Mechanism Of Environmental Carcinogen Induced Mammary Tumorigenesis

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Mechanism of Environmental Carcinogen-Induced Mammary Tumorigenesis

Author : Zhi-Xiong J. Xiao
Publisher :
ISBN 13 :
Total Pages : 27 pages
Book Rating : 4.:/5 (742 download)

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Book Synopsis Mechanism of Environmental Carcinogen-Induced Mammary Tumorigenesis by : Zhi-Xiong J. Xiao

Download or read book Mechanism of Environmental Carcinogen-Induced Mammary Tumorigenesis written by Zhi-Xiong J. Xiao and published by . This book was released on 2001 with total page 27 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental pollutants such as polycyclic aromatic hydrocarbons (PAH) are believed to contribute to the recent increase in breast cancer incidence and mortality. Yet, the molecular mechanism is poorly understood. In this study, we use a carcinogen-induced breast cancer animal model in which the female Sprague-Dawley (S-D) rats develop mammary tumors after a single intragastric dose of treatment of 7,l2-dimethylbenz(a)anthracene (DMBA), a member of the PAH family. Estrogen is indispensable for the DMBA-mediated mammary tumorigenesis. We hypothesize that DMBA-mediated rat mammary tumorigenesis involves in the activation of protooncogene Mdm2 which in turn negatively regulates the tumor suppressor protein p53. We have confirmed that MDM2 is indeed overproduced in DMBA-mammary tumors by Western blot analysis and immunohistochemical staining. We have also found a clear correlation between MDM2 expression and the status of the aromatic hydrocarbon receptor (AhR) and ER in a number of human breast cancer cells. MDM2 expression in MCF-7 cells is activated in a DMBA dose- and time-dependent manner. We show that at least two cellular proteins can specifically interact with an AhR site in MDM2 5' UTR. Moreover, we have evidence that IGF-1 protects DNA damage-induced cell death by upregulation of p21 and MDM2. We conclude that overproduction of MDM2 may play a pathological role in carcinogen-induced mammary tumorigenesis, that MDM2 is upregulated by AhR and ER independent of p53 action.

Mechanisms of Environmental Carcinogenesis: Multistep models of carcinogenesis

Author :
Publisher :
ISBN 13 :
Total Pages : 154 pages
Book Rating : 4.:/5 (45 download)

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Download or read book Mechanisms of Environmental Carcinogenesis: Multistep models of carcinogenesis written by and published by . This book was released on 1987 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mechanisms of Carcinogenesis

Author : Elizabeth K. Weisburger
Publisher : Springer Science & Business Media
ISBN 13 : 9400925263
Total Pages : 210 pages
Book Rating : 4.4/5 (9 download)

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Book Synopsis Mechanisms of Carcinogenesis by : Elizabeth K. Weisburger

Download or read book Mechanisms of Carcinogenesis written by Elizabeth K. Weisburger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: but also the possibility of intervention in specific stages. In Human behavior, including stress and other factors, plays an important role in neoplasia, although too little is known addition, variables which affect cancer development as well on the reasons for such development. Carcinogens, which as some endogenous factors can be better delineated help initiate the neoplastic process, may be either synthetic through such investigations. The topics of this volume encompass premalignant non or naturally-occurring. Cancer causation may be ascribed to invasive lesions, species-specific aspects of carcinogenicity, certain chemicals, physical agents, radioactive materials, viruses, parasites, the genetic make-up of the organism, and radiation, viruses, a quantum theory of carinogenesis, onco bacteria. Humans, eumetazoan animals and vascular plants genes, and selected environmental carcinogens. are susceptible to the first six groups of cancer causes, whe reas the last group, bacteria, seems to affect only vascular plants. Neoplastic development may begin with impairment ofJmdy defenses by a toxic material (carcinogen) which acts as an initiator, followed by promotion and progression to an overt neoplastic state. Investigation of these processes Series Editor Volume Editor allows not only a better insight into the mechanism of action Hans E. Kaiser Elizabeth K. Weisburger vii ACKNOWLEDGEMENT Inspiration and encouragement for this wide ranging project on cancer distribution and dissemination from a comparative biological and clinical point of view, was given by my late friend E. H. Krokowski.

MECHANISM OF ENVIRONMENTAL CARCINOGENESIS

Author : J. Carl Barrett
Publisher : CRC-Press
ISBN 13 : 9780849346729
Total Pages : 144 pages
Book Rating : 4.3/5 (467 download)

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Book Synopsis MECHANISM OF ENVIRONMENTAL CARCINOGENESIS by : J. Carl Barrett

Download or read book MECHANISM OF ENVIRONMENTAL CARCINOGENESIS written by J. Carl Barrett and published by CRC-Press. This book was released on 1987-07-31 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Reducing Environmental Cancer Risk

Author : Suzanne H. Reuben
Publisher : DIANE Publishing
ISBN 13 : 1437934218
Total Pages : 240 pages
Book Rating : 4.4/5 (379 download)

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Book Synopsis Reducing Environmental Cancer Risk by : Suzanne H. Reuben

Download or read book Reducing Environmental Cancer Risk written by Suzanne H. Reuben and published by DIANE Publishing. This book was released on 2010-10 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Though overall cancer incidence and mortality have continued to decline in recent years, cancer continues to devastate the lives of far too many Americans. In 2009 alone, 1.5 million American men, women, and children were diagnosed with cancer, and 562,000 died from the disease. There is a growing body of evidence linking environmental exposures to cancer. The Pres. Cancer Panel dedicated its 2008¿2009 activities to examining the impact of environmental factors on cancer risk. The Panel considered industrial, occupational, and agricultural exposures as well as exposures related to medical practice, military activities, modern lifestyles, and natural sources. This report presents the Panel¿s recommend. to mitigate or eliminate these barriers. Illus.

Cancer and the Environment

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309169240
Total Pages : 160 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Cancer and the Environment by : Institute of Medicine

Download or read book Cancer and the Environment written by Institute of Medicine and published by National Academies Press. This book was released on 2002-08-01 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Roundtable on Environmental Health Sciences, Research, and Medicine wanted to address the link between environmental factors and the development of cancer in light of recent advances in genomics. They asked what research tools are needed, how new scientific information can be applied in a timely manner to reduce the burden of cancer, and how this can be flexible enough to treat the individual.

Comparative Oncology

Author : Alecsandru Ioan Baba
Publisher :
ISBN 13 : 9789732714577
Total Pages : 787 pages
Book Rating : 4.7/5 (145 download)

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Book Synopsis Comparative Oncology by : Alecsandru Ioan Baba

Download or read book Comparative Oncology written by Alecsandru Ioan Baba and published by . This book was released on 2007 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Environmental Carcinogenesis

Author :
Publisher : Elsevier
ISBN 13 : 0323997767
Total Pages : 382 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Environmental Carcinogenesis by :

Download or read book Environmental Carcinogenesis written by and published by Elsevier. This book was released on 2023-02-28 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental Carcinogenesis, Volume 96 in the Advances in Pharmacology series, reports on work done with carcinogenic metals and the mechanisms of their carcinogenicity, including Arsenic and Chromate. Chapters in this release include Breast cancer carcinogenesis by organophosphate pesticides, Polyadenylation of Canonical histone H3.1 in Carcinogenesis, Epigenomic reprogramming in iAs-mediated carcinogenesis, MicroRNAs and epigenetic regulation in metal-induced angiogenesis and carcinogenesis, Environmental epigenetics and new mechanistic markers of chemical exposure, Arsenic carcinogenesis by inhibition of DNA repair, Genetic and environmental reprogramming of the sarcoma epigenome, Mechanism of chromate carcinogenesis by chromatin alterations, and more. Other chapters cover Arsenic carcinogenesis and microRNAs, Epigenetic mechanism of Cr(VI)-induced cell malignant transformation and tumorigenesis, The dark side of NRF2 in arsenic carcinogenesis, and Chemical mechanisms of DNA damage by carcinogenic chromium(VI). - Covers metal carcinogens - Includes discussions on the mechanisms of cancer formation - Provides updates on the diverse mechanisms that drive cancer formation by metals

How Tobacco Smoke Causes Disease

Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General

Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Carcinogens and Anticarcinogens in the Human Diet

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309053919
Total Pages : 434 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Carcinogens and Anticarcinogens in the Human Diet by : National Research Council

Download or read book Carcinogens and Anticarcinogens in the Human Diet written by National Research Council and published by National Academies Press. This book was released on 1996-03-12 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite increasing knowledge of human nutrition, the dietary contribution to cancer remains a troubling question. Carcinogens and Anticarcinogens assembles the best available information on the magnitude of potential cancer riskâ€"and potential anticarcinogenic effectâ€"from naturally occurring chemicals compared with risk from synthetic chemical constituents. The committee draws important conclusions about diet and cancer, including the carcinogenic role of excess calories and fat, the anticarcinogenic benefit of fiber and other substances, and the impact of food additive regulation. The book offers recommendations for epidemiological and diet research. Carcinogens and Anticarcinogens provides a readable overview of issues and addresses critical questions: Does diet contribute to an appreciable proportion of human cancer? Are there significant interactions between carcinogens and anticarcinogens in the diet? The volume discusses the mechanisms of carcinogenic and anticarcinogenic properties and considers whether techniques used to evaluate the carcinogenic potential of synthetics can be used with naturally occurring chemicals. The committee provides criteria for prioritizing the vast number of substances that need to be tested. Carcinogens and Anticarcinogens clarifies the issues and sets the direction for further investigations into diet and cancer. This volume will be of interest to anyone involved in food and health issues: policymakers, regulators, researchers, nutrition professionals, and health advocates.

Drinking Water and Health,

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309036879
Total Pages : 476 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Drinking Water and Health, by : National Research Council

Download or read book Drinking Water and Health, written by National Research Council and published by National Academies Press. This book was released on 1986-02-01 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most recent volume in the Drinking Water and Health series contains the results of a two-part study on the toxicity of drinking water contaminants. The first part examines current practices in risk assessment, identifies new noncancerous toxic responses to chemicals found in drinking water, and discusses the use of pharmacokinetic data to estimate the delivered dose and response. The second part of the book provides risk assessments for 14 specific compounds, 9 presented here for the first time.

Environmental Factors, Genes, and the Development of Human Cancers

Author : Deodutta Roy
Publisher : Springer Science & Business Media
ISBN 13 : 1441967524
Total Pages : 521 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Environmental Factors, Genes, and the Development of Human Cancers by : Deodutta Roy

Download or read book Environmental Factors, Genes, and the Development of Human Cancers written by Deodutta Roy and published by Springer Science & Business Media. This book was released on 2010-09-11 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is a complex disease. Only 5-10% of human cancers are hereditary in nature. Many of us think of environmental agents when we think of carcinogens. The environment includes all that surrounds us, and environmental influences include not only chemical, physical and biological toxicants, but also diet and lifestyle. In this broadest sense, the environment contributes substantially in the development of human cancer. This book will describe how environment contributes to malignant transformation leading to profound changes in the genetic and signaling networks that control the functioning of the cell. It will critically discuss the understanding of the effects of environment on the development, progression and metastasis of cancer with current knowledge of the signaling networks that support functioning of transformed human cells. Genes and environmental factors that influence the origins of cancer are not necessarily the same as those that contribute to its progression and metastasis. Susceptibility gene variants for each specific cancer are being identified with emerging evidence of gene–environment interaction. Gene-environment interactions will be discussed through each specific cancer-based approach to address the question of how genetic variations can influence susceptibility to the individual type of cancer. It will also highlight and summarize epigenetic changes that increase the risk for susceptibility to a particular type of cancer, particularly in the presence of specific environmental factors. Thus, this book will contain chapters from the world’s experts focused on the current evidences that support the role of environment in the cancer etiology and in the growth of malignant lesions, and discuss who may be susceptible to environmental influences.

Environmental Carcinogenesis

Author : Piet Emmelot
Publisher : North Holland
ISBN 13 :
Total Pages : 424 pages
Book Rating : 4.:/5 (42 download)

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Book Synopsis Environmental Carcinogenesis by : Piet Emmelot

Download or read book Environmental Carcinogenesis written by Piet Emmelot and published by North Holland. This book was released on 1979 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Health Risks from Exposure to Low Levels of Ionizing Radiation

Author : Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation
Publisher : National Academies Press
ISBN 13 : 0309133343
Total Pages : 422 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Health Risks from Exposure to Low Levels of Ionizing Radiation by : Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation

Download or read book Health Risks from Exposure to Low Levels of Ionizing Radiation written by Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation and published by National Academies Press. This book was released on 2006-03-23 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.

Cancer as an Environmental Disease

Author : P. Nicolopoulou-Stamati
Publisher : Springer Science & Business Media
ISBN 13 : 9781402020193
Total Pages : 242 pages
Book Rating : 4.0/5 (21 download)

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Book Synopsis Cancer as an Environmental Disease by : P. Nicolopoulou-Stamati

Download or read book Cancer as an Environmental Disease written by P. Nicolopoulou-Stamati and published by Springer Science & Business Media. This book was released on 2004-03-31 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: During recent decades the somatic mutation theory for the causation of cancer has held sway. The influence of environmental factors in the aetiology of cancer has become a matter of debate between those who maintain that it is largely a degenerative phenomenon and other voices who increasingly support the hypothesis that environmental factors predominate. An examination of some aspects of this debate is the prime purpose of this book. The increasing incidence of cancer across many parts of the world, particularly in children, has happened over a very short period of time in evolutionary terms. One can infer that it is connected to changes in the environment and/or our lifestyles. A major counter-argument to this contention is that rising cancer incidence is mainly because the average life expectancy has increased.These pages contain a number of chapters from specialists in the field who consider, from a number of different perspectives, the currently available evidence that supports the environmental cancer,aetiology hypothesis. This constitutes the first part of the book. In the second part of the book, an examination of the policy implications of accepting that the cancer epidemic may essentially be preventable is presented. This will pose some difficult problems for politicians and decision-makers, who will have to consider adopting policies that may damage the economy in the short term in order to reap health benefits which will only become apparent several decades in the future.

Environmental Epigenetics

Author : L. Joseph Su
Publisher : Springer
ISBN 13 : 1447166787
Total Pages : 327 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Environmental Epigenetics by : L. Joseph Su

Download or read book Environmental Epigenetics written by L. Joseph Su and published by Springer. This book was released on 2015-05-18 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Mechanism of Aromatic Hydrocarbon Induced Mammary Tumorigenesis

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (946 download)

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Book Synopsis Mechanism of Aromatic Hydrocarbon Induced Mammary Tumorigenesis by :

Download or read book Mechanism of Aromatic Hydrocarbon Induced Mammary Tumorigenesis written by and published by . This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent evidence suggests that the rise in breast cancer rates reflects increased exposure to and bioaccumulation of environmental pollutants, such as 7,12-dimethylbenz(a)anthracene (DMBA). Female Sprague-Dawley rats treated with DMBA develop mammary (breast) tumors by about 15 weeks. Here we proposed to elucidate the roles of the aromatic hydrocarbon (Ah) and estrogen receptors and the c-myc oncogene. The hypothesis investigated was that administration of DMBA would lead to AhR-mediated induction of P-45O enzymes.