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Metabolism Of Xenobiotics
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Book Synopsis Metabolism of Drugs and Other Xenobiotics by : Pavel Anzenbacher
Download or read book Metabolism of Drugs and Other Xenobiotics written by Pavel Anzenbacher and published by John Wiley & Sons. This book was released on 2012-05-29 with total page 755 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse including nicotine, alcohol and "designer" drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular toxicology. Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.
Book Synopsis Handbook of Metabolic Pathways of Xenobiotics by : Philip Lee
Download or read book Handbook of Metabolic Pathways of Xenobiotics written by Philip Lee and published by Wiley. This book was released on 2014-03-17 with total page 2560 pages. Available in PDF, EPUB and Kindle. Book excerpt: If you’re working on or studying the effects of drug metabolisms, then this reference is for you! Handbook of Metabolic Pathways of Xenobiotics is an essential new reference which presents the metabolic fate of xenobiotics in animals and plants, and shows the metabolic pathways in the environment. Presenting a comprehensive guide to understanding the metabolisms of xenobiotics, the Handbook of Metabolic Pathways of Xenobiotics spans five volumes: Volumes 1-2 are Review Articles and Volumes 3-5 are Compound Articles. Review Articles present detailed reviews on the techniques and methods used to establish in vitro and in vivo metabolic pathways. Compound Articles are carefully selected lists of key chemicals representing agrochemicals, pharmaceuticals, animal health products and industrial chemicals. An essential addition to every library, this introduction, guide and catalogue presents: Current topics in the metabolism of xenobiotics Topics of both scientific and regulatory importance are covered, including in vitro high throughput metabolism screens, computer-aided metabolism predictions, and advances in bioanalytical techniques. Techniques and methods used in metabolic pathways 29 chapters provide an introduction to the understanding of drug metabolism and detail how to establish in vitro and in vivo metabolic pathways. Biotransformation pathways Presented as a catalogue of short articles covering major pharmaceuticals, agrochemicals, animal health products and industrial chemicals. Each article summarizes the chemical properties and uses, and presents a detailed review of the chemical and metabolic pathways in soil, plants and animals. Over 450 examples of xenobiotics and their fate in animals and plants Each compound includes systematic information about the metabolic pathway of drugs for human and veterinary medicine, agrochemicals and major industrial chemicals. Chemical and biological fate data The Handbook summarises data from scientific literature, patent literature, industrial resources and regulatory agencies, such as the EPA, FDA, EU, WHO and FAO, in a single reference for the first time. An essential reference for everyone working and studying pharmacokinetics and drug metabolism Coverage of the chemical and biological reactivity of molecules and primary sub-structures makes this an ideal reference for students and research scientists. The broad and diverse coverage of chemical and biological fate under different exposure and biological compartments make this a useful resource for regulatory and developmental scientists. Experience the scope of content offered in the Handbook of Metabolic Pathways of Xenobiotics for yourself, download these articles today: Review Article: Fundamentals of organic chemistry as applicable to the biotransformation of foreign compounds Review Article: Metabolic stability screen in drug discovery Review Article: Unusual metabolic reactions and pathways Compound Article: Ganoderic acid D Compound Article: Milnacipran Compound Article: Tenofovir Online Edition Coming Soon! Featuring the same great content as the five volume print set, the Handbook of Metabolic Pathways for Xenobiotics will be available on Wiley Online Library in summer 2014. The online reference will benefit from the enhanced functionality powered by The Smart Article – learn more about The Smart Article at wileyonlinelibrary.com/thesmartarticle. Free trials will be available when the Online Edition goes live, bookmark this page or sign-up for regular product alerts at www.wiley.com/email to stay informed.
Book Synopsis Metabolism of Drugs and Other Xenobiotics by : Pavel Anzenbacher
Download or read book Metabolism of Drugs and Other Xenobiotics written by Pavel Anzenbacher and published by John Wiley & Sons. This book was released on 2012-02-23 with total page 755 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse including nicotine, alcohol and "designer" drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular toxicology. Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.
Author :International Society for the Study of Xenobiotics Publisher :Taylor & Francis Group ISBN 13 : Total Pages :400 pages Book Rating :4.3/5 (91 download)
Book Synopsis Metabolism of Xenobiotics by : International Society for the Study of Xenobiotics
Download or read book Metabolism of Xenobiotics written by International Society for the Study of Xenobiotics and published by Taylor & Francis Group. This book was released on 1988 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Enzyme Systems that Metabolise Drugs and Other Xenobiotics by : Costas Ioannides
Download or read book Enzyme Systems that Metabolise Drugs and Other Xenobiotics written by Costas Ioannides and published by John Wiley & Sons. This book was released on 2002 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference work focuses on the enzyme systems that participate in the metabolism of chemicals and other xenobiotics, with emphasis being placed on drug metabolism. Each chapter focuses on a specific enzyme system.
Book Synopsis Metabolism of xenobiotics (detoxification) by : U Satyanarayana
Download or read book Metabolism of xenobiotics (detoxification) written by U Satyanarayana and published by Elsevier Health Sciences. This book was released on 2014-11-07 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolism of xenobiotics (detoxification) Metabolism of xenobiotics (detoxification)
Book Synopsis Microbial Metabolism of Xenobiotic Compounds by : Pankaj Kumar Arora
Download or read book Microbial Metabolism of Xenobiotic Compounds written by Pankaj Kumar Arora and published by Springer. This book was released on 2019-06-27 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: Xenobiotic compounds including pesticides, nitrophenols, pyridine, polycyclic aromatic compounds and polychlorinated biphenyls are widely spread in environment due to anthropogenic activities. Most of them are highly toxic to living beings due to their mutagenic and carcinogenic properties. Therefore, the removal of these compounds from environment is an essential step for environmental sustainability. Microbial remediation has emerged as an effective technology for degradation of these xenobiotic compounds as microorganisms have unique ability to utilize these compounds as their sole source of carbon and energy. The primary goal of this book is to provide detailed information of microbial degradation of many xenobiotic compounds in various microorganisms.
Book Synopsis Biotransformation and Metabolite Elucidation of Xenobiotics by : Ala F. Nassar
Download or read book Biotransformation and Metabolite Elucidation of Xenobiotics written by Ala F. Nassar and published by John Wiley & Sons. This book was released on 2011-03-23 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of this book is to improve the readers' knowledge of metabolite elucidation in drug metabolism by exposing them to in depth coverage of the biotransformation of xenobiotics, strategies for identifying and characterizing metabolites, FDA guidelines, and case studies on how to improve the decision-making process in structural modification of drug candidates to reduce toxicity. The book consists of 8 chapters; it first provides an introduction on biotransformation of xenobiotics, and then presents modern approaches and strategies for dealing with metabolite characterization, using tools such as LC-MS, H-D exchange, stable isotopes LC-MS-NMR, and radiolabeled compounds. Also, strategies for dealing with reactive intermediates in drug discovery and development are presented as well as case studies on improving the decision-making process in the structural modification of drug candidates. The last chapter discusses the regulatory perspectives of safety testing of drug metabolites and why, how, and when to test their safety.
Book Synopsis Intermediary Xenobiotic Metabolism in Animals by : David Herd Hutson
Download or read book Intermediary Xenobiotic Metabolism in Animals written by David Herd Hutson and published by Taylor & Francis Group. This book was released on 1989 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Papers based on a symposium forming part of the Third Chemical Congress of No America held in Toronto, June, 1988 They deal with reactive chemicals formed the body from foreign compounds, which can have toxic or carcinogenic properties, but which are not normally excreted or isolated in conventiona
Book Synopsis Encyclopedia of Cancer by : Manfred Schwab
Download or read book Encyclopedia of Cancer written by Manfred Schwab and published by Springer Science & Business Media. This book was released on 2008-09-23 with total page 3307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.
Book Synopsis Biological Reactive Intermediates III by : James J. Kocsis
Download or read book Biological Reactive Intermediates III written by James J. Kocsis and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 1028 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapid growth of mechanistic toxicology over the last decade. These conferences were initially stimulated by the attempt to uncover the significance behind the observations that the toxicity of carcinogenic responses produced by many chemicals was associated with the observation that their metabolism led to the formation of chemcially reactive electrophiles which covalently bound to nucleophilic sites in cells such as proteins, nucleic acid or fats. Recently, newer concepts have arisen which have necessitated the expansion of subjects covered by the conference. For example, the application of newer knowledge of the role of active oxygen species in reactive metabolite formation, the concept of suicide substrates, examination of the function of glutathione in cells, application of immunological techniques and molecular biological probes to the solution of toxicological problems all had an impact on the study of the biological reactive intermediates.
Book Synopsis Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes by : Emel Arinç
Download or read book Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes written by Emel Arinç and published by Springer Science & Business Media. This book was released on 1999-01-31 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by leading researchers in the fields of biochemistry, molecular biology, genetics, pharmacology, toxicology, biotechnology and cancer, this is a comprehensive update on molecular biology and biochemistry of cytochromes P450 and flavin containing monoxygenases. The volume provides expert analysis of the genetic polymorphism of these enzymes in the clinic, in drug discovery and development, and discussion of their role in predisposition for, and prevention of chemical carcinogens in humans.
Book Synopsis Plant Responses to Xenobiotics by : Anita Singh
Download or read book Plant Responses to Xenobiotics written by Anita Singh and published by Springer. This book was released on 2016-12-28 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is compilation of studies related with the xenobiotics i.e. chemical or other substance that is not normally found in the ecosystems and get accumulated at higher concentration in the biological system due to rampant industrialisation and urbanisation activities. This book has tried to give information on various issues to give comprehensive and concise knowledge of the recent advancement in the field of environmental xenobiotics and how it disturbs the plants metabolism. Other key features of the book are related to xenobiotic toxicity and detoxification mechanism, biochemical tools toward its remediation processes, molecular mechanism for xenobiotics detoxification and effect on metallomics. It also focuses on recent development in the field of waste water remediation concerned with the xenobiotics involvement. This book is different in such a way that it includes all the initial information along with the new researches. It includes the description of problem along with its solution. This volume describe the effects of xenobiotics at different levels i.e. biochemical, physiological and molecular, giving the details on signaling pathways to modify the responses of xenobiotics in plant system. Thus, it gives confirming crosstalk between xenobiotic effects and signalling pathways. This book includes description about both the organic contaminants such as pesticides, solvents and petroleum products as well as inorganic xenobiotics that include heavy metals, non-metals, metalloids, and simple soluble salts. Here the plant is main objective and that have to deal with these kinds of compounds either by avoiding accumulation of these compounds or by exhibiting several enzymatic reactions for detoxification including oxidation, reduction, and conjugation reactions. Affected plants exhibit several enzymatic and non-enzymatic antioxidant and other reactions for detoxification of ROS including oxidation, reduction, hydrolysis and conjugation reactions. The book focuses on different forms and sources of xenobiotics including organic and inorganic xenobiotics. The matter of this book will definitely increase the knowledge about the impacts of xenobiotics on plants system. There must be potentially broad readership who could find this fruitful for their study as well as for their research. As this book has balance between basic plant physiology and toxicity caused by the xenobiotics so it can be widely used in several disciplines. Overall, the book will bring deep knowledge in the field of xenobiotics toxicity in plants during recent years and it is definitely a compilation of interesting information which isn't fully covered elsewhere in the current market.
Book Synopsis Hydrolysis in Drug and Prodrug Metabolism by : Bernard Testa
Download or read book Hydrolysis in Drug and Prodrug Metabolism written by Bernard Testa and published by John Wiley & Sons. This book was released on 2003-08 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many drugs and other xenobiotics (e.g., preservatives, insecticides, and plastifiers) contain hydrolyzable moieties such as ester or amide groups. In biological media, such foreign compounds are, therefore, important substrates for hydrolytic reactions catalyzed by hydrolases or proceeding non-enzymatically. Despite their significance, until now, no book has been dedicated to hydrolysis and hydrolases in the metabolism of drugs and other xenobiotics. This work fills a gap in the literature and reviews metabolic reactions of hydrolysis and hydarion from the point of views of enzymes, substrates, and reactions.
Book Synopsis Cytochromes P450 by : Costas Ioannides
Download or read book Cytochromes P450 written by Costas Ioannides and published by Royal Society of Chemistry. This book was released on 2008-06-27 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: During half a century, cytochrome P450 in its original uniqueness as an optically "wrong" cytochrome has attracted many investigators, who have contributed to the unveiling of a bewildering multiplicity of biologically important functions of the, by now very large, superfamily of cytochrome P 450 enzymes. With its discovery in 1958 and with the advent of more refined spectroscopic methodologies, through the double wavelength spectrophotometry, the mysterious enzyme system began to reveal its secrets in a swift stream of investigative successes. As one of the most extensively studied enzyme systems worldwide the interest in cytochromes P450 very much reflects its importance in the elimination of drugs and other chemicals from the body and its role in chemical toxicity and in the aetiology of diseases such as cancer. There has been significant progress in research in this area in recent years and current books on this subject are now out of date. This much needed, new, fully up-to-date publication fills this gap and emphasises the new relevant topics that have emerged during the last decade in an easily accessible manner. The enzyme system, cytochromes P450, comprises a number of families/subfamilies, and the focus of the book is to deal with each individually, furnishing information directly relevant to scientists involved in the development of chemicals, in particular in the evaluation of their safety. The book has contributions from internationally respected scientists who are research-active in the relevant areas. The authors have made extensive use of figures and tables so that the reader can access the necessary information without always having to read the text. In addition, a very extensive, user-friendly index is a unique hallmark of the book. Part A of this monograph introduces the reader to the current knowledge of the evolutionary development of cytochrome P450 structure and function. Furthermore, it deals with the role of this enzyme in the formation of reactive intermediates. The shrewd and extensive utilisation of the molecular biology methodology very rapidly led to a vast body of enzymes calling for a classification of the plethora of different cytochromes P450 (the superfamily) into families and subfamilies. This is aptly exemplified by the ten chapters in Part B of this book, dealing with ten subfamilies and two families of cytochrome P450. Part C offers an insight into another aspect of cytochrome P450 research, namely its regulation through receptor-mediated stimuli - as opposed to enzyme induction or inhibition. The final chapter translates the current data on one of several drug metabolising systems into clinical application and highlights the role of cytochromes P450 in the treatment of neoplastic growth. The book deals extensively with each family/subfamily of the cytochromes P450 that contribute to the metabolism of xenobiotics. Essential and invaluable information is provided for the industrial research scientist working with fine chemicals, and especially those in the pharmaceutical industry, dealing with the safety evaluation of chemicals or being involved in the study of their metabolism, pharmacokinetics and toxicological properties. It should also prove of interest to Regulators concerned with the safety evaluation of chemicals, research pharmacologists and toxicologists, and postgraduate students studying drug metabolism and toxicology at an advanced level.
Book Synopsis Intentional Human Dosing Studies for EPA Regulatory Purposes by : National Research Council
Download or read book Intentional Human Dosing Studies for EPA Regulatory Purposes written by National Research Council and published by National Academies Press. This book was released on 2004-06-04 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: The EPA commissioned The National Academies to provide advice on the vexing question of whether and, if so, under what circumstances EPA should accept and consider intentional human dosing studies conducted by companies or other sources outside the agency (so-called third parties) to gather evidence relating to the risks of a chemical or the conditions under which exposure to it could be judged safe. This report recommends that such studies be conducted and used for regulatory purposes only if all of several strict conditions are met, including the following: The study is necessary and scientifically valid, meaning that it addresses an important regulatory question that can't be answered with animal studies or nondosing human studies; The societal benefits of the study outweigh any anticipated risks to participants. At no time, even when benefits beyond improved regulation exist, can a human dosing study be justified that is anticipated to cause lasting harm to study participants; and All recognized ethical standards and procedures for protecting the interests of study participants are observed. In addition, EPA should establish a Human Studies Review Board (HSRB) to evaluate all human dosing studiesâ€"both at the beginning and upon completion of the experimentsâ€"if they are carried out with the intent of affecting the agency's policy-making.
Book Synopsis Biochemistry of Redox Reactions by : Bernard Testa
Download or read book Biochemistry of Redox Reactions written by Bernard Testa and published by Academic Press. This book was released on 1995 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surpassing the 1976 book by Testa and Jenner, Drug Metabolism: Chemical and Biochemical Aspects (Dekker), this informative, up-to-date text includes the following features, unavailable elsewhere: First in a set of books to provide a comprehensive coverage of drug metabolism; Opening chapter provides a general introduction to the complete set of books; Other chapters cover reaction mechanisms, catalytic cycles, regio- and stereoselectivities, types of substrates, reactivity of intermediates, and drug-enzyme interactions; Extensive detailed diagrams of reaction pathways and chemical structures * First in a set of books providing a comprehensive coverage of drug metabolism * Opening chapter provides a general introduction to the complete set of books * Other chapters cover reaction mechanisms, catalytic cycles, regio and stereoselectivities, types of substrates, reactivity of intermediates and drug-enzyme interactions * Extensive detailed diagrams of reaction pathways and chemical structures
