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Author : David Thomas Hart
Publisher :
ISBN 13 :
Total Pages : 1041 pages
Book Rating : 4.:/5 (193 download)
Download or read book Leishmaniasis written by David Thomas Hart and published by . This book was released on 1989 with total page 1041 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : D.T. Hart
Publisher : Springer Science & Business Media
ISBN 13 : 1461315751
Total Pages : 979 pages
Book Rating : 4.4/5 (613 download)
Download or read book Leishmaniasis: The Current Status and New Strategies for Control written by D.T. Hart and published by Springer Science & Business Media. This book was released on 2013-11-27 with total page 979 pages. Available in PDF, EPUB and Kindle. Book excerpt: V Pentostam, an uncharacterized complex of Sb and carbohydrate derived from gluconic acid, is concentrated by Leishmania amastigotes via protein binding. Biochemical consequences of the interaction of amastigotes with Pentostam are inhibition of parasite bioenergetics and inhibition of ATP synthesis. REFERENCES 1. J.C. Mottram and G.H. Coombs. Enzyme activities of amastigotes and promastigotes and their inhibition by antimonials and arsenicqls. Exper. Parasitol. 59:151 (1985). 125 2. S.L. Croft, K.D. Neame and C.A. Homewood. Accumulation of [Sb] sodium stibogluconate by Leishmania mexicana amazonensis and Leishmania donovani in vitro. Compo Biochem. Physiol. 68c:95 (1981). 3. J.D. Berman, J.V. Gallalee, and B.D. Hansen. Leishmania mexicana: uptake of sodium stibogluconate (Pentostam) and pentamidine by parasite and macrophages. Exper. Parasitol. 64:127 (1987). 4. J.D. Berman, D. Waddell and B.D. Hanson. Biochemical meChanisms of the antileishmanial activity of sodium stibogluconate. Antimicrobial Agents Chemotherapy. 27:916 (1985). 5. J.D. Berman, J.V. Gallalee, and J.M. Best. Sodium stibogluconate (Pentostam) inhibition of glucose catabolism via the glycolytic pathway, and fatty acid B-oxidation in Leishmania mexicana amastigotes. Biochem. Pharmacol. 36:197 (1987). 6. D.T. Hart and G.H. Coombs. Leishmania mexicana: Energy metabolism of amastigotes and promastigotes. Exper. Parasitol. 54:397 (1982). 478 EFFECTS OF SINEFUNGIN ON CELLULAR AND BIOCHEMICAL EVENTS IN PROMASTIGOTES OF LEISHMANIA d. donovani Fran~oise Lawrence, and MaIka Robert-Cero Institut de Chimie des Substances Naturelles C.N.R.S.
Author : Jay P. Farrell
Publisher : Springer Science & Business Media
ISBN 13 : 1461509556
Total Pages : 195 pages
Book Rating : 4.4/5 (615 download)
Download or read book Leishmania written by Jay P. Farrell and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leishmania parasites cause a diverse group of diseases endemic to many tropical and subtropical regions of the world. This volume seeks to bring together recent research on cell and molecular biology of Leishmania with chapters on the host response to infection, the current epidemiology of leishmaniasis, explanations of the many different species, vector control, and strategies for vaccine development and drug treatment. Leishmania, volume four of World Class Parasites, is written for researchers, students and scholars who enjoy reading research that has a major impact on human health, or agricultural productivity, and against which we have no satisfactory defense. It is intended to supplement more formal texts that cover taxonomy, life cycles, morphology, vector distribution, symptoms and treatment. It integrates vector, pathogen and host biology and celebrates the diversity of approach that comprises modern parasitological research.
Author : Alane Beatriz Vermelho
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (115 download)
Download or read book Leishmaniasis: Possible New Strategies for Treatment written by Alane Beatriz Vermelho and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Leishmaniasis: Possible New Strategies for Treatment.
Author : Mukesh Samant
Publisher : Academic Press
ISBN 13 : 0128227982
Total Pages : 281 pages
Book Rating : 4.1/5 (282 download)
Download or read book Pathogenesis, Treatment and Prevention of Leishmaniasis written by Mukesh Samant and published by Academic Press. This book was released on 2021-08-18 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leishmaniasis is a neglected tropical disease that is known to be transmitted by 90 different species of sandflies which carry 20 Leishmania species that cause human infection particularly in endemic countries. Pathogenesis, Treatment, and Prevention of Leishmaniasis aims to provide information on this vector-borne disease and explore strategies for diagnosis and treatment. The book begins with an overview of leishmaniasis which includes historical and future perspectives of the disease. It also discusses the clinical manifestation of the disease, mechanisms of infection, therapeutic strategies, diagnostics, prevention, and cure of Leishmania parasite. The book goes on to explain new insights and challenges in the development of promising drug targets, biomarkers identification and advance vaccination strategies against leishmaniasis. Chapter contributions brings together diverse areas of expertise making Pathogenesis, Treatment, and Prevention of Leishmaniasis aims to bring together elements of leishmaniasis into one place and be a valuable resource for researchers, health care professionals, and graduate students, working in the field of leishmaniasis. Provides an overview Leishmania and leishmanisis which include its history, transmission, clinical picture, and treatment Discusses novel approaches to study parasite infection and treatment Explores recent advances in the development of diagnostic kits, drug development and various vaccination strategies
Author : WHO Expert Committee on the Control of the Leishmaniases
Publisher :
ISBN 13 :
Total Pages : 162 pages
Book Rating : 4.3/5 ( download)
Download or read book Control of the Leishmaniases written by WHO Expert Committee on the Control of the Leishmaniases and published by . This book was released on 1990 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John Gyapong
Publisher : Springer
ISBN 13 : 3319254715
Total Pages : 421 pages
Book Rating : 4.3/5 (192 download)
Download or read book Neglected Tropical Diseases - Sub-Saharan Africa written by John Gyapong and published by Springer. This book was released on 2016-01-13 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview on the major neglected tropical diseases (NTDs) occurring in Sub-Saharan Africa, such as Leishmaniasis, Buruli Ulcer and Schistosomiasis. In well-structured chapters epidemiology and biology of these parasitic diseases will be discussed in detail. Further, diagnostics and therapeutic approaches as well as prevention strategies will be reviewed. The book will be of interest to basic researchers and clinicians engaged in infectious disease, tropical medicine, and parasitology, and a must-have for scientists specialized in the characteristics of the Sub-Saharan region.
Author : Abhay Satoskar
Publisher : Springer Science & Business
ISBN 13 : 1461491088
Total Pages : 98 pages
Book Rating : 4.4/5 (614 download)
Download or read book Pathogenesis of Leishmaniasis written by Abhay Satoskar and published by Springer Science & Business. This book was released on 2014-04-19 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses recent developments in several laboratories studying leishmaniasis. Sequencing of the human genome, as well as of the leishmania genome, has led to significant advances in our understanding of host-immune responses against leishmania, and mechanisms of infection-induced pathology, which is responsible for morbidity and mortality. Pathogenesis of Leishmaniasis focuses on the latest basic research into leishmaniasis, but also addresses how advances in understanding can be applied to prevention, control and treatment of what the WHO has classified a neglected tropical disease.
Author : Alicia Ponte-Sucre
Publisher : Springer Science & Business Media
ISBN 13 : 3709111250
Total Pages : 458 pages
Book Rating : 4.7/5 (91 download)
Download or read book Drug Resistance in Leishmania Parasites written by Alicia Ponte-Sucre and published by Springer Science & Business Media. This book was released on 2012-09-04 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the main problems concerning therapeutic tools for the treatment of parasitic diseases, including leishmaniasis, is that some field parasites are naturally resistant to the classical drugs; additionally, current therapies may select parasites prone to be resistant to the applied drugs. These features are (at least partially) responsible for the disappointing persistence of the disease and resultant deaths worldwide. This book provides a comprehensive view of the pathology of the disease itself, and of parasitic drug resistance, its molecular basis, consequences and possible treatments. Scientists both from academic fields and from the industry involved in biomedical research and drug design, will find in this book a valuable and fundamental guide that conveys the knowledge needed to understand and to improve the success in combating this disease worldwide.
Author : E. Noiri
Publisher : Springer
ISBN 13 : 3319471015
Total Pages : 310 pages
Book Rating : 4.3/5 (194 download)
Download or read book Kala Azar in South Asia written by E. Noiri and published by Springer. This book was released on 2017-01-11 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Visceral leishmaniasis (VL), (also known as black fever or Kala-azar) is a life-threatening disease first reported from the Indian subcontinent. VL ranks as the world’s second largest parasitic disease killer and is a neglected tropical disease. Most of those infected by this life-threatening disease are uneducated daily wagers working to support their families, and vectors easily disseminate the disease to their neighbors. Owing to recent involvement of stakeholders, the number of patients is decreasing, but eradication remains a distant goal. This second edition presents latest reports of visceral Leishmaniasis by specialists working at the forefront of the endemic areas in Indian subcontinent. It also introduces vaccine development and inhibitors to Trypanosomatidae; some of them describing feasibility studies in visceral Leishmaniasis for the first time. Recent progress of the Science and Technology Research Partnership for Sustainable Development (SATREPS) is also reviewed and the contents share this collaborative research from the forefront of endemic sites in Bangladesh. Widely covering basic, clinical, epidemiological and entomological aspects, this volume will be of great interest to dedicated researchers interested inLeishmaniasis and to experts of NTDs in global health. There is a tide in the affairs of men. Which, taken at the flood, leads on to fortune; Omitted, all the voyage of disease control is bound in shallows and in miseries. ~modified from Shakespeare ~
Author : Carlos Brisola Marcondes
Publisher : Springer
ISBN 13 : 3319138847
Total Pages : 642 pages
Book Rating : 4.3/5 (191 download)
Download or read book Arthropod Borne Diseases written by Carlos Brisola Marcondes and published by Springer. This book was released on 2016-11-09 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arthropod borne diseases cause enormous morbidity and mortality in most countries, mostly in those situated in tropical areas, but also in temperate regions. This book provides organized information on all arthropod related diseases, to prevent suffering and deaths, for medical students and professionals. Since arthropod borne diseases are present in many regions of the world and can even surprise professionals and lays in non-endemic regions, like malaria in UK and Canada, the author and its many expert collaborators are sure that it will be essential in all hospitals, clinics and medical libraries around the world. As arthropod borne diseases of domesticated animals are very numerous and in some cases related to human diseases, they are also included in the book.
Author : David Claborn
Publisher : BoD – Books on Demand
ISBN 13 : 9535112325
Total Pages : 538 pages
Book Rating : 4.5/5 (351 download)
Download or read book Leishmaniasis written by David Claborn and published by BoD – Books on Demand. This book was released on 2014-03-19 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of all the parasitic diseases, leishmaniasis is one of the most diverse, with a variety of manifestations, from relatively minor cutaneous lesions to deadly visceral infections. It is also widespread, causing human disease in the Americas, Asia, Europe and Africa. The environments in which this disease occurs range from desert to tropical jungle to urban habitats. Not surprisingly, the literature on this disease is written in a variety of languages including Portuguese, Arabic, English and French among others. This book provides a synopsis in English of much of the recent research on leishmaniasis, with a focus on the epidemiology, diagnosis and treatment of the disease as described by researchers around the world, but with a focus on the research from Brazil and the Middle East.
Author : Dean T. Jamison
Publisher : World Bank Publications
ISBN 13 : 0821361805
Total Pages : 1449 pages
Book Rating : 4.8/5 (213 download)
Download or read book Disease Control Priorities in Developing Countries written by Dean T. Jamison and published by World Bank Publications. This book was released on 2006-04-02 with total page 1449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on careful analysis of burden of disease and the costs ofinterventions, this second edition of 'Disease Control Priorities in Developing Countries, 2nd edition' highlights achievable priorities; measures progresstoward providing efficient, equitable care; promotes cost-effectiveinterventions to targeted populations; and encourages integrated effortsto optimize health. Nearly 500 experts - scientists, epidemiologists, health economists,academicians, and public health practitioners - from around the worldcontributed to the data sources and methodologies, and identifiedchallenges and priorities, resulting in this integrated, comprehensivereference volume on the state of health in developing countries.
Author : Awanish Kumar
Publisher : Springer Science & Business Media
ISBN 13 : 1461488699
Total Pages : 90 pages
Book Rating : 4.4/5 (614 download)
Download or read book Leishmania and Leishmaniasis written by Awanish Kumar and published by Springer Science & Business Media. This book was released on 2013-09-13 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leishmania-related illnesses remain among the world’s deadliest neglected tropical diseases, affecting approximately 12 million people in 88 countries. The mortality rate is substantial, contributing to nearly two million disability-adjusted life years. As more is understood about this parasite and its effects, work toward prevention, control, and treatment continues apace. Leishmania and Leishmaniasis will address the parasite and its attendant disease, which manifests in three syndromes: Visceral (VL), Cutaneous (CL) and Mucocutaneous Leishmaniasis (ML). The morphology and life cycles of the various species will be among the topics addressed in Part One. Part Two will focus on immunology, including host-immune response to Leishmania infection, cross-immunity between the different species and adoptive transfer of immunity. Parts Three and Four will address how Leishmania invade and survive, the clinical features of the disease, and its diagnosis. Drugs, vaccines and treatment will be thoroughly explored, including experimental models of therapeutics. Leishmania and Leishmaniasis will provide a thorough examination of a parasite, the illnesses it causes and the misery it continues to visit upon large segments of the population.
Author : Fabrizio Bruschi
Publisher : Springer
ISBN 13 : 3319723863
Total Pages : 249 pages
Book Rating : 4.3/5 (197 download)
Download or read book The Leishmaniases: Old Neglected Tropical Diseases written by Fabrizio Bruschi and published by Springer. This book was released on 2018-01-12 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Out of the 20 neglected tropical diseases (NTDs) prioritized by the World Health Organization, the leishmaniases rank in the top 3 among those caused by protozoa. The purpose of this book is to provide the reader with a comprehensive and updated overview of all the aspects of leishmaniasis with a worldwide perspective – authors of many chapters include eminent scientists from both the Old and New Worlds. The chapters cover a wide range of topics, classically organized into biology and epidemiology, followed by clinical and control aspects. Following an introductory chapter intended to take the reader into the leishmaniasis complexity, a chapter on Leishmania taxonomy reports on the most recent advances in molecular and phylogenetic data. Parasite biology is then described in detail by means of two separate chapters devoted to phlebotomine vectors and reservoir hosts, respectively. The medical part of the book begins with a chapter on basic immunology and immunopathology associated with Leishmania infection, followed by a classical chapter on clinical aspects of different disease entities. The complexity of disease case management is presented by means of 3 chapters, respectively on diagnosis, treatment of visceral forms and treatment of tegumentary forms. Finally, the last chapter deals with the available approaches to control leishmaniasis and related public health issues.
Author : David Claborn
Publisher : BoD – Books on Demand
ISBN 13 : 9535129716
Total Pages : 178 pages
Book Rating : 4.5/5 (351 download)
Download or read book The Epidemiology and Ecology of Leishmaniasis written by David Claborn and published by BoD – Books on Demand. This book was released on 2017-03-01 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leishmaniasis is a vector-borne, parasitic disease with tremendous variety in presentation, biology, and epidemiology. Any book on this disease must acknowledge the nearly impossible task of providing an exhaustive account of leishmaniasis simply because the epidemiology of the disease is so very complex. This book addresses some of this variety with chapters on the epidemiology of leishmaniasis in North Africa, Central America, and South America. The purpose of the book is not to specifically address diagnosis and treatment of the disease, but rather to provide a sample of the differing epidemiologies of leishmaniasis that occur due to variations in local habitats; the presence of different vectors, reservoirs, and agents; and the wide variety of cultures in which this disease occurs.
Author : World Health Organization
Publisher : World Health Organization
ISBN 13 : 9241564865
Total Pages : 211 pages
Book Rating : 4.2/5 (415 download)
Download or read book Investing to Overcome the Global Impact of Neglected Tropical Diseases written by World Health Organization and published by World Health Organization. This book was released on 2015-08-05 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The presence, or absence, of neglected tropical diseases (NTDs) can be seen as a proxy for poverty and for the success of interventions aimed at reducing poverty. Today, coverage of the public-health interventions recommended by the World Health Organization (WHO) against NTDs may be interpreted as a proxy for universal health coverage and shared prosperity - in short, a proxy for coverage against neglect. As the world's focus shifts from development to sustainable development, from poverty eradication to shared prosperity, and from disease-specific goals to universal health coverage, control of NTDs will assume an important role towards the target of achieving universal health coverage, including individual financial risk protection. Success in overcoming NTDs is a "litmus test" for universal health coverage against NTDs in endemic countries. The first WHO report on NTDs (2010) set the scene by presenting the evidence for how these interventions had produced results. The second report (2013) assessed the progress made in deploying them and detailed the obstacles to their implementation. This third report analyses for the first time the investments needed to achieve the scale up of implementation required to achieve the targets of the WHO Roadmap on NTDs and universal coverage against NTDs. INVESTING TO OVERCOME THE GLOBAL IMPACT OF NEGLECTED TROPICAL DISEASES presents an investment strategy for NTDs and analyses the specific investment case for prevention, control, elimination and eradication of 12 of the 17 NTDs. Such an analysis is justified following the adoption by the Sixty-sixth World Health Assembly in 2013 of resolution WHA6612 on neglected tropical diseases, which called for sufficient and predictable funding to achieve the Roadmap's targets and sustain control efforts. The report cautions, however, that it is wise investment and not investment alone that will yield success. The report registers progress and challenges and signals those that lie ahead. Climate change is expected to increase the spread of several vector-borne NTDs, notably dengue, transmission of which is directly influenced by temperature, rainfall, relative humidity and climate variability primarily through their effects on the vector. Investments in vector-borne diseases will avoid the potentially catastrophic expenditures associated with their control. The presence of NTDs will thereby signal an early warning system for climate-sensitive diseases. The ultimate goal is to deliver enhanced and equitable interventions to the most marginalized populations in the context of a changing public-health and investment landscape to ensure that all peoples affected by NTDs have an opportunity to lead healthier and wealthier lives."--Publisher's description.
