Methods Of Therapeutic Drug Monitoring Including Pharmacogenetics

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Methods of Therapeutic Drug Monitoring Including Pharmacogenetics

Author : Georg Hempel
Publisher : Elsevier
ISBN 13 : 0444640673
Total Pages : 380 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Methods of Therapeutic Drug Monitoring Including Pharmacogenetics by : Georg Hempel

Download or read book Methods of Therapeutic Drug Monitoring Including Pharmacogenetics written by Georg Hempel and published by Elsevier. This book was released on 2019-10-17 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods of Therapeutic Drug Monitoring Including Pharmacogenetics, Second Edition, Volume Seven in the Handbook of Analytical Separations series, covers all aspects of drug monitoring, including laboratory work, pharmacokinetic analysis and clinical aspects, thus enabling readers from different fields to understand the whole process of therapeutic drug monitoring and how to avoid common pitfalls. The book contains analytical techniques for the quantification of drugs, along with pharmacogenetic and pharmacogenomic methods. Also included are updates on sample preparation, including dried blood spot technology and microextraction methods. In addition, the book includes new drugs, such as tyrosine kinase inhibitors and the monitoring of immunosuppressant drugs. Presents a unique, interdisciplinary approach that appeals to a wide range of users Written by authors from international labs, providing a global perspective that can be applied in various regulatory environments Features additional therapeutic drugs to reflect the rising number of immunocompromised patients Includes a new mass spectroscopic methods chapter to capture the frequent use in TDM and the improved availability of LC-MS across laboratories

Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology

Author : Seth Kwabena Amponsah
Publisher : Springer Nature
ISBN 13 : 3031123980
Total Pages : 384 pages
Book Rating : 4.0/5 (311 download)

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Book Synopsis Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology by : Seth Kwabena Amponsah

Download or read book Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology written by Seth Kwabena Amponsah and published by Springer Nature. This book was released on 2022-10-25 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives an overview of therapeutic drug monitoring (TDM) and its clinical application. It also highlights recent advances in toxicological studies, as they relate to therapeutic drug monitoring. This is one of the few books available on the market that covers TDM. Therapeutic drug monitoring (TDM) is a clinical decision-making tool that enables dosage regimen adjustments based on clinical and laboratory measurements. TDM not only involves the measuring of drug concentrations but also interpretation of the results. There is a strong correlation between drug concentrations in body fluids and outcome than between dose and outcome. The chapters include coverage of analytical techniques, pharmacokinetics, therapeutic indices, artificial intelligence and recent advances in toxicological studies. The book fills a gap in published literature and provides reliable information on; Analytical techniques in TDM and clinical toxicology TDM and pharmacokinetic studies TDM of drugs with narrow therapeutic indices Artificial intelligence in TDM and clinical toxicology Future directions and challenges

Therapeutic Drug Monitoring

Author : Amitava Dasgupta
Publisher : Academic Press
ISBN 13 : 0123854687
Total Pages : 469 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Therapeutic Drug Monitoring by : Amitava Dasgupta

Download or read book Therapeutic Drug Monitoring written by Amitava Dasgupta and published by Academic Press. This book was released on 2012-06-07 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapeutic Drug Monitoring: Newer Drugs and Biomarkers features timely topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This reference also discusses the limitations of current commercially available immunoassays for therapeutic monitoring. It presents new and sophisticated techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs. Written by leading international experts and geared toward clinical pathologists, toxicologists, clinical chemists, laboratory professionals and physicians, this book is an essential resource on the current practice of therapeutic drug monitoring in improving patient safety. Includes both the technical and clinical issues associated with therapeutic drug monitoring Discusses the utility of therapeutic drug monitoring of newer drugs such as antiretroviral agents, anticonvulsants, antidepressants etc. Provides up-to-date information on issues in pharmacogenomics and personalized medicine with emphasis on therapy with warfarin, certain anticancer drugs and antidepressants Covers important content on the limitations of commercially available immunoassays (chemical tests) for therapeutic drug monitoring and additional analytical techniques

Analytical Methods for Therapeutic Drug Monitoring and Toxicology

Author : Q. Alan Xu
Publisher : John Wiley & Sons
ISBN 13 : 0470922796
Total Pages : 913 pages
Book Rating : 4.4/5 (79 download)

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Book Synopsis Analytical Methods for Therapeutic Drug Monitoring and Toxicology by : Q. Alan Xu

Download or read book Analytical Methods for Therapeutic Drug Monitoring and Toxicology written by Q. Alan Xu and published by John Wiley & Sons. This book was released on 2011-04-12 with total page 913 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compilation of summarized analytical methods designed to serve the needs of pharmacologists, toxicologists, and other allied health professionals involved the development, use, or monitoring of pharmaceuticals. The summaries are structured monographs on 511 different drug entities detailing 964 different analytical methods, providing the reader with a thorough description of method validation. These analytical methods include not only high performance liquid chromatography (HPLC), but also gas chromatography (GC), immunoassay, electrophoresis, ultra performance liquid chromatography (UPLC) coupled with UV (UPLC-UV) detection and mass spectrometry (UPLC-MS/MS). With more detailed and complete summaries than sketchy and abbreviated formats used in the other books, this book provides a thorough description of method validation and results, as well as the operating parameters.

Pharmacogenomics in Clinical Therapeutics

Author : Loralie J. Langman
Publisher : John Wiley & Sons
ISBN 13 : 1119959586
Total Pages : 400 pages
Book Rating : 4.1/5 (199 download)

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Book Synopsis Pharmacogenomics in Clinical Therapeutics by : Loralie J. Langman

Download or read book Pharmacogenomics in Clinical Therapeutics written by Loralie J. Langman and published by John Wiley & Sons. This book was released on 2012-01-09 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacogenomics is the basis of personalized medicine which will be the medicine of the future. Through both reducing the numbers of adverse drug reactions and improving the use of existing drugs in targeted populations, pharmacogenomics represents a real advance on traditional therapeutic drug monitoring. Pharmacogenomics in Clinical Therapeutics provides an introduction to the principles of pharmacogenomics before addressing the pharmacogenomic aspects of key therapeutic areas such as warfarin therapy, cancer chemotherapy, therapy with immunosuppressants, antiretroviral therapy, and psychoactive drugs. It also includes methods of pharmacogenomic testing and the pharmacogenomic aspects of drug–drug interactions. From a team of expert contributors, Pharmacogenomics in Clinical Therapeutics is a comprehensive overview of the current state of pharmacogenomics in pharmacotherapy for all clinicians, pharmacologists and clinical laboratory professionals. It is also a guide for practicing clinicians and health care professionals to the basic principles of pharmacogenomics, laboratory tests currently available to aid clinicians, and the future promise of this developing field.

Handbook of Drug Monitoring Methods

Author : Amitava Dasgupta
Publisher : Springer Science & Business Media
ISBN 13 : 1597450316
Total Pages : 441 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Handbook of Drug Monitoring Methods by : Amitava Dasgupta

Download or read book Handbook of Drug Monitoring Methods written by Amitava Dasgupta and published by Springer Science & Business Media. This book was released on 2007-10-05 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written in a handbook style with specific methods and tips on eliminating false positive and false negative results, this book is a practical guide to the detailed mechanisms of such occurrences.

Clinical Challenges in Therapeutic Drug Monitoring

Author : William Clarke
Publisher : Elsevier
ISBN 13 : 0128020520
Total Pages : 378 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Clinical Challenges in Therapeutic Drug Monitoring by : William Clarke

Download or read book Clinical Challenges in Therapeutic Drug Monitoring written by William Clarke and published by Elsevier. This book was released on 2016-05-17 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics focuses on critical issues in therapeutic drug monitoring including special requirements of therapeutic drug monitoring important to special populations (infants and children, pregnant women, elderly patients, and obese patients). The book also covers issues of free drug monitoring and common interferences in using immunoassays for therapeutic drug monitoring. This book is essential reading for any clinician, fellow, or trainee who wants to gain greater insight into the process of therapeutic drug monitoring for individual dosage adjustment and avoiding drug toxicity for certain drugs within a narrow therapeutic window. The book is written specifically for busy clinicians, fellows, and trainees who order therapeutic drug monitoring and need to get more familiar with testing methodologies, issues of interferences, and interpretation of results in certain patient populations. Offers busy clinicians, pathologists, and trainees a concise resource on the key aspects and critical issues in therapeutic drug monitoring Focuses on patient populations such as infants and children, pregnant women, elderly patients, and obese patients, who have special requirements in therapeutic drug monitoring Explores special topics in therapeutic drug monitoring including free drug monitoring and common immunoassay interference Explains how individual dosage adjustments can prevent drug toxicity for certain drugs within a narrow therapeutic window

Therapeutic drug monitoring

Author : Benjamin Gerson
Publisher :
ISBN 13 :
Total Pages : 231 pages
Book Rating : 4.:/5 (643 download)

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Book Synopsis Therapeutic drug monitoring by : Benjamin Gerson

Download or read book Therapeutic drug monitoring written by Benjamin Gerson and published by . This book was released on 1987 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Therapeutic Drug Monitoring Data

Author : Amitava Dasgupta
Publisher : Academic Press
ISBN 13 : 0128158506
Total Pages : 382 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Therapeutic Drug Monitoring Data by : Amitava Dasgupta

Download or read book Therapeutic Drug Monitoring Data written by Amitava Dasgupta and published by Academic Press. This book was released on 2019-09-14 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapeutic Drug Monitoring Data: A Concise Guide, Fourth Edition serves as a ready resource of information on commonly monitored drugs that will help readers make decisions relating to the monitoring and interpretation of results. It is an easy-to-read source of information on intended use, pharmacokinetics, therapeutic range, and toxic concentrations, as well as bioavailability, disposition, metabolism and the excretion of commonly monitored therapeutic drugs. This fully updated fourth edition includes sections on new anticonvulsants, anti-depressant and anti-HIV drugs, new drugs for advanced cancer treatment, and thoroughly updated chapters that address new pitfalls and problems in the lab. Serves as a ready resource of information for commonly monitored drugs Presents a useful, quick guide for those making decisions related to monitoring and interpretation of results Provides concise, easily digestible content for clinical laboratory scientists, toxicologists and clinicians

Pharmacogenomics in Precision Medicine

Author : Weimin Cai
Publisher : Springer Nature
ISBN 13 : 9811538956
Total Pages : 290 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Pharmacogenomics in Precision Medicine by : Weimin Cai

Download or read book Pharmacogenomics in Precision Medicine written by Weimin Cai and published by Springer Nature. This book was released on 2020-06-12 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an introduction to the principles of pharmacogenomics and precision medicine, followed by the pharmacogenomics aspects of major therapeutic areas such as cardiovascular disease, cancer, organ transplantation, psychiatry, infection, antithrombotic drugs. It also includes genotyping technology and therapeutic drug monitoring in Pharmacogenomics; ethical, Legal and Regulatory Issues; cost-effectiveness of pharmacogenetics-guided treatment; application of pharmacogenomics in drug discovery and development and clinical Implementation of Pharmacogenomics for Personalized Precision Medicine. The contributors of Pharmacogenomics in Precision Medicine come from a team of experts, including professors from academic institutions and practitioner from hospital. It will give an in-depth overview of the current state of pharmacogenomics in drug therapy for all health care professionals and graduate students in the era of precision medicine.

Therapeutic Drug Monitoring and Toxicology by Liquid Chromatography

Author : Steven H.Y. Wong
Publisher : Routledge
ISBN 13 : 135140847X
Total Pages : 521 pages
Book Rating : 4.3/5 (514 download)

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Book Synopsis Therapeutic Drug Monitoring and Toxicology by Liquid Chromatography by : Steven H.Y. Wong

Download or read book Therapeutic Drug Monitoring and Toxicology by Liquid Chromatography written by Steven H.Y. Wong and published by Routledge. This book was released on 2017-09-19 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important, new reference provides the first , up-to-date, and comprehensive treatmentof the various liquid chromatography (LC) instrumentation for Therapeutic DrugMonitoring (TDM) and toxicology drug assays and reviews the clinical pharmacologyof major classes of drugs and their LC analyses.Written by authoritative contributors who bring many years of personal laboratory/clinical experience to the book, this interdisciplinary work : presents the principlesof TDM, sampling techniques, and various instrumentation topics, including computerinterfacing, mass spectrometry, fluorescence , electrochemical detection, and bloodcollection devices . .. examines six primary classes of drugs, complete with recommendedLC procedures and emphasizing recently introduced drugs and their LC analyses. .. and documents medicolegal guidelines and laboratory management considerations,providing a contemporary assessment of today's laboratory needs.The only practical, current guide available on the subject, Therapeutic Drug Monitoringand Toxicology by Li([uid Chromatography belongs in the personal libraries of clinicaland analytical chemists and biochemists, clinical pharmacologists, clinical toxicologists,clinical pathologists, immunologists, liquid chromatographers, mass spectroscopists, laboratorydirectors, laboratory instrument manufacturers , and medical technologists. Thebook is also vital supplementary reading for advanced undergraduate and graduate-levelclinical chemistry, toxicology, clinical pathology, and liquid chromatography course.

Interpretations in Therapeutic Drug Monitoring

Author : Daniel M. Baer
Publisher :
ISBN 13 :
Total Pages : 418 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Interpretations in Therapeutic Drug Monitoring by : Daniel M. Baer

Download or read book Interpretations in Therapeutic Drug Monitoring written by Daniel M. Baer and published by . This book was released on 1981 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Applied Pharmacokinetics

Author : William E. Evans
Publisher : Applied Therapeutics, Incorporated
ISBN 13 :
Total Pages : 1236 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Applied Pharmacokinetics by : William E. Evans

Download or read book Applied Pharmacokinetics written by William E. Evans and published by Applied Therapeutics, Incorporated. This book was released on 1992 with total page 1236 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Third Edition of Applied Pharmacokinetics remains the gold standard by which all other clinical pharmacokinetics texts are measured. Written by leading pharmacokinetics researchers and practitioners, this book is the most advanced kinetics reference available. All chapters have been extensively updated or completely rewritten for this edition, and six new chapters have been added on pharmacodynamics, pharmacogenetics, pharmacokinetic considerations in the obese, dietary influences on drug disposition, zidovudine, and corticosteroids. Each chapter is tightly focused on the most important concepts and issues. Chapters on specific drugs are organized in a consistent format for quick, easy information retrieval. Major subheadings include Clinical Pharmacokinetics, Pharmacodynamics, Clinical Application of Pharmacokinetic Data, Analytical Methods, and Prospectus.

Applied Therapeutic Drug Monitoring

Author :
Publisher :
ISBN 13 :
Total Pages : 414 pages
Book Rating : 4.:/5 (311 download)

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Book Synopsis Applied Therapeutic Drug Monitoring by :

Download or read book Applied Therapeutic Drug Monitoring written by and published by . This book was released on 1982 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook of Analytical Therapeutic Drug Monitoring and Toxicology (1996)

Author : Steven H.Y. Wong
Publisher : CRC Press
ISBN 13 : 1351364278
Total Pages : 570 pages
Book Rating : 4.3/5 (513 download)

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Book Synopsis Handbook of Analytical Therapeutic Drug Monitoring and Toxicology (1996) by : Steven H.Y. Wong

Download or read book Handbook of Analytical Therapeutic Drug Monitoring and Toxicology (1996) written by Steven H.Y. Wong and published by CRC Press. This book was released on 2017-11-22 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adapting modern advances in analytical techniques to daily laboratory practices challenges many toxicologists, clinical laboratories, and pharmaceutical scientists. The Handbook of Analytical Therapeutic Drug Monitoring and Toxicology helps you keep abreast of the innovative changes that can make your laboratory - and the studies undertaken in it - a success. This volume simplifies your search for appropriate techniques, describes recent contributions from leading investigators, and provides valuable evaluations and advice.

Textbook of Personalized Medicine

Author : Kewal K. Jain
Publisher : Humana Press
ISBN 13 : 1493925539
Total Pages : 762 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Textbook of Personalized Medicine by : Kewal K. Jain

Download or read book Textbook of Personalized Medicine written by Kewal K. Jain and published by Humana Press. This book was released on 2015-03-17 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in the technology used in personalized medicine and increased applications for clinical use have created a need for this expansion and revision of Kewal K. Jain’s Textbook of Personalized Medicine. As the first definitive work on this topic, this book reviews the fundamentals and development of personalized medicine and subsequent adoptions of the concepts by the biopharmaceutical industry and the medical profession. It also discusses examples of applications in key therapeutic areas, as well as ethical and regulatory issues, providing a concise and comprehensive source of reference for those involved in healthcare management, planning and politics. Algorithms are included as a guide to those involved in the management of important diseases where decision-making is involved due to the multiple choices available. Textbook of Personalized Medicine, Second Edition will serve as a convenient source of information for physicians, scientists, decision makers in the biopharmaceutical and healthcare industries and interested members of the public.

Advances in Chromatographic Techniques for Therapeutic Drug Monitoring

Author : Amitava Dasgupta
Publisher : CRC Press
ISBN 13 : 9781420067583
Total Pages : 0 pages
Book Rating : 4.0/5 (675 download)

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Book Synopsis Advances in Chromatographic Techniques for Therapeutic Drug Monitoring by : Amitava Dasgupta

Download or read book Advances in Chromatographic Techniques for Therapeutic Drug Monitoring written by Amitava Dasgupta and published by CRC Press. This book was released on 2009-10-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: For drugs with a narrow therapeutic index, therapeutic drug monitoring methods are essential for patient management. Although immunoassays are commercially available for many drugs and most laboratories use these assays for routine therapeutic monitoring, they have many limitations which hinder their efficacy. Providing practical guidelines for implementing preferred gas and liquid chromatographic methods, Advances in Chromatographic Techniques for Therapeutic Drug Monitoring is a comprehensive reference describing the theory and application of therapeutic drug monitoring in clinical laboratories. Edited by a distinguished authority in the field and containing contributions from a variety of experts, the book discusses preanalytical variables, the pitfalls of immunoassays, tandem mass spectrometry, issues related to pain management and herbal supplements, and therapeutic drug monitoring for a range of medications, including: Anticonvulsants Digitalis Cardioactive drugs Antidepressants Immunosuppressants Anti-cancer drugs Vancomycin and aminoglycosides Antibiotics Antiretroviral drugs Nonnarcotic analgesics Anti-inflammatory drugs Examing older and newer drugs, the book contains detailed discussions on the rationale for therapeutic drug monitoring of each class of drugs, along with their basic pharmacology and toxicology. An extensive list of references is provided at the end of each chapter so that those interested in implementing a new drug assay can find the most appropriate method for the intended drug.