Advancing Prion Science

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Advancing Prion Science

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309090601
Total Pages : 289 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Advancing Prion Science by : Institute of Medicine

Download or read book Advancing Prion Science written by Institute of Medicine and published by National Academies Press. This book was released on 2004-04-04 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Advancing Prion Science, the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defense's National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions' normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEsâ€"from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment.

Advancing Prion Science

Author : Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science
Publisher :
ISBN 13 : 9780309382885
Total Pages : 126 pages
Book Rating : 4.3/5 (828 download)

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Book Synopsis Advancing Prion Science by : Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science

Download or read book Advancing Prion Science written by Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science and published by . This book was released on 2003-03-20 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Advancing Prion Science, the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defense's National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions' normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEs' from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment. This report summarizes the progress thus far.

Prions

Author : Akikazu Sakudo
Publisher : Caister Academic Press Limited
ISBN 13 : 9781908230249
Total Pages : 0 pages
Book Rating : 4.2/5 (32 download)

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Book Synopsis Prions by : Akikazu Sakudo

Download or read book Prions written by Akikazu Sakudo and published by Caister Academic Press Limited. This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prions are infectious, self-propagating proteinaceous agents that cause fatal neurodegenerative diseases, including Creutzfeldt-Jakob Disease (CJD) in humans, scrapie in sheep and goats, and bovine spongiform encephalopathy (BSE) in cattle. In recent years, great strides have been made in the understanding of the mechanism of prion propagation and neurotoxicity, however much remains to be discovered. A better understanding of the cell biology of the prion protein is essential for this, allowing for the development of novel anti-prion strategies. In this book, renowned prion experts review the most recent advances to provide a timely and up-to-date overview of the field. The topics covered include: prion proteins (PrP) and their family members * PrP function * molecular mechanisms of prions diseases * immunological strategies for the prevention and treatment of prion disease * microglial inflammation and prion diseases * methods for prion inactivation * clinical aspects of CJD * the BSE and scrapie prions * chronic wasting disease * future strategies for the prevention and treatment of prion diseases. The book closes with a look to the future of prion research. It will be essential reading for everyone with an interest in prions and prion diseases, and it is recommended for all biology, veterinary, and medical libraries.

Fatal Flaws

Author : Jay Ingram
Publisher : Yale University Press
ISBN 13 : 0300189893
Total Pages : 294 pages
Book Rating : 4.3/5 (1 download)

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Book Synopsis Fatal Flaws by : Jay Ingram

Download or read book Fatal Flaws written by Jay Ingram and published by Yale University Press. This book was released on 2013-03-19 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: DIVThe story of the revolutionary science that is unraveling the mysteries of mad cow and other fatal brain diseases/div

Madness and Memory

Author : Stanley B. Prusiner
Publisher : Yale University Press
ISBN 13 : 0300191146
Total Pages : 344 pages
Book Rating : 4.3/5 (1 download)

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Book Synopsis Madness and Memory by : Stanley B. Prusiner

Download or read book Madness and Memory written by Stanley B. Prusiner and published by Yale University Press. This book was released on 2014-04-29 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The author, a 1997 recipient of the Noble Prize in medicine, describes the years he spent researching and demonstrating how the infectious proteins known as prions were responsible for brain diseases and how his theory has now become widely accepted in the science establishment.

The Prion Protein

Author : Jorg Tatzelt
Publisher :
ISBN 13 : 9780954333522
Total Pages : 80 pages
Book Rating : 4.3/5 (335 download)

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Book Synopsis The Prion Protein by : Jorg Tatzelt

Download or read book The Prion Protein written by Jorg Tatzelt and published by . This book was released on 2010 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: A conformational transition of the cellular prion protein (PrPC) into an aberrantly folded isoform designated scrapie prion protein (PrPSc) is the hallmark of a variety of neurodegenerative disorders collectively called prion diseases. They include Creutzfeldt-Jakob disease and Gerstmann-Stäussler-Scheinker syndrome in humans, scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and chronic wasting disease (CWD) in free-ranging deer. In contrast to the deadly properties of misfolded PrP, PrPC seems to possess a neuroprotective activity. More-over, animal models indicated that the stress-protective activity of PrPC and the neurotoxic effects of PrPSc are somehow interconnected. In this timely book, leading scientists in the field have come together to highlight the apparently incongruous activities of different PrP conformers. The articles outline current research on celluar pathways implicated in the formation and signaling of neurotoxic and physiological PrP isoforms and delineate future research direction. Topics covered include the physiologcial activity of PrPC and its possible role as a neurotrophic factor, the finding that aberrant PrP conformers can cause neurodegeneration in the absence of infectious prion propagation, the requirement of the GPI anchor of PrPC for the neurotoxic effects of scrapie prions, the pathways implicated in the formation and neurotoxic properties of cytosolically localized PrP, the impact of metal ions on the processing of PrP, and the role of autophagy in the propagation and clearance of PrPSc. The book is fully illustrated and chapters include comprehensive reference sections. Essential reading for scientists involved in prion research.

Human Prion Diseases

Author :
Publisher : Elsevier
ISBN 13 : 0444639535
Total Pages : 512 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Human Prion Diseases by :

Download or read book Human Prion Diseases written by and published by Elsevier. This book was released on 2018-06-07 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems. Offers an authoritative overview of prion diseases in humans, detailing the pathogenesis of the disease, clinical investigations, and the diagnosis of both the genetic and acquired forms Provides clarity and context by presenting prion diseases in relation to other neurodegenerative diseases in humans Emphasizes the unique properties of prion diseases and consequent problems they can cause, both clinically and in public health terms

Prion Biology

Author : Stanley B. Prusiner
Publisher : Perspectives Cshl
ISBN 13 : 9781621820932
Total Pages : 0 pages
Book Rating : 4.8/5 (29 download)

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Book Synopsis Prion Biology by : Stanley B. Prusiner

Download or read book Prion Biology written by Stanley B. Prusiner and published by Perspectives Cshl. This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Prions are infectious proteins responsible for diseases such as Creutzfeldt-Jakob disease and "mad cow" disease. They are misfolded versions of normal proteins that replicate by converting their normal cellular counterparts into abnormal prion proteins that disrupt cell function and can be transmitted to other cells and individuals. This book exam

The Collectors of Lost Souls

Author : Warwick Anderson
Publisher : JHU Press
ISBN 13 : 1421433613
Total Pages : 349 pages
Book Rating : 4.4/5 (214 download)

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Book Synopsis The Collectors of Lost Souls by : Warwick Anderson

Download or read book The Collectors of Lost Souls written by Warwick Anderson and published by JHU Press. This book was released on 2019-08-27 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: This riveting account of medical detective work traces the story of kuru, a fatal brain disease, and the pioneering scientists who spent decades searching for its cause and cure. Winner, William H. Welch Medal, American Association for the History of Medicine Winner, Ludwik Fleck Prize, Society for Social Studies of Science Winner, General History Award, New South Wales Premier's History Awards When whites first encountered the Fore people in the isolated highlands of colonial New Guinea during the 1940s and 1950s, they found a people in the grip of a bizarre epidemic. Women and children succumbed to muscle weakness, uncontrollable tremors, and lack of coordination, until death inevitably supervened. Facing extinction, the Fore attributed their unique and terrifying affliction to a particularly malign form of sorcery. In The Collectors of Lost Souls, Warwick Anderson tells the story of the resilience of the Fore through this devastating plague, their transformation into modern people, and their compelling attraction for a throng of eccentric and adventurous scientists and anthropologists. Battling competing scientists and the colonial authorities, the brilliant and troubled American doctor D. Carleton Gajdusek determined that the cause of the epidemic—kuru—was a new and mysterious agent of infection, which he called a slow virus (now called a prion). Anthropologists and epidemiologists soon realized that the Fore practice of eating their loved ones after death had spread the slow virus. Though the Fore were never convinced, Gajdusek received the Nobel Prize for his discovery. Now revised and updated, the book includes an extensive new afterword that situates its impact within the fields of science and technology studies and the history of science. Additionally, the author now reflects on his long engagement with the scientists and the people afflicted, describing what has happened to them since the end of kuru. This astonishing story links first-contact encounters in New Guinea with laboratory experiments in Bethesda, Maryland; sorcery with science; cannibalism with compassion; and slow viruses with infectious proteins, reshaping our understanding of what it means to do science.

PrPSc Prions: State of the Art

Author : Joaquín Castilla
Publisher : MDPI
ISBN 13 : 3038973084
Total Pages : 211 pages
Book Rating : 4.0/5 (389 download)

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Book Synopsis PrPSc Prions: State of the Art by : Joaquín Castilla

Download or read book PrPSc Prions: State of the Art written by Joaquín Castilla and published by MDPI. This book was released on 2018-11-07 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "PrP^Sc prions: state of the art" that was published in Pathogens

Prion Biology and Diseases

Author : Stanley B. Prusiner
Publisher : CSHL Press
ISBN 13 : 9780879696931
Total Pages : 1130 pages
Book Rating : 4.6/5 (969 download)

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Book Synopsis Prion Biology and Diseases by : Stanley B. Prusiner

Download or read book Prion Biology and Diseases written by Stanley B. Prusiner and published by CSHL Press. This book was released on 2004 with total page 1130 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a new edition of the most authoritative book on Prion Biology, first published in 1999 and edited by the Nobel Prize-winning founder of the field. This expanded edition has been completely updated, and includes chapters on therapeutics, and diagnostic methods and approaches.

A Century of Nature

Author : Laura Garwin
Publisher : University of Chicago Press
ISBN 13 : 0226284166
Total Pages : 382 pages
Book Rating : 4.2/5 (262 download)

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Book Synopsis A Century of Nature by : Laura Garwin

Download or read book A Century of Nature written by Laura Garwin and published by University of Chicago Press. This book was released on 2010-03-15 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many of the scientific breakthroughs of the twentieth century were first reported in the journal Nature. A Century of Nature brings together in one volume Nature's greatest hits—reproductions of seminal contributions that changed science and the world, accompanied by essays written by leading scientists (including four Nobel laureates) that provide historical context for each article, explain its insights in graceful, accessible prose, and celebrate the serendipity of discovery and the rewards of searching for needles in haystacks.

Doing Global Science

Author : InterAcademy Partnership
Publisher : Princeton University Press
ISBN 13 : 1400881153
Total Pages : 177 pages
Book Rating : 4.4/5 (8 download)

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Book Synopsis Doing Global Science by : InterAcademy Partnership

Download or read book Doing Global Science written by InterAcademy Partnership and published by Princeton University Press. This book was released on 2016-03-01 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential introduction to the responsible conduct of science in today's interconnected world This concise introductory guide explains the values that should inform the responsible conduct of scientific research in today's global setting. Featuring accessible discussions and ample real-world scenarios, Doing Global Science covers proper conduct, fraud and bias, the researcher's responsibilities to society, communication with the public, and much more. The book places special emphasis on the international and highly networked environment in which modern research is done, presenting science as an enterprise that is being transformed by globalization, interdisciplinary research projects, team science, and information technologies. Accessibly written by an InterAcademy Partnership committee comprised of leading scientists from around the world, Doing Global Science is required reading for students, practitioners, and anyone concerned about the responsible conduct of science today. Provides practical guidance and instructions for doing scientific research in today's global setting Covers everything from responsible conduct to communication with the public Features numerous real-world scenarios drawn from an array of disciplines and national contexts Focuses on issues commonly encountered in international collaborations Written by a panel of leading experts from around the world An essential guide for practicing scientists and anyone concerned about fostering research integrity

Fundamentals of Protein Structure and Function

Author : Engelbert Buxbaum
Publisher : Springer
ISBN 13 : 331919920X
Total Pages : 521 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Fundamentals of Protein Structure and Function by : Engelbert Buxbaum

Download or read book Fundamentals of Protein Structure and Function written by Engelbert Buxbaum and published by Springer. This book was released on 2015-11-27 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book serves as an introduction to protein structure and function. Starting with their makeup from simple building blocks, called amino acids, the 3-dimensional structure of proteins is explained. This leads to a discussion how misfolding of proteins causes diseases like cancer, various encephalopathies, or diabetes. Enzymology and modern concepts of enzyme kinetics are then introduced, taking into account the physiological, pharmacological and medical significance of this often neglected topic. This is followed by thorough coverage of hæmoglobin and myoglobin, immunoproteins, motor proteins and movement, cell-cell interactions, molecular chaperones and chaperonins, transport of proteins to various cell compartments and solute transport across biological membranes. Proteins in the laboratory are also covered, including a detailed description of the purification and determination of proteins, as well as their characterisation for size and shape, structure and molecular interactions. The book emphasises the link between protein structure, physiological function and medical significance. This book can be used for graduate and advanced undergraduate classes covering protein structure and function and as an introductory text for researchers in protein biochemistry, molecular and cell biology, chemistry, biophysics, biomedicine and related courses. About the author: Dr. Buxbaum is a biochemist with interest in enzymology and protein science. He has been working on the biochemistry of membrane transport proteins for nearly thirty years and has taught courses in biochemistry and biomedicine at several universities.

Mad Cow Disease and Related Spongiform Encephalopathies

Author : David A. Harris
Publisher : Springer Science & Business Media
ISBN 13 : 9783540201076
Total Pages : 236 pages
Book Rating : 4.2/5 (1 download)

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Book Synopsis Mad Cow Disease and Related Spongiform Encephalopathies by : David A. Harris

Download or read book Mad Cow Disease and Related Spongiform Encephalopathies written by David A. Harris and published by Springer Science & Business Media. This book was released on 2004-03-18 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bovine spongiform encephalopathy (BSE) has become the most publicly recognizable example of a group of fatal neurodegenerative diseases caused by proteinaceous infectious particles called prions. The contributors to this volume, all internationally recognized experts in their fields, provide an introduction to prion biology, followed by reviews of the latest information on BSE, vCJD, and chronic wasting disease, an animal prion disease that has recently emerged in North America.

Viruses, Plagues, and History

Author : Michael B. A. Oldstone
Publisher : Oxford University Press, USA
ISBN 13 : 0190056789
Total Pages : 513 pages
Book Rating : 4.1/5 (9 download)

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Book Synopsis Viruses, Plagues, and History by : Michael B. A. Oldstone

Download or read book Viruses, Plagues, and History written by Michael B. A. Oldstone and published by Oxford University Press, USA. This book was released on 2020 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Here, my previous edition of Viruses, Plagues, & History is updated to reflect both progress and disappointment since that publication. This edition describes newcomers to the range of human infections, specifically, plagues that play important roles in this 21st century. The first is Middle East Respiratory Syndrome (MERS), an infection related to Sudden Acute Respiratory Syndrome (SARS). SARS was the first new-found plague of this century. Zika virus, which is similar to yellow fever virus in being transmitted by mosquitos, is another of the recent scourges. Zika appearing for the first time in the Americas is associated with birth defects and a paralytic condition in adults. Lastly, illness due to hepatitis viruses were observed prominently during the second World War initially associated with blood transfusions and vaccine inoculations. Since then, hepatitis virus infections have afflicted millions of individuals, in some leading to an acute fulminating liver disease or more often to a life-long persistent infection. A subset of those infected has developed liver cancer. However, in a triumph of medical treatments for infectious diseases, pharmaceuticals have been developed whose use virtually eliminates such maladies. For example, Hepatitis C virus infection has been eliminated from almost all (>97%) of its victims. This incredible result was the by-product of basic research in virology as well as cell and molecular biology during which intelligent drugs were designed to block events in the hepatitis virus life-cycle"--

Deadly Feasts

Author : Richard Rhodes
Publisher : Simon and Schuster
ISBN 13 : 1471104575
Total Pages : 305 pages
Book Rating : 4.4/5 (711 download)

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Book Synopsis Deadly Feasts by : Richard Rhodes

Download or read book Deadly Feasts written by Richard Rhodes and published by Simon and Schuster. This book was released on 2012-12-11 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this brilliant and gripping medical detective story. Richard Rhodes follows virus hunters on three continents as they track the emergence of a deadly new brain disease that first kills cannibals in New Guinea, then cattle and young people in Britain and France -- and that has already been traced to food animals in the United States. In a new Afterword for the paperback, Rhodes reports the latest U.S. and worldwide developments of a burgeoning global threat.