Marine Natural Products As Anticancer Agents

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Marine Natural Products as Anticancer Agents 2.0

Author : Celso Alves
Publisher : Mdpi AG
ISBN 13 : 9783036575681
Total Pages : 0 pages
Book Rating : 4.5/5 (756 download)

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Book Synopsis Marine Natural Products as Anticancer Agents 2.0 by : Celso Alves

Download or read book Marine Natural Products as Anticancer Agents 2.0 written by Celso Alves and published by Mdpi AG. This book was released on 2023-06-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Global cancer incidence and death are expected to increase in the next decades. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes, which is critical to the discovery and development of new anticancer drugs. Over the last few decades, the marine environment has proved to be a key source of molecules with potent anticancer properties. The Special Issue, "Marine Natural Products as Anticancer Agents 2.0", gathered eleven publications, including two reviews and nine research articles, about the anticancer activities of marine natural and/or derived products on in vitro 2D and 3D cellular models, and/or in vivo models of colorectal, breast, lung, myeloma, liver, leukemia, and melanoma cancers. Altogether, the eleven scientific papers published in this Special Issue provide an exciting overview of marine natural products as potential anticancer agents.

Handbook of Anticancer Drugs from Marine Origin

Author : Se-Kwon Kim
Publisher : Springer
ISBN 13 : 3319071459
Total Pages : 801 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Handbook of Anticancer Drugs from Marine Origin by : Se-Kwon Kim

Download or read book Handbook of Anticancer Drugs from Marine Origin written by Se-Kwon Kim and published by Springer. This book was released on 2014-11-27 with total page 801 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely desk reference focuses on marine-derived bioactive substances which have biological, medical and industrial applications. The medicinal value of these marine natural products are assessed and discussed. Their function as a new and important resource in novel, anticancer drug discovery research is also presented in international contributions from several research groups. For example, the potential role of Spongistatin, Apratoxin A, Eribulin mesylate, phlorotannins, fucoidan, as anticancer agents is explained. The mechanism of action of bioactive compounds present in marine algae, bacteria, fungus, sponges, seaweeds and other marine animals and plants are illustrated via several mechanisms. In addition, this handbook lists various compounds that are active candidates in chemoprevention and their target actions. The handbook also places into context the demand for anticancer nutraceuticals and their use as potential anti-cancer pharmaceuticals and medicines. This study of advanced and future types of natural compounds from marine sources is written to facilitate the understanding of Biotechnology and its application to marine natural product drug discovery research.

Marine Natural Products as Anticancer Agents

Author : Celso Alves
Publisher :
ISBN 13 : 9783036518190
Total Pages : 150 pages
Book Rating : 4.5/5 (181 download)

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Book Synopsis Marine Natural Products as Anticancer Agents by : Celso Alves

Download or read book Marine Natural Products as Anticancer Agents written by Celso Alves and published by . This book was released on 2021 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer remains one of the most significant threats to human health and one of the deadliest diseases worldwide, making it crucial to develop new drugs. Over the last few decades, natural products have become one of the key drivers in the development of innovative cancer treatments. Despite drug development from terrestrial resources, the marine environment only recently emerged as a prolific source of unparalleled structurally active metabolites. Due to their excellent scaffold diversity, structural complexity, and ability to act on multiple cell signaling networks involved in carcinogenesis, marine natural products (MNPs) are ideal candidates to inspire the development of novel anticancer medicines. This book gathers nine publications of the Special Issue "Marine Natural Products as Anticancer Agents," providing an excellent overview of the chemical richness offered by marine organisms, such as sponges, myxobacteria, fungi, and soft corals. MNPs or derived products belong to distinct chemical classes, including terpenoids, alkaloids, cyclodepsipeptides, polyketides, and hydroxyphenylacetic acid derivatives. These compounds modulate cancer cell mechanisms in in vitro and in vivo models, exhibiting high specificity and great affinity to interact with biological targets linked to specific intracellular signaling pathways, including mitochondrial dysfunction, autophagy, endoplasmic reticulum stress induction, apoptosis, inflammation, migration, and invasion. This volume provides an exciting overview of marine natural products as potential therapeutic agents for cancer treatment.

Marine Natural Products as Anticancer Agents

Author : Celso Alves
Publisher : Mdpi AG
ISBN 13 : 9783036518206
Total Pages : 166 pages
Book Rating : 4.5/5 (182 download)

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Book Synopsis Marine Natural Products as Anticancer Agents by : Celso Alves

Download or read book Marine Natural Products as Anticancer Agents written by Celso Alves and published by Mdpi AG. This book was released on 2021-11-12 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer remains one of the most significant threats to human health and one of the deadliest diseases worldwide, making it crucial to develop new drugs. Over the last few decades, natural products have become one of the key drivers in the development of innovative cancer treatments. Despite drug development from terrestrial resources, the marine environment only recently emerged as a prolific source of unparalleled structurally active metabolites. Due to their excellent scaffold diversity, structural complexity, and ability to act on multiple cell signaling networks involved in carcinogenesis, marine natural products (MNPs) are ideal candidates to inspire the development of novel anticancer medicines. This book gathers nine publications of the Special Issue "Marine Natural Products as Anticancer Agents," providing an excellent overview of the chemical richness offered by marine organisms, such as sponges, myxobacteria, fungi, and soft corals. MNPs or derived products belong to distinct chemical classes, including terpenoids, alkaloids, cyclodepsipeptides, polyketides, and hydroxyphenylacetic acid derivatives. These compounds modulate cancer cell mechanisms in in vitro and in vivo models, exhibiting high specificity and great affinity to interact with biological targets linked to specific intracellular signaling pathways, including mitochondrial dysfunction, autophagy, endoplasmic reticulum stress induction, apoptosis, inflammation, migration, and invasion. This volume provides an exciting overview of marine natural products as potential therapeutic agents for cancer treatment.

Anticancer Agents from Natural Products

Author : Gordon M. Cragg
Publisher : CRC Press
ISBN 13 : 1420039652
Total Pages : 610 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Anticancer Agents from Natural Products by : Gordon M. Cragg

Download or read book Anticancer Agents from Natural Products written by Gordon M. Cragg and published by CRC Press. This book was released on 2005-06-13 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants, marine organisms, and microorganisms have evolved complex chemical defense and signaling systems that are designed to protect them from predators and provide other biological benefits. These organisms thus produce substances containing novel chemotypes that may have beneficial effects for humans. As collection methods improve and new screen

Marine Compounds and Cancer

Author : Friedemann Honecker
Publisher : MDPI
ISBN 13 : 3038427659
Total Pages : 119 pages
Book Rating : 4.0/5 (384 download)

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Book Synopsis Marine Compounds and Cancer by : Friedemann Honecker

Download or read book Marine Compounds and Cancer written by Friedemann Honecker and published by MDPI. This book was released on 2018-06-26 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Marine Compounds and Cancer" that was published in Marine Drugs

Natural Products as Anticancer Agents

Author : Bimal Krishna Banik
Publisher : Elsevier
ISBN 13 : 0323997112
Total Pages : 444 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Natural Products as Anticancer Agents by : Bimal Krishna Banik

Download or read book Natural Products as Anticancer Agents written by Bimal Krishna Banik and published by Elsevier. This book was released on 2023-11-21 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural Products as Anticancer Agents introduces the different types of natural products that have been used for cancer treatment. Divided into four parts, covering anticancer agents derived from terrestrial plants, anticancer agents derived from the marine environment, and anticancer agents derived from microorganisms, as well as evaluation of new anticancer agents, each part includes discussion of the properties, synthesis/extraction, storage, mechanism of action, and usage of the molecules. Discussion of the future prospects in anticancer natural products—including several new trends and an indication of where research in this area is likely to go in the future—is also included. Assists in the identification of risk factors associated with the drug development process Includes process diagrams detailing the procedure for the isolation and purification of molecules Covers cost-effective green approaches in the development of anticancer drugs

Phylum Bryozoa

Author : Thomas Schwaha
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110586312
Total Pages : 458 pages
Book Rating : 4.1/5 (15 download)

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Book Synopsis Phylum Bryozoa by : Thomas Schwaha

Download or read book Phylum Bryozoa written by Thomas Schwaha and published by Walter de Gruyter GmbH & Co KG. This book was released on 2020-11-23 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: With an account of over 6.000 recent and 15.000 fossil species, phylum Bryozoa represents a quite large and important phylum of colonial filter feeders. This volume of the series Handbook of Zoology contains new findings on phylogeny, morphology and evolution that have significantly improved our knowledge and understanding of this phylum. It is a comprehensive book that will be a standard for many specialists but also newcomers to the field of bryozoology.

Characterization of Marine Natural Products as Anticancer Agents

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (895 download)

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Book Synopsis Characterization of Marine Natural Products as Anticancer Agents by :

Download or read book Characterization of Marine Natural Products as Anticancer Agents written by and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Studies in Natural Products Chemistry

Author : Ajai Prakash Gupta
Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128084731
Total Pages : 70 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Studies in Natural Products Chemistry by : Ajai Prakash Gupta

Download or read book Studies in Natural Products Chemistry written by Ajai Prakash Gupta and published by Elsevier Inc. Chapters. This book was released on 2013-06-25 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is a dreadful human disease, increasing with changing lifestyle, nutrition, and global warming. Its treatments do not have potent medicine as the currently available drugs results in severe side effects. Past activities in this area focused on the natural products derived from medicinal plants. According to the WHO, 80% of the world’s population primarily those from developing countries rely on plant-derived medicines for the health care. Over the past few decades, significant efforts have been made, jointly by pharmaceutical and academic institutions, to isolate and identify new marine-derived natural products. With the advancement of technology and methodology in this area, numerous new compounds have been isolated and several novel anticancer compounds are under clinical investigations. The ocean biomass, covering two-third of the earth, with huge unexplored natural product offers enormous scope and presents an effective alternative in natural product drug discovery. The uniqueness in oceanic mega-diversity is due to spatial as well as temporal competition along with unique habitat with extreme pressure, temperature, and saline conditions. As a result of this, marine organisms have adapted and evolved themselves successfully since centuries in these conditions by producing molecules which are unique in structures, biosynthesis, and function. This “chemical adaptations” is an excellent source of novel chemical entities which is absent in land-based organisms. The past decade has seen more than 10,000 compounds isolated from marine sources which have dramatically increased the number of preclinical anticancers drug under evaluation, and over 300 patents on bioactive natural products from marine sources were granted during this tenure. Efforts, in this direction, became more serious and focused with National Cancer Institute, USA taking a lead role. By collaborative interactions between pharmaceutical companies and research organization, numerous drug-like molecules with several of them having clinical and preclinical potential were discovered. Ecteinascidin-743/ET-743 from Caribbean tunicate and Didemnin and Aplidine from Aplidium albicans are some of the successful examples. Sterols and dietary fibers from seaweeds also hold immense potential. However, investigation of the marine floras chemical entities as drug-like molecule is still in its embryonic stage. The present chapter showcases the past research and reviews the baseline data for promoting further research in this field.

Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer Therapeutics

Author : Pandurangan, Ashok Kumar
Publisher : IGI Global
ISBN 13 : 1799892603
Total Pages : 643 pages
Book Rating : 4.7/5 (998 download)

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Book Synopsis Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer Therapeutics by : Pandurangan, Ashok Kumar

Download or read book Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer Therapeutics written by Pandurangan, Ashok Kumar and published by IGI Global. This book was released on 2022-03-18 with total page 643 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many chemotherapeutic agents are available in today’s market that are highly effective against a variety of cancer types; however, the major drawbacks of these chemotherapeutic agents are the many side effects. As an alternative to these chemotherapeutic agents, there are a number of natural agents that are effective against cancer that have been tested in preclinical and clinical models over the years. These natural products must be documented and discussed in order to provide a thorough overview of all the options available for cancer treatment. The Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer Therapeutics emphasizes the list of natural agents against all types of cancers and discusses the current state of research in the fields of natural products and their derivatives against cancer in preclinical and clinical models. This book also provides insight into the applications of meditation and mindfulness-based interventions in clinical and non-clinical conditions. Covering topics such as cancer therapy, antioxidants, and flavonoids, it is ideal for students, research scholars, academicians, professors, scientists, oncologists, doctors, and medical practitioners.

Anticancer Agents from Natural Products, Second Edition

Author : Gordon M. Cragg
Publisher : CRC Press
ISBN 13 : 1439813825
Total Pages : 786 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Anticancer Agents from Natural Products, Second Edition by : Gordon M. Cragg

Download or read book Anticancer Agents from Natural Products, Second Edition written by Gordon M. Cragg and published by CRC Press. This book was released on 2011-10-10 with total page 786 pages. Available in PDF, EPUB and Kindle. Book excerpt: The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products, Second Edition covers the: History of each covered drug—a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery Important biosynthetic approaches to "unnatural" natural products Anticancer Agents from Natural Products, Second Edition discusses how complex target-oriented synthesis—enabled by historic advances in methodology—has enormously expanded the scope of the possible. This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. It also reviews drug candidates currently in clinical development since many of these will be clinically used drugs in the future. Examples include the drugs etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan, derived from camptothecin; and the synthetic clinical candidates, E7389 and HTI-286, developed from the marine leads, halichondrin B and hemiasterlin.

Evolutionary Diversity as a Source for Anticancer Molecules

Author : Akhileshwar Kumar Srivastava
Publisher : Academic Press
ISBN 13 : 0128216980
Total Pages : 392 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Evolutionary Diversity as a Source for Anticancer Molecules by : Akhileshwar Kumar Srivastava

Download or read book Evolutionary Diversity as a Source for Anticancer Molecules written by Akhileshwar Kumar Srivastava and published by Academic Press. This book was released on 2020-09-21 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evolutionary Diversity as a Source for Anticancer Molecules discusses evolutionary diversity as source for anticancer agents derived from bacteria, algae, bryophytes, pteridophytes, and gymnosperms. The book goes over the isolation of anticancer agents and the technologyenabled screening process used to develop anticancer drugs. The book also includes discussion of the nutraceuticals and natural productsderived from invertebrates that can be used as part of cancer treatment. Evolutionary Diversity as a Source for Anticancer Molecules also deals with some of the current challenges in the prevention of cancer as well as the side effects of conventional drugs used for cancer patients.This book is a valuable resource for cancer researchers, oncologists, biotechnologists, pharmacologists, and any member of the biomedicalfield interested in understanding more about natural products with anticancer potential. Discusses the application of natural products in place of conventional drugs to minimize the side effects in cancer treatment Explains the relation between evolutionary mechanisms and climate change for production of secondary metabolites

Bioactive Marine Natural Products

Author : Dewan S. Bhakuni
Publisher : Springer Science & Business Media
ISBN 13 : 1402034849
Total Pages : 397 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Bioactive Marine Natural Products by : Dewan S. Bhakuni

Download or read book Bioactive Marine Natural Products written by Dewan S. Bhakuni and published by Springer Science & Business Media. This book was released on 2006-06-30 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioactive Marine Natural Products is the first book available that covers all aspects of bioactive marine natural products. It fills the void in the literature for bioactive marine natural products. The book covers various aspects of marine natural products and it is hoped that all the major classes of bioactive compounds are included. Different classes of marine organisms and the separation and isolation techniques are discussed. The chemistry and biology of marine toxins, peptides, alkaloids, nucleosides and prostanoids are discussed in detail. Biological, toxicological and clinical evaluations are also dealt with to ensure that the book may be adopted at any stage by any practicing organic chemist or biologist, working in academia or in R and D divisions of pharmaceutical companies. Each chapter in the book includes an abstract to highlight the major points discussed in the text and concluding remarks are given. References to books, monographs, review articles and original papers are provided at the end of each chapter.

Marine Natural Products

Author : Hiromasa Kiyota
Publisher : Springer
ISBN 13 : 9783642070280
Total Pages : 0 pages
Book Rating : 4.0/5 (72 download)

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Book Synopsis Marine Natural Products by : Hiromasa Kiyota

Download or read book Marine Natural Products written by Hiromasa Kiyota and published by Springer. This book was released on 2010-11-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Natural Products for Cancer Prevention and Therapy

Author : Anupam Bishayee
Publisher : MDPI
ISBN 13 : 3038973106
Total Pages : 285 pages
Book Rating : 4.0/5 (389 download)

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Book Synopsis Natural Products for Cancer Prevention and Therapy by : Anupam Bishayee

Download or read book Natural Products for Cancer Prevention and Therapy written by Anupam Bishayee and published by MDPI. This book was released on 2018-11-07 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Natural Products for Cancer Prevention and Therapy" that was published in Nutrients

Natural Products and Cancer Drug Discovery

Author : Frank E. Koehn
Publisher : Springer Science & Business Media
ISBN 13 : 1461446546
Total Pages : 248 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Natural Products and Cancer Drug Discovery by : Frank E. Koehn

Download or read book Natural Products and Cancer Drug Discovery written by Frank E. Koehn and published by Springer Science & Business Media. This book was released on 2012-11-09 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will cover the natural products as they relate to cancer chemotherapy. The topics will include history and current status , recent launches, new clinical candidates and approved drugs directly derived from natural products, current and future cancer target opportunities for natural products, leveraging natural products as tools for new target generation , new approaches to cancer drug discovery through natural products based lead generation, and enabling technologies which leverage the unique attributes of natural products.