Metalloproteins

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Chemistry of Metalloproteins

Author : Joseph J. Stephanos
Publisher : John Wiley & Sons
ISBN 13 : 1118801520
Total Pages : 448 pages
Book Rating : 4.1/5 (188 download)

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Book Synopsis Chemistry of Metalloproteins by : Joseph J. Stephanos

Download or read book Chemistry of Metalloproteins written by Joseph J. Stephanos and published by John Wiley & Sons. This book was released on 2014-07-22 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addresses the full gamut of questions in metalloprotein science Formatted as a question-and-answer guide, this book examines all major families of metal binding proteins, presenting our most current understanding of their structural, physicochemical, and functional properties. Moreover, it introduces new and emerging medical applications of metalloproteins. Readers will discover both the underlying chemistry and biology of this important area of research in bioinorganic chemistry. Chemistry of Metalloproteins features a building block approach that enables readers to master the basics and then advance to more sophisticated topics. The book begins with a general introduction to bioinorganic chemistry and metalloproteins. Next, it covers: Alkali and alkaline earth cations Metalloenzymes Copper proteins Iron proteins Vitamin B12 Chlorophyll Chapters are richly illustrated to help readers fully grasp all the chemical concepts that govern the biological action of metalloproteins. In addition, each chapter ends with a list of suggested original research articles and reviews for further investigation of individual topics. Presenting our most current understanding of metalloproteins, Chemistry of Metalloproteins is recommended for students and researchers in coordination chemistry, biology, and medicine. Each volume of the Wiley Series in Protein and Peptide Science addresses a specific facet of the field, reviewing the latest findings and presenting a broad range of perspectives. The volumes in this series constitute essential reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, and physiologists as well as researchers in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides.

Metalloproteins

Author : Yilin Hu
Publisher : Humana Press
ISBN 13 : 9781493988631
Total Pages : 275 pages
Book Rating : 4.9/5 (886 download)

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Book Synopsis Metalloproteins by : Yilin Hu

Download or read book Metalloproteins written by Yilin Hu and published by Humana Press. This book was released on 2018-10-31 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an up-to-date, in-depth overview of the methods that have been applied to studying the complex metalloproteins at a molecular level. Chapters cover a wide range of approaches focusing on genetic, biochemical, spectroscopic, chemical methods, and theoretical calculations. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Metalloproteins: Methods and Protocols aims to be useful for anyone who is interested in metalloprotein research and wants to address the unanswered mechanistic and biosynthetic questions of these fascinating enzyme systems.

Metalloproteins

Author : Art E. Cho
Publisher : CRC Press
ISBN 13 : 1439813191
Total Pages : 294 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Metalloproteins by : Art E. Cho

Download or read book Metalloproteins written by Art E. Cho and published by CRC Press. This book was released on 2015-04-17 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Numerous essential biological functions involve metalloproteins; therefore, understanding metalloproteins and how to manipulate them is significant in the biological and medical fields. An examination of current research, Metalloproteins: Theory, Calculations, and Experiments explores the interplay between theory and experiment, detailing the role of theoretical modeling in the field and explaining how it aids experiments. The text also presents the current state of computational protein modeling, enabling researchers to adopt computation as an integral component of their studies. This book addresses two different aspects on metalloproteins in unison. It reviews the development of theoretical and computational methods for metalloprotein simulation with specific examples. The authors also present some of the most intriguing and important experimental results on metalloprotein systems. Although a connection can be made between these two aspects of the research, the authors do not do so explicitly. Rather, they provide the platform required to ignite further collaboration between experimentalists and theoreticians. A collection of works from top researchers in this field, the text presents diverse subjects that comprehensively reflect the current state of metalloprotein research. With these advances in structural information, theory and computation are starting to play a more significant role, particularly in identifying the reaction mechanism. The book summarizes some of the recent progress in both experiments and theory/computation showing the synergy that is now developing.

Brain Diseases and Metalloproteins

Author : David R. Brown
Publisher : CRC Press
ISBN 13 : 9814316016
Total Pages : 440 pages
Book Rating : 4.8/5 (143 download)

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Book Synopsis Brain Diseases and Metalloproteins by : David R. Brown

Download or read book Brain Diseases and Metalloproteins written by David R. Brown and published by CRC Press. This book was released on 2012-08-07 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the latest research on neurodegenerative disease and metal-binding proteins. It lays strong emphasis on biochemistry and cell biology. The diseases covered in the book include Parkinson’s disease, Alzheimer’s disease, prion disease, and ALS. The chapters separately examine such issues as mechanisms of metal binding, metal-induced structural changes in proteins, alterations in cellular metal metabolism in disease, and attempts at a therapeutic approach based on protein metal binding.

Handbook on Metalloproteins

Author : Ivano Bertini
Publisher : CRC Press
ISBN 13 : 9780824705206
Total Pages : 1382 pages
Book Rating : 4.7/5 (52 download)

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Book Synopsis Handbook on Metalloproteins by : Ivano Bertini

Download or read book Handbook on Metalloproteins written by Ivano Bertini and published by CRC Press. This book was released on 2001-06-29 with total page 1382 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Handbook on Metalloproteins focuses on the available structural information of proteins and their metal ion coordination spheres. It centers on the metal ions indispensable for life but also considers metal ions used as substitution probes in studies of metalloproteins. Emphasizing the structure-function relationship, the book covers the common and distinct characterstics of metallo- enzymes, proteins, and amino acids bonded to copper, zinc, iron, and more.

Metalloprotein Active Site Assembly

Author : Michael K. Johnson
Publisher : John Wiley & Sons
ISBN 13 : 1119159857
Total Pages : 424 pages
Book Rating : 4.1/5 (191 download)

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Book Synopsis Metalloprotein Active Site Assembly by : Michael K. Johnson

Download or read book Metalloprotein Active Site Assembly written by Michael K. Johnson and published by John Wiley & Sons. This book was released on 2017-08-14 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Summarizes the essential biosynthetic pathways for assembly of metal cofactor sites in functional metalloproteins Metalloprotein Active Site Assembly focuses on the processes that have evolved to orchestrate the assembly of metal cofactor sites in functional metalloproteins. It goes beyond the simple incorporation of single metal ions in a protein framework, and includes metal cluster assembly, metal-cofactor biosynthesis and insertion, and metal-based post-translational modifications of the protein environments that are necessary for function. Several examples of each of these areas have now been identified and studied; the current volume provides the current state-of-the-art understanding of the processes involved. An excellent companion to the earlier book in this series Metals in Cells—which discussed both the positive and negative effects of cellular interactions with metals—this comprehensive book provides a diverse sampling of what is known about metalloprotein active site assembly processes. It covers all major biological transition metal components (Mn, Fe, Co, Ni, Mo), as well as the other inorganic components, metal-binding organic cofactors (e.g., heme, siroheme, cobalamin, molybdopterin), and post-translationally modified metal binding sites that make up the patchwork of evolved biological catalytic sites. The book compares and contrasts the biosynthetic assembly of active sites involving all biological metals. This has never been done before since it is a relatively new, fast-developing area of research. Metalloprotein Active Site Assembly is an ideal text for practitioners of inorganic biochemistry who are studying the biosynthetic pathways and gene clusters involved in active site assembly, and for inorganic chemists who want to apply the concepts learned to potential synthetic pathways to active site mimics.

Encyclopedia of Metalloproteins

Author : Robert H. Kretsinger
Publisher : Springer
ISBN 13 : 9781461415329
Total Pages : 0 pages
Book Rating : 4.4/5 (153 download)

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Book Synopsis Encyclopedia of Metalloproteins by : Robert H. Kretsinger

Download or read book Encyclopedia of Metalloproteins written by Robert H. Kretsinger and published by Springer. This book was released on 2013-05-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In biochemistry, a metalloprotein is a generic term for a protein that contains a metal cofactor. The metal may be an isolated ion or may be coordinated with a nonprotein organic compound, such as the porphyrin found in hemoproteins. In some cases, the metal is co-coordinated with a side chain of the protein and an inorganic nonmetallic ion. This kind of protein-metal-nonmetal structure is seen in iron-sulfur clusters Metalloproteins deals with all aspects related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The biological roles of metal cations and metal-binding proteins are endless. They are involved in all crucial cellular activities. Many pathological conditions are related to the problematic metal metabolism. Research in metalloprotein-related topics is therefore rapidly growing, and different aspects of metal-binding proteins progressively enter curricula at Universities and even at the High School level on occasion. However, no key resource providing basic, but comprehensible knowledge on this rapidly expanding field exists. The Encyclopedia of Metalloproteins aims to bridge this gap, and will attempt to cover various aspects of metalloprotein/metalloproteomics and will deal with the different issues related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The goal is to cover exhaustively all catalytically and biologically crucial metal ions and to find at least one interacting protein for other metal ions. The Encyclopedia of Metalloproteins will provide a key resource for advanced undergraduate and graduate students, researchers, instructors, and professors interested in protein science, biochemistry, cell biology, and genetics.

Metalloproteins

Author : P.M. Harrison
Publisher : Springer
ISBN 13 : 134906372X
Total Pages : 265 pages
Book Rating : 4.3/5 (49 download)

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Book Synopsis Metalloproteins by : P.M. Harrison

Download or read book Metalloproteins written by P.M. Harrison and published by Springer. This book was released on 1985-06-18 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Brain Diseases and Metalloproteins

Author : David R. Brown
Publisher : CRC Press
ISBN 13 : 981436407X
Total Pages : 300 pages
Book Rating : 4.8/5 (143 download)

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Book Synopsis Brain Diseases and Metalloproteins by : David R. Brown

Download or read book Brain Diseases and Metalloproteins written by David R. Brown and published by CRC Press. This book was released on 2012-08-07 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the latest research on neurodegenerative disease and metal-binding proteins. It lays strong emphasis on biochemistry and cell biology. The diseases covered in the book include Parkinson’s disease, Alzheimer’s disease, prion disease, and ALS. The chapters separately examine such issues as mechanisms of metal binding, metal-induced structural changes in proteins, alterations in cellular metal metabolism in disease, and attempts at a therapeutic approach based on protein metal binding.

Metalloproteins—Advances in Research and Application: 2012 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464998272
Total Pages : 296 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Metalloproteins—Advances in Research and Application: 2012 Edition by :

Download or read book Metalloproteins—Advances in Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metalloproteins—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Metalloproteins. The editors have built Metalloproteins—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Metalloproteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Metalloproteins—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Metalloproteins: Metal proteins with non-redox roles

Author : Pauline M. Harrison
Publisher : Wiley-VCH
ISBN 13 :
Total Pages : 360 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Metalloproteins: Metal proteins with non-redox roles by : Pauline M. Harrison

Download or read book Metalloproteins: Metal proteins with non-redox roles written by Pauline M. Harrison and published by Wiley-VCH. This book was released on 1985 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Metalloprotein Active Site Assembly

Author : Michael K. Johnson
Publisher : John Wiley & Sons
ISBN 13 : 1119159849
Total Pages : 424 pages
Book Rating : 4.1/5 (191 download)

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Book Synopsis Metalloprotein Active Site Assembly by : Michael K. Johnson

Download or read book Metalloprotein Active Site Assembly written by Michael K. Johnson and published by John Wiley & Sons. This book was released on 2017-08-30 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Summarizes the essential biosynthetic pathways for assembly of metal cofactor sites in functional metalloproteins Metalloprotein Active Site Assembly focuses on the processes that have evolved to orchestrate the assembly of metal cofactor sites in functional metalloproteins. It goes beyond the simple incorporation of single metal ions in a protein framework, and includes metal cluster assembly, metal-cofactor biosynthesis and insertion, and metal-based post-translational modifications of the protein environments that are necessary for function. Several examples of each of these areas have now been identified and studied; the current volume provides the current state-of-the-art understanding of the processes involved. An excellent companion to the earlier book in this series Metals in Cells—which discussed both the positive and negative effects of cellular interactions with metals—this comprehensive book provides a diverse sampling of what is known about metalloprotein active site assembly processes. It covers all major biological transition metal components (Mn, Fe, Co, Ni, Mo), as well as the other inorganic components, metal-binding organic cofactors (e.g., heme, siroheme, cobalamin, molybdopterin), and post-translationally modified metal binding sites that make up the patchwork of evolved biological catalytic sites. The book compares and contrasts the biosynthetic assembly of active sites involving all biological metals. This has never been done before since it is a relatively new, fast-developing area of research. Metalloprotein Active Site Assembly is an ideal text for practitioners of inorganic biochemistry who are studying the biosynthetic pathways and gene clusters involved in active site assembly, and for inorganic chemists who want to apply the concepts learned to potential synthetic pathways to active site mimics.

Handbook of Metalloproteins, Handbook of Metalloproteins

Author : Albrecht Messerschmidt
Publisher : Wiley-Blackwell
ISBN 13 :
Total Pages : 816 pages
Book Rating : 4.:/5 (89 download)

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Book Synopsis Handbook of Metalloproteins, Handbook of Metalloproteins by : Albrecht Messerschmidt

Download or read book Handbook of Metalloproteins, Handbook of Metalloproteins written by Albrecht Messerschmidt and published by Wiley-Blackwell. This book was released on 2001 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first two volumes of the "Handbook of Metalloproteins", published in 2001, focused on a number of metals, including iron, nickel, manganese, cobalt, copper and vanadium. Now we are delighted to present volume three which extends the wealth of knowledge and focuses on proteins found in the redox-inactive ions of zinc and calcium. (Midwest).

Peptide, Protein and Enzyme Design

Author :
Publisher : Academic Press
ISBN 13 : 0128054344
Total Pages : 684 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Peptide, Protein and Enzyme Design by :

Download or read book Peptide, Protein and Enzyme Design written by and published by Academic Press. This book was released on 2016-08-27 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: De Novo Enzyme Design, the newest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume includes the design of metal binding maquettes, insertion of non-natural cofactors, Cu metallopeptides, non-covalent interactions in peptide assemblies, peptide binding and bundling, heteronuclear metalloenzymes, florinated peptides, De Novo imaging agents, and protein-protein interaction. Continues the legacy of this premier serial with quality chapters on de novo enzyme design Represents the newest volume in the Methods in Enzymology series, providing premier, quality chapters authored by leaders in the field Ideal reference for those interested in the study of enzyme design that looks at both structure and mechanism

High Resolution EPR

Author : Graeme Hanson
Publisher : Springer Science & Business Media
ISBN 13 : 0387848568
Total Pages : 666 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis High Resolution EPR by : Graeme Hanson

Download or read book High Resolution EPR written by Graeme Hanson and published by Springer Science & Business Media. This book was released on 2009-06-19 with total page 666 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metalloproteins comprise approximately 30% of all known proteins, and are involved in a variety of biologically important processes, including oxygen transport, biosynthesis, electron transfer, biodegradation, drug metabolism, proteolysis, and hydrolysis of amides and esters, environmental sulfur and nitrogen cycles, and disease mechanisms. EPR spectroscopy has an important role in not only the geometric structural characterization of the redox cofactors in metalloproteins but also their electronic structure, as this is crucial for their reactivity. The advent of x-ray crystallographic snapshots of the active site redox cofactors in metalloenzymes in conjunction with high-resolution EPR spectroscopy has provided detailed structural insights into their catalytic mechanisms. This volume was conceived in 2005 at the Rocky Mountain Conference on Analytical Chemistry (EPR Symposium) to highlight the importance of high-resolution EPR spectroscopy to the structural (geometric and electronic) characterization of redox active cofactors in metalloproteins. We have been fortunate to have enlisted internationally recognized experts in this joint venture to provide the scientific community with an overview of high-resolution EPR and its application to metals in biology. This volume, High-Resolution EPR: Applications to Metalloenzymes and Metals in Medicine, covers high-resolution EPR methods, iron proteins, nickel and copper enzymes, and metals in medicine. An eloquent synopsis of each chapter is provided by John Pilbrow in the Introduction. A second volume, Metals in Biology: Applications of High-Resolution EPR to Metalloenzymes, will appear later this year covering the complement of other metalloproteins. One of the pioneers in the development of pulsed EPR and its application to metalloproteins was Arthur Schweiger, whose contribution we include in this volume. Unfortunately, he passed away suddenly during the preparation of this volume. The editors and coauthors are extremely honored to dedicate this volume to the memory of Arthur Schweiger in recognition of his technical advances and insights into pulsed EPR and its application to metalloproteins. Arthur was extremely humble and treated everyone with equal respect. He was a gifted educator with an ability to explain complex phenomena in terms of simple intuitive pictures, had a delightful personality, and continues to be sadly missed by the community. It is an honor for the editors to facilitate the dissemination of these excellent contributions to the scientific community. Suggestions for future volumes are always appreciated.

The Evolution of Metalloenzymes, Metalloproteins, and Related Materials

Author : G. J. Leigh
Publisher :
ISBN 13 :
Total Pages : 136 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Evolution of Metalloenzymes, Metalloproteins, and Related Materials by : G. J. Leigh

Download or read book The Evolution of Metalloenzymes, Metalloproteins, and Related Materials written by G. J. Leigh and published by . This book was released on 1977 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook on Metalloproteins

Author : Ivano Bertini
Publisher : CRC Press
ISBN 13 : 148227082X
Total Pages : 1108 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Handbook on Metalloproteins by : Ivano Bertini

Download or read book Handbook on Metalloproteins written by Ivano Bertini and published by CRC Press. This book was released on 2001-06-29 with total page 1108 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Handbook on Metalloproteins focuses on the available structural information of proteins and their metal ion coordination spheres. It centers on the metal ions indispensable for life but also considers metal ions used as substitution probes in studies of metalloproteins. Emphasizing the structure-function relationship, the book covers the commo