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Investigation Into The Control Of Milk Protein Secretion From Mouse Mammary Epithelial Cells
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Book Synopsis Investigation Into the Control of Milk Protein Secretion from Mouse Mammary Epithelial Cells by : Michelle Elizabeth Rennison
Download or read book Investigation Into the Control of Milk Protein Secretion from Mouse Mammary Epithelial Cells written by Michelle Elizabeth Rennison and published by . This book was released on 1993 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Intercellular Signalling in the Mammary Gland by : C.H. Knight
Download or read book Intercellular Signalling in the Mammary Gland written by C.H. Knight and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: All being done, we went to Mrs Shipmans, who is a great butter-woman; and I did see there the most of milke and cream, and the cleanest, that I ever saw in my life (29 May 1661). Among others, Sir Wm. Petty did tell me that in good earnest, he hath in his will left such parts of his estate to him that could invent such and such things -as among others, that could discover truly the way of milk coming into the breasts of a woman ... (22 March 1665). My wife tells me that she hears that my poor aunt James hath had her breast cut off here in tow- her breast having long been out of order (5 May 1665). From the Diary of Samuel Pepys, published as The Shorter Pepys (edited by R. Latham), Penguin Books (1987) The long-standing ultimate importance of research on the mammary gland is illustrated by the importance attached to cows' milk for human consumption, to human lactation and to breast cancer by Samuel Pepys and his contemporaries in the middle of the 17th century. Research has tended to develop in isolation in these three areas of continuing contemporary importance largely because in most countries, the underlying science of agricultural productivity is funded separately from the underlying science of human health and welfare.
Book Synopsis Hormonal Control of Milk Protein Synthesis in Mouse Mammary Epithelial Cells in Vitro by : Jumpei Enami
Download or read book Hormonal Control of Milk Protein Synthesis in Mouse Mammary Epithelial Cells in Vitro written by Jumpei Enami and published by . This book was released on 1977 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Mammary Gland / Human Lactation / Milk Synthesis by : Bruce L. Larson
Download or read book The Mammary Gland / Human Lactation / Milk Synthesis written by Bruce L. Larson and published by Elsevier. This book was released on 2013-10-22 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lactation: A Comprehensive Treatise, Volume IV, The Mammary Gland/Human Lactation/Milk Synthesis, forms the fourth in a series. When the first three volumes were published in 1974, publication of future volumes was not contemplated. However, the gratifying acceptance by the scientific community and the continuation of rapid advances in lactation, have provided the impetus for the continuation of the series. The present volume is concerned with general aspects of the mammary gland, human lactation, and mechanisms of milk synthesis. The volume is divided into three main parts. Part I covers some aspects of the mammary gland and lactation not discussed in the first three volumes and expands on others. Topics discussed include the development of the mammary apparatus and neuroendocrine control of lactation. Part II is devoted to more specific consideration of human lactation as a whole. It includes studies on breast feeding and the breast cancer process. Part III on milk synthesis deals with the mechanisms of milk synthesis; enzymology and control of lactose biosynthesis; molecular aspects of milk protein biosynthesis; and ion and water transport in the mammary gland.
Book Synopsis Endoplasmic Reticulum Homeostasis in the Mouse Mammary Epithelium During Lactation by : Kristen Ross Davis
Download or read book Endoplasmic Reticulum Homeostasis in the Mouse Mammary Epithelium During Lactation written by Kristen Ross Davis and published by . This book was released on 2015 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lactation is an essential stage of mammalian life. Milk is a complex fluid that provides complete nutrition for neonates in the early stages of postnatal life. The organic components of milk, such as milk proteins and lipids, are synthesized and secreted by mammary epithelial cells (MEC). A key differentiation event in MEC is the development of an extensive endoplasmic reticulum (ER) network. At the onset of lactation, copious amount of lipid and protein synthesis could perturb the ER luminal environment. However, little is known about ER function in the context of lactation. Professional secretory cells rely on adaptive mechanisms to maintain ER homeostasis including the Unfolded Protein Response (UPR) and elimination of misfolded and improperly modified proteins via the Endoplasmic Reticulum Associated Degradation (ERAD). Two components of the UPR and ERAD, XBP1 and Sel1L respectively, have been implicated in maintaining ER function in secretory cells. However, the roles of XBP1 and Sel1L during lactation have not been investigated. To this end, we specifically ablated XBP1 and Sel1L in MEC during lactation. Our findings indicate that XBP1 is required for sustaining pup growth during lactation. Absence of XBP1 resulted in a severe reduction of the ER compartment and substantially smaller mammary epithelial compartment during lactation. Notably, our findings are the first to directly demonstrate that XBP1 is absolutely necessary for the development and expansion of an extensive ER network in the MEC. In the case of Sel1L, its absence had little impact on lactation, even though the morphology of the ER was abnormal and markers of ER stress were elevated. More importantly, our findings are the first to suggest that Sel1L is dispensable for MEC function. Taken together, our findings provide novel insight of the contribution of the two ER homeostatic systems during the dynamic and metabolically demanding stage of lactation.
Book Synopsis Biology of the Mammary Gland by : John A. Mol
Download or read book Biology of the Mammary Gland written by John A. Mol and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the European Cooperation in the Field of Scientific and Technical Research (COST 825) Symposium on Mammary Gland Biology, held September 16-18, 1999, in Tours, France. It is difficult to overstate the evolutionary and functional significance of mammary tissue in biology. Substantial progress has been made by researchers in various disciplines, particularly over the last fifteen years, towards realizing the potential of this tissue to yield powerful experimental models for morphogenesis and tissue development; for cellular differentiation; for the biosynthesis and secretion of proteins, lipids, small molecules and inorganic salts; and for the coordination and regulation of these processes. More recently, the possibility of exploiting the secretory epithelial cells of mammary tissue as `cell factories' has become a reality and the recombinant production by lactating animals of an increasing number of proteins, valuable both in the pharmaceutical and `nutraceutical' fields, is in progress or under development. Also in this sphere of agricultural production, genetic as well as nutritional technologies are under investigation and exploitation to optimize milk composition for various end-uses - for instance in food process and manufacture. The possibilities of deriving health benefit from the bioactive properties of some of the minor constituents of milk are emerging to counter the highly-publicized negative health impact of excessive consumption of saturated animal fats. In human nutrition and medicine, the mammary gland is both a source of nutrition to the neonate and a potential health threat to the adult female - breast cancer remains the major single cause of female mortality in most developed countries. This volume provides a unique glimpse into our understanding, at the cutting edge of a variety of disciplines, of this versatile and extraordinary tissue, at the birth of the twenty-first century.
Book Synopsis Regulation of Mammary Lactogenic Differentiation by Singleminded-2s by : Elizabeth Wellberg
Download or read book Regulation of Mammary Lactogenic Differentiation by Singleminded-2s written by Elizabeth Wellberg and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Sim2s is a basic helix-loop-helix Per-Arnt-Sim (bHLH-PAS) transcription factor. In Drosophila, the Sim2 homolog, sim, is necessary for cell fate determination during central nervous system (CNS) development. In mammals, both Sim2 isoforms are involved in development of various tissues, including muscle, cartilage, and mammary gland. Loss-of-function studies revealed a role for Sim2s in specifying epithelial cell fate during mammary development and inhibiting growth and invasion of aggressive breast cancer cells. This study determined the role of Sim2s in mammary epithelial cell differentiation. Our hypothesis is that Sim2s is sufficient to promote lactogenic differentiation in vivo, characterized by expression of lactation-specific genes. Two models were used to test this hypothesis: (1) a transgenic mouse, expressing Sim2s under control of the MMTV-LTR, and (2) the mouse mammary epithelial cell line HC11. Together, these models allow analysis of the effect of Sim2s on global mammary gland differentiation and the mechanism through which it accomplishes this in a relatively homogenous population of cells. We determined that precocious expression of Sim2s in vivo is associated with upregulation of a subset of milk protein genes in nulliparous females. During early pregnancy, Sim2s regulation of lactogenic differentiation extended to a larger group of genes. Following pup removal, Sim2s appears to promote survival of alveolar epithelial cells. In vitro, Sim2s expression is necessary for maximal Csn2 expression, as determined by loss-of-function studies. Overexpression of Sim2s is sufficient to enhance prolactin-mediated Csn2 expression. Chromatin immunoprecipitation assays performed in HC11 cells revealed enhanced recruitment of Stat5a and RNA Polymerase II (RNAPII) to the regulatory region of Csn2 in the presence of Sim2s. In addition, Sim2s and RNAPII were found in a complex that was localized to both the promoter and coding region of the Csn2 gene. These studies support the idea that Sim2s is upregulated in a developmental stage-specific manner in the mouse mammary gland to promote the survival and differentiation of alveolar epithelial cells expressing high levels of milk protein genes. Further, Sim2s may regulate the function of a specific subset of alveolar cells by targeting the RNAPII holoenzyme complex to genes expressed during lactogenic differentiation.
Book Synopsis Animal Cell Technology: Basic & Applied Aspects by : Y. Kitagawa
Download or read book Animal Cell Technology: Basic & Applied Aspects written by Y. Kitagawa and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal cell technology is a growing discipline of cell biology which aims not only to understand structures, functions and behaviors of differentiated animal cells but also to ascertain their abilities to be used for industrial and medical purposes. The goal of animal cell technology includes accomplishments of clonal expansion of differentiated cells with useful ability, optimization of their culture conditions, modulation of their ability for production of medically and pharmaceutically important proteins, and the application of animal cells to gene therapy and artificial organs. This Volume gives the readers a complete review of the present state of the art in Japan. The Proceedings will be useful for cell biologists, biochemists, molecular biologists, immunologists, biochemical engineers and other disciplines related to animal cell culture, working either in academic environments or in industries of biotechnology and pharmacy.
Download or read book Lactogenesis written by Monica Reynolds and published by University of Pennsylvania Press. This book was released on 2016-11-11 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of a symposium, satellite to the 24th International Congress of Physiological Sciences, University of Pennsylvania.
Download or read book ダブルクライシス written by and published by . This book was released on 1965 with total page 50 pages. Available in PDF, EPUB and Kindle. Book excerpt: Raised to be a thief, blind orphan Peter Nimble, age ten, steals from a mysterious stranger three pairs of magical eyes, that lead him to a hidden island where he must decide to become a hero or resume his life of crime.
Book Synopsis Designing Foods by : National Research Council
Download or read book Designing Foods written by National Research Council and published by National Academies Press. This book was released on 1988-02-01 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: This lively book examines recent trends in animal product consumption and diet; reviews industry efforts, policies, and programs aimed at improving the nutritional attributes of animal products; and offers suggestions for further research. In addition, the volume reviews dietary and health recommendations from major health organizations and notes specific target levels for nutrients.
Book Synopsis Lactogenic Hormone Regulation of Epidermal Growth Factor Gene Expression in Mouse Mammary Epithelial Cells by : Yanchu Fang
Download or read book Lactogenic Hormone Regulation of Epidermal Growth Factor Gene Expression in Mouse Mammary Epithelial Cells written by Yanchu Fang and published by . This book was released on 1997 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biology of Lactation by : Herbert-H Head
Download or read book Biology of Lactation written by Herbert-H Head and published by Quae. This book was released on 1999-01-01 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: A presentation of the most fundamental features of the biology of the mammary gland, a unique model of an organ capable of an abundant synthesis of proteins: endocrinology of lactation, role of prolactin, genetics and protein synthesis, immunology and the mammary gland, nutrition and dairy products. Readership: students, teachers, researchers, health and agriculture professionals. Lactation Biology was first published in French in 1993. The English version is not merely a translation: it has been updated by the author.
Book Synopsis An Introduction to Clinical Pharmaceutics by : Alexander Taylor Florence
Download or read book An Introduction to Clinical Pharmaceutics written by Alexander Taylor Florence and published by Pharmaceutical Press. This book was released on 2010 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook describes a variety of dosage forms and their clinical importance and use. The use and behaviour of dosage forms in different age groups and patient groups will also be considered along with recent developments such as personalised therapies and genomics. It contains relevant examples and clinical case studies.
Book Synopsis Protecting Infants through Human Milk by : Larry K. Pickering
Download or read book Protecting Infants through Human Milk written by Larry K. Pickering and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protecting Infants through Human Milk: Advancing the Scientific Evidence provides a forum in which basic scientists, clinicians, epidemiologists, and policy makers exchange the latest findings regarding the effects of human milk and breastfeeding on infant and maternal health, thereby fostering new and promising collaborations. This volume also integrates data from animal and in vitro laboratory studies with clinical and population studies to examine human milk production and composition, the mechanisms of infant protection and/or risk from human milk feeding, and proposed interventions related to infant feeding practices. Additionally, it stimulates critical evaluation of, and advances in, the scientific evidence base and research methods, and identifies the research priorities in various areas.
Book Synopsis Epithelial Cell Culture Protocols by : Scott H. Randell
Download or read book Epithelial Cell Culture Protocols written by Scott H. Randell and published by Humana Press. This book was released on 2016-08-23 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fascinating biology occurs at epithelial interfaces, whether between organism and environment or within body compartments, and many diseases inflicting huge personal and societal burdens result from dysfunction of epithelial systems, e.g., carcinomas. Epithelial cell cultures have been an integral and crucial part of the biomedical research enterprise, adding unique capabilities and enabling mechanistic approaches. In the past decade there have been many research advances, such as directed differentiation of embryonic stem cells and induced pluripotent stem cells, robotic high throughput screening, whole genome siRNA and shRNA libraries, massively parallel sequencing at low cost, identification of somatic stem cells in key organs, to name a few. Epithelial Cell Culture Protocols, Second Edition provides a cross section of up-to-date culture protocols for the most heavily studied cell systems and featured supporting technologies. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Epithelial Cell Culture Protocols, Second Edition will serve outstanding investigators with the best possible information for the advancement of biomedical science.
Book Synopsis The Mammary Gland by : Margaret C. Neville
Download or read book The Mammary Gland written by Margaret C. Neville and published by Springer. This book was released on 1987-11-30 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt:
