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Medical Genetics Of Non Small Cell Lung Cancer
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Book Synopsis Medical Genetics of Non-Small Cell Lung Cancer by : Garden Grove Garden Grove Press
Download or read book Medical Genetics of Non-Small Cell Lung Cancer written by Garden Grove Garden Grove Press and published by . This book was released on 2017-03-30 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: This article collection reviews the medical genetics of non-small cell lung cancer and includes 25 papers by various authors. Topics include: Gene mutation discovery research of non-smoking lung cancer patients due to indoor radon exposure; Osteopontin genetic variants are associated with overall survival in advanced non-small-cell lung cancer patients and bone metastasis; Emerging roles of Nrf2 signal in non-small cell lung cancer; Osteopontin is a prognostic biomarker in non-small cell lung cancer; PIWIL2 promotes progression of non-small cell lung cancer by inducing CDK2 and Cyclin A expression; Metabolic diversity in human non-small cell lung cancer; Clinical outcomes in ALK-rearranged lung adenocarcinomas according to ALK fusion variants; MiR-133a is downregulated in non-small cell lung cancer: a study of clinical significance; A genetic variant in long non-coding RNA MALAT1 associated with survival outcome among patients with advanced lung adenocarcinoma: a survival cohort analysis; Mutation status concordance between primary lesions and metastatic sites of advanced non-small-cell lung cancer and the impact of mutation testing methodologies: a literature review; Predictive biomarkers in precision medicine and drug development against lung cancer; Characterization of a genetic mouse model of lung cancer: a promise to identify Non-Small Cell Lung Cancer therapeutic targets and biomarkers; Genetic polymorphisms in the endothelial nitric oxide synthase gene correlate with overall survival in advanced non-small-cell lung cancer patients treated with platinum-based doublet chemotherapy; Major milestones in translational oncology; Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting; SFRP1 is a possible candidate for epigenetic therapy in non-small cell lung cancer; Synthetic lethality in lung cancer and translation to clinical therapies; Targeted therapies for patients with advanced NSCLC harboring wild-type EGFR: what's new and what's enough; Cisplatin sensitivity is enhanced in non-small cell lung cancer cells by regulating epithelial-mesenchymal transition through inhibition of eukaryotic translation initiation factor 5A2; Genetic polymorphisms of glutathione S-transferase M1 and T1, and evaluation of oxidative stress in patients with non-small cell lung cancer; PD-L1 biomarker testing for non-small cell lung cancer: truth or fiction?; CD73/NT5E is a target of miR-30a-5p and plays an important role in the pathogenesis of non-small cell lung cancer; Genetic polymorphisms of human cytochrome P450 CYP1A1 in an Egyptian population and tobacco-induced lung cancer; Clinical outcome and expression of mutant P53, P16, and Smad4 in lung adenocarcinoma: a prospective study; Towards standardization of next-generation sequencing of FFPE samples for clinical oncology: intrinsic obstacles and possible solutions. Proceeds from the sale of this book go to the support of an elderly disabled person.
Book Synopsis The Molecular Genetics of Lung Cancer by : David N Cooper
Download or read book The Molecular Genetics of Lung Cancer written by David N Cooper and published by Springer Science & Business Media. This book was released on 2005-11-20 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer is the leading cause of cancer mortality in Western countries. It also provides an archetypal example of how inherited predisposing genetic variants may interact with an environmental influence (smoking) to modulate individual cancer risk. The Molecular Genetics of Lung Cancer describes how the new techniques, methods and approaches of molecular genetics are being used to unravel the complexities of the mechanisms underlying lung tumorigenesis by analysis at the DNA, RNA and protein levels with potentially important implications for tumour classification, diagnosis, prognosis and treatment as well as providing new insights into how lung tumours arise and how they progress to malignancy.
Download or read book Genes and Cancer written by Karol Sikora and published by Wiley. This book was released on 1990-10-26 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work serves as an introduction to the applications of molecular biology in the field of oncology. It provides a basic understanding of the genetic events involved in fully developed human cancer, including research into inherited and acquired gene defects initiating new neoplasms and the subsequent genetic alterations involved in tumor progression. Some of the specific topics explored include gene control, molecular therapy and antibodies, drug resistance, growth factors and receptors, and tumor biology. While intended primarily as an advanced text for oncologists, postgraduate molecular geneticists and molecular biologists, the book will certainly be of interest to other researchers who frequently encounter cancer in their practice.
Book Synopsis Molecular Pathology of Lung Cancer by : Philip T. Cagle
Download or read book Molecular Pathology of Lung Cancer written by Philip T. Cagle and published by Springer Science & Business Media. This book was released on 2012-06-14 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: As with other books in the Molecular Pathology Library Series, Molecular Pathology of Lung Cancer bridges the gap between the molecular specialist and the clinical practitioner, including the surgical pathologist who now has a key role in decisions regarding molecular targeted therapy for lung cancer. Molecular Pathology of Lung Cancer provides the latest information and current insights into the molecular basis for lung cancer, including precursor and preinvasive lesions, molecular diagnosis, molecular targeted therapy, molecular prognosis, molecular radiology and related fields for lung cancer generally and for the specific cell types. As many fundamental concepts about lung cancer have undergone revision in only the past few years, this book will likely be the first to comprehensively cover the new molecular pathology of lung cancer. It provides a foundation in this field for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, thoracic radiologists and their trainees, physician assistants, and nursing staff.
Download or read book Cancer Genomics written by Zhaolin Xu and published by Elsevier Inc. Chapters. This book was released on 2013-11-21 with total page 49 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer remains the leading cause of cancer-related death worldwide. Although surgical resections of these tumors are considered as one of the most effective treatments, most lung cancer patients present at an advanced stage of the disease at the time of diagnosis and are not candidates for surgical resection. Overall, the prognosis of lung cancer is very poor and the 5-year survival rate is only about 16 %, which has not significantly changed in the past several decades. Therefore, seeking new directions of treatment for this most deadly disease becomes crucial. Recent development in the understanding of the molecular pathogenesis of lung cancer has led to new strategies of treatment. Development of lung cancers is thought to be driven by gene mutations in most, if not all, cases. Detailed analysis at the molecular level to identify these gene mutations or alterations in lung cancer provides the insight for understanding the disease and is fundamental for establishment of personalized targeted therapy. Personalized targeted therapy based on particular gene mutations has shown to be effective and is believed to be one of the new directions of the treatment in dealing with this disease. In modern oncology, there is an increasing need to facilitate the development and implementation of biomarkers based on known gene mutations/alterations in clinical practice and identification of new gene mutations/alterations through high-throughput DNA sequencing technology to enter a new era of personalized targeted therapy for lung cancer patients.
Book Synopsis Epidemiology of Lung Cancer by : Jonathan M. Samet
Download or read book Epidemiology of Lung Cancer written by Jonathan M. Samet and published by CRC Press. This book was released on 1994-03-08 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a historical perspective on the etiology of lung cancer, this comprehensive reference presents an in-depth analysis of the epidemiology of cancer of the lung-describing the current understanding of risk factors and the use of epidemiological data to design programs for the control of this leading cause of death worldwide.
Book Synopsis Treatment for Non Small Cell Lung Cancer in Distinct Patient Populations by : Junji Uchino
Download or read book Treatment for Non Small Cell Lung Cancer in Distinct Patient Populations written by Junji Uchino and published by Frontiers Media SA. This book was released on 2022-02-24 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Fast Facts: Non-Small-Cell Lung Cancer by : Mary O'Brien
Download or read book Fast Facts: Non-Small-Cell Lung Cancer written by Mary O'Brien and published by Karger Medical and Scientific Publishers. This book was released on 2022-02-28 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite an overall decrease in tobacco use, lung cancer (80–85% of which is non-small-cell lung cancer [NSCLC]) is still the leading cause of cancer death in both men and women worldwide. Annual low-dose CT screening of high-risk individuals has the potential to detect early-stage tumors, which can usually be successfully treated with a combination of surgery, radiotherapy and chemotherapy and, in some cases, targeted therapy. However, most patients with NSCLC still present with advanced or metastatic disease. For these patients, initial therapy is guided by the tumor’s molecular characteristics and patient’s performance status. Targeted therapies have significantly improved clinical outcomes and, for some patients with no targetable genetic alterations, immunotherapy has demonstrated significant overall survival benefit. This insightful guide is designed to bring you up to speed with the latest developments and is important reading for all health professionals and medical trainees working in this fast-moving field. Table of Contents: • Prevention and screening • Diagnosis and staging • Surgery • Radiotherapy • Systemic therapy in non-metastatic NSCLC • Systemic therapy in advanced-stage/metastatic disease without a molecular driver • Personalized treatment in advanced NSCLC • Oligometastatic disease and brain metastases
Book Synopsis Molecular Genetic Characterizations of Human Non-Small Cell Lung Cancer by : Lai-Shan Tai
Download or read book Molecular Genetic Characterizations of Human Non-Small Cell Lung Cancer written by Lai-Shan Tai and published by . This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Recent Advances in the Molecular Genetics and Precision Medicine of Lung Carcinoma by : Mehdi Pirooznia
Download or read book Recent Advances in the Molecular Genetics and Precision Medicine of Lung Carcinoma written by Mehdi Pirooznia and published by Frontiers Media SA. This book was released on 2024-01-25 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung Carcinoma is the 2nd most common cancer worldwide, with more than 2.2 million cases recorded globally in the year 2020, as well as 1.8 million deaths. It is the most common cancer in men and the 2nd most common cancer in women, with an estimated lifetime risk of developing the disease of 1 in 15 for men and 1 in 17 for women. Whilst being the most prevalent cancer, it is important to note that smoking is the single biggest risk factor for developing Lung Cancer, with over 70% of cases being estimated to have been caused by tobacco smoke, and excessive smoking potentially leading to as much as a 25x increase in the likelihood of the disease developing. Mortality rates have been steadily dropping globally due to declining smoking rates, especially in younger generations who are now more aware of the potential dangers, but also because of the increasing advancements being made in our understanding of the disease. Improved screening methods mean many more cases are now caught earlier than they would otherwise have been, and our ever-advancing ranges of treatments can begin earlier than they could have previously. Recent advances in sequencing technology, computational approaches, and our biological understanding of lung cancer have revolutionized how we diagnose, prognosticate, and treat lung carcinoma. Genetic studies into this disease have revealed a plethora of information which can be used to combat the Cancer, such as novel biomarkers and gene signatures, as well as opening the door to more of a ‘personalized medicine’ approach.
Book Synopsis Cytogenetic Studies of Lung Tumors by : Maria Johansson Soller
Download or read book Cytogenetic Studies of Lung Tumors written by Maria Johansson Soller and published by . This book was released on 1994 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Update on the Treatment of Metastatic Non-small Cell Lung Cancer (NSCLC) in New Era of Personalised Medicine by : Vera Hirsh
Download or read book Update on the Treatment of Metastatic Non-small Cell Lung Cancer (NSCLC) in New Era of Personalised Medicine written by Vera Hirsh and published by Frontiers Media SA. This book was released on 2018-01-24 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer remains a major cause of death in of both women and men in our society. Lung cancer treatment paradigms have changed enormously as we’ve started to understand the genetic complexity and the multiple driver mutations influencing the disease. Therapeutics directed towards, or to inhibit signaling pathways has resulted in increased life spans for our patients. Over the last two decades, we have gone from simple chemotherapy used to treat all, to a personalized medicine approach for the majority. For non-small cell lung cancer patients without driver mutations, the world of immune oncology has arrived. These improved long-term outcomes mean that now our lung cancer patients can live with their cancers, but without progression. The aim of this book is to catalogue the current state of knowledge for the many facets of advanced lung cancer. It describes current treatment approaches for driver mutations, rare mutations, and rare thoracic malignancies such as neuroendocrine tumors. Most importantly, this book addresses the topics of palliative treatment and care which allow our patients to enjoy longer survival with the highest quality of life. We hope you enjoy this e-book. The future is brighter for lung cancer patients and as lung cancer specialists; we finally feel sense optimism about treatment options for our patients.
Book Synopsis Fast Facts for Patients: Non-small Cell Lung Cancer with KRAS Mutation by : A.-M. Baird
Download or read book Fast Facts for Patients: Non-small Cell Lung Cancer with KRAS Mutation written by A.-M. Baird and published by Karger Medical and Scientific Publishers. This book was released on 2023-03-09 with total page 39 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-small cell lung cancer (NSCLC) is one of two main types of lung cancer. Some lung cancers spread to other parts of the body before they are diagnosed. A cancer that has spread is called ‘metastatic’. New lung cancer treatments are being developed that directly target the gene mutations that control how cancers grow and spread. The most important gene mutations in cancer are called ‘driver mutations’. In NSCLC, this includes KRAS mutations, which can be used as targets for treatment. There are new treatments designed for lung cancers with a KRAS mutation that are already available. And more are being developed. Treatments in development are tested in clinical trials. There are several different phases of clinical trials that people with cancer can take part in. This booklet aims to help patients with NSCLC understand their options so that they can talk to their doctors, nurses, and medical team about their cancer and its treatment. Table of Contents: • What is non-small cell lung cancer? • How can lung cancer develop? • What is metastatic NSCLC? • More about genes and cancer • Oncogenes and cancer • Driver mutations and biomarkers • How your doctor knows your cancer is KRAS-positive • More about KRAS • What does having a KRAS-positive cancer mean for me? • Talking to your doctor about your treatment • About clinical trials and research • Finding further information and support
Book Synopsis Emerging Biomarkers for NSCLC: Recent Advances in Diagnosis and Therapy by : Umberto Malapelle
Download or read book Emerging Biomarkers for NSCLC: Recent Advances in Diagnosis and Therapy written by Umberto Malapelle and published by Frontiers Media SA. This book was released on 2021-06-28 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Cytopathology by : Bin Yang
Download or read book Molecular Cytopathology written by Bin Yang and published by Springer. This book was released on 2016-08-12 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the current applications of molecular tools in cytopathology and provides a concise handbook for those who provide care in this era of personalized medicine. Specifically, the text provides a comprehensive and concise review of the emerging molecular tests available clinically in different subspecialities of diagnostic pathology. It reviews the current data of molecular testing already applied in cytopathology, discusses some of the biomarkers with potential utility in cytopathology in the near future and reviews the technical challenges in applying and validating molecular tools in liquid-based cytologic materials. Molecular Cytopathology will serve as a valuable resource for cytopathologists, cytotechnologists, pathology trainees, and clinicians with an interest in molecular applications in cytopathology.
Book Synopsis Elucidation of Genetic Alterations to Understand The Biology of Non Small Cell Lung Cancer Patient by : Mirza Masroor Ali Beg
Download or read book Elucidation of Genetic Alterations to Understand The Biology of Non Small Cell Lung Cancer Patient written by Mirza Masroor Ali Beg and published by Ary Publisher. This book was released on 2023-02-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of genetics has undergone a revolution in recent years, thanks to the development of powerful tools such as CRISPR-Cas9, gene editing, and genome engineering. These tools allow scientists to study genes in unprecedented detail, and to modify them in ways that were previously impossible. This has opened up new possibilities for precision medicine, gene therapy, and the treatment of genetic diseases. Genetic engineering and modification have also been used to study the function of genes and to elucidate their role in various biological processes. Gene regulation and expression, transcription factors, and RNA interference are some of the key areas of research in genetics. Epigenetics, which refers to changes in gene expression that do not involve alterations to the DNA sequence, is another important area of study. Overall, genetics has enormous potential to improve our understanding of biology and to revolutionize healthcare. As the field continues to evolve, we can expect to see more exciting discoveries and breakthroughs in the years ahead
Book Synopsis Lung Cancer and Personalized Medicine by : Aamir Ahmad
Download or read book Lung Cancer and Personalized Medicine written by Aamir Ahmad and published by Springer. This book was released on 2015-12-14 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This, the first of two volumes on personalized medicine in lung cancer, touches on the core issues related to the understanding of lung cancer—statistics and epidemiology of lung cancer—along with the incidence of lung cancer in non-smokers. A major focus of this volume is the state of current therapies against lung cancer—immune, targeted therapies against EGFR TKIs, KRAS, ALK, angiogenesis; the associated challenges, especially resistance mechanisms; and recent progress in targeted drug development based on metal chemistry. Chapters are written by some of the leading experts in the field, who provide a better understanding of lung cancer, the factors that make it lethal, and current research focused on developing personalized treatment plans. With a unique mix of topics, this volume summarizes the current state-of-knowledge on lung cancer and the available therapies.
