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Mapping Quantitative Trait Loci In Outbred Half Sib Populations
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Book Synopsis Mapping Quantitative Trait Loci in Outbred Half-sib Populations by :
Download or read book Mapping Quantitative Trait Loci in Outbred Half-sib Populations written by and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative trait loci (QTL) mapping in outbred populations faces some challenges unique to the divergent genetic background and complex pedigree relationships. Motivated by a dairy cattle half-sib data set from a grand daughter design, we present in this dissertation a series of endeavors to address various challenges along the analysis flow of QTL mapping. A first step is to infer the haplotypes in sires based on the observed genotypes in sires and his offspring. Our method was shown to outperform peer methods with greater robustness and accuracy yet with fast speed performance. Then in light of adapting the multiple interval mapping method to within-family QTL analysis, we extended the modeling framework by allowing for heteroscedastic residual variances and upgraded the Windows QTL Cartographer accordingly. The advantageous post-analysis result parsing from Windows QTL Cartographer and more importantly, the improved analysis outputs due to more powerful maximum likelihood-based mixture modeling than the least squares regression manifest our efforts in delivering better methodology via practically user friendly software. We further developed a mixed model approach for the purpose of QTL mapping across multiple families that was aimed at modeling QTL effects as both the fixed effect across families and the random effect within families. Our mixed model was shown to encompass similar or higher statistical testing performance on QTL variation than the widely used variance component modeling approach, yet still allowing permutations for obtaining chromosome-wide or genome-wide significance threshold. What's more, the flexibility of our mixed model in constructing alternative hypotheses testing on either fixed or random QTL effects or both was shown to offer interesting insight into the varying sources of signal that would not be unveiled by least squares regression or variance component methods. In concluding our comprehensive approach to QTL linkage mapping in dair.
Book Synopsis Mapping Quantitative Trait Loci in Outbred Half-sib Populations by : Xiaohua Gong
Download or read book Mapping Quantitative Trait Loci in Outbred Half-sib Populations written by Xiaohua Gong and published by . This book was released on 2009 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Keywords: QTL, half-sib, variance component, mixed model, EM algorithm, haplotyping.
Book Synopsis Quantitative Trait Loci by : Nicola J. Camp
Download or read book Quantitative Trait Loci written by Nicola J. Camp and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Quantitative Trait Loci: Methods and Protocols, a panel of highly experienced statistical geneticists demonstrate in a step-by-step fashion how to successfully analyze quantitative trait data using a variety of methods and software for the detection and fine mapping of quantitative trait loci (QTL). Writing for the nonmathematician, these experts guide the investigator from the design stage of a project onwards, providing detailed explanations of how best to proceed with each specific analysis, to find and use appropriate software, and to interpret results. Worked examples, citations to key papers, and variations in method ease the way to understanding and successful studies. Among the cutting-edge techniques presented are QTDT methods, variance components methods, and the Markov Chain Monte Carlo method for joint linkage and segregation analysis.
Book Synopsis Quantitative Trait Loci Analysis in Animals by : Joel Ira Weller
Download or read book Quantitative Trait Loci Analysis in Animals written by Joel Ira Weller and published by CABI. This book was released on 2009 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative Trait Loci (QTL) is a topic of major agricultural significance for efficient livestock production. This book covers various statistical methods that have been used or proposed for detection and analysis of QTL and marker-and gene-assisted selection in animal genetics and breeding.
Book Synopsis Statistical Genetics of Quantitative Traits by : Rongling Wu
Download or read book Statistical Genetics of Quantitative Traits written by Rongling Wu and published by Springer Science & Business Media. This book was released on 2007-07-17 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the basic concepts and methods that are useful in the statistical analysis and modeling of the DNA-based marker and phenotypic data that arise in agriculture, forestry, experimental biology, and other fields. It concentrates on the linkage analysis of markers, map construction and quantitative trait locus (QTL) mapping, and assumes a background in regression analysis and maximum likelihood approaches. The strength of this book lies in the construction of general models and algorithms for linkage analysis, as well as in QTL mapping in any kind of crossed pedigrees initiated with inbred lines of crops.
Book Synopsis Statistical Methods to Map Quantitative Trait Loci for Binary Traits in Half-sib Populations by :
Download or read book Statistical Methods to Map Quantitative Trait Loci for Binary Traits in Half-sib Populations written by and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Designing Experiments for Mapping Quantitative Trait Loci in Segregating Animal Populations by : Fengxing Du
Download or read book Designing Experiments for Mapping Quantitative Trait Loci in Segregating Animal Populations written by Fengxing Du and published by . This book was released on 1999 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis A Guide to QTL Mapping with R/qtl by : Karl W. Broman
Download or read book A Guide to QTL Mapping with R/qtl written by Karl W. Broman and published by Springer. This book was released on 2011-12-02 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive discussion of QTL mapping concepts and theory Detailed instructions on the use of the R/qtl software, the most featured and flexible software for QTL mapping Two case studies illustrate QTL analysis in its entirety
Book Synopsis Genetics and Analysis of Quantitative Traits by : Michael Lynch
Download or read book Genetics and Analysis of Quantitative Traits written by Michael Lynch and published by Sinauer Associates Incorporated. This book was released on 1998-01 with total page 980 pages. Available in PDF, EPUB and Kindle. Book excerpt: Professors Lynch and Walsh bring together the diverse array of theoretical and empirical applications of quantitative genetics in a work that is comprehensive and accessible to anyone with a rudimentary understanding of statistics and genetics.
Book Synopsis Bioinformatics in Aquaculture by : Zhanjiang (John) Liu
Download or read book Bioinformatics in Aquaculture written by Zhanjiang (John) Liu and published by John Wiley & Sons. This book was released on 2017-04-17 with total page 605 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioinformatics derives knowledge from computer analysis of biological data. In particular, genomic and transcriptomic datasets are processed, analysed and, whenever possible, associated with experimental results from various sources, to draw structural, organizational, and functional information relevant to biology. Research in bioinformatics includes method development for storage, retrieval, and analysis of the data. Bioinformatics in Aquaculture provides the most up to date reviews of next generation sequencing technologies, their applications in aquaculture, and principles and methodologies for the analysis of genomic and transcriptomic large datasets using bioinformatic methods, algorithm, and databases. The book is unique in providing guidance for the best software packages suitable for various analysis, providing detailed examples of using bioinformatic software and command lines in the context of real world experiments. This book is a vital tool for all those working in genomics, molecular biology, biochemistry and genetics related to aquaculture, and computational and biological sciences.
Book Synopsis Quantitative Trait Loci (QTL) by : Scott A. Rifkin
Download or read book Quantitative Trait Loci (QTL) written by Scott A. Rifkin and published by Humana Press. This book was released on 2016-08-23 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last two decades advances in genotyping technology, and the development of quantitative genetic analytical techniques have made it possible to dissect complex traits and link quantitative variation in traits to allelic variation on chromosomes or quantitative trait loci (QTLs). In Quantitative Trait Loci (QTLs):Methods and Protocols, expert researchers in the field detail methods and techniques that focus on specific components of the entire process of quantitative train loci experiments. These include methods and techniques for the mapping populations, identifying quantitative trait loci, extending the power of quantitative trait locus analysis, and case studies. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Quantitative Trait Loci (QTLs):Methods and Protocols aids scientists in the further study of the links between phenotypic and genotypic variation in fields from medicine to agriculture, from molecular biology to evolution to ecology.
Author :Davood Kolbehdari Publisher :Library and Archives Canada = Bibliothèque et Archives Canada ISBN 13 :9780494019061 Total Pages :120 pages Book Rating :4.0/5 (19 download)
Book Synopsis Fine Mapping of Quantitative Trait Loci (QTL) Using Linkage and Linkage Disequilibrium Analysis in Half-sib Designs [microform] by : Davood Kolbehdari
Download or read book Fine Mapping of Quantitative Trait Loci (QTL) Using Linkage and Linkage Disequilibrium Analysis in Half-sib Designs [microform] written by Davood Kolbehdari and published by Library and Archives Canada = Bibliothèque et Archives Canada. This book was released on 2004 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Quantitative Trait Loci (QTL) by : Scott A. Rifkin
Download or read book Quantitative Trait Loci (QTL) written by Scott A. Rifkin and published by Humana Press. This book was released on 2012-05-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last two decades advances in genotyping technology, and the development of quantitative genetic analytical techniques have made it possible to dissect complex traits and link quantitative variation in traits to allelic variation on chromosomes or quantitative trait loci (QTLs). In Quantitative Trait Loci (QTLs):Methods and Protocols, expert researchers in the field detail methods and techniques that focus on specific components of the entire process of quantitative train loci experiments. These include methods and techniques for the mapping populations, identifying quantitative trait loci, extending the power of quantitative trait locus analysis, and case studies. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Quantitative Trait Loci (QTLs):Methods and Protocols aids scientists in the further study of the links between phenotypic and genotypic variation in fields from medicine to agriculture, from molecular biology to evolution to ecology.
Book Synopsis Mapping Quantitative Trait Loci Using Genetic Markers in an F2 Population by : Fengxing Du
Download or read book Mapping Quantitative Trait Loci Using Genetic Markers in an F2 Population written by Fengxing Du and published by . This book was released on 1998 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Genetic Dissection of Complex Traits by : D.C. Rao
Download or read book Genetic Dissection of Complex Traits written by D.C. Rao and published by Academic Press. This book was released on 2008-04-23 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of genetics is rapidly evolving and new medical breakthroughs are occuring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Five sections on the latest advances in complex traits Methods for testing with ethical, legal, and social implications Hot topics include discussions on systems biology approach to drug discovery; using comparative genomics for detecting human disease genes; computationally intensive challenges, and more
Book Synopsis Systems Genetics by : Florian Markowetz
Download or read book Systems Genetics written by Florian Markowetz and published by Cambridge University Press. This book was released on 2015-07-02 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Whereas genetic studies have traditionally focused on explaining heritance of single traits and their phenotypes, recent technological advances have made it possible to comprehensively dissect the genetic architecture of complex traits and quantify how genes interact to shape phenotypes. This exciting new area has been termed systems genetics and is born out of a synthesis of multiple fields, integrating a range of approaches and exploiting our increased ability to obtain quantitative and detailed measurements on a broad spectrum of phenotypes. Gathering the contributions of leading scientists, both computational and experimental, this book shows how experimental perturbations can help us to understand the link between genotype and phenotype. A snapshot of current research activity and state-of-the-art approaches to systems genetics are provided, including work from model organisms such as Saccharomyces cerevisiae and Drosophila melanogaster, as well as from human studies.
Book Synopsis Fine-mapping Quantitative Trait Loci for Meat Quality Using Linkages and Linkage Disequilibrium Analyses by : Gelson Luís Dias Feijó
Download or read book Fine-mapping Quantitative Trait Loci for Meat Quality Using Linkages and Linkage Disequilibrium Analyses written by Gelson Luís Dias Feijó and published by . This book was released on 2007 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt:
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