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Investigations Into Phosphodiesterases As Targets For Antimalarial Drug Discovery
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Book Synopsis Investigations Into Phosphodiesterases as Targets for Antimalarial Drug Discovery by : Laura Gabrielle Drought
Download or read book Investigations Into Phosphodiesterases as Targets for Antimalarial Drug Discovery written by Laura Gabrielle Drought and published by . This book was released on 2014 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Investigations Into Phosphodieterases as Targets for Antimalarial Drug Discovery by : L. G. Drought
Download or read book Investigations Into Phosphodieterases as Targets for Antimalarial Drug Discovery written by L. G. Drought and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Antimalarial Agents by : Graham L. Patrick
Download or read book Antimalarial Agents written by Graham L. Patrick and published by Elsevier. This book was released on 2020-05-30 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antimalarial Agents: Design and Mechanism of Action seeks to support medicinal chemists in their work toward antimalarial solutions, providing practical guidance on past and current developments and highlighting promising leads for the future. Malaria is a deadly disease which threatens half of the world’s population. Advances over several decades have seen vast improvements in the eff ectiveness of both preventative measures and treatments, but the rapid adaptability of the disease means that the ongoing search for improved and novel antimalarial drugs is essential. Beginning with a historical overview of malaria and antimalarial research, this book goes on to describe the biological aspects of malaria, highlighting the lifecycle of the parasite responsible for malaria, the problem of resistance, genetic mapping of the parasite’s genome, established drug targets, and potential drug targets for the future. This sets the scene for the following chapters which provide a detailed study of the medicinal chemistry of antimalarial agents, with a focus on the design of antimalarial drugs. Drawing on the knowledge of its experienced authors, and coupling historic research with current fi ndings to provide a full picture of both past and current milestones, Antimalarial Agents: Design and Mechanism of Action is a comprehensive yet accessible guide for all those involved in the design, development, and administration of antimalarial drugs, including student academic researchers, medicinal chemists, malaria researchers, and pharmaceutical scientists. Consolidates both past and current developments in the discovery and design of antimalarial drugs Presents content in a style that is both thorough and engaging, providing a supportive and guiding reference to students and researchers from interdisciplinary backgrounds Highlights drug targets currently considered to be the most promising for future therapies, and the classes of compounds that are currently being studied and perfected
Book Synopsis Deep Learning for the Life Sciences by : Bharath Ramsundar
Download or read book Deep Learning for the Life Sciences written by Bharath Ramsundar and published by O'Reilly Media. This book was released on 2019-04-10 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Deep learning has already achieved remarkable results in many fields. Now it’s making waves throughout the sciences broadly and the life sciences in particular. This practical book teaches developers and scientists how to use deep learning for genomics, chemistry, biophysics, microscopy, medical analysis, and other fields. Ideal for practicing developers and scientists ready to apply their skills to scientific applications such as biology, genetics, and drug discovery, this book introduces several deep network primitives. You’ll follow a case study on the problem of designing new therapeutics that ties together physics, chemistry, biology, and medicine—an example that represents one of science’s greatest challenges. Learn the basics of performing machine learning on molecular data Understand why deep learning is a powerful tool for genetics and genomics Apply deep learning to understand biophysical systems Get a brief introduction to machine learning with DeepChem Use deep learning to analyze microscopic images Analyze medical scans using deep learning techniques Learn about variational autoencoders and generative adversarial networks Interpret what your model is doing and how it’s working
Book Synopsis Privileged Scaffolds in Drug Discovery by : Bin Yu
Download or read book Privileged Scaffolds in Drug Discovery written by Bin Yu and published by Elsevier. This book was released on 2023-07-19 with total page 988 pages. Available in PDF, EPUB and Kindle. Book excerpt: Privileged Scaffolds in Drug Discovery is the most complete and up-to-date work in the area. Covering a wide range of privileged structures, it is a perfect reference for scientists involved in targeted drug development. The editors recruited epserts from several prestigious Chinese institutions to cover the areas of antiviral drugs, chalcone, pyrimidine, (benz)imidazoles, natural product-derived privileged scaffolds, N-Sulfonyl carboxamides, kinase inhibitors, antitumor molecules, antineurodegenerative drugs, triazoles, oxazolidinone, indole and indoline scaffolds, tigliane diterpenoids, peptide and peptide-based drugs, quassinoids, and others including pseudonatural products, macrocycles, stable peptides and peptidomimetics. The book also explores scaffolds in drug molecules approved in recent years. Privileged Scaffolds in Drug Discovery is a complete reference for researchers in drug discovery and organic synthesis, in academic and corporate settings, who are investigating privileged structures upon which to base new drugs. Researchers in medicinal chemistry and chemical biology will also find the contents of this book valuable. Provides wide coverage of privileged scaffolds in new drug discovery Includes complex and diverse natural product scaffolds Covers applications to peptides and peptide-based drugs
Book Synopsis Phosphodiesterases and Their Inhibitors by : Spiros Liras
Download or read book Phosphodiesterases and Their Inhibitors written by Spiros Liras and published by John Wiley & Sons. This book was released on 2014-03-03 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug. Beginning with a review of the first wave of phosphodiesterase (PDE) inhibitors, this book focuses on new and emerging PDE targets and their inhibitors. Drug development options for all major human PDE families are discussed and cover diverse therapeutic fields, such as neurological/psychiatric, cardiovascular/metabolic, pain, and allergy/respiratory diseases. Finally, emerging chemotherapeutic applications of PDE inhibitors against malaria and other tropical diseases are discussed.
Book Synopsis Antimalarial Agents by : Graham L. Patrick
Download or read book Antimalarial Agents written by Graham L. Patrick and published by Elsevier. This book was released on 2020-06-16 with total page 622 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antimalarial Agents: Design and Mechanism of Action seeks to support medicinal chemists in their work toward antimalarial solutions, providing practical guidance on past and current developments and highlighting promising leads for the future. Malaria is a deadly disease which threatens half of the world's population. Advances over several decades have seen vast improvements in the eff ectiveness of both preventative measures and treatments, but the rapid adaptability of the disease means that the ongoing search for improved and novel antimalarial drugs is essential. Beginning with a historical overview of malaria and antimalarial research, this book goes on to describe the biological aspects of malaria, highlighting the lifecycle of the parasite responsible for malaria, the problem of resistance, genetic mapping of the parasite's genome, established drug targets, and potential drug targets for the future. This sets the scene for the following chapters which provide a detailed study of the medicinal chemistry of antimalarial agents, with a focus on the design of antimalarial drugs. Drawing on the knowledge of its experienced authors, and coupling historic research with current fi ndings to provide a full picture of both past and current milestones, Antimalarial Agents: Design and Mechanism of Action is a comprehensive yet accessible guide for all those involved in the design, development, and administration of antimalarial drugs, including student academic researchers, medicinal chemists, malaria researchers, and pharmaceutical scientists. Consolidates both past and current developments in the discovery and design of antimalarial drugs Presents content in a style that is both thorough and engaging, providing a supportive and guiding reference to students and researchers from interdisciplinary backgrounds Highlights drug targets currently considered to be the most promising for future therapies, and the classes of compounds that are currently being studied and perfected
Book Synopsis Drug Repurposing by : Farid A. Badria
Download or read book Drug Repurposing written by Farid A. Badria and published by BoD – Books on Demand. This book was released on 2020-12-02 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug repurposing or drug repositioning is a new approach to presenting new indications for common commercial and clinically approved existing drugs. For example, chloroquine, an old antimalarial drug, showed promising results for treating COVID-19, interfering with MDR in several types of cancer, and chemosensitizing human leukemic cells.This book focuses on the hypothesis, risk/benefits, and economic impacts of drug repurposing on drug discovery in dermatology, infectious diseases, neurological disorders, cancer, and orphan diseases. It brings together up-to-date research to provide readers with an informative, illustrative, and easy-to-read book useful for students, clinicians, and the pharmaceutical industry.
Book Synopsis Protein Kinases as Drug Targets by : Bert Klebl
Download or read book Protein Kinases as Drug Targets written by Bert Klebl and published by John Wiley & Sons. This book was released on 2011-03-16 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely guide to kinase inhibitor drug development is the first to cover the entire drug pipeline, from target identification to compound development and clinical application. Edited by the pioneers in the field, on the drug development side this ready reference discusses classical medicinal chemistry approaches as well as current chemical genomics strategies. On the clinical side, both current and future therapeutic application areas for kinase inhibitor drugs are addressed, with a strong focus on oncology drugs. Backed by recent clinical experience with first-generation drugs in the battle against various forms of cancer, this is crucial reading for medicinal, pharmaceutical and biochemists, molecular biologists, and oncologists, as well as those working in the pharmaceutical industry.
Book Synopsis Drug Discovery and Development - E-Book by : Raymond G Hill
Download or read book Drug Discovery and Development - E-Book written by Raymond G Hill and published by Elsevier Health Sciences. This book was released on 2012-07-20 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historical account from its origins in the mediaeval apothecaries’ trade, and discusses the changing understanding of what we mean by disease, and what therapy aims to achieve, as well as summarising case histories of the discovery and development of some important drugs. The second part focuses on the science and technology involved in the discovery process: the stages by which a promising new chemical entity is identified, from the starting point of a medical need and an idea for addressing it. A chapter on biopharmaceuticals, whose discovery and development tend to follow routes somewhat different from synthetic compounds, is included here, as well as accounts of patent issues that arise in the discovery phase, and a chapter on research management in this environment. The third section of the book deals with drug development: the work that has to be undertaken to turn the drug candidate that emerges from the discovery process into a product on the market. The definitive introduction to how a pharmaceutical company goes about its business of discovering and developing drugs. The second edition has a new editor: Professor Raymond Hill ● non-executive director of Addex Pharmaceuticals, Covagen and of Orexo AB ● Visiting Industrial Professor of Pharmacology in the University of Bristol ● Visiting Professor in the School of Medical and Health Sciences at the University of Surrey ● Visiting Professor in Physiology and Pharmacology at the University of Strathclyde ● President and Chair of the Council of the British Pharmacological Society ● member of the Nuffield Council on Bioethics and the Advisory Council on Misuse of Drugs. New to this edition: Completely rewritten chapter on The Role of Medicinal Chemistry in the Drug Discovery Process. New topic - DMPK Optimization Strategy in drug discovery. New chapter on Scaffolds: Small globular proteins as antibody substitutes. Totally updated chapters on Intellectual Property and Marketing 50 new illustrations in full colour Features Accessible, general guide to pharmaceutical research and development. Examines the interfaces between cost and social benefit, quality control and mass production, regulatory bodies, patent management, and all interdisciplinary intersections essential to effective drug development. Written by a strong team of scientists with long experience in the pharmaceutical industry. Solid overview of all the steps from lab bench to market in an easy-to-understand way which will be accessible to non-specialists. From customer reviews of the previous edition: ‘... it will have everything you need to know on this module. Deeply referenced and, thus, deeply reliable. Highly Commended in the medicine category of the BMA 2006 medical book competition Winner of the Royal Society of Medicine Library Prize for Medical Book of the Year
Book Synopsis Medicinal Chemistry of Neglected and Tropical Diseases by : Venkatesan Jayaprakash
Download or read book Medicinal Chemistry of Neglected and Tropical Diseases written by Venkatesan Jayaprakash and published by CRC Press. This book was released on 2019-08-15 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Chemistry of Neglected and Tropical Diseases: Advances in the Design and Synthesis of Antimicrobial Agents consolidates and describes modern drug discovery and development approaches currently employed to identify effective chemotherapeutic agents for the treatment of Neglected Tropical Diseases (NTDs) from a medicinal chemistry perspective. Chapters are designed to cater to the needs of medicinal chemists who work with chemotherapeutic developments for NTDs, as well as serve as a guide to budding medicinal chemists who wish to work in this area. It will introduce rational drug design approaches adopted in designing chemotherapeutics and validated targets available for the purpose.
Book Synopsis Current Research on Pre-clinical Aspects of Cancer Therapy by : Current Cancer Research Project Analysis Center (U.S.)
Download or read book Current Research on Pre-clinical Aspects of Cancer Therapy written by Current Cancer Research Project Analysis Center (U.S.) and published by . This book was released on 1975 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1038 references to research projects being conducted in the United States and elsewhere. Entries arranged under 5 topics, e.g., Preclinical studies of anticancer drugs, Preclinical radiation therapy, and Preclinical immunotherapy. Entriesinclude title, researcher, address, contract number, summary, and supporting agency. Indexes by subjects, investigators, contractors, supporting agencies, and contractor numbers.
Book Synopsis International Review of Cell and Molecular Biology by : Kwang W. Jeon
Download or read book International Review of Cell and Molecular Biology written by Kwang W. Jeon and published by Academic Press. This book was released on 2013-01-10 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology--both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field Provides up-to-date information and directions for future research Valuable reference material for advanced undergraduates, graduate students and professional scientists
Book Synopsis The Zebrafish in Biomedical Research by : Samuel Cartner
Download or read book The Zebrafish in Biomedical Research written by Samuel Cartner and published by Academic Press. This book was released on 2019-11-22 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications is a comprehensive work that fulfills a critical need for a thorough compilation of information on this species. The text provides significant updates for working vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators using the species to gain critical insights into human physiology and disease. As the zebrafish has become an important model organism for the study of vertebrate development and disease, organ function, behavior, toxicology, cancer, and drug discovery, this book presents an important resource for future research. Presents a complete view of the zebrafish, covering their biology, husbandry, diseases and research applications Includes the work of world-renowned authors Provides the first authoritative and comprehensive treatment of zebrafish in biomedical research as part of the ACLAM series
Book Synopsis Rising Contagious Diseases by : Seth Kwabena Amponsah
Download or read book Rising Contagious Diseases written by Seth Kwabena Amponsah and published by John Wiley & Sons. This book was released on 2024-01-24 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive yet succinct insight into the prevention, diagnosis, and treatment of infectious diseases including COVID-19, mpox, Ebola, and Lyme disease Rising Contagious Diseases provides basic information about preventing and treating threatening infectious diseases from viral, bacterial, and parasitic sources, including 28 emerging or recurring diseases like COVID-19, mpox, Ebola, bird and swine flu, malaria, Legionnaires', and others. The text highlights molecular surveillance and epidemiology (including zoonotic pathogens or their variants), innovative strategies for pathogen detection, drug and vaccine development, appropriate preventive measures, cost-effective diagnostic procedures (assays), and effective therapeutic strategies. The text is unique due to its broad coverage of today's infectious diseases, covering several which are not similarly addressed elsewhere, with detailed insight from experts around the world. Composed of 30 chapters of fundamental facts alongside practical and clinical data, Rising Contagious Diseases covers sample topics such as: Re-emergence of certain diseases in recent decades due to dynamic host-pathogen interactions, anthropogenic selection, and climate change How real-time epidemiological surveillance can improve detection of infectious disease outbreaks or new infections of public health importance Up-to-date insight on transmission dynamics, epidemiology, clinical manifestation, advances in diagnostics, and management of covered diseases Effects of disease outbreaks on the world at large, such as through high morbidity and mortality rates and rising healthcare costs With detailed insight on the prevention, diagnosis, and treatment of infectious diseases, Rising Contagious Diseases is an essential reference for health care professionals, academics in the field of microbiology, immunology, infectious diseases, pathology, pharmacology and public health, and undergraduates and postgraduates in related disciplines.
Book Synopsis Structural Biology in Drug Discovery by : Jean-Paul Renaud
Download or read book Structural Biology in Drug Discovery written by Jean-Paul Renaud and published by John Wiley & Sons. This book was released on 2020-01-09 with total page 1367 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins
Book Synopsis Bioassay Techniques for Drug Development by : Atta-ur-Rahman
Download or read book Bioassay Techniques for Drug Development written by Atta-ur-Rahman and published by CRC Press. This book was released on 2001-10-04 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of an activity-directed isolation process is to isolate bioactive compounds which may provide structural leads of therapeutic importance. Whereas the traditional process of drug development is long and expensive, simple and rapid bioassays can serve as the starting point for drug discovery. This book presents a range of "bench top" bioassa
