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Lymphocyte Activation By The Trypanosoma Cruzi Trans Sialidase
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Book Synopsis Molecular Mechanisms of Parasite Invasion by : Barbara A. Burleigh
Download or read book Molecular Mechanisms of Parasite Invasion written by Barbara A. Burleigh and published by Springer Science & Business Media. This book was released on 2008-12-05 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: All of the parasitic organisms highlighted in this new book represent medically important human pathogens that contribute significantly to the global burden of disease. As such there is intense interest in understanding the molecular basis of infection by these pathogens—not only with regard to their clinical relevance but also the fascinating biology they reveal. For most of the parasites discussed here the ability to penetrate biological barriers and/or to establish intracellular residence is critical to survival of the pathogen in the mammalian hosts. For other parasites, a tissue invasive phenotype is a key virulence determinant. In the ensuing 18 chapters, select members of this diverse set of protozoan parasites, as well as some examples of the extremely reduced fungal parasites classified as Microsporidia, are discussed within the context of the fascinating molecular strategies employed by these organisms to migrate across biological barriers and to establish residence within target host cells.
Book Synopsis American Trypanosomiasis by : Jenny Telleria
Download or read book American Trypanosomiasis written by Jenny Telleria and published by Elsevier. This book was released on 2010-09-03 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chagas disease causes severe socioeconomic impact and a high medical cost in Latin America. WHO and the World Bank consider Chagas disease as the fourth most transmittable disease to have a major impact on public health in Latin America: 120 million persons are potentially exposed, 16 to 18 million of whom are presently infected, causing 45,000 to 50,000 deaths per year. It has been calculated that approximately 2.4 million potential working years are lost because of incapacity and mortality due to the disease, for an annual cost estimated at 20 billion Euros. American Trypanosomiasis provides a comprehensive overview of Chagas disease and discusses the latest discoveries concerning the three elements that compose the transmission chain of the disease: - The host: human and mammalian reservoirs - The insect vectors: domestic and sylvatic vectors - The causative parasite: Trypanosoma cruzi - Informs and updates on all the latest developments in the field - Contributions from leading authorities and industry experts
Book Synopsis The African Trypanosomes by : Samuel J. Black
Download or read book The African Trypanosomes written by Samuel J. Black and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: African trypanosomes are tsetse-transmitted protozoa that inhabit the extracellular compartment of host blood. They cause fatal sleeping sickness in people, and Nagana, a wasting and generally fatal disease, in cattle. While trypanosomes are most common to Africa (about 30% of Africa's cattle graze on the fringe of the tsetse habitat), some species have spread beyond its boarders to Asia, the Middle East and South America. The African Trypanosomes, volume one of World Class Parasites, is written for researchers, students and scholars who enjoy reading research that has a major impact on human health, or agricultural productivity, and against which we have no satisfactory defense. It is intended to supplement more formal texts that cover taxonomy, life cycles, morphology, vector distribution, symptoms and treatment. It integrates vector, pathogen and host biology and celebrates the diversity of approach that comprises modern parasitological research.
Book Synopsis Molecular Mechanisms of Pathogenesis in Chagas' Disease by : John M. Kelly
Download or read book Molecular Mechanisms of Pathogenesis in Chagas' Disease written by John M. Kelly and published by Springer Science & Business Media. This book was released on 2003-08-31 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chagas' disease, which results from infection with the single cell parasite Trypanosoma cruzi, is a debilitating condition that is a major problem in many parts of Latin America. Rapid technical progress is now facilitating dissection of the molecular mechanisms of disease pathogenesis, a process that will ultimately provide new strategies to alleviate the enormous public health burden associated with the infection. In this book, international experts review the buoyant status of Chagas' disease research as we enter the "post-genome" era and speculate on how the new findings will impact on drug and vaccine development. The chapters outline how progress is being made on several fronts ranging from parasite population genetics to human immunology. Researchers, physicians and students with an interest in any aspect of molecular parasitology should find this book to be a valuable reference
Book Synopsis Interaction of Trypanosoma cruzi with Host Cells by : Wanderley De Souza
Download or read book Interaction of Trypanosoma cruzi with Host Cells written by Wanderley De Souza and published by Frontiers E-books. This book was released on 2014-12-10 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: Trypanosoma cruzi is a pathogenic protozoan of the Trypanosomatidade Family, which is the etiological agent of Chagas’ disease. Chagas’ disease stands out for being endemic among countries in Latin America, affecting about 15 million people. Recently, Chagas has become remarkable in European countries as well due to cases of transmission via infected blood transfusion. An important factor that has exacerbated the epidemiological picture in Brazil, Colombia and Venezuela is infection after the oral intake of contaminated foods such as sugar cane, açai and bacaba juices. Trypanosoma cruzi is an intracellular protozoan that exhibits a complex life cycle, involving multiple developmental stages found in both vertebrate and invertebrate hosts. In vertebrate hosts, the trypomastigote form invades a large variety of nucleated cells using multiple mechanisms. The invasion process involves several steps: (a) attraction of the protozoan to interact with the host cell surface; (b) parasite-host cell recognition; (c) adhesion of the parasite to the host cell surface; (d) cell signalling events that culminate in the internalization of the parasite through endocytic processes; (e) biogenesis of a large vacuole where the parasite is initially located, and is also known as parasitophorous vacuole (PV); (f) participation of endocytic pathway components in the internalization process; (g) participation of cytoskeleton components in the internalization process; (h) transformation of the trypomastigote into the amastigote form within the PV; (i) lysis of the membrane of the PV; (j) multiplication of amastigotes within the host cell in direct contact with cell structures and organelles; (k) transformation of amastigotes into trypomastigotes, and (l) rupture of the host cell releasing trypomastigotes into the extracellular space. The kinetics of the interaction process and even the fate of the parasite within the cell vary according to the nature of the host cell and its state of immunological activation.
Book Synopsis Control of Chagas Disease by : World Health Organization
Download or read book Control of Chagas Disease written by World Health Organization and published by World Health Organization. This book was released on 2002-05 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report of a WHO Expert Committee reviews current knowledge of Chagas disease and its pathogenesis discusses the causative parasite the triatomine vectors and the natural reservoirs of infection and considers the epidemiology and incidence trends of the disease. Prevention and control strategies are described as are the various formal initiatives for interruption of disease transmission. The report concludes by identifying priorities for research and offering guidance for the planning implementation and strengthening of national control programmes. ... this book makes an extremely valuable contribution toward understanding Chagas disease and promoting solid prevention and control efforts. It will no doubt be an important addition to the library of anyone student and expert alike with interests in Chagas disease. The authors are to be congratulated on the completion of a work of excellence - an extremely difficult endeavour at a time when our knowledge of vectors parasites and methodologies is expanding so rapidly. - Transactions of the Royal Society of Tropical Medicine and Hygiene
Book Synopsis The Third Component of Complement by : John D. Lambris
Download or read book The Third Component of Complement written by John D. Lambris and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third component of complement, C3, is one of the most versatile proteins and an important participant in immune surveillance and immune response pathways. Its multifunctio nality is based on its ability to interact specifically with multiple serum complement proteins, cell surface receptors, and mem brant;-associated regulatory proteins. One of its most intriguing strategies of interaction with cell surfaces is the covalent binding of activated C3 through the internal thioester. The field has expanded over the past 10 years and a wealth of information has accumulated. C3 from various species and many of the human C3 binding proteins have been cloned and expressed. Numerous cellular responses mediated by the diffe rent fragments of C3 have been described. The findings that C3 interacts in a ligand-receptor-like fashion with proteins of nonself origin such as the gC of herpes simplex virus, a 70-kDa protein from Candida albicans, proteins from Epstein-Barr virus, etc. has opened a new field of investigation. The papers assembled in this volume summarize the wealth of data on the various aspects of the C3 interactions; together they bring to the reader new information on the chemistry, molecular gene tics, biology, and pathophysiology of C3 and C3-binding proteins. Emphasis is given to structural features as they relate to functions. Spring 1989 JOHN D. LAMBRIS, HANS J. MULLER-EBERHARD Table of Contents J. E. VOLANAKIS: Participation of C3 and Its Ligands in Complement Activation . . . . . . . . . . . 1 S. R. BARNUM, G. FEY, and B. F. TACK: Biosynthesis and Genetics of C3 . . . . . . . . . . . . .
Download or read book Endocrine Immunology written by W. Savino and published by Karger Medical and Scientific Publishers. This book was released on 2017-02-28 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decades, several in vitro and in vivo studies have revealed the existence of a very complex network between the neuroendocrine and immune system. Important molecular mechanisms underlying these interactions, in both physiological and pathological conditions, have also been described. Indeed, hormones play a pivotal role in the development and functional regulation of the immune system – both innate and acquired responses. Immune system cells present specific hormone receptors and themselves produce some hormones, thus influencing hormone secretion. More recently, the modulation of hormone secretion has been attempted for treating associated autoimmune disorders, further supporting the strong interplay between the endocrine and immune system. Distinguished experts, who have published extensively in their fields, have contributed comprehensive chapters to this volume. The focus is on the various aspects of endocrine-neuro-immune connections, providing an updated panorama - from basics to clinical applications - of current knowledge and still debated issues.
Book Synopsis Immune evasion strategies in protozoan-host interactions by : Alexandre Morrot
Download or read book Immune evasion strategies in protozoan-host interactions written by Alexandre Morrot and published by Frontiers Media SA. This book was released on 2024-08-13 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: The protozoa are the most ancient members of the animal kingdom and they have evolved the intracellular parasitism to ensure their survival strategies. Protozoan parasites that infect humans are extremely diverse among eukaryotes. They are responsible for many human diseases such as amebiasis, Chagas disease, malaria, toxoplasmosis, leishmaniasis and African sleeping sickness. The ability of protozoans to cause disease depends on the nature and number of infecting organisms, the route of infection, the virulence factors associated with the microorganism, and the strength of host defenses. This host-parasite interaction is also subject to constant change as the infection proceeds and can lead to a range of outcomes, from elimination of the pathogen to death of the host, depending on the states of latency and the extent of colonization that the protozoan achieves in the course of infection. Several species of parasitic protozoa harbor specialized virulence factors whose products can overcome the host´s immunity and promote their survival. These factors act at several different checkpoints of the host immune responses, from the first components of the innate immune response to the induction and maintenance of adaptive memory responses. Many protozoan species have evolved mechanisms that modulate and inhibit host sensors, microRNA circuits and signaling pathways that permit the host to detect infection. These factors can act, inter alia, by inhibiting the complement cascade, subverting phagocyte activation and impairing leukocyte migratory responses, so undermining the immune system thus facilitating the pathogen evasion and its continued persistence in the host. In this research topic we welcome the contribution of original research article as well as reviews on the field.
Book Synopsis Veterinary Vaccines by : Samia Metwally
Download or read book Veterinary Vaccines written by Samia Metwally and published by John Wiley & Sons. This book was released on 2021-06-14 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a concise and authoritative reference on the use of vaccines against diseases of livestock Compiled by Senior Animal Health Officers at The Food and Agriculture Organization of the United Nations, and with contributions from international leading experts, Veterinary Vaccines: Principles and Applications is a concise and authoritative reference featuring easily readable reviews of the latest research in vaccinology and vaccine immune response to pathogens of major economic impact to livestock. It covers advice and recommendations for vaccine production, quality control, and effective vaccination schemes including vaccine selection, specifications, vaccination programs, vaccine handling in the field, application, failures, and assessment of herd protection. In addition, the book presents discussions on the current status and potential future developments of vaccines and vaccination against selected transboundary animal diseases. Provides a clear and comprehensive guide on using veterinary vaccines to protect livestock from diseases Teaches the principles of vaccinology and vaccine immune response Highlights the vaccine production schemes and standards for quality control testing Offers easy-to-read reviews of the most current research on the subject Gives readers advice and recommendations on which vaccination schemes are most effective Discusses the today’s state of vaccines and vaccination against selected transboundary animal diseases as well as possible future developments in the field Veterinary Vaccines: Principles and Applications is an important resource for veterinary practitioners, animal health department officials, vaccine scientists, and veterinary students. It will also be of interest to professional associations and NGO active in livestock industry.
Author :Michael B. A. Oldstone Publisher :Springer Science & Business Media ISBN 13 :3540307915 Total Pages :166 pages Book Rating :4.5/5 (43 download)
Book Synopsis Molecular Mimicry: Infection Inducing Autoimmune Disease by : Michael B. A. Oldstone
Download or read book Molecular Mimicry: Infection Inducing Autoimmune Disease written by Michael B. A. Oldstone and published by Springer Science & Business Media. This book was released on 2006-01-09 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: (Text will follow)
Book Synopsis Biology of the Sialic Acids by : A. Rosenberg
Download or read book Biology of the Sialic Acids written by A. Rosenberg and published by Springer Science & Business Media. This book was released on 1995-07-31 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abraham Rosenberg assembles the groundbreaking work of preeminent international scientists to provide the most current, state-of-the-art presentation of research in siabiology. This concise volume examines the historical development of the field and reviews current knowledge on the genetic, immunologic, oncologic, neurodevelopmental, pathogenic, and cell regulatory properties of sialic acid. Outstanding features of this work include exhaustive reference material and detailed information tables.
Book Synopsis Membrane Recycling by : Geralyn M. Collins
Download or read book Membrane Recycling written by Geralyn M. Collins and published by Financial Times/Prentice Hall. This book was released on 1982 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neopterin written by Helmut Wachter and published by . This book was released on 1992 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Index Medicus written by and published by . This book was released on 2003 with total page 1568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Book Synopsis Essentials of Glycobiology by : Ajit Varki
Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Book Synopsis Chagas Disease by : Jaime Marcelo Altcheh
Download or read book Chagas Disease written by Jaime Marcelo Altcheh and published by Springer Nature. This book was released on 2019-09-09 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chagas disease is a potentially life threatening condition that was historically mainly endemic to Latin America. Over the last decade, however, the disease has spread to and is increasingly prevalent in other continents such as North America and Europe, with an estimated 7 million people infected worldwide. It is primarily transmitted by insect vectors that carry the parasite Trypanosoma cruzi, the disease agent. In areas where there is vector control and in non-endemic countries, it is mainly transmitted via congenital infection. Cardiac and gastrointestinal complications are common in untreated individuals. This book offers a comprehensive overview of Chagas disease, including its vectorial and congenital transmission, and molecular diagnosis, which is essential for screening, and developing and providing timely, effective anti-trypanosomal treatment. Written by experts working with infected patients on a daily basis, it discusses the pathogenesis of congenital, cardiac, gastrointestinal and oral Chagas disease, as well as its treatment and the pharmacological aspects of drug development in this area. Chapter "Chagas Disease Treatment Efficacy Biomarkers: Myths and Realities" is available open access under a via link.springer.com.
