Maladies A Prions

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Prions and Diseases

Author : Wen-Quan Zou
Publisher : Springer Nature
ISBN 13 : 3031205650
Total Pages : 773 pages
Book Rating : 4.0/5 (312 download)

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Book Synopsis Prions and Diseases by : Wen-Quan Zou

Download or read book Prions and Diseases written by Wen-Quan Zou and published by Springer Nature. This book was released on 2023-01-01 with total page 773 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transmissible spongiform encephalopathies (TSE), known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. Modern studies, including the protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In the second edition of Prions and Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date discussion of these unique infectious pathogens and their associated diseases. The book provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the full range of animal and human prion diseases. As a result, the book contains by far the most authoritative views about the past, present, and future of prions and prion diseases. The new second edition covers such important emerging topics such as inherited human prion disease, stem-cell models in prion research, human prion disease surveillance, and gene therapy strategies.

Prions and Diseases

Author : Wen-Quan Zou
Publisher : Springer Science & Business Media
ISBN 13 : 1461453380
Total Pages : 322 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Prions and Diseases by : Wen-Quan Zou

Download or read book Prions and Diseases written by Wen-Quan Zou and published by Springer Science & Business Media. This book was released on 2012-11-08 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.

The Pathological Protein

Author : Philip Yam
Publisher : Springer Science & Business Media
ISBN 13 : 038721755X
Total Pages : 290 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis The Pathological Protein by : Philip Yam

Download or read book The Pathological Protein written by Philip Yam and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prions are an entirely new class of pathogens, and scientists are just beginning to understand them. Although they have plagued humans and animals for 3 centuries, only in the last 2 decades have researchers linked them to diseases like Mad Cow. This book tells the strange story of their discovery, and the medical controversies that swirl around them. The author, Philip Yam, is a well-respected and connected journalist who is now an editor at Scientific American.

Prions and Brain Diseases in Animals and Humans

Author : Douglas R.O. Morrison
Publisher : Springer Science & Business Media
ISBN 13 : 1489918965
Total Pages : 349 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Prions and Brain Diseases in Animals and Humans by : Douglas R.O. Morrison

Download or read book Prions and Brain Diseases in Animals and Humans written by Douglas R.O. Morrison and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most of the world's experts on prions met for a workshop in Erice in August 1996. The aim of the workshop was to discuss the fundamentals of the science ofprions. It was for tunate that so many could be present given the pressure that they were under because of the data presented in March 1996, indicating that Bovine Spongiform Encephalopathy, BSE or Mad Cow Disease, had penetrated the species barrier and was beginning to cause a new dis ease in humans--the new variant ofCreutzfeldt-Jakob Disease, nvCJD. This important and urgent subject became an additional major topic at the workshop. This is a book containing most of the talks plus the abstracts of those unable to find time to write up their talks. Almost all papers were written in the spring and summer of 1997 and contain material added after the workshop; thus Bob Will's paper on the new variant of cm contains data up to July 1997 and four contributions arrived in October 1997. In addition to the talks given at our workshop, there was a special joint session with the Planetary Emergencies Workshop where many distinguished scientists, including three Nobel laureates, discussed major issues affecting our planet. Six talks were given by us to this other workshop, five about prions, BSE, and nvCJD, and one on the broader issue of new epi demics by Luc Montagnier. Although most of the talks concerned research issues, there were a few special talks.

Prions in Humans and Animals

Author : Beat Hörnlimann
Publisher : Walter de Gruyter
ISBN 13 : 3110200171
Total Pages : 743 pages
Book Rating : 4.1/5 (12 download)

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Book Synopsis Prions in Humans and Animals by : Beat Hörnlimann

Download or read book Prions in Humans and Animals written by Beat Hörnlimann and published by Walter de Gruyter. This book was released on 2009-05-08 with total page 743 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive work, aimed at both students and researchers alike, systematically covers all aspects of prion diseases (transmissible spongiform encephalopathies), from their history, microbiology and pathology to their transmissibility and prevention. The book describes diseases such as Creutzfeldt-Jakob disease, kuru, mad cow disease (BSE), chronic wasting disease and scrapie, highlighting their biochemical, molecular biological, genetic, and clinical aspects. A detailed presentation of the impact of prion diseases in fields such as pharmaceutics, blood products, disinfection, surgical instruments and epidemiology concludes with a discussion of preventive measures. A renowned editorial team, representing the fields of medicine, veterinary medicine and molecular biology, brought together 80 internationally respected authors for this translation and new edition of the successful German publication, not only from relevant research fields, but also from industry and public health institutions. The book includes chapters by, among many other notable scientists, William J. Hadlow, who discovered the relationship between the human and animal forms of prion diseases and Michael P. Alpers, with 45 years of experience in Papua New Guinea investigating the first known human epidemic form, kuru, transmitted by endocannibalism. Further contributions from Gerald A. H. Wells, a veterinary pathologist who described BSE and recognised its similarity to scrapie, thus recording the first cases in 1986 of the most important animal epidemic of modern times, and Robert G. Will, a medical neurologist and epidemiologist who discovered the emergence of the variant form of Creutzfeldt-Jakob disease in 1996, underscore the strength of this author team. Carefully edited with numerous illustrations, this work offers a systematic approach committed to a clear presentation of the current knowledge of prion diseases. It aims to inspire and stimulate interdisciplinary cooperation, innovative research ideas and effective prevention.

Prion Diseases

Author : Martin H. Groschup
Publisher : Springer Science & Business Media
ISBN 13 : 3709163080
Total Pages : 284 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Prion Diseases by : Martin H. Groschup

Download or read book Prion Diseases written by Martin H. Groschup and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The overwhelming interest and the participation of more than 500 scientists from 26 countries made this symposium the largest meeting ever held in the field. In this book twenty-six invited speakers comprehensively present their data on the pathogenesis of prion diseases in humans and animals, on molecular mechanisms involved in the transmissibility across species barriers, on animal and in-vitro models currently available for the detection and quantification of infectivity and on the characterization of prion strains.

Prion Diseases of Humans and Animals

Author : Stanley B. Prusiner
Publisher : Prentice Hall
ISBN 13 :
Total Pages : 628 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Prion Diseases of Humans and Animals by : Stanley B. Prusiner

Download or read book Prion Diseases of Humans and Animals written by Stanley B. Prusiner and published by Prentice Hall. This book was released on 1992 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Prions and Neurodegenerative Diseases

Author :
Publisher : Academic Press
ISBN 13 : 0128200030
Total Pages : 400 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Prions and Neurodegenerative Diseases by :

Download or read book Prions and Neurodegenerative Diseases written by and published by Academic Press. This book was released on 2020-09-19 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prions and Neurodegenerative Diseases, Volume 172, in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. The series includes in-depth knowledge on the molecular biological aspects of organismal physiology, with this release including chapters on Cell-free amplification of prions: where do we stand? Transgenic mouse models for the study of prion diseases and much more. - Includes comprehensive coverage of molecular biology - Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided - Contains contributions from renowned experts in the field - Includes comprehensive coverage of molecular biology - Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided - Contains contributions from renowned experts in the field

The Social Construction of Disease

Author : Kiheung Kim
Publisher : Taylor & Francis
ISBN 13 : 9780415360517
Total Pages : 253 pages
Book Rating : 4.3/5 (65 download)

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Book Synopsis The Social Construction of Disease by : Kiheung Kim

Download or read book The Social Construction of Disease written by Kiheung Kim and published by Taylor & Francis. This book was released on 2007 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: A historical exploration of scientific disputes on the causation of so-called â€˜prion diseasesâ€™, this fascinating book covers diseases including Scrapie, Creutzfeldt-Jakob Disease (CJD) and Bovine Spongiform Encephalopathy (BSE). Firstly tracing the twentieth-century history of disease research and biomedicine, the text then focuses on the relations between scientific practice and wider social transformations, before finally building upon the sociologically informed methodological framework. Incisive and thought-provoking, The Social Construction of Diseaseprovides a valuable contribution to that well-established tradition of social history of science, which refers primarily to the theoretical works of the sociology of scientific knowledge.

Prions

Author : Stanley B. Prusiner
Publisher :
ISBN 13 :
Total Pages : 568 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Prions by : Stanley B. Prusiner

Download or read book Prions written by Stanley B. Prusiner and published by . This book was released on 1987 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt:

PrPSc Prions: State of the Art

Author : Joaquín Castilla
Publisher : MDPI
ISBN 13 : 3038973084
Total Pages : 211 pages
Book Rating : 4.0/5 (389 download)

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Book Synopsis PrPSc Prions: State of the Art by : Joaquín Castilla

Download or read book PrPSc Prions: State of the Art written by Joaquín Castilla and published by MDPI. This book was released on 2018-11-07 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "PrP^Sc prions: state of the art" that was published in Pathogens

Fatal Flaws

Author : Jay Ingram
Publisher : Yale University Press
ISBN 13 : 0300189893
Total Pages : 294 pages
Book Rating : 4.3/5 (1 download)

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Book Synopsis Fatal Flaws by : Jay Ingram

Download or read book Fatal Flaws written by Jay Ingram and published by Yale University Press. This book was released on 2013-03-19 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: DIVThe story of the revolutionary science that is unraveling the mysteries of mad cow and other fatal brain diseases/div

Prions

Author : Holger F. Rabenau
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805571240
Total Pages : 173 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Prions by : Holger F. Rabenau

Download or read book Prions written by Holger F. Rabenau and published by Karger Medical and Scientific Publishers. This book was released on 2000-12-31 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past decades, the public has been forced to revise its perception of the apparent triumph of modern hygiene and medical microbiology over infectious diseases. Not only have older infections reemerged but new epidemics, like AIDS, have lead to public uncertainty. With the onset of the bovine spongiform encephalopathy epidemic in Great Britain, novel infectious agents came into the public spotlight, ones that do not cause classical inflammation but a slow and irreversible degeneration of the central nervous system. Sensational from a scientific point of view, these agents, called proteinaceous infectious organisms or prions, were shown to be self-replicating without nucleic acid sequences to encode genomic information. In this volume, leading scientists deal with the medical, scientific and public health questions that prion infections raise. Besides the 'prion or virus' discussion, the structures of prions and their molecular biological analysis as well as the questions of strain variations and species barrier are presented. The etiological, clinical and diagnostic aspects of transmissible spongiform encephalopathies are given special attention. The epidemiology of human and animal prion diseases, disease management and possibilities for inactivation of prions are discussed from a public health perspective. Directed at scientists, physicians and the public health sector, the monograph uses a multidisciplinary approach to present the latest findings on prion infection.

Madness and Memory

Author : Stanley B. Prusiner
Publisher : Yale University Press
ISBN 13 : 0300199260
Total Pages : 445 pages
Book Rating : 4.3/5 (1 download)

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Book Synopsis Madness and Memory by : Stanley B. Prusiner

Download or read book Madness and Memory written by Stanley B. Prusiner and published by Yale University Press. This book was released on 2014-04-28 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this “utterly fascinating” science memoir, the Nobel Prize–winning author chronicles his revolutionary discovery of a major cause of brain diseases (The New York Times). In 1997, Stanley B. Prusiner received the Nobel Prize in Physiology or Medicine for his research on devastating brain diseases. That he was the award’s sole recipient was entirely appropriate. His struggle to identify the agent responsible for scrapie and mad cow disease in animals, and Creutzfeldt-Jakob disease in humans, had been waged largely alone, and in some cases, in the face of strenuous opposition. In Madness and Memory, Prusiner recounts the journey to his remarkable discovery of prions—infectious proteins that replicate and cause disease, but surprisingly contain no genetic material. Along the way, he sheds light on the world of contemporary science and the meticulousness and perseverance it requires. Through his telling, the agony and triumph of years of research comes to life, along with fascinating portraits of fellow scientists racing to make breakthrough discoveries. Prusiner’s hypothesis, once considered heresy, now stands as accepted science and provides a path toward conquering such pervasive scourges as Alzheimer’s, Parkinson’s, Lou Gehrig’s, and others diseases. “Madness and Memory is the story of one of the most important discoveries in recent medical history, and it is also a vivid and compelling portrait of a life in science.” —Oliver Sacks, MD, neurologist and author of Hallucinations

Prions

Author : Holger F. Rabenau
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805576560
Total Pages : 233 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Prions by : Holger F. Rabenau

Download or read book Prions written by Holger F. Rabenau and published by Karger Medical and Scientific Publishers. This book was released on 2004 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second, completely revised and extended edition of Prions: A Challenge for Science, Medicine and the Public Health System is a comprehensive, up-to-date review of prions and prion-associated diseases. Leading scientists discuss the structure, molecular biology and origin of prions as well as strain variations and species barriers. Human prion diseases, prion inactivation and risks to public health are considered in detail. The new edition provides an update on basic findings of the last three years since publication of the previous edition and emphasizes practical aspects of fighting human and animal prion diseases. In addition, chapters on regulatory aspects of BSE and CJD as well as on veterinary measures have been included. A valuable single source of information on what is currently known about prions, this book will be of interest to any scientist or clinician who wants to keep up with the latest developments in this fast-moving field.

Human Prion Diseases

Author :
Publisher : Elsevier
ISBN 13 : 0444639535
Total Pages : 520 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Human Prion Diseases by :

Download or read book Human Prion Diseases written by and published by Elsevier. This book was released on 2018-06-07 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems. - Offers an authoritative overview of prion diseases in humans, detailing the pathogenesis of the disease, clinical investigations, and the diagnosis of both the genetic and acquired forms - Provides clarity and context by presenting prion diseases in relation to other neurodegenerative diseases in humans - Emphasizes the unique properties of prion diseases and consequent problems they can cause, both clinically and in public health terms

Advancing Prion Science

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309087449
Total Pages : 125 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Advancing Prion Science by : Institute of Medicine

Download or read book Advancing Prion Science written by Institute of Medicine and published by National Academies Press. This book was released on 2003-04-20 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Advancing Prion Science, the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defense's National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions' normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEs' from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment. This report summarizes the progress thus far.