Metal Carcinogenesis Testing

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Metal Carcinogenesis Testing

Author : Max Costa
Publisher : Springer Science & Business Media
ISBN 13 : 1603274030
Total Pages : 177 pages
Book Rating : 4.6/5 (32 download)

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Book Synopsis Metal Carcinogenesis Testing by : Max Costa

Download or read book Metal Carcinogenesis Testing written by Max Costa and published by Springer Science & Business Media. This book was released on 2008-02-07 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal Carcinogenesis Testing explains fundamental principles of metal carcinogenesis as they are currently understood, and provides detailed practical descriptions of rapid and inexpensive in vitro assay methodology presently in use for the detection of potentially carci nogenic metals and their compounds. Mounting experimental evidence has suggested that a number of metals and their compounds are potentially carcinogenic to humans. Since humans are exposed to these potentially carcinogenic metals in industrial situations and through environmental pollution, it is essential that experimental protocols be available to identify the specific metal compounds that are potentially carcinogenic. This book affords a thorough description of the various carcinogenesis test systems available for metals, centering on those that are rapid, inexpensive, and most reliable. The principles are discussed at the level of human exposure, of animal studies, and of research in vitro. Additionally, the molecular mechanisms of metal-induced cancer are considered at each ofthese three levels.In large part, the emphasis rests on the use of in vitro, biochemical and bacterial studies, including tissue culture, because these methods are the basis of the rapid and inexpensive screening of potentially carcinogenic substances.

Mechanisms of Carcinogenesis

Author : Elizabeth K. Weisburger
Publisher : Springer Science & Business Media
ISBN 13 : 9400925263
Total Pages : 210 pages
Book Rating : 4.4/5 (9 download)

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Book Synopsis Mechanisms of Carcinogenesis by : Elizabeth K. Weisburger

Download or read book Mechanisms of Carcinogenesis written by Elizabeth K. Weisburger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: but also the possibility of intervention in specific stages. In Human behavior, including stress and other factors, plays an important role in neoplasia, although too little is known addition, variables which affect cancer development as well on the reasons for such development. Carcinogens, which as some endogenous factors can be better delineated help initiate the neoplastic process, may be either synthetic through such investigations. The topics of this volume encompass premalignant non or naturally-occurring. Cancer causation may be ascribed to invasive lesions, species-specific aspects of carcinogenicity, certain chemicals, physical agents, radioactive materials, viruses, parasites, the genetic make-up of the organism, and radiation, viruses, a quantum theory of carinogenesis, onco bacteria. Humans, eumetazoan animals and vascular plants genes, and selected environmental carcinogens. are susceptible to the first six groups of cancer causes, whe reas the last group, bacteria, seems to affect only vascular plants. Neoplastic development may begin with impairment ofJmdy defenses by a toxic material (carcinogen) which acts as an initiator, followed by promotion and progression to an overt neoplastic state. Investigation of these processes Series Editor Volume Editor allows not only a better insight into the mechanism of action Hans E. Kaiser Elizabeth K. Weisburger vii ACKNOWLEDGEMENT Inspiration and encouragement for this wide ranging project on cancer distribution and dissemination from a comparative biological and clinical point of view, was given by my late friend E. H. Krokowski.

The Carcinogenicity of Metals

Author : Alan B. G. Lansdown
Publisher : Royal Society of Chemistry
ISBN 13 : 1849737185
Total Pages : 450 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis The Carcinogenicity of Metals by : Alan B. G. Lansdown

Download or read book The Carcinogenicity of Metals written by Alan B. G. Lansdown and published by Royal Society of Chemistry. This book was released on 2013 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important text comprehensively examines each of the elements for which carcinogenicity has been established, providing detailed information on the carcinogenicity and toxicity and detailing the most up-to-date research in this area.

Handbook of Carcinogen Testing

Author : Harry A. Milman
Publisher : William Andrew Inc.
ISBN 13 : 9780815513568
Total Pages : 856 pages
Book Rating : 4.5/5 (135 download)

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Book Synopsis Handbook of Carcinogen Testing by : Harry A. Milman

Download or read book Handbook of Carcinogen Testing written by Harry A. Milman and published by William Andrew Inc.. This book was released on 1994-01-01 with total page 856 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1961 the National Cancer Institute initiated a program to conduct bioassays of selected compounds to determine whether they might be carcinogens. Although some similarities continue with the program as it was in 1961, there are many more differences. Since 1985 when the first edition of this book appeared, these differences have been substantial enough to merit an updated version. This updated edition will provide the reader with an overview of how to proceed with the various tests and how the data are eventually used for regulatory decisions.

Molecular Mechanisms of Metal Toxicity and Carcinogenesis

Author : Xianglin Shi
Publisher : Springer Science & Business Media
ISBN 13 : 1461507936
Total Pages : 232 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Molecular Mechanisms of Metal Toxicity and Carcinogenesis by : Xianglin Shi

Download or read book Molecular Mechanisms of Metal Toxicity and Carcinogenesis written by Xianglin Shi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: These proceedings focus on the latest research in molecular mechanisms of metal-induced toxicity and carcinogenesis. The conference promoted a multidisciplinary investigative approach and included presentations from international experts on state-of-the-art information in this field.

Biological Effects of Heavy Metals

Author : E. C. Foulkes
Publisher : CRC-Press
ISBN 13 : 9780849342424
Total Pages : 216 pages
Book Rating : 4.3/5 (424 download)

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Book Synopsis Biological Effects of Heavy Metals by : E. C. Foulkes

Download or read book Biological Effects of Heavy Metals written by E. C. Foulkes and published by CRC-Press. This book was released on 1990-09-06 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fascinating volume reviews general mechanisms of metal carcinogenesis. It illustrates this effect by detailed reference to some specific metals, including Cd, Co and Ni. The material illustrates the common threads running through the field of metal carcinogenesis. Leading investigators in the field present their understanding of metal carcinogenicity. Toxicologists, molecular biologists, and nutritionists will find this book interesting and informative.

Carcinogens and Anticarcinogens in the Human Diet

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309053919
Total Pages : 434 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Carcinogens and Anticarcinogens in the Human Diet by : National Research Council

Download or read book Carcinogens and Anticarcinogens in the Human Diet written by National Research Council and published by National Academies Press. This book was released on 1996-03-12 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite increasing knowledge of human nutrition, the dietary contribution to cancer remains a troubling question. Carcinogens and Anticarcinogens assembles the best available information on the magnitude of potential cancer riskâ€"and potential anticarcinogenic effectâ€"from naturally occurring chemicals compared with risk from synthetic chemical constituents. The committee draws important conclusions about diet and cancer, including the carcinogenic role of excess calories and fat, the anticarcinogenic benefit of fiber and other substances, and the impact of food additive regulation. The book offers recommendations for epidemiological and diet research. Carcinogens and Anticarcinogens provides a readable overview of issues and addresses critical questions: Does diet contribute to an appreciable proportion of human cancer? Are there significant interactions between carcinogens and anticarcinogens in the diet? The volume discusses the mechanisms of carcinogenic and anticarcinogenic properties and considers whether techniques used to evaluate the carcinogenic potential of synthetics can be used with naturally occurring chemicals. The committee provides criteria for prioritizing the vast number of substances that need to be tested. Carcinogens and Anticarcinogens clarifies the issues and sets the direction for further investigations into diet and cancer. This volume will be of interest to anyone involved in food and health issues: policymakers, regulators, researchers, nutrition professionals, and health advocates.

Cancer Risk Assessment

Author : Ching-Hung Hsu
Publisher : John Wiley & Sons
ISBN 13 : 1118035127
Total Pages : 727 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis Cancer Risk Assessment by : Ching-Hung Hsu

Download or read book Cancer Risk Assessment written by Ching-Hung Hsu and published by John Wiley & Sons. This book was released on 2010-12-08 with total page 727 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, along with the impacts on regulatory guidelines and standards. By providing insightful perspective, Cancer Risk Assessment helps researchers develop a discriminate eye when it comes to interpreting data accurately and separating relevant information from erroneous.

Genotoxic and Carcinogenic Metals

Author : Lawrence Fishbein
Publisher :
ISBN 13 :
Total Pages : 360 pages
Book Rating : 4.:/5 (3 download)

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Book Synopsis Genotoxic and Carcinogenic Metals by : Lawrence Fishbein

Download or read book Genotoxic and Carcinogenic Metals written by Lawrence Fishbein and published by . This book was released on 1987 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Mechanisms of Metal Toxicity and Carcinogenesis

Author : Xianglin Shi
Publisher :
ISBN 13 :
Total Pages : 184 pages
Book Rating : 4.:/5 (489 download)

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Book Synopsis Molecular Mechanisms of Metal Toxicity and Carcinogenesis by : Xianglin Shi

Download or read book Molecular Mechanisms of Metal Toxicity and Carcinogenesis written by Xianglin Shi and published by . This book was released on 2004 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:

How Tobacco Smoke Causes Disease

Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General

Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Carcinogenesis and Mutagenesis Testing

Author : J F Douglas
Publisher :
ISBN 13 : 9781461251651
Total Pages : 356 pages
Book Rating : 4.2/5 (516 download)

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Book Synopsis Carcinogenesis and Mutagenesis Testing by : J F Douglas

Download or read book Carcinogenesis and Mutagenesis Testing written by J F Douglas and published by . This book was released on 1984-10-05 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Guidelines for the Testing of Chemicals for Carcinogenicity

Author : Great Britain. Committee on Carcinogenicity of Chemicals in Food, Consumer Products, and the Environment
Publisher :
ISBN 13 :
Total Pages : 46 pages
Book Rating : 4.3/5 ( download)

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Book Synopsis Guidelines for the Testing of Chemicals for Carcinogenicity by : Great Britain. Committee on Carcinogenicity of Chemicals in Food, Consumer Products, and the Environment

Download or read book Guidelines for the Testing of Chemicals for Carcinogenicity written by Great Britain. Committee on Carcinogenicity of Chemicals in Food, Consumer Products, and the Environment and published by . This book was released on 1982 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Essential and Non-essential Metals

Author : Anuradha Mudipalli
Publisher :
ISBN 13 : 9783319554471
Total Pages : 228 pages
Book Rating : 4.5/5 (544 download)

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Book Synopsis Essential and Non-essential Metals by : Anuradha Mudipalli

Download or read book Essential and Non-essential Metals written by Anuradha Mudipalli and published by . This book was released on 2017 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Carcinogenicity and Immnotoxicity of Embedded Depleted Uranium and Heavy-Metal Tungsten Alloy in Rodents

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (946 download)

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Book Synopsis Carcinogenicity and Immnotoxicity of Embedded Depleted Uranium and Heavy-Metal Tungsten Alloy in Rodents by :

Download or read book Carcinogenicity and Immnotoxicity of Embedded Depleted Uranium and Heavy-Metal Tungsten Alloy in Rodents written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study investigates the carcinogenic and immunotoxic potential of embedded fragments of depleted uranium (DU) and a heavy-metal tungsten alloy (HMTA) to determine if carcinogenicity and immunotoxicity are correlated with tissue-metal content. We hypothesize that long-term chronic exposure to embedded DU and HMTA initiates changes in normal immune function that will eventually result in a carcinogenic response characterized by both tumor formation at the fragment implantation site (solid-state or foreign-body carcinogenesis) and at distant tissue sites ("true" carcinogenesis). To test this hypothesis, male Fischer 344 rats are surgically implanted with pellets of DU or HMTA. Responses in these rats are compared with those from rats implanted with a known carcinogen, nickel, or an inert metal, tantalum. At selected times after implantation, we assess tissue metal content, mutagenicity, and genotoxicity as well as perform tests to assess cell-mediated, humoral, and innate immunity. This report summarizes accomplishments of the project after the first year of work. Year one milestones are met: assays and other systems have been established and standardized, implant pellets and other materials contracted for and obtained, and over 300 rats have undergone pellet implantation surgery.

A Review of Human Carcinogens

Author : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Conference
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (815 download)

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Book Synopsis A Review of Human Carcinogens by : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Conference

Download or read book A Review of Human Carcinogens written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Conference and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Reducing Environmental Cancer Risk

Author : Suzanne H. Reuben
Publisher : DIANE Publishing
ISBN 13 : 1437934218
Total Pages : 240 pages
Book Rating : 4.4/5 (379 download)

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Book Synopsis Reducing Environmental Cancer Risk by : Suzanne H. Reuben

Download or read book Reducing Environmental Cancer Risk written by Suzanne H. Reuben and published by DIANE Publishing. This book was released on 2010-10 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Though overall cancer incidence and mortality have continued to decline in recent years, cancer continues to devastate the lives of far too many Americans. In 2009 alone, 1.5 million American men, women, and children were diagnosed with cancer, and 562,000 died from the disease. There is a growing body of evidence linking environmental exposures to cancer. The Pres. Cancer Panel dedicated its 2008¿2009 activities to examining the impact of environmental factors on cancer risk. The Panel considered industrial, occupational, and agricultural exposures as well as exposures related to medical practice, military activities, modern lifestyles, and natural sources. This report presents the Panel¿s recommend. to mitigate or eliminate these barriers. Illus.