Introduction to Computational Genomics

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Publisher : Cambridge University Press
ISBN 13 : 9780521856034
Total Pages : 200 pages
Book Rating : 4.8/5 (56 download)

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Book Synopsis Introduction to Computational Genomics by : Nello Cristianini

Download or read book Introduction to Computational Genomics written by Nello Cristianini and published by Cambridge University Press. This book was released on 2006-12-14 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Where did SARS come from? Have we inherited genes from Neanderthals? How do plants use their internal clock? The genomic revolution in biology enables us to answer such questions. But the revolution would have been impossible without the support of powerful computational and statistical methods that enable us to exploit genomic data. Many universities are introducing courses to train the next generation of bioinformaticians: biologists fluent in mathematics and computer science, and data analysts familiar with biology. This readable and entertaining book, based on successful taught courses, provides a roadmap to navigate entry to this field. It guides the reader through key achievements of bioinformatics, using a hands-on approach. Statistical sequence analysis, sequence alignment, hidden Markov models, gene and motif finding and more, are introduced in a rigorous yet accessible way. A companion website provides the reader with Matlab-related software tools for reproducing the steps demonstrated in the book.

Computational Genomics with R

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Publisher : CRC Press
ISBN 13 : 1498781861
Total Pages : 462 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Computational Genomics with R by : Altuna Akalin

Download or read book Computational Genomics with R written by Altuna Akalin and published by CRC Press. This book was released on 2020-12-16 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Genomics with R provides a starting point for beginners in genomic data analysis and also guides more advanced practitioners to sophisticated data analysis techniques in genomics. The book covers topics from R programming, to machine learning and statistics, to the latest genomic data analysis techniques. The text provides accessible information and explanations, always with the genomics context in the background. This also contains practical and well-documented examples in R so readers can analyze their data by simply reusing the code presented. As the field of computational genomics is interdisciplinary, it requires different starting points for people with different backgrounds. For example, a biologist might skip sections on basic genome biology and start with R programming, whereas a computer scientist might want to start with genome biology. After reading: You will have the basics of R and be able to dive right into specialized uses of R for computational genomics such as using Bioconductor packages. You will be familiar with statistics, supervised and unsupervised learning techniques that are important in data modeling, and exploratory analysis of high-dimensional data. You will understand genomic intervals and operations on them that are used for tasks such as aligned read counting and genomic feature annotation. You will know the basics of processing and quality checking high-throughput sequencing data. You will be able to do sequence analysis, such as calculating GC content for parts of a genome or finding transcription factor binding sites. You will know about visualization techniques used in genomics, such as heatmaps, meta-gene plots, and genomic track visualization. You will be familiar with analysis of different high-throughput sequencing data sets, such as RNA-seq, ChIP-seq, and BS-seq. You will know basic techniques for integrating and interpreting multi-omics datasets. Altuna Akalin is a group leader and head of the Bioinformatics and Omics Data Science Platform at the Berlin Institute of Medical Systems Biology, Max Delbrück Center, Berlin. He has been developing computational methods for analyzing and integrating large-scale genomics data sets since 2002. He has published an extensive body of work in this area. The framework for this book grew out of the yearly computational genomics courses he has been organizing and teaching since 2015.

Computational Genome Analysis

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Publisher : Springer Science & Business Media
ISBN 13 : 0387288074
Total Pages : 543 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis Computational Genome Analysis by : Richard C. Deonier

Download or read book Computational Genome Analysis written by Richard C. Deonier and published by Springer Science & Business Media. This book was released on 2005-12-27 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the foundations of key problems in computational molecular biology and bioinformatics. It focuses on computational and statistical principles applied to genomes, and introduces the mathematics and statistics that are crucial for understanding these applications. The book features a free download of the R software statistics package and the text provides great crossover material that is interesting and accessible to students in biology, mathematics, statistics and computer science. More than 100 illustrations and diagrams reinforce concepts and present key results from the primary literature. Exercises are given at the end of chapters.

Introduction To Computational Metagenomics

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Publisher : World Scientific
ISBN 13 : 9811242488
Total Pages : 210 pages
Book Rating : 4.8/5 (112 download)

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Book Synopsis Introduction To Computational Metagenomics by : Zhong Wang

Download or read book Introduction To Computational Metagenomics written by Zhong Wang and published by World Scientific. This book was released on 2022-04-11 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breakthroughs in high-throughput genome sequencing and high-performance computing technologies have empowered scientists to decode many genomes including our own. Now they have a bigger ambition: to fully understand the vast diversity of microbial communities within us and around us, and to exploit their potential for the improvement of our health and environment. In this new field called metagenomics, microbial genomes are sequenced directly from the habitats without lab cultivation. Computational metagenomics, however, faces both a data challenge that deals with tens of tera-bases of sequences and an algorithmic one that deals with the complexity of thousands of species and their interactions.This interdisciplinary book is essential reading for those who are interested in beginning their own journey in computational metagenomics. It is a prism to look through various intricate computational metagenomics problems and unravel their three distinctive aspects: metagenomics, data engineering, and algorithms. Graduate students and advanced undergraduates from genomics science or computer science fields will find that the concepts explained in this book can serve as stepping stones for more advanced topics, while metagenomics practitioners and researchers from similar disciplines may use it to broaden their knowledge or identify new research targets.

Introduction to Computational Biology

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Publisher : Springer Science & Business Media
ISBN 13 : 3764373873
Total Pages : 329 pages
Book Rating : 4.7/5 (643 download)

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Book Synopsis Introduction to Computational Biology by : Bernhard Haubold

Download or read book Introduction to Computational Biology written by Bernhard Haubold and published by Springer Science & Business Media. This book was released on 2006-08-09 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written with the advanced undergraduate in mind, this book introduces into the field of Bioinformatics. The authors explain the computational and conceptional background to the analysis of large-scale sequence data. Many of the corresponding analysis methods are rooted in evolutionary thinking, which serves as a common thread throughout the book. The focus is on methods of comparative genomics and subjects covered include: alignments, gene finding, phylogeny, and the analysis of single nucleotide polymorphisms (SNPs). The volume contains exercises, questions & answers to selected problems.

Introduction to Computational Genomics

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Publisher : Cambridge University Press
ISBN 13 : 1139460153
Total Pages : 7 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Introduction to Computational Genomics by : Nello Cristianini

Download or read book Introduction to Computational Genomics written by Nello Cristianini and published by Cambridge University Press. This book was released on 2006-12-14 with total page 7 pages. Available in PDF, EPUB and Kindle. Book excerpt: Where did SARS come from? Have we inherited genes from Neanderthals? How do plants use their internal clock? The genomic revolution in biology enables us to answer such questions. But the revolution would have been impossible without the support of powerful computational and statistical methods that enable us to exploit genomic data. Many universities are introducing courses to train the next generation of bioinformaticians: biologists fluent in mathematics and computer science, and data analysts familiar with biology. This readable and entertaining book, based on successful taught courses, provides a roadmap to navigate entry to this field. It guides the reader through key achievements of bioinformatics, using a hands-on approach. Statistical sequence analysis, sequence alignment, hidden Markov models, gene and motif finding and more, are introduced in a rigorous yet accessible way. A companion website provides the reader with Matlab-related software tools for reproducing the steps demonstrated in the book.

Computational Methods for Understanding Bacterial and Archaeal Genomes

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Publisher : World Scientific
ISBN 13 : 1860949827
Total Pages : 494 pages
Book Rating : 4.8/5 (69 download)

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Book Synopsis Computational Methods for Understanding Bacterial and Archaeal Genomes by : Ying Xu

Download or read book Computational Methods for Understanding Bacterial and Archaeal Genomes written by Ying Xu and published by World Scientific. This book was released on 2008 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over 500 prokaryotic genomes have been sequenced to date, and thousands more have been planned for the next few years. While these genomic sequence data provide unprecedented opportunities for biologists to study the world of prokaryotes, they also raise extremely challenging issues such as how to decode the rich information encoded in these genomes. This comprehensive volume includes a collection of cohesively written chapters on prokaryotic genomes, their organization and evolution, the information they encode, and the computational approaches needed to derive such information. A comparative view of bacterial and archaeal genomes, and how information is encoded differently in them, is also presented. Combining theoretical discussions and computational techniques, the book serves as a valuable introductory textbook for graduate-level microbial genomics and informatics courses.

An Introduction to Computational Systems Biology

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Publisher : CRC Press
ISBN 13 : 0429944527
Total Pages : 359 pages
Book Rating : 4.4/5 (299 download)

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Book Synopsis An Introduction to Computational Systems Biology by : Karthik Raman

Download or read book An Introduction to Computational Systems Biology written by Karthik Raman and published by CRC Press. This book was released on 2021-05-30 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book delivers a comprehensive and insightful account of applying mathematical modelling approaches to very large biological systems and networks—a fundamental aspect of computational systems biology. The book covers key modelling paradigms in detail, while at the same time retaining a simplicity that will appeal to those from less quantitative fields. Key Features: A hands-on approach to modelling Covers a broad spectrum of modelling, from static networks to dynamic models and constraint-based models Thoughtful exercises to test and enable understanding of concepts State-of-the-art chapters on exciting new developments, like community modelling and biological circuit design Emphasis on coding and software tools for systems biology Companion website featuring lecture videos, figure slides, codes, supplementary exercises, further reading, and appendices: https://ramanlab.github.io/SysBioBook/ An Introduction to Computational Systems Biology: Systems-Level Modelling of Cellular Networks is highly multi-disciplinary and will appeal to biologists, engineers, computer scientists, mathematicians and others.

Sequence — Evolution — Function

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Publisher : Springer Science & Business Media
ISBN 13 : 1475737831
Total Pages : 482 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Sequence — Evolution — Function by : Eugene V. Koonin

Download or read book Sequence — Evolution — Function written by Eugene V. Koonin and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.

Bioinformatics and Computational Biology

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Publisher : Springer Nature
ISBN 13 : 9811642419
Total Pages : 239 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Bioinformatics and Computational Biology by : Basant K. Tiwary

Download or read book Bioinformatics and Computational Biology written by Basant K. Tiwary and published by Springer Nature. This book was released on 2021-11-23 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook introduces fundamental concepts of bioinformatics and computational biology to the students and researchers in biology, medicine, veterinary science, agriculture, and bioengineering . The respective chapters provide detailed information on biological databases, sequence alignment, molecular evolution, next-generation sequencing, systems biology, and statistical computing using R. The book also presents a case-based discussion on clinical, veterinary, agricultural bioinformatics, and computational bioengineering for application-based learning in the respective fields. Further, it offers readers guidance on reconstructing and analysing biological networks and highlights computational methods used in systems medicine and genome-wide association mapping of diseases. Given its scope, this textbook offers an essential introductory book on bioinformatics and computational biology for undergraduate and graduate students in the life sciences, botany, zoology, physiology, biotechnology, bioinformatics, and genomic science as well as systems biology, bioengineering and the agricultural, and veterinary sciences.

Introduction to Evolutionary Genomics

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Publisher : Springer Science & Business Media
ISBN 13 : 1447153049
Total Pages : 476 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Introduction to Evolutionary Genomics by : Naruya Saitou

Download or read book Introduction to Evolutionary Genomics written by Naruya Saitou and published by Springer Science & Business Media. This book was released on 2014-01-22 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first of its kind to explain the fundamentals of evolutionary genomics. The comprehensive coverage includes concise descriptions of a variety of genome organizations, a thorough discussion of the methods used, and a detailed review of genome sequence processing procedures. The opening chapters also provide the necessary basics for readers unfamiliar with evolutionary studies. Features: introduces the basics of molecular biology, DNA replication, mutation, phylogeny, neutral evolution, and natural selection; presents a brief evolutionary history of life from the primordial seas to the emergence of humans; describes the genomes of prokaryotes, eukaryotes, vertebrates, and humans; reviews methods for genome sequencing, phenotype data collection, homology searches and analysis, and phylogenetic tree and network building; discusses databases of genome sequences and related information, evolutionary distances, and population genomics; provides supplementary material at an associated website.

Kernel Methods in Computational Biology

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Publisher : MIT Press
ISBN 13 : 9780262195096
Total Pages : 428 pages
Book Rating : 4.1/5 (95 download)

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Book Synopsis Kernel Methods in Computational Biology by : Bernhard Schölkopf

Download or read book Kernel Methods in Computational Biology written by Bernhard Schölkopf and published by MIT Press. This book was released on 2004 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: A detailed overview of current research in kernel methods and their application to computational biology.

Introduction to Computational Genomics

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Publisher :
ISBN 13 : 9781316099469
Total Pages : pages
Book Rating : 4.0/5 (994 download)

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Book Synopsis Introduction to Computational Genomics by : Nello Cristianini

Download or read book Introduction to Computational Genomics written by Nello Cristianini and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advances in Bioinformatics

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Publisher : Springer Nature
ISBN 13 : 9813361913
Total Pages : 446 pages
Book Rating : 4.8/5 (133 download)

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Book Synopsis Advances in Bioinformatics by : Vijai Singh

Download or read book Advances in Bioinformatics written by Vijai Singh and published by Springer Nature. This book was released on 2021-07-31 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest developments in bioinformatics, highlighting the importance of bioinformatics in genomics, transcriptomics, metabolism and cheminformatics analysis, as well as in drug discovery and development. It covers tools, data mining and analysis, protein analysis, computational vaccine, and drug design. Covering cheminformatics, computational evolutionary biology and the role of next-generation sequencing and neural network analysis, it also discusses the use of bioinformatics tools in the development of precision medicine. This book offers a valuable source of information for not only beginners in bioinformatics, but also for students, researchers, scientists, clinicians, practitioners, policymakers, and stakeholders who are interested in harnessing the potential of bioinformatics in many areas.

A Primer for Computational Biology

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Publisher :
ISBN 13 : 9780870719264
Total Pages : 0 pages
Book Rating : 4.7/5 (192 download)

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Book Synopsis A Primer for Computational Biology by : Shawn T. O'Neil

Download or read book A Primer for Computational Biology written by Shawn T. O'Neil and published by . This book was released on 2017-12-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Primer for Computational Biology aims to provide life scientists and students the skills necessary for research in a data-rich world. The text covers accessing and using remote servers via the command-line, writing programs and pipelines for data analysis, and provides useful vocabulary for interdisciplinary work. The book is broken into three parts: Introduction to Unix/Linux: The command-line is the "natural environment" of scientific computing, and this part covers a wide range of topics, including logging in, working with files and directories, installing programs and writing scripts, and the powerful "pipe" operator for file and data manipulation. Programming in Python: Python is both a premier language for learning and a common choice in scientific software development. This part covers the basic concepts in programming (data types, if-statements and loops, functions) via examples of DNA-sequence analysis. This part also covers more complex subjects in software development such as objects and classes, modules, and APIs. Programming in R: The R language specializes in statistical data analysis, and is also quite useful for visualizing large datasets. This third part covers the basics of R as a programming language (data types, if-statements, functions, loops and when to use them) as well as techniques for large-scale, multi-test analyses. Other topics include S3 classes and data visualization with ggplot2.

Introduction to Computational Genomics

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Publisher :
ISBN 13 : 9781107166288
Total Pages : 182 pages
Book Rating : 4.1/5 (662 download)

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Book Synopsis Introduction to Computational Genomics by : Nello Cristianini

Download or read book Introduction to Computational Genomics written by Nello Cristianini and published by . This book was released on 2007 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Are we related to Neanderthals? Where did SARS come from? Which part of our genome is evolving the fastest? These are some of the questions that can be answered by statistical and computational analysis of genetic data. This text presents an introduction to computational genomics.

Handbook of Computational Molecular Biology

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Publisher : CRC Press
ISBN 13 : 1420036270
Total Pages : 1108 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Handbook of Computational Molecular Biology by : Srinivas Aluru

Download or read book Handbook of Computational Molecular Biology written by Srinivas Aluru and published by CRC Press. This book was released on 2005-12-21 with total page 1108 pages. Available in PDF, EPUB and Kindle. Book excerpt: The enormous complexity of biological systems at the molecular level must be answered with powerful computational methods. Computational biology is a young field, but has seen rapid growth and advancement over the past few decades. Surveying the progress made in this multidisciplinary field, the Handbook of Computational Molecular Biology of