomics: Development in Technologies and Applications written by Divakar Sharma and published by Bentham Science Publishers. This book was released on 2020-12-31 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume brings current knowledge of proteomics technologies and related developments with special reference to diseases caused by microbes. The editor has compiled chapters written by expert academicians which distill the information about useful methods in microbial proteomics for the benefit of readers. Chapters cover several methods used to investigate the microbial proteome and special topics such as antimicrobial drug resistance mechanisms, biomarker developments, post translational modifications. Key Features: -overview of several biochemical methods in proteomics -full-color, high quality images of the most frequent technologies and applications -concise, well organized, and didactic format -updates in basic applied information -bibliographic references -information on proteomics for tuberculosis treatment This reference work is intended for researchers seeking information on laboratory techniques applied in proteomics research and microbiology.
Book Synopsis Microbial Proteomics by : Divakar Sharma
Download or read book Microbial Proteomics written by Divakar Sharma and published by . This book was released on 2020-12-31 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume brings current knowledge of proteomics technologies and related developments with special reference to diseases caused by microbes. The editor has compiled chapters written by expert academicians which distill the information about useful methods in microbial proteomics for the benefit of readers. Chapters cover several methods used to investigate the microbial proteome and special topics such as antimicrobial drug resistance mechanisms, biomarker developments, post translational modifications.Key Features: -overview of several biochemical methods in proteomics-full-color, high quality images of the most frequent technologies and applications-concise, well organized, and didactic format-updates in basic applied information-bibliographic references-information on proteomics for tuberculosis treatmentThis reference work is intended for researchers seeking information on laboratory techniques applied in proteomics research and microbiology
Book Synopsis Proteomics of Microorganisms by : Michael Hecker
Download or read book Proteomics of Microorganisms written by Michael Hecker and published by Springer Science & Business Media. This book was released on 2003-07-18 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Starting with the discovery of penicillin, other antibiotics, and insulin, the quest for understanding and use of biological systems, i. e. , microorganisms and ani mal tissue, for the production of value products has lead to a dramatic increase in microbiological and bioengineering research in the last decades. Chemical and pharmaceutical companies quickly realized the huge commercial potential of these bioproducts and have spent millions of US dollars on R &D as well as on a build up of production facilities. Although there was limited knowledge about the cell's molecular mechanisms, which are the basis for the formation of the desired products, products from fermentation and extraction of biological matrices were a success right from the start. R&D projects within industry and academia on the continuous improvement of production processes, especially microbial productivity and down stream processing, allowed a fast return of investment and secured competitiveness in the market. Whereas the focus of such research projects was mainly on the discovery of strains with higher pro ductivity for the product of interest, e. g. , antibiotics, a lot of expertise and knowledge was generated allowing the use of biotechnological products and processes outside the pharmaceutical arena. The tremendous increase in knowl edge and the technological developments in microbial genetics where driven by these research projects and, accompanied with the advancements in nucleotide chemistry leading to a much better understanding of intracellular processes, served as a basis for modern molecular biology and recombinant biotech nology.
Book Synopsis Proteomics in Foods by : Fidel Toldrá
Download or read book Proteomics in Foods written by Fidel Toldrá and published by Springer Science & Business Media. This book was released on 2012-12-16 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: Food proteomics is one of the most dynamic and fast-developing areas in food science. The goal of this book is to be a reference guide on the principles and the current and future potential applications of proteomics in food science and technology. More specifically, the book will discuss recent developments and the expected trends of the near future in food proteomics. The book will be divided into two parts. The first part (7 chapters) will focus on the basic principles for proteomics, e.g., sample preparation, such as extraction and separation techniques, analytical instrumentation currently in use, and available databases for peptide and protein identification. The second part of the book (26 chapters) will focus on applications in foods. It will deal with quality issues related to post-mortem processes in animal foods and quality traits for all foods in general, as well as the identification of bioactive peptides and proteins, which are very important from the nutritional point of view. Furthermore, consumers are now extremely susceptible to food safety issues, and proteomics can provide reassurance with different safety aspects, such as food authenticity, detection of animal species in the food, and identification of food allergens. All of these issues will be covered in this book. It is also worth noting that both editors are internationally recognized experts in the field of food science, and both have edited numerous food science books and handbooks.
Book Synopsis Microbial Proteomics by : Ian Humphery-Smith
Download or read book Microbial Proteomics written by Ian Humphery-Smith and published by John Wiley & Sons. This book was released on 2006-06-30 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover important lessons learned about whole organism biology via microbial proteomics This text provides an exhaustive analysis and presentation of current research in the field of microbial proteomics, with an emphasis on new developments and applications and future directions in research. The editors and authors show how and why the relative simplicity of microbes has made them attractive targets for extensive experimental manipulation in a quest for both improved disease prevention and treatment and an improved understanding of whole organism functional biology. In particular, the text demonstrates how microbial proteomic analyses can aid in drug discovery, including identification of new targets, novel diagnostic markers, and lead optimization. Each chapter is written by one or more leading experts in the field and carefully edited to ensure a consistent and thorough approach throughout. Methods, technologies, and tools associated with the most promising approaches are stressed. Key topics covered include: Microbial pathogenesis at the proteome level Whole cell modeling Structural proteomics and computational analysis Biomolecular interactions Physiological proteomics Metabolic reconstruction using proteomics data While presenting the practical utility of proteomics data, the text is also clear on the field's current limitations, pointing to areas where further investigation is needed. Offering a state-of-the-art perspective from internationally recognized experts, this text is ideally suited for researchers and students across the gamut of genomic sciences, including biochemistry, microbiology, molecular biology, genetics, biomedical and pharmaceutical sciences, biotechnology, and veterinary science.
Book Synopsis Proteomics Technologies and Applications by : Ibrokhim Y. Abdurakhmonov
Download or read book Proteomics Technologies and Applications written by Ibrokhim Y. Abdurakhmonov and published by BoD – Books on Demand. This book was released on 2019-09-25 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteomics Technologies and Applications reviews and describes the nature and application of molecules with proteins or peptides, and elucidates and predicts the possible molecular and physiological causes related to changing proteomic profiles. Chapters target various methods and tools available for analysis, detection, separation, quantification, and localization of cell proteomes of a biological system, which are helpful as biomarkers for various disease prognoses and diagnoses.
Book Synopsis The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology by : Fernando Cobo
Download or read book The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology written by Fernando Cobo and published by Academic Press. This book was released on 2018-08-03 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology presents the state-of the-art for MALDI-TOF mass spectrometry. It is a key reference defining how MALDI-TOF mass spectrometry is used in clinical settings as a diagnostic tool of microbial identification and characterization that is based on the detection of a mass of molecules. The book provides updated applications of MALDI-TOF techniques in clinical microbiology, presenting the latest information available on a technology that is now used for rapid microbial identification at relatively low cost, thus offering an alternative to conventional laboratory diagnosis and proteomic identification systems. Although the main use of the technology has, until now, been identification or typing of bacteria from a positive culture, applications in the field of virology, mycology, microbacteriology and resistances are opening up new opportunities. Presents updated applications of MALDI-TOF techniques in clinical microbiology Describes the use of mass spectrometry in the lab, the principles of the technology, preparation of samples, device calibration and maintenance, treatment of microorganisms, and quality control Presents key information for researchers, including possible uses of the technology, differences between devices, how to interpret results, and future applications Covers the topic in a systematic and comprehensive manner that is useful to both clinicians and researchers
Book Synopsis Food Proteomics by : Maria Lopez Pedrouso
Download or read book Food Proteomics written by Maria Lopez Pedrouso and published by Academic Press. This book was released on 2022-06-02 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Food Proteomics: Technological Advances, Current Applications and Future Perspectives addresses many of the food proteomic issues in the industry today. Food proteomics continues to be an emerging field, becoming increasingly important in product innovation, food safety, food quality and health. The book is divided into sections describing the role of proteomics in the field of food science, conceptual background methodological aspects, and bioinformatic tools employed in the field. The book describes proteomic studies collected from the most relevant animal and vegetables species in food production and discusses important food challenges from a proteomic point-of-view. This is an essential and practical reference that provides analytical tools to help introduce technical innovations in the food industry with the latest scientific information useful and accessible to new researchers in the field as well as advanced. Includes precise proteomic information on a specific category Provides proteomic studies of the most common vegetable and animal species Presents proteomic methodologies, including bioinformatics for effective analysis in food science Discusses food challenges such as allergens, authentication and food safety
Book Synopsis Proteomics of Microorganisms by : Michael Hecker
Download or read book Proteomics of Microorganisms written by Michael Hecker and published by Springer. This book was released on 2014-03-12 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Starting with the discovery of penicillin, other antibiotics, and insulin, the quest for understanding and use of biological systems, i. e. , microorganisms and ani mal tissue, for the production of value products has lead to a dramatic increase in microbiological and bioengineering research in the last decades. Chemical and pharmaceutical companies quickly realized the huge commercial potential of these bioproducts and have spent millions of US dollars on R &D as well as on a build up of production facilities. Although there was limited knowledge about the cell's molecular mechanisms, which are the basis for the formation of the desired products, products from fermentation and extraction of biological matrices were a success right from the start. R&D projects within industry and academia on the continuous improvement of production processes, especially microbial productivity and down stream processing, allowed a fast return of investment and secured competitiveness in the market. Whereas the focus of such research projects was mainly on the discovery of strains with higher pro ductivity for the product of interest, e. g. , antibiotics, a lot of expertise and knowledge was generated allowing the use of biotechnological products and processes outside the pharmaceutical arena. The tremendous increase in knowl edge and the technological developments in microbial genetics where driven by these research projects and, accompanied with the advancements in nucleotide chemistry leading to a much better understanding of intracellular processes, served as a basis for modern molecular biology and recombinant biotech nology.
Book Synopsis Mass Spectrometry-based Proteomics for Studying Microbial Physiology from Isolates to Communities by :
Download or read book Mass Spectrometry-based Proteomics for Studying Microbial Physiology from Isolates to Communities written by and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: With the advent of whole genome sequencing, a new era of biology was ushered in allowing for "systems-biology" approaches to characterizing microbial systems. The field of systems biology aims to catalogue and understand all of the biological components, their functions, and all their interactions in a living system as well as communities of living systems. Systems biology can be considered an attempt to measure all of the components of a living system and then produce a data-driven model of the system. This model can then be used to generate hypotheses about how the system will respond to perturbations, which can be tested experimentally. The first step in the process is the determination of a microbial genome. This process has, to a large extent, been fully developed, with hundreds of microbial genome sequences completed and hundreds more being characterized at a breathtaking pace. The developments of technologies to use this information and to further probe the functional components of microbes at a global level are currently being developed. The field of gene expression analysis at the transcript level is one example; it is now possible to simultaneously measure and compare the expression of thousands of mRNA products in a single experiment. The natural extension of these experiments is to simultaneously measure and compare the expression of all the proteins present in a microbial system. This is the field of proteomics. With the development of electrospray ionization, rapid tandem mass spectrometry and database-searching algorithms, mass spectrometry (MS) has become the leader in the attempts to decipher proteomes. This research effort is very young and many challenges still exist. The goal of the work described here was to build a state-of-the-art robust MSbased proteomics platform for the characterization of microbial proteomes from isolates to communities. The research presented here describes the successes and challenges of this objective. Proteome analyses of the metal-reducing bacteria Shewanella oneidensis and the metabolically versatile bacteria Rhodopseudomonas palustris are given as examples of the power of this technology to elucidate proteins important to different metabolic states at a global level. The analysis of microbial proteomes from isolates is only the first step of the challenge. In nature, microbial species do not act alone but are always found in mixtures with other species where their intricate interactions are critical for survival. These studies conclude with some of the first efforts to develop methodologies to measure proteomes of simple controlled mixtures of microbial species and then present the first attempt at measuring the proteome of a natural microbial community, a biofilm from an acid mine drainage system. This microbial system illustrates life at the extreme of nature where life not only exists but flourishes in very acidic conditions with high metal concentrations and high temperatures. The technologies developed through these studies were applied to the first deep characterization of a microbial community proteome, the deciphering of the expressed proteome of the acid mine drainage biofilm. The research presented here has led to development of a state-of-the-art robust proteome pipeline, which can now be applied to the proteome analysis of any microbial isolate for a sequenced species. The first steps have also been made toward developing methodologies to characterize microbial proteomes in their natural environments. These developments are key to integrating proteome technologies with genome and transcriptome technologies for global characterizations of microbial species at the system level. This will lead to understanding of microbial physiology from a global view where instead of analyzing one gene or protein at a time, hundreds of genes/proteins will be interrogated in microbial species as the adapt and survive in the environment.
Book Synopsis Evolution of Translational Omics by : Institute of Medicine
Download or read book Evolution of Translational Omics written by Institute of Medicine and published by National Academies Press. This book was released on 2012-09-13 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
Book Synopsis Microbial Biotechnology by : Taylor & Francis Group
Download or read book Microbial Biotechnology written by Taylor & Francis Group and published by Apple Academic Press. This book was released on 2021-03-31 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: "CRC Press, Taylor & Francis Group"--Cover.
Book Synopsis Genomics and Proteomics by : Devarajan Thangadurai
Download or read book Genomics and Proteomics written by Devarajan Thangadurai and published by CRC Press. This book was released on 2015-06-09 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides scope and knowledge on advanced techniques and its applications into the modern fields of biotechnology-genomics and proteomics. In this book, different genomics and proteomics technologies and principles are examined. The fundamental knowledge presented in this book opens up an entirely new way of approaching DNA chip technology,
Book Synopsis Sequencing Technologies in Microbial Food Safety and Quality by : Devarajan Thangardurai
Download or read book Sequencing Technologies in Microbial Food Safety and Quality written by Devarajan Thangardurai and published by CRC Press. This book was released on 2021-04-14 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular landscape for food safety analysis is rapidly revolutionizing because of high resolution and value added resulting analysis of next-generation sequencing (NGS) approaches. These modern sequencing technologies drive worldwide advancements in food safety and quality. Sequencing Technologies in Microbial Food Safety and Quality reviews several practices in that NGS contributes to foodborne pathogens functional characterization, management and control. This book focuses on potential uses of sequencing technologies in microbial food safety and quality and highlights present challenges in the food industry. Key Features: Application of whole genome sequencing technologies in disease diagnostics, surveillance, transmission, and outbreak investigation in food sector Impact of sequencing tools in the area of food microbiology Recent advances in genomic DNA sequencing of microbial species from single cells Microbial bioinformatics resources for food microbiology High-throughput insertion tracking by deep sequencing for the analysis of food pathogens This book includes contributions from experts who have manipulated sequencing tools in relation to microbial food safety and quality. Presenting comprehensive details about NGS approaches in food science, this book is an updated and reliable reference for food scientists, nutritionists, food product investigators to study and implement the sequencing technologies for developing quality and safe food. This book would also serve as informative resource for food industry officials, government researchers, food science or food nutrition students who seek comprehensive knowledge about the role of emerging sequencing technologies in revolutionizing the food industry.
Book Synopsis Applications of Genomics and Proteomics for Analysis of Bacterial Biological Warfare Agents by : Vito G. DelVecchio
Download or read book Applications of Genomics and Proteomics for Analysis of Bacterial Biological Warfare Agents written by Vito G. DelVecchio and published by IOS Press. This book was released on 2003 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Proteomics of Microbial Human Pathogens by : Nelson C. Soares
Download or read book Proteomics of Microbial Human Pathogens written by Nelson C. Soares and published by Frontiers Media SA. This book was released on 2017-01-17 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: According to the World Health Organization (WHO), in 2012 infectious diseases and related conditions account for more than 70% of premature deaths across 22 African countries and estimated 450 000 people worldwide developed multi-drug resistant tuberculosis. This alarming situation, of great public health concern, calls for the urgent development of novel and efficient responding strategies. The employment of important research platforms, such as genomics and proteomics, has contributed significant insight into the mechanisms underlying microbial infection and microbe-host interaction. In this Frontiers Research Topic, we aim to produce a timely and pertinent discussion regarding the current status of “Proteomics of microbial Human pathogens” and the role of proteomics in combating the challenges posed by microbial infection and indeed acquired anti-microbial resistance. As the field of proteomics progressed from 2-DE gel based approaches to modern LC-MS/MS based workflows, remarkable advances have been reported in terms of data quantity and quality. Given the immediate and enormous advantages that high resolution and accurate mass spectrometers have brought to the field, proteomics has now evolved into a robust platform capable of generating large amounts of comprehensive data comparable to that reported previously in genomics studies. For example, detection of the complete yeast proteome has been reported and other small proteomes, such as those of bacteria, are within reach. Mass spectrometry-based proteomics has become an essential tool for biologists and biochemists, and is now considered by many as an essential component of modern structural biology. Additionally, the introduction of high-resolution mass spectrometers has driven the development of various different strategies aimed at accurate quantification of absolute and relative amount of protein(s) of interest. Emerging targeted mass spectrometry methodologies such as; Selected Reaction Monitoring (SRM), Parallel Reaction Monitoring (PRM) and SWATH, are perhaps the latest breakthrough within the proteomics community. Indeed, through a label free approach, targeted mass spectrometry offers an unequalled capability to characterize and quantify a specific set of proteins reproducibility, in any biological sample. Usefully, Aebersold and colleagues have recently generated and validated a number of assays to quantify 97% of the 4,012 annotated Mycobacterium tuberculosis (Mtb) proteins by SRM. As such, the Mtb Proteome library represents a valuable experimental resource that will undoubtedly bring new insight to the complex life cycle of Mtb. Finally, as reviewed recently in Frontiers Research Topic, mass spectrometry-based proteomics has had a tremendous impact on our current understanding of post translational modification (PTM) in bacteria including the key role of PTMs during interaction of pathogenic bacteria and host interactions. We believe that our understanding of microbial Human pathogens has benefited enormously from both 2-DE gel and modern LC-MS/MS based proteomics. It is our wish to produce an integrated discussion surrounding this topic to highlight the existing synergy between these research fields. We envisage this Research Topic as a window to expert opinions and perspectives on the realistic practicalities of proteomics as an important tool to address healthcare problems caused by microbial pathogens.
Book Synopsis Microbial Bioremediation and Multiomics Technologies for Sustainable Development by : Fuad Ameen
Download or read book Microbial Bioremediation and Multiomics Technologies for Sustainable Development written by Fuad Ameen and published by Royal Society of Chemistry. This book was released on 2024-08-02 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: The steadily increasing presence of both natural and anthropogenic pollutants in our environment poses a considerable challenge, given the recalcitrance of many of these pollutants. Microbial bioremediation presents a promising and sustainable strategy that harnesses a diverse array of microorganisms, operating either concurrently or sequentially, to eliminate or mitigate the presence of pollutants within the environment. Recent years have witnessed the application of multiomics techniques to the study of biodegradation and bioremediation, yielding an abundance of novel data that enrich our comprehension of pivotal pathways and offer fresh perspectives on the adaptability of organisms amidst shifting environmental conditions. This book brings together recent progress in microbial bioremediation, emphasizing the emerging field of multiomics technologies. It serves as a valuable reference for microbiologists exploring multiomics applications and environmental scientists seeking innovative remediation solutions.
