Metabolic Pathway Engineering

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The Metabolic Pathway Engineering Handbook

Author : Christina Smolke
Publisher : CRC Press
ISBN 13 : 9781420077667
Total Pages : 581 pages
Book Rating : 4.0/5 (776 download)

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Book Synopsis The Metabolic Pathway Engineering Handbook by : Christina Smolke

Download or read book The Metabolic Pathway Engineering Handbook written by Christina Smolke and published by CRC Press. This book was released on 2009-07-28 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second volume of the Metabolic Pathway Engineering Handbook delves into evolutionary tools and gene expression tools for metabolic pathway engineering. It covers applications of emerging technologies including recent research genome-wide technologies, DNA and phenotypic microarrays, and proteomics tools for experimentally determining flux through pathways. This volume also looks at emerging applications for producing fine chemicals, drugs, and alternative fuels. Christine Smolke, who recently developed a novel way to churn out large quantities of drugs from genetically modified brewer’s yeast, is regarded as one of the most brilliant new minds in biomedical engineering. In this handbook, she brings together pioneering scientists from dozens of disciplines to provide a complete record of accomplishment in metabolic pathway engineering. With a wealth of cutting edge research and analysis, this work also serves as an invaluable resource for those seeking to add their own contributions. Organized by topic, this 3000 page reference is available as two volumes that can be purchased individually or as a set.

The Metabolic Pathway Engineering Handbook

Author : Christina Smolke
Publisher : CRC Press
ISBN 13 : 1439802971
Total Pages : 680 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis The Metabolic Pathway Engineering Handbook by : Christina Smolke

Download or read book The Metabolic Pathway Engineering Handbook written by Christina Smolke and published by CRC Press. This book was released on 2009-07-28 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first volume of the Metabolic Pathway Engineering Handbook provides an overview of metabolic pathway engineering with a look towards the future. It discusses cellular metabolism, including transport processes inside the cell and energy generating reactions, as well as rare metabolic conversions. This volume also explores balances and reaction

The Metabolic Pathway Engineering Handbook, Two Volume Set

Author : Christina Smolke
Publisher : CRC Press
ISBN 13 : 1420005626
Total Pages : 1259 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis The Metabolic Pathway Engineering Handbook, Two Volume Set by : Christina Smolke

Download or read book The Metabolic Pathway Engineering Handbook, Two Volume Set written by Christina Smolke and published by CRC Press. This book was released on 2009-08-18 with total page 1259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Christina Smolke, who recently developed a novel way to churn out large quantities of drugs from genetically modified brewer's yeast, is regarded as one of the most brilliant minds in biomedical engineering. In this handbook, she brings together pioneering scientists from dozens of disciplines to provide a complete record of accomplishment in metab

Metabolic Pathway Engineering

Author : Jean F. Challacombe
Publisher : CRC Press
ISBN 13 : 1000260542
Total Pages : 116 pages
Book Rating : 4.0/5 (2 download)

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Book Synopsis Metabolic Pathway Engineering by : Jean F. Challacombe

Download or read book Metabolic Pathway Engineering written by Jean F. Challacombe and published by CRC Press. This book was released on 2021-07-14 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic systems engineering combines the tools and approaches of systems biology, synthetic biology, and evolutionary engineering. This book reviews studies on metabolism, from the earliest work of Lavoisier and Buchner to current cutting-edge research in metabolic systems engineering. This technology has been used in bioengineering applications to create high-performing microbes and plants that produce important chemicals, pharmaceuticals, crops, and other natural products. Current applications include optimizing metabolic pathways to enhance degradation of biomass for biofuel production and accelerated processing of environmental waste products and contaminants. The book includes examples to illustrate the applications of this technology in the optimization of metabolic pathways to create robust industrial strains as well as in the engineering of biological processes involving health and diseases of humans, animals, and plants. Written by a seasoned computational biologist with many years of experience in genomics, bioinformatics, and systems biology, this book will appeal to anyone interested in metabolic systems analysis and metabolic pathway engineering.

Metabolic Pathway Engineering

Author : Michael E. Himmel
Publisher :
ISBN 13 : 9781071601952
Total Pages : pages
Book Rating : 4.6/5 (19 download)

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Book Synopsis Metabolic Pathway Engineering by : Michael E. Himmel

Download or read book Metabolic Pathway Engineering written by Michael E. Himmel and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates experimental and computational methodologies used to achieve cost effective biological processes for the production of fuels and biochemicals through multiple approaches to increasing yield, titers, and productivity in a robust host. The volume includes the most recent and cutting-edge aspects of pathway engineering, flux analysis, and metabolic enzyme engineering. Each chapter highlights the complexity and challenges of the problem as well as the methods used to solve this problem or changes needed in current methods. As a part of the highly successful Methods in Molecular Biology series, chapters include the kind of detailed implementation advice that gives researchers a much needed boost. Authoritative and practical, Metabolic Pathway Engineering benefits not only scientists working on more fundamental aspects of this endeavor but also those in the biochemical industry working on strain engineering for robust industrial processes.

Pathway Analysis and Optimization in Metabolic Engineering

Author : Néstor V. Torres
Publisher : Cambridge University Press
ISBN 13 : 9781139437615
Total Pages : 328 pages
Book Rating : 4.4/5 (376 download)

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Book Synopsis Pathway Analysis and Optimization in Metabolic Engineering by : Néstor V. Torres

Download or read book Pathway Analysis and Optimization in Metabolic Engineering written by Néstor V. Torres and published by Cambridge University Press. This book was released on 2002-12-19 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Facility in the targeted manipulation of the genetic and metabolic composition of organisms, combined with unprecedented computational power, is forging a niche for a new subspecialty of biotechnology called metabolic engineering. First published in 2002, this book introduces researchers and advanced students in biology and engineering to methods of optimizing biochemical systems of biotechnological relevance. It examines the development of strategies for manipulating metabolic pathways, demonstrates the need for effective systems models, and discusses their design and analysis, while placing special emphasis on optimization. The authors propose power-law models and methods of biochemical systems theory toward these ends. All concepts are derived from first principles, and the text is richly illustrated with numerous graphs and examples throughout. Special features include: nontechnical and technical introductions to models of biochemical systems; a review of basic methods of model design and analysis; concepts of optimization; and detailed case studies.

Metabolic Engineering

Author : Sang Yup Lee
Publisher : John Wiley & Sons
ISBN 13 : 352782345X
Total Pages : 1075 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Metabolic Engineering by : Sang Yup Lee

Download or read book Metabolic Engineering written by Sang Yup Lee and published by John Wiley & Sons. This book was released on 2021-06-02 with total page 1075 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn more about foundational and advanced topics in metabolic engineering in this comprehensive resource edited by leaders in the field Metabolic Engineering: Concepts and Applications delivers a one-stop resource for readers seeking a complete description of the concepts, models, and applications of metabolic engineering. This guide offers practical insights into the metabolic engineering of major cell lines, including E. Coli, Bacillus and Yarrowia Lipolytica, and organisms, including human, animal, and plant). The distinguished editors also offer readers resources on microbiome engineering and the use of metabolic engineering in bioremediation. Written in two parts, Metabolic Engineering begins with the essential models and strategies of the field, like Flux Balance Analysis, Quantitative Flux Analysis, and Proteome Constrained Models. It also provides an overview of topics like Pathway Design, Metabolomics, and Genome Editing of Bacteria and Eukarya. The second part contains insightful descriptions of the practical applications of metabolic engineering, including specific examples that shed light on the topics within. In addition to subjects like the metabolic engineering of animals, humans, and plants, you’ll learn more about: Metabolic engineering concepts and a historical perspective on their development The different modes of analysis, including flux balance analysis and quantitative flux analysis An illuminating and complete discussion of the thermodynamics of metabolic pathways The Genome architecture of E. coli, as well as genome editing of both bacteria and eukarya An in-depth treatment of the application of metabolic engineering techniques to organisms including corynebacterial, bacillus, and pseudomonas, and more Perfect for students of biotechnology, bioengineers, and biotechnologists, Metabolic Engineering: Concepts and Applications also has a place on the bookshelves of research institutes, biotechnological institutes and industry labs, and university libraries. It's comprehensive treatment of all relevant metabolic engineering concepts, models, and applications will be of use to practicing biotechnologists and bioengineers who wish to solidify their understanding of the field.

Metabolic Engineering

Author : Jens Nielsen
Publisher : Springer
ISBN 13 : 3540453008
Total Pages : 184 pages
Book Rating : 4.5/5 (44 download)

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Book Synopsis Metabolic Engineering by : Jens Nielsen

Download or read book Metabolic Engineering written by Jens Nielsen and published by Springer. This book was released on 2003-07-03 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic engineering is a rapidly evolving field that is being applied for the optimization of many different industrial processes. In this issue of Advances in Biochemical Engineering/Biotechnology, developments in different areas of metabolic engineering are reviewed. The contributions discuss the application of metabolic engineering in the improvement of yield and productivity - illustrated by amino acid production and the production of novel compounds - in the production of polyketides and extension of the substrate range - and in the engineering of S. cerevisiae for xylose metabolism, and the improvement of a complex biotransformation process.

Introduction To Metabolic And Cellular Engineering, An (Second Edition)

Author : Cortassa Sonia Del Carmen
Publisher : World Scientific
ISBN 13 : 9814405175
Total Pages : 448 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Introduction To Metabolic And Cellular Engineering, An (Second Edition) by : Cortassa Sonia Del Carmen

Download or read book Introduction To Metabolic And Cellular Engineering, An (Second Edition) written by Cortassa Sonia Del Carmen and published by World Scientific. This book was released on 2011-12-28 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic and Cellular Engineering (MCE) is more than an exciting scientific enterprise. It has become the cornerstone for coping with the challenges ahead of mankind. Continuous developments, new concepts, and technological innovations will enable us to deal with emerging challenges, and solve problems once thought impossible ten years ago. Challenges in MCE are broad- from unraveling fundamental aspects of cellular function to meeting unsatiated energy and food demands that are rising in parallel with population growth.In charting the progress of MCE during the last decade, we could not help but feel in awe of the enormous strides of progress made from the nascent Metabolic Engineering to the Systems Bioengineering of today. The burgeoning availability of genomic sequences from diverse species has been spectacular. It has become the engine that drives the genetic means for the modification of existing organisms and the generation of synthetic, man-made ones. From the initial attempts at purposeful genetic modification of a cell for the production of valuable compounds, we have now moved on to changing microbes genetically or metabolically.The arsenal of experimental and theoretical tools available for Metabolic and Cellular Engineering has expanded enormously, driven by the re-emergence of Physiology as Systems Biology. The revival of the concept of networks fueled by new developments has become central to Systems Biology. Networks represent an integrative vision of how processes of disparate nature relate to each other, and as such is becoming a key analytical and conceptual tool for MCE. This book reflects and addresses all these ongoing changes while providing the essential conceptual and analytical tools needed to understand and work in the MCE research field.

The Future of Metabolic Engineering

Author : Abhishek Sharma
Publisher :
ISBN 13 : 9781685073626
Total Pages : 372 pages
Book Rating : 4.0/5 (736 download)

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Book Synopsis The Future of Metabolic Engineering by : Abhishek Sharma

Download or read book The Future of Metabolic Engineering written by Abhishek Sharma and published by . This book was released on 2022-01-20 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last two decades of scientific research have progressed to the point where metabolic engineering, which involves the modifying of metabolic pathways of animals, plants, and bacterial cells at biochemical and molecular levels, is feasible. Conceptually, metabolic engineering takes into account the identification of major blocks or control points in a metabolic pathway at the molecular level followed by removal of these limitations with the help of various cellular engineering interventions. Understanding the metabolic pathways requires appropriate experiment setup, molecular biology and biochemistry methods, computational modelling, data analysis, and interpretation to allow the researchers to manipulate them as per their needs. This book comprises a total of 12 chapters from multiple contributors of different countries around the world, including Brazil, Egypt, India, Saudi Arabia, and Turkey. This book provides deep insight into the past, present, and future of metabolic engineering in the animal, microbial, and plant system, communicating interdisciplinary research and relevant results in biochemistry, molecular biology, applied microbiology, cellular physiology, cellular nutrition in health and disease, and biochemical engineering.

Metabolic Pathway Design

Author : Pablo Carbonell
Publisher : Springer Nature
ISBN 13 : 3030298655
Total Pages : 168 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Metabolic Pathway Design by : Pablo Carbonell

Download or read book Metabolic Pathway Design written by Pablo Carbonell and published by Springer Nature. This book was released on 2019-11-05 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook presents solid tools for in silico engineering biology, offering students a step-by-step guide to mastering the smart design of metabolic pathways. The first part explains the Design-Build-Test-Learn-cycle engineering approach to biology, discussing the basic tools to model biological and chemistry-based systems. Using these basic tools, the second part focuses on various computational protocols for metabolic pathway design, from enzyme selection to pathway discovery and enumeration. In the context of industrial biotechnology, the final part helps readers understand the challenges of scaling up and optimisation. By working with the free programming language Scientific Python, this book provides easily accessible tools for studying and learning the principles of modern in silico metabolic pathway design. Intended for advanced undergraduates and master’s students in biotechnology, biomedical engineering, bioinformatics and systems biology students, the introductory sections make it also useful for beginners wanting to learn the basics of scientific coding and find real-world, hands-on examples.

Metabolic Engineering

Author : G. Stephanopoulos
Publisher :
ISBN 13 : 9780126662603
Total Pages : 725 pages
Book Rating : 4.6/5 (626 download)

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Book Synopsis Metabolic Engineering by : G. Stephanopoulos

Download or read book Metabolic Engineering written by G. Stephanopoulos and published by . This book was released on 1998 with total page 725 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic engineering is a new field with applications in the production of chemicals, fuels, materials, pharmaceuticals, and medicine at the genetic level. The field's novelty is in the synthesis of molecular biology techniques and the tools of mathematical analysis, which allow rational selection of targets for genetic modification through measurements and control of metabolic fluxes. The objective is to identify specific genetics or environmental manipulations that result in improvements in yield and productivities of biotechnological processes. Key features of the book are pathway integration and the focus on metabolic flux as a fundamental determinant of cell physiology. The book keeps mathematical complexity to a minimum, and provides a glossary of biological terms to facilitate use of the book by a broader spectrum of readers. A web page exists to communicate updates of the codes and homework problems. Key Features * Demonstrates metabolic engineering in action with numerous examples of pathway modification * Includes methods for identifying key enzymes in metabolic networks * Contains a comprehensive review of metabolic biochemistry * Discusses metabolic regulation at the gene, enzyme, operon, and cell levels * Explains concepts of stoichiometry, kinetics, and thermodynamics of metabolic pathways * Minimizes mathematical complexity * Links to a Web page to communicate updates of the software code and homework problems

Engineering of Microbial Biosynthetic Pathways

Author : Vijai Singh
Publisher : Springer Nature
ISBN 13 : 9811526044
Total Pages : 326 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Engineering of Microbial Biosynthetic Pathways by : Vijai Singh

Download or read book Engineering of Microbial Biosynthetic Pathways written by Vijai Singh and published by Springer Nature. This book was released on 2020-07-16 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the basic and advanced metabolic engineering technologies used to generate natural metabolites and industrially important biomolecules. Metabolic engineering has the potential to produce large quantities of valuable biomolecules in a renewable and sustainable manner by extending or modifying biosynthetic pathways in a wide range of organisms. It has been successfully used to produce chemicals, drugs, enzymes, amino acids, antibiotics, biofuels, and industrially important pharmaceuticals. The book comprehensively reviews the various metabolites detection, extraction and biosensors and the metabolic engineering of microbial strains for the production of industrially useful enzymes, proteins, organic acids, vitamins and antibiotics, therapeutics, chemicals, and biofuels. It also discusses various genetic engineering and synthetic biology tools for metabolic engineering. In closing, the book discusses ethical, patenting and regulatory issues in the metabolic engineering of microbes. This book is a valuable source not only for beginners in metabolic engineering, but also students, researchers, biotechnology and metabolic engineering based company.

Yeast Metabolic Engineering

Author : Valeria Mapelli
Publisher : Springer Nature
ISBN 13 : 1071623990
Total Pages : 300 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Yeast Metabolic Engineering by : Valeria Mapelli

Download or read book Yeast Metabolic Engineering written by Valeria Mapelli and published by Springer Nature. This book was released on 2022-07-04 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition volume expands on the previous edition with new and updated chapters on the latest developments in the study of yeast within the biotechnology field. The chapters in this book cover topics such as transformation protocols for genetic engineering of Saccaromyces cerevisiae and Komagataella spp.; an overview of selection markers, promoters, and strains used for metabolic engineering of S. cerevisiae, P. pastoris, and Z. bailii; the use of yeast in CRISPR/Cas9 technology; tools to study metabolic pathway in Yarrowia lypolitica; and a discussion on the “universal expression system” that is applied in a broad spectrum of fungal species. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Yeast Metabolic Engineering: Methods and Protocols, Second Edition is a valuable resource for researchers and scientists interested in learning more about this important and developing field.

Recent Trends and Techniques in Plant Metabolic Engineering

Author : Sudesh Kumar Yadav
Publisher : Springer
ISBN 13 : 9811322511
Total Pages : 179 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Recent Trends and Techniques in Plant Metabolic Engineering by : Sudesh Kumar Yadav

Download or read book Recent Trends and Techniques in Plant Metabolic Engineering written by Sudesh Kumar Yadav and published by Springer. This book was released on 2018-11-23 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Remarkable research has yielded whole genome data in plants, resulting in the documentation of an ever-increasing number of genes, without establishing their functions. The huge data resources available at the genome, transcriptome, proteome and metabolome levels are of enormous value in the field of functional genomics. This book provides insights into interpreting the sea of data in order to understand basic and practical aspects of plant metabolic engineering. It discusses in detail ways to tap into this enormous pool of data to increase productivity, and offers information that is both interesting and necessary for exploring the manipulation of metabolic pathways. The interdisciplinary approaches presented here also serve as a source of ideas for practical applications.

Metabolic Engineering for Bioprocess Commercialization

Author : Stephen Van Dien
Publisher : Springer
ISBN 13 : 3319419668
Total Pages : 122 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Metabolic Engineering for Bioprocess Commercialization by : Stephen Van Dien

Download or read book Metabolic Engineering for Bioprocess Commercialization written by Stephen Van Dien and published by Springer. This book was released on 2016-07-16 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews the current metabolic engineering tools and technologies from a practical point of view, and guides researchers as they overcome challenges at various stages of organism and bioprocess development. Microbes have been engineered to produce a variety of industrial products such as fuels, basic chemicals, fine chemicals, nutritional supplements, and pharmaceutical intermediates, and new tools such as gene synthesis, advanced cloning techniques, ‘omics’ analysis, and mathematical modeling have greatly accelerated the pace of innovation in the field. Written by leading experts in the field from both academia and industry, key topics include synthetic biology, pathway engineering, metabolic flux manipulation, adaptive evolution, and fermentation process scale-up. It is suitable for non-specialists, and is a valuable resource for anyone embarking on the exciting path to harnessing the metabolic potential of microorganisms.

Synthetic Biology and Metabolic Engineering in Plants and Microbes Part B: Metabolism in Plants

Author :
Publisher : Elsevier
ISBN 13 : 0128111232
Total Pages : 446 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Synthetic Biology and Metabolic Engineering in Plants and Microbes Part B: Metabolism in Plants by :

Download or read book Synthetic Biology and Metabolic Engineering in Plants and Microbes Part B: Metabolism in Plants written by and published by Elsevier. This book was released on 2016-07-29 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic Biology and Metabolic Engineering in Plants and Microbes, Part B, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods, synthetic biology, and metabolic engineering in plants and microbes, and includes sections on such topics as the usage of integrases in microbial engineering, biosynthesis, and engineering of tryptophan derived metabolites, regulation and discovery of fungal natural products, and elucidation and localization of plant pathways. Continues the legacy of this premier serial with quality chapters authored by leaders in the field of enzymology Contains two volumes covering research methods in synthetic biology and metabolic engineering in plants and microbes Includes sections on such topics as the uses of integrases in microbial engineering, biosynthesis and engineering of tryptophan derived metabolites, regulation and discovery of fungal natural products, and elucidation and localization of plant pathways