Invariant Natural Killer T Cells

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Invariant Natural Killer T-Cells

Author : Chaohong Liu
Publisher : Humana
ISBN 13 : 9781071617748
Total Pages : 195 pages
Book Rating : 4.6/5 (177 download)

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Book Synopsis Invariant Natural Killer T-Cells by : Chaohong Liu

Download or read book Invariant Natural Killer T-Cells written by Chaohong Liu and published by Humana. This book was released on 2021-10-16 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed book focuses on various aspects of Invariant Natural Killer T-Cells (iNKT), which are known to contribute to homeostasis and autoimmunity and can also cause various pathological responses such as allergy, infection, excessive autoimmune response, and cancer. The volume explores techniques for identification and isolation of iNKT cells, iNKT cell activation and transformation, as well as proliferation and differentiation and much more. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Invariant Natural Killer T-Cells: Methods and Protocols is an ideal guide for researchers working with and studying iNKT cells, perhaps to provide a deeper knowledge of the human immune system.

Signaling Mechanisms Regulating T Cell Diversity and Function

Author : Jonathan Soboloff
Publisher : CRC Press
ISBN 13 : 149870509X
Total Pages : 258 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Signaling Mechanisms Regulating T Cell Diversity and Function by : Jonathan Soboloff

Download or read book Signaling Mechanisms Regulating T Cell Diversity and Function written by Jonathan Soboloff and published by CRC Press. This book was released on 2017-03-27 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.

Natural Killer T cells

Author : Masaki Terabe
Publisher : Springer Science & Business Media
ISBN 13 : 1461406137
Total Pages : 212 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Natural Killer T cells by : Masaki Terabe

Download or read book Natural Killer T cells written by Masaki Terabe and published by Springer Science & Business Media. This book was released on 2011-09-22 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will cover primary roles of NKT cells in immunity to cancer, in both mouse tumor models and cancer patients. There are several chapters describing general aspects of NKT cells.

Natural Killer T-cells

Author : Nathan V. Fournier
Publisher : Nova Publishers
ISBN 13 : 9781604562873
Total Pages : 222 pages
Book Rating : 4.5/5 (628 download)

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Book Synopsis Natural Killer T-cells by : Nathan V. Fournier

Download or read book Natural Killer T-cells written by Nathan V. Fournier and published by Nova Publishers. This book was released on 2008 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural killer T (NKT) cells are a heterogeneous group of T cells that share properties of both T cells and natural killer (NK) cells. Many of these cells recognize the non-polymorphic CD1d molecule, an antigen-presenting molecule that binds self- and foreign lipids and glycolipids. Upon activation, NK T cells are able to produce large quantities of interferon-gamma, IL-4, and granulocyte-macrophage colony-stimulating factor, as well as multiple other cytokines and chemokines (such as IL-2 and TNF-alpha). NKT cells seem to be essential for several aspects of immunity because their dysfunction or deficiency has been shown to lead to the development of autoimmune diseases (such as diabetes or atherosclerosis) and cancers. NKT cells have recently been implicated in the disease progression of human asthma. The clinical potential of NKT cells lies in the rapid release of cytokines (such as IL-2, IFN-gamma, TNF-alpha, and IL-4) that promote or suppress different immune responses.

Immunologic Concepts in Transfusion Medicine

Author : Robert W Maitta
Publisher : Elsevier Health Sciences
ISBN 13 : 0323675107
Total Pages : 380 pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Immunologic Concepts in Transfusion Medicine by : Robert W Maitta

Download or read book Immunologic Concepts in Transfusion Medicine written by Robert W Maitta and published by Elsevier Health Sciences. This book was released on 2019-08-27 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunological Concepts in Transfusion Medicine provides a thorough discussion of the immune aspects of blood component transfusion, with in-depth information on the intricacies of immune responses to blood components and the immune processes that may be initiated in response to blood exposure. Written to increase knowledge and awareness of immune challenges such as alloimmunization and transfusion-related acute lung injury, this title bridges current basic scientific discoveries and the potential effects seen in blood recipients. Complies the knowledge and expertise of Dr. Robert Maitta, an expert in immune responses and antibody function/structure studies. Helps clinicians in the daily practice of caring for patients in need of transfusion support, as well as physicians in training when considering utilizing blood transfusions in a limited scope or in the setting of massive transfusion. Includes an immunology primer as an introduction to in-depth chapters covering allergic immune reactions to blood components, transfusion-related immunomodulation, fetal and neonatal alloimmune thrombocytopenia and neonatal neuthropenia, complications of haploidentical and mismatched HSC transplantation, chimeric antibody receptor therapies, and much more. Consolidates today’s available information on this timely topic into a single, convenient resource.

Role of CD1- and MR1-restricted T cells in Immunity and Disease

Author : Kazuya Iwabuchi
Publisher : Frontiers Media SA
ISBN 13 : 2889631222
Total Pages : 429 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Role of CD1- and MR1-restricted T cells in Immunity and Disease by : Kazuya Iwabuchi

Download or read book Role of CD1- and MR1-restricted T cells in Immunity and Disease written by Kazuya Iwabuchi and published by Frontiers Media SA. This book was released on 2019-10-18 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: CD1 and MR1 are major histocompatibility complex (MHC) class I-related proteins that bind and present non-peptide antigens to subsets of T cells with specialized functions. CD1 proteins typically present lipid antigens to CD1-restricted T cells, whereas MR1 presents vitamin B-based ligands and a variety of drugs and drug-like molecules to MR1-restricted T cells. The CD1 family of antigen presenting molecules has been divided into two groups: Group 1 contains CD1a, CD1b and CD1c, and Group 2 contains CD1d. Additionally, CD1e is expressed intracellularly and is involved in the loading of lipid antigens onto Group 1 CD1 proteins. Humans express both Groups 1 and 2 CD1 proteins, whereas mice only express CD1d. Group 1 CD1 proteins present lipid antigens to T cells that generally express diverse T cell receptors (TCRs) and exhibit adaptive-like functions, whereas CD1d presents lipid antigens to subsets of T cells that express either diverse or highly restricted TCRs and exhibit innate-like functions. CD1d-restricted T cells are called natural killer T (NKT) cells, which includes Type I or invariant NKT (iNKT) cells expressing semi-invariant TCRs, and Type II NKT cells expressing more diverse TCRs. CD1-restricted T cells have been implicated in a wide variety of diseases, including cancer, infections, and autoimmune, inflammatory and metabolic diseases. Additionally, NKT cells have been targeted for immunotherapy of disease with ligands such as α-galactosylceramide for iNKT cells, or sulfatide for Type II NKT cells. Like iNKT cells, MR1-restricted T cells express semi-invariant TCRs and display innate-like functions. MR1-restricted T cells, also called mucosal-associated invariant T (MAIT) cells, have been implicated in immune responses against a variety of pathogens such as Mycobacterium tuberculosis, Pseudomonas aeruginosa, Helicobacter pylori, hepatitis C virus and influenza virus. Moreover, these cells contribute to autoimmune and inflammatory diseases, including colitis, rheumatoid arthritis, psoriasis, lupus, and diabetes.

CD1- and MR1-restricted T Cells in Antimicrobial Immunity

Author : S.M. Mansour Haeryfar
Publisher : Frontiers Media SA
ISBN 13 : 2889197506
Total Pages : 191 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis CD1- and MR1-restricted T Cells in Antimicrobial Immunity by : S.M. Mansour Haeryfar

Download or read book CD1- and MR1-restricted T Cells in Antimicrobial Immunity written by S.M. Mansour Haeryfar and published by Frontiers Media SA. This book was released on 2016-01-21 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell-mediated immunity to extracellular and intracellular microbes has been traditionally linked to CD4+ and CD8+ T cells that recognize pathogen-derived peptides in the context of major histocompatibility complex (MHC) class II and class I molecules, respectively. Recent progress in our understanding of early host defense mechanisms has brought ‘unconventional’, innate-like T cells into the spotlight. These are a heterogeneous population of non-MHC-restricted T cells that exhibit ‘memory-like’ properties and mount emergency responses to infection. They may directly detect and destroy infected cells, but are best known for their ability to regulate downstream effector cells including but not limited to conventional T cells. Innate-like T cells include among others CD1-restricted natural killer T (NKT) cells and MR1-restricted mucosa-associated invariant T (MAIT) cells. NKT cells recognize lipid antigens, and MAIT cells were recently demonstrated to respond to microbe-derived vitamin B metabolites. However, much remains to be learned about the antigen specificity range of these cells, their activation mode and their true potentials in immunotherapeutic applications. Like in many other areas of biology, uncertainties and controversies surrounding these cells and some of the experimental models, techniques and reagents employed to study them have brought about excitement and sometimes hot debates. This Special Topic was launched to provide updated reviews on protective and/or pathogenic roles of NKT and MAIT cells during infection. Leading experts discuss current controversies, pressing questions and the challenges that lie ahead for the advancement of this intriguing and rapidly evolving area of immunology. Unlike MHC, CD1 and MR1 display very limited polymorphism. Therefore, NKT and MAIT cells may be considered attractive targets for various diseases in diverse human populations. The potential benefits of NKT cell- and MAIT cell-based vaccination and treatment strategies in infectious diseases is an important subject that is also covered in this Topic.

NKT Cells in Cancer Immunotherapy, 2nd Edition

Author : Tonya J. Webb
Publisher : Frontiers Media SA
ISBN 13 : 2889661539
Total Pages : 178 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis NKT Cells in Cancer Immunotherapy, 2nd Edition by : Tonya J. Webb

Download or read book NKT Cells in Cancer Immunotherapy, 2nd Edition written by Tonya J. Webb and published by Frontiers Media SA. This book was released on 2020-11-20 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

T-Lymphocytes—Advances in Research and Application: 2012 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481621971
Total Pages : 39 pages
Book Rating : 4.4/5 (816 download)

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Book Synopsis T-Lymphocytes—Advances in Research and Application: 2012 Edition by :

Download or read book T-Lymphocytes—Advances in Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 39 pages. Available in PDF, EPUB and Kindle. Book excerpt: T-Lymphocytes—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about T-Lymphocytes in a concise format. The editors have built T-Lymphocytes—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about T-Lymphocytes in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of T-Lymphocytes—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

T Cell Activation by CD1 and Lipid Antigens

Author : Branch D. Moody
Publisher : Springer Science & Business Media
ISBN 13 : 3540695117
Total Pages : 346 pages
Book Rating : 4.5/5 (46 download)

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Book Synopsis T Cell Activation by CD1 and Lipid Antigens by : Branch D. Moody

Download or read book T Cell Activation by CD1 and Lipid Antigens written by Branch D. Moody and published by Springer Science & Business Media. This book was released on 2007-05-10 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is increasing evidence that the CD1 system has been conserved throughout mammalian evolution and is capable of presenting structurally diverse diacyglycerol, sphingolipid, polyisoprenol and lipopeptide antigens. This volume provides a comprehensive discussion of these basic aspects of CD1 biology and summarizes the most recent research into the role of CD1 in infectious, autoimmune, allergic and neoplastic disease.

Role of Invariant Natural Killer T Cells in Tularemia-like Disease in Mice

Author : Timothy Michael Hill
Publisher :
ISBN 13 :
Total Pages : 193 pages
Book Rating : 4.:/5 (929 download)

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Book Synopsis Role of Invariant Natural Killer T Cells in Tularemia-like Disease in Mice by : Timothy Michael Hill

Download or read book Role of Invariant Natural Killer T Cells in Tularemia-like Disease in Mice written by Timothy Michael Hill and published by . This book was released on 2015 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt:

CD1 Antigens—Advances in Research and Application: 2012 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481634976
Total Pages : 21 pages
Book Rating : 4.4/5 (816 download)

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Book Synopsis CD1 Antigens—Advances in Research and Application: 2012 Edition by :

Download or read book CD1 Antigens—Advances in Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 21 pages. Available in PDF, EPUB and Kindle. Book excerpt: CD1 Antigens—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about CD1 Antigens in a compact format. The editors have built CD1 Antigens—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about CD1 Antigens in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of CD1 Antigens—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Molecular Biology of The Cell

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of The Cell by : Bruce Alberts

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

In Vitro Differentiation of T-Cells

Author : Shin Kaneko
Publisher : Humana
ISBN 13 : 9781493997305
Total Pages : 267 pages
Book Rating : 4.9/5 (973 download)

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Book Synopsis In Vitro Differentiation of T-Cells by : Shin Kaneko

Download or read book In Vitro Differentiation of T-Cells written by Shin Kaneko and published by Humana. This book was released on 2020-08-14 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the vital importance of T-cell differentiation in areas as wide-ranging as pathological analysis, drug development, and cell therapy of human T-cells. Focusing on human embryonic stem cells and human induced pluripotent stem cells, the chapters explore a variety of in vitro T-cell differentiation protocols as well as useful techniques to develop and evaluate cellular medicines. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, In Vitro Differentiation of T-Cells: Methods and Protocols serves as an ideal guide for researchers seeking to differentiate T-cells from pluripotent stem cells in order to achieve any number of significant goals.

Mucosal Vaccines

Author : Hiroshi Kiyono
Publisher : Elsevier
ISBN 13 : 0080537057
Total Pages : 501 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Mucosal Vaccines by : Hiroshi Kiyono

Download or read book Mucosal Vaccines written by Hiroshi Kiyono and published by Elsevier. This book was released on 1996-10-23 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive, authoritative treatise covers all aspects of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology. Provides the latest views on mucosal vaccines Applies basic principles to the development of new vaccines Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases Unique and user-friendly organization

T-Cell Development

Author : Rémy Bosselut
Publisher : Humana
ISBN 13 : 9781493928088
Total Pages : 0 pages
Book Rating : 4.9/5 (28 download)

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Book Synopsis T-Cell Development by : Rémy Bosselut

Download or read book T-Cell Development written by Rémy Bosselut and published by Humana. This book was released on 2015-08-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides simple and accessible experiment protocols to explore thymus biology. T-Cell Development: Methods and Protocols is divided into three parts presenting short reviews on T cell development, analysis strategies, protocols for cell preparation, flow cytometry analyses, and multiple aspects of thymocyte biology. As a volume in the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Concise and easy-to-use, T-Cell Development: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Therapeutic Potential of Innate and Innate-like Effector Lymphocytes in Autoimmune and Inflammatory Diseases

Author :
Publisher : Frontiers Media SA
ISBN 13 : 2832539327
Total Pages : 166 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Therapeutic Potential of Innate and Innate-like Effector Lymphocytes in Autoimmune and Inflammatory Diseases by :

Download or read book Therapeutic Potential of Innate and Innate-like Effector Lymphocytes in Autoimmune and Inflammatory Diseases written by and published by Frontiers Media SA. This book was released on 2023-11-22 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: