Lahitas Systemic Lupus Erythematosus

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Lahita's Systemic Lupus Erythematosus

Author : Robert G. Lahita
Publisher : Academic Press
ISBN 13 : 0323914888
Total Pages : 732 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Lahita's Systemic Lupus Erythematosus by : Robert G. Lahita

Download or read book Lahita's Systemic Lupus Erythematosus written by Robert G. Lahita and published by Academic Press. This book was released on 2021-07-23 with total page 732 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness.To date, lupus has no known cause or cure. Early detection and treatment are the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, antimalarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, like those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well-regarded reference combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus, Sixth Edition, is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a reference work for hospital libraries. Completely updated, revised, and expanded with the most comprehensive and accessible reference on SLE for clinicians and scientists Full-color presentation throughout the book Provides the latest information available on diagnosis and treatment Incorporates an international panel of authors who are experts in their fields, with an emphasis on young, cutting-edge scientists and physicians

Systemic Lupus Erythematosus

Author : Josef S. Smolen
Publisher : Springer Science & Business Media
ISBN 13 : 3642716423
Total Pages : 397 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Systemic Lupus Erythematosus by : Josef S. Smolen

Download or read book Systemic Lupus Erythematosus written by Josef S. Smolen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 140 years ago, lupus erythematosus (LE) was recognized as a disease entity by clinicians working in the field of dermatology, which had only recently become an independent medical discipline. Soon after cutaneous lupus was first reported, it was realized that, apart from the skin, the disease could involve other organs and thus be systemic in nature. The latter observations were first made by MORITZ KApOSI [1], whose work has attracted renewed attention re cently and who succeeded FERDINAND VON HEBRA to the chair of dermatology at the Medical Faculty in Vienna. The early description of lupus erythematosus in both its cutaneous and systemic manifes tations was thus intimately associated with Vienna and its Medical School. The next phase in the study of lupus was characterized by an in crease in knowledge of the type and extent of organ involvement. The work by OSLER [2], LIBMANN and SACKS [3], and KLEMPERER [4] best represents these advances. The increase in clinical knowledge of LE finally led to DUBOIS' famous monograph [5], which was pub lished at a time of renewed interest in SLE, elicited by the descrip tion by HARGRAVES et al. [6] of the LE-cell phenomenon. A more detailed analysis of this finding revealed that the disease was charac terized by an abnormal immune response, although its pathogenetic implications were still unclear.

Systemic Lupus Erythematosus

Author : Robert G. Lahita
Publisher : Elsevier
ISBN 13 : 0080474543
Total Pages : 1376 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Systemic Lupus Erythematosus by : Robert G. Lahita

Download or read book Systemic Lupus Erythematosus written by Robert G. Lahita and published by Elsevier. This book was released on 2004-06-09 with total page 1376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic Lupus Erythematosus, Fourth Edition, provides an understanding of the basic mechanisms as well as the diagnostic and therapeutic aspects of lupus. This book is attractive to both the investigative community and clinicians. As lupus has become a paradigm for the study of autoimmune disease, immunologists investigating autoimmunity are becoming more interested in lupus. Basic immunology of phospholipid antibodies, clotting abnormailities, issues concerning pathogenetic fit with SLE, and newest methods of therapy of APLS are given in this newest edition of a classic reference. Comprehensive current coverage of basic models of etiology and pathogenesis Complete catalog of autoantibodies produced Includes an outstanding review of imaging techniques for the diagnosis of lupus and its complications for each organ system Includes CD-ROM of images excellent for teaching purposes and downloading into presentations

Systemic Lupus Erythematosus, An Issue of Rheumatic Disease Clinics

Author : Ellen M. Ginzler
Publisher : Elsevier Health Sciences
ISBN 13 : 032332388X
Total Pages : 185 pages
Book Rating : 4.3/5 (233 download)

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Book Synopsis Systemic Lupus Erythematosus, An Issue of Rheumatic Disease Clinics by : Ellen M. Ginzler

Download or read book Systemic Lupus Erythematosus, An Issue of Rheumatic Disease Clinics written by Ellen M. Ginzler and published by Elsevier Health Sciences. This book was released on 2014-08-28 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: In only the last four years, there have been dramatic changes in the understanding of the immunology, genetic/epigenetic associations, and identification of new targets for therapy in Systemic Lupus Erythematosus. The editors have enlisted a superb group of authors to present articles detailing cutting-edge advances in these areas.

Advanced Handbook of Systemic Lupus Erythematosus

Author : Laurent Arnaud
Publisher : Springer
ISBN 13 : 3319430351
Total Pages : 179 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Advanced Handbook of Systemic Lupus Erythematosus by : Laurent Arnaud

Download or read book Advanced Handbook of Systemic Lupus Erythematosus written by Laurent Arnaud and published by Springer. This book was released on 2017-09-10 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will provide an introduction to the epidemiology, etiology and pathogenesis of the condition while also exploring the classification, diagnosis, and current and emerging therapies for systemic lupus erythematosus. Systemic lupus erythematosus is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue. It can affect the skin, joints, kidneys, brain, and other organs. The underlying cause of the disease is not fully known, and SLE is much more common in women than in men. It may occur at any age but most often occurs in people between 10 and 50 years of age. This is the second Adis title from Ronald F van Vollenhoven, who previously authored Biologics for the Treatment of Rheumatoid Arthritis.

Cutaneous Lupus Erythematosus

Author : Annegret Kuhn
Publisher : Springer Science & Business Media
ISBN 13 : 3540265813
Total Pages : 452 pages
Book Rating : 4.5/5 (42 download)

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Book Synopsis Cutaneous Lupus Erythematosus by : Annegret Kuhn

Download or read book Cutaneous Lupus Erythematosus written by Annegret Kuhn and published by Springer Science & Business Media. This book was released on 2005-12-05 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: - Based on multidisciplinary knowledge and written by leading clinicians and scientists. - Includes chapters on classification and clinical aspects, pathologic features, and treatment and management of lupus erythematosus. - Although the lupus erythematosus is primarily a skin disease, because it can affect other areas such as joints, kidneys, lungs, heart, liver, brain, and blood vessels this book is also useful to specialists in internal medicine.

Dubois' Lupus Erythematosus

Author : Daniel Jeffrey Wallace
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781793940
Total Pages : 1516 pages
Book Rating : 4.7/5 (939 download)

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Book Synopsis Dubois' Lupus Erythematosus by : Daniel Jeffrey Wallace

Download or read book Dubois' Lupus Erythematosus written by Daniel Jeffrey Wallace and published by Lippincott Williams & Wilkins. This book was released on 2007 with total page 1516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Established for forty years as the definitive reference on lupus, Dubois' Lupus Erythematosus is now in its thoroughly revised, updated Seventh Edition. More than ninety distinguished contributing authors—twenty of them new to this edition—provide comprehensive coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education. This edition focuses on evidence-based findings, treatment consensuses, and practical clinical information. New chapters cover cytokines and interferons, pathogenesis of atherosclerosis, immune tolerance, clinical indices in assessment of lupus, mixed connective tissue disease, reproductive issues, fibromyalgia, gender-related issues, and biomarkers.

Lupus

Author : Sophia Lionaki
Publisher : BoD – Books on Demand
ISBN 13 : 1838801693
Total Pages : 140 pages
Book Rating : 4.8/5 (388 download)

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Book Synopsis Lupus by : Sophia Lionaki

Download or read book Lupus written by Sophia Lionaki and published by BoD – Books on Demand. This book was released on 2020-03-25 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic lupus erythematosus, the prototype of an autoimmune disorder, may affect several organs and may run a chronic course between relapse and remission. This book covers important aspects of the disease, including epidemiology, pathophysiology, and neuropsychiatric manifestations, including basic science and clinical features and management. In affected patients, the fundamental problem of fertility is reassessed including the risk of the disease, the possibility of fetal loss, the safety of drugs during pregnancy, and the current diagnostic and suggested therapeutic strategies of reproductive medicine. Finally, the issue of pathogenesis is revisited with a thorough description of animal models in relation to physiology and potential novel therapies.

Systemic Lupus Erythematosus E-Book

Author : George Tsokos
Publisher : Elsevier Health Sciences
ISBN 13 : 0323070876
Total Pages : 607 pages
Book Rating : 4.3/5 (23 download)

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Book Synopsis Systemic Lupus Erythematosus E-Book by : George Tsokos

Download or read book Systemic Lupus Erythematosus E-Book written by George Tsokos and published by Elsevier Health Sciences. This book was released on 2007-02-23 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new companion to Hochberg et al.'s Rheumatology masterwork provides new insights into the causes, detection and therapy of this challenging disease. In this state-of-the-art resource, you'll find ‘one stop' coverage of all the latest scientific and clinical developments in SLE: new concepts in epidemiology, disease activity measures and outcomes; new concepts in immunoregulation, genetic and pathogenic mechanisms; new understanding and novel presentation of the processes of tissue/organ damage; comprehensive coverage of clinical features; and the very latest concepts in treatment. Provides the very latest understanding of the pathogenesis of SLE. Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the disease. Includes comprehensive coverage of clinical features, including fatigue, organ system manifestations, overlap syndromes, infections, and more. Conveys the very latest understanding of mechanisms of tissue damage, including immune complexes, antibodies, and other mechanisms that lead to organ damage. Contains expert discussion of processes that are responsible for tissue injury - a hallmark of this text. Incorporates the latest treatment modalities, including steroids and non-steroidals, cytotoxic drug treatment, PAP's, and therapies on the horizon. Discusses the latest treatment options on disease modifying or disease controlling agents.

Pathogenesis of Systemic Lupus Erythematosus

Author : Alberta Hoi
Publisher : Springer Nature
ISBN 13 : 3030851613
Total Pages : 192 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Pathogenesis of Systemic Lupus Erythematosus by : Alberta Hoi

Download or read book Pathogenesis of Systemic Lupus Erythematosus written by Alberta Hoi and published by Springer Nature. This book was released on 2021-11-15 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scope of this contributed volume is to provide an overview of the latest translational research in the field of lupus pathogenesis, with particular emphasis on how these discoveries progress in parallel with therapeutic drug development. Systemic lupus erythematosus (SLE) is a multifaceted disease with a number of well-defined immune pathways that are dysregulated, resulting in an immune-mediated chronic inflammatory injury at target organs. As knowledge of these pathways evolves to provide opportunities for targeted drug therapy and lays the foundation for personalized medicine, clinicians and researchers need to keep up with the ever-expanding medical literature. This book will critically appraise the current understanding of important immunological pathways that contribute to the pathogenesis of lupus. We will review the role of interferons as part of the innate immune defects that perpetuate the loss of self-tolerance in SLE. B cell hyperactivity, as a defining hallmark of SLE, and different strategies of B cell targeted therapy will be discussed. The role of co-stimulation or immune checkpoint molecules in activating B and T cells will be reviewed, as well as other cytokines that serve in the amplification loop promoting a more proinflammatory Th1 or Th17 responses. Intracellular targets, such as signaling molecules in the JAK/STAT pathway, or a variety of kinases and proteasomes, can cause a cascading downstream effect of transcriptional responses that are important in SLE. Immune homeostasis can also be restored by bolstering the naturally occurring anti-inflammatory mechanisms. Glucocorticoid, as a potent natural anti-inflammatory hormone, can mediate its effects by recruiting histone deacetylase that serve to repress gene transcription. Glucocorticoid-induced leucine zipper is a gene upregulated by glucocorticoid that can be a potential target for development of anti-inflammatory strategy. Finally, T regulatory cells can be utilized to help restore to immune tolerance and are amongst the latest focus of therapeutic development in SLE.

Lupus Erythematosus

Author : Edmund L. Dubois (Ed)
Publisher :
ISBN 13 :
Total Pages : 798 pages
Book Rating : 4.:/5 (476 download)

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Book Synopsis Lupus Erythematosus by : Edmund L. Dubois (Ed)

Download or read book Lupus Erythematosus written by Edmund L. Dubois (Ed) and published by . This book was released on 1974 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Lupus Erythematosus

Author : Peter H. Schur
Publisher : Springer Science & Business Media
ISBN 13 : 1461411890
Total Pages : 266 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Lupus Erythematosus by : Peter H. Schur

Download or read book Lupus Erythematosus written by Peter H. Schur and published by Springer Science & Business Media. This book was released on 2012-07-06 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Often considered the prototypic autoimmune disease, Lupus is characterized by protean manifestations and affects a wide range of organ systems. Despite widespread availability of anti nuclear antibody testing and other technological diagnostic advances, the diagnosis of lupus can be elusive, difficult, and inexact. Treatment of the disease can also be challenging. Advances in immunology and biotechnology have led to a burgeoning world of new therapies in development that offer patients the real possibility of new therapies and physicians and scientists novel insights into the pathogenesis of this complicated immunological disease. Lupus Erythematosus: Clinical Evaluation and Treatment summarizes the clinical aspects of lupus facing the general clinician in the 21st century. In this invaluable, practical book, the reader will find introductory chapters regarding general diagnostic and treatment principles, followed by chapters addressing the lupus-specific organ manifestations. Special topics regarding pregnancy and comorbidities are also presented. Written by highly experienced physicians with special expertise in lupus, Lupus Erythematosus: Clinical Evaluation and Treatment is an indispensable reference for the common and not so common problems affecting patients with lupus.

Progress in Systemic Lupus Erythematosus Research

Author : Tomas I. Seward
Publisher : Nova Publishers
ISBN 13 : 9781600218613
Total Pages : 284 pages
Book Rating : 4.2/5 (186 download)

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Book Synopsis Progress in Systemic Lupus Erythematosus Research by : Tomas I. Seward

Download or read book Progress in Systemic Lupus Erythematosus Research written by Tomas I. Seward and published by Nova Publishers. This book was released on 2007 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new book is devoted to leading-edge research developments in lupus which is a condition of chronic inflammation caused by an autoimmune disease. Autoimmune diseases are illnesses that occur when the body's tissues are attacked by its own immune system. The immune system is a complex system within the body that is designed to fight infectious agents, for example, bacteria, and other foreign invaders. One of the mechanisms that the immune system uses to fight infections is the production of antibodies. Patients with lupus produce abnormal antibodies in their blood that target tissues within their own body rather than foreign infectious agents. Because the antibodies and accompanying cells of inflammation can involve tissues anywhere in the body, lupus has the potential to affect a variety of areas of the body. Sometimes lupus can cause disease of the skin, heart, lungs, kidneys, joints, and/or nervous system. When only the skin is involved, the condition is called discoid lupus. When internal organs are involved, the condition is called systemic lupus erythematosus (SLE).

Systemic Lupus Erythematosus

Author : George C. Tsokos
Publisher : Elsevier Health Sciences
ISBN 13 : 0323044344
Total Pages : 602 pages
Book Rating : 4.3/5 (23 download)

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Book Synopsis Systemic Lupus Erythematosus by : George C. Tsokos

Download or read book Systemic Lupus Erythematosus written by George C. Tsokos and published by Elsevier Health Sciences. This book was released on 2007-01-01 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new companion to Hochberg et al.'s Rheumatology masterwork provides new insights into the causes, detection and therapy of this challenging disease. In this state-of-the-art resource, you'll find 'one stop' coverage of all the latest scientific and clinical developments in SLE: new concepts in epidemiology, disease activity measures and outcomes; new concepts in immunoregulation, genetic and pathogenic mechanisms; new understanding and novel presentation of the processes of tissue/organ damage; comprehensive coverage of clinical features; and the very latest concepts in treatment. Provides the very latest understanding of the pathogenesis of SLE. Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the disease. Includes comprehensive coverage of clinical features, including fatigue, organ system manifestations, overlap syndromes, infections, and more. Conveys the very latest understanding of mechanisms of tissue damage, including immune complexes, antibodies, and other mechanisms that lead to organ damage. Contains expert discussion of processes that are responsible for tissue injury - a hallmark of this text. Incorporates the latest treatment modalities, including steroids and non-steroidals, cytotoxic drug treatment, PAP's, and therapies on the horizon. Discusses the latest treatment options on disease modifying or disease controlling agents.

Case Studies in Immunology: Systemic Lupus Erythematosus

Author : Raif Geha
Publisher : Garland Science
ISBN 13 : 1136982205
Total Pages : 39 pages
Book Rating : 4.1/5 (369 download)

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Book Synopsis Case Studies in Immunology: Systemic Lupus Erythematosus by : Raif Geha

Download or read book Case Studies in Immunology: Systemic Lupus Erythematosus written by Raif Geha and published by Garland Science. This book was released on 2010-01-01 with total page 39 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents case histories that are chosen for two purposes: to illustrate in a clinical context essential points about the mechanisms of immunity; and to describe and explain some of the immunological problems often seen in the clinic.

Outcome Measures and Metrics in Systemic Lupus Erythematosus

Author : Zahi Touma
Publisher : Springer Nature
ISBN 13 : 3030733033
Total Pages : 418 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Outcome Measures and Metrics in Systemic Lupus Erythematosus by : Zahi Touma

Download or read book Outcome Measures and Metrics in Systemic Lupus Erythematosus written by Zahi Touma and published by Springer Nature. This book was released on 2021-07-22 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that manifests with a myriad of clinical and laboratory features. The assessment of SLE is comprehensive and includes different core set domains; disease activity, damage, health-related quality of life, adverse events and economic impact. This comprehensive book is focused on the instruments and outcome measures utilized in the assessment of SLE. It targets different audiences including physicians, scientists/researchers and different health professionals interested in learning about the art of measurement in SLE. The book highlights the importance of measurement in the assessment of SLE in a clinical settings, research and clinical trials. Each of the chapters provide a systematic approach to the instruments utilized in the assessment of a specific construct in SLE (e.g., disease activity, fatigue, etc.) and incorporate a comprehensive coverage of disease specific and disease generic measures. It also discusses different patient-reported outcomes that are crucial to reflect patient perceptions of their health condition and cover constructs such as fatigue, pain, anxiety and depression, cognition, frailty, and many others.

Systemic Lupus Erythematosus

Author : George C. Tsokos
Publisher : Academic Press
ISBN 13 : 0128020091
Total Pages : 642 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Systemic Lupus Erythematosus by : George C. Tsokos

Download or read book Systemic Lupus Erythematosus written by George C. Tsokos and published by Academic Press. This book was released on 2015-12-23 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic Lupus Erythematosus combines basic science with clinical science to provide a translational treatment of the disease and is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries. Provides the very latest overview of the pathogenesis of SLE Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the disease Includes comprehensive coverage of clinical features, including fatigue, organ system manifestations, overlap syndromes, infections, and more Conveys the very latest understanding of mechanisms of tissue damage, including immune complexes, antibodies, and other mechanisms that lead to organ damage Discusses the latest treatment options on disease modifying or disease controlling agents Provides 'one stop' coverage of all the latest scientific and clinical developments in SLE