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Interim Study Report
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Book Synopsis Data Monitoring Committees in Clinical Trials by : Susan S. Ellenberg
Download or read book Data Monitoring Committees in Clinical Trials written by Susan S. Ellenberg and published by John Wiley & Sons. This book was released on 2003-01-17 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been substantial growth in the use of data monitoring committees in recent years, by both government agencies and the pharmaceutical industry. This growth has been brought about by increasing recognition of the value of such committees in safeguarding trial participants as well as protecting trial integrity and the validity of conclusions. This very timely book describes the operation of data monitoring committees, and provides an authoritative guide to their establishment, purpose and responsibilities. * Provides a practical overview of data monitoring in clinical trials. * Describes the purpose, responsibilities and operation of data monitoring committees. * Provides directly applicable advice for those managing and conducting clinical trials, and those serving on data monitoring committees. * Gives insight into clinical data monitoring to those sitting on regulatory and ethical committees. * Discusses issues pertinent to those working in clinical trials in both the US and Europe. The practical guidance provided by this book will be of use to professionals working in and/or managing clinical trials, in academic, government and industry settings, particularly medical statisticians, clinicians, trial co-ordinators, and those working in regulatory affairs and bioethics.
Book Synopsis Defining Primary Care by : Karl D. Yordy
Download or read book Defining Primary Care written by Karl D. Yordy and published by National Academies. This book was released on 1994 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Future of Supercomputing by : National Research Council
Download or read book The Future of Supercomputing written by National Research Council and published by National Academies Press. This book was released on 2003-10-08 with total page 59 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Committee on the Future of Supercomputing was tasked to assess prospects for supercomputing technology research and development in support of U.S. needs, to examine key elements of context-the history of supercomputing, the erosion of research investment, the changing nature of problems demanding supercomputing, and the needs of government agencies for supercomputing capabilities-and to assess options for progress. This interim report establishes context-including the history and current state of supercomputing, application requirements, technology evolution, the socioeconomic context-to identify some of the issues that may be explored in more depth in the second phase of the study.
Book Synopsis Recent Advances in Clinical Trial Design and Analysis by : Peter F. Thall
Download or read book Recent Advances in Clinical Trial Design and Analysis written by Peter F. Thall and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical trials have two purposes -- to treat the patients in the trial, and to obtain information which increases our understanding of the disease and especially how patients respond to treatment. Statistical design provides a means to achieve both these aims, while statistical data analysis provides methods for extracting useful information from the trial data. Recent advances in statistical computing have enabled statisticians to implement very rapidly a broad array of methods which previously were either impractical or impossible. Biostatisticians are now able to provide much greater support to medical researchers working in both clinical and laboratory settings. As our collective toolkit of techniques for analyzing data has grown, it has become increasingly difficult for biostatisticians to keep up with all the developments in our own field. Recent Advances in Clinical Trial Design and Analysis brings together biostatisticians doing cutting-edge research and explains some of the more recent developments in biostatistics to clinicians and scientists who work in clinical trials.
Book Synopsis Sharing Clinical Trial Data by : Institute of Medicine
Download or read book Sharing Clinical Trial Data written by Institute of Medicine and published by National Academies Press. This book was released on 2015-04-20 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Data sharing can accelerate new discoveries by avoiding duplicative trials, stimulating new ideas for research, and enabling the maximal scientific knowledge and benefits to be gained from the efforts of clinical trial participants and investigators. At the same time, sharing clinical trial data presents risks, burdens, and challenges. These include the need to protect the privacy and honor the consent of clinical trial participants; safeguard the legitimate economic interests of sponsors; and guard against invalid secondary analyses, which could undermine trust in clinical trials or otherwise harm public health. Sharing Clinical Trial Data presents activities and strategies for the responsible sharing of clinical trial data. With the goal of increasing scientific knowledge to lead to better therapies for patients, this book identifies guiding principles and makes recommendations to maximize the benefits and minimize risks. This report offers guidance on the types of clinical trial data available at different points in the process, the points in the process at which each type of data should be shared, methods for sharing data, what groups should have access to data, and future knowledge and infrastructure needs. Responsible sharing of clinical trial data will allow other investigators to replicate published findings and carry out additional analyses, strengthen the evidence base for regulatory and clinical decisions, and increase the scientific knowledge gained from investments by the funders of clinical trials. The recommendations of Sharing Clinical Trial Data will be useful both now and well into the future as improved sharing of data leads to a stronger evidence base for treatment. This book will be of interest to stakeholders across the spectrum of research-from funders, to researchers, to journals, to physicians, and ultimately, to patients.
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309465052 Total Pages :69 pages Book Rating :4.3/5 (94 download)
Book Synopsis Envisioning the Data Science Discipline by : National Academies of Sciences, Engineering, and Medicine
Download or read book Envisioning the Data Science Discipline written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-03-05 with total page 69 pages. Available in PDF, EPUB and Kindle. Book excerpt: The need to manage, analyze, and extract knowledge from data is pervasive across industry, government, and academia. Scientists, engineers, and executives routinely encounter enormous volumes of data, and new techniques and tools are emerging to create knowledge out of these data, some of them capable of working with real-time streams of data. The nation's ability to make use of these data depends on the availability of an educated workforce with necessary expertise. With these new capabilities have come novel ethical challenges regarding the effectiveness and appropriateness of broad applications of data analyses. The field of data science has emerged to address the proliferation of data and the need to manage and understand it. Data science is a hybrid of multiple disciplines and skill sets, draws on diverse fields (including computer science, statistics, and mathematics), encompasses topics in ethics and privacy, and depends on specifics of the domains to which it is applied. Fueled by the explosion of data, jobs that involve data science have proliferated and an array of data science programs at the undergraduate and graduate levels have been established. Nevertheless, data science is still in its infancy, which suggests the importance of envisioning what the field might look like in the future and what key steps can be taken now to move data science education in that direction. This study will set forth a vision for the emerging discipline of data science at the undergraduate level. This interim report lays out some of the information and comments that the committee has gathered and heard during the first half of its study, offers perspectives on the current state of data science education, and poses some questions that may shape the way data science education evolves in the future. The study will conclude in early 2018 with a final report that lays out a vision for future data science education.
Book Synopsis Principles and Practice of Clinical Trials by : Steven Piantadosi
Download or read book Principles and Practice of Clinical Trials written by Steven Piantadosi and published by Springer Nature. This book was released on 2022-07-19 with total page 2573 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a comprehensive major reference work for our SpringerReference program covering clinical trials. Although the core of the Work will focus on the design, analysis, and interpretation of scientific data from clinical trials, a broad spectrum of clinical trial application areas will be covered in detail. This is an important time to develop such a Work, as drug safety and efficacy emphasizes the Clinical Trials process. Because of an immense and growing international disease burden, pharmaceutical and biotechnology companies continue to develop new drugs. Clinical trials have also become extremely globalized in the past 15 years, with over 225,000 international trials ongoing at this point in time. Principles in Practice of Clinical Trials is truly an interdisciplinary that will be divided into the following areas: 1) Clinical Trials Basic Perspectives 2) Regulation and Oversight 3) Basic Trial Designs 4) Advanced Trial Designs 5) Analysis 6) Trial Publication 7) Topics Related Specific Populations and Legal Aspects of Clinical Trials The Work is designed to be comprised of 175 chapters and approximately 2500 pages. The Work will be oriented like many of our SpringerReference Handbooks, presenting detailed and comprehensive expository chapters on broad subjects. The Editors are major figures in the field of clinical trials, and both have written textbooks on the topic. There will also be a slate of 7-8 renowned associate editors that will edit individual sections of the Reference.
Book Synopsis American Study Programs in China by : Peggy Blumenthal
Download or read book American Study Programs in China written by Peggy Blumenthal and published by National Academies. This book was released on 1981 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt: American study programs in China were assessed, based on interviews with American undergraduate or graduate students studying or doing research at various China institutions during the 1980-81 academic year and with Chinese administrators from the institutions. Four channels exist through which American students can arrange placement in China: national competition, institution-to-institution links, individual application (either to a Chinese university or the Ministry of Education), and short-term study programs packaged in the United States. Somewhere between 70 and 100 formal exchange agreements to facilitate the sharing of academic resources have been concluded between U.S. and Chinese institutions. A list of American institutions reporting such agreements is appended. Data are presented on the distribution of American students at Chinese universities during the 1980-81 academic year (excluding short-term language programs). In all the arrangements (except for the summer language programs), the majority of those going to China are American graduate students who are either taking coursework or doing dissertation research. Several small groups of undergraduates participate during the academic year, mainly in language programs. A summary is presented on general curricula, language classes, research difficulties, and field research. In addition, the following concerns are addressed: socializing with Chinese, housing, travel, supervision of students, university administration, credit and grading, and summer language programs. Appended materials include: U.S.-Chinese Institutional agreements, summer language programs in China, and a bibliography on U.S-China educational exchange. (SW)
Book Synopsis OECD Economic Outlook, Interim Report March 2020 by : OECD
Download or read book OECD Economic Outlook, Interim Report March 2020 written by OECD and published by OECD Publishing. This book was released on 2020-03-02 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Interim Report provides updates for G20 country projections made in the November 2019 issue of OECD Economic Outlook (Number 106).
Book Synopsis The Daylight Saving Time Study: Final report on the operation and effects of daylight saving time by : United States. Department of Transportation
Download or read book The Daylight Saving Time Study: Final report on the operation and effects of daylight saving time written by United States. Department of Transportation and published by . This book was released on 1975 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Interim Planning for a Future Strategic Highway Research Program by : Ann Margaret Brach
Download or read book Interim Planning for a Future Strategic Highway Research Program written by Ann Margaret Brach and published by Transportation Research Board. This book was released on 2003 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Strengthening Forensic Science in the United States by : National Research Council
Download or read book Strengthening Forensic Science in the United States written by National Research Council and published by National Academies Press. This book was released on 2009-07-29 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scores of talented and dedicated people serve the forensic science community, performing vitally important work. However, they are often constrained by lack of adequate resources, sound policies, and national support. It is clear that change and advancements, both systematic and scientific, are needed in a number of forensic science disciplines to ensure the reliability of work, establish enforceable standards, and promote best practices with consistent application. Strengthening Forensic Science in the United States: A Path Forward provides a detailed plan for addressing these needs and suggests the creation of a new government entity, the National Institute of Forensic Science, to establish and enforce standards within the forensic science community. The benefits of improving and regulating the forensic science disciplines are clear: assisting law enforcement officials, enhancing homeland security, and reducing the risk of wrongful conviction and exoneration. Strengthening Forensic Science in the United States gives a full account of what is needed to advance the forensic science disciplines, including upgrading of systems and organizational structures, better training, widespread adoption of uniform and enforceable best practices, and mandatory certification and accreditation programs. While this book provides an essential call-to-action for congress and policy makers, it also serves as a vital tool for law enforcement agencies, criminal prosecutors and attorneys, and forensic science educators.
Book Synopsis Climate Data Records from Environmental Satellites by : National Research Council
Download or read book Climate Data Records from Environmental Satellites written by National Research Council and published by National Academies Press. This book was released on 2004-08-26 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: The report outlines key elements to consider in designing a program to create climate-quality data from satellites. It examines historical attempts to create climate data records, provides advice on steps for generating, re-analyzing, and storing satellite climate data, and discusses the importance of partnering between agencies, academia, and industry. NOAA will use this report-the first in a two-part study-to draft an implementation plan for climate data records.
Book Synopsis Group Sequential Methods with Applications to Clinical Trials by : Christopher Jennison
Download or read book Group Sequential Methods with Applications to Clinical Trials written by Christopher Jennison and published by CRC Press. This book was released on 1999-09-15 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Group sequential methods answer the needs of clinical trial monitoring committees who must assess the data available at an interim analysis. These interim results may provide grounds for terminating the study-effectively reducing costs-or may benefit the general patient population by allowing early dissemination of its findings. Group sequential methods provide a means to balance the ethical and financial advantages of stopping a study early against the risk of an incorrect conclusion. Group Sequential Methods with Applications to Clinical Trials describes group sequential stopping rules designed to reduce average study length and control Type I and II error probabilities. The authors present one-sided and two-sided tests, introduce several families of group sequential tests, and explain how to choose the most appropriate test and interim analysis schedule. Their topics include placebo-controlled randomized trials, bio-equivalence testing, crossover and longitudinal studies, and linear and generalized linear models. Research in group sequential analysis has progressed rapidly over the past 20 years. Group Sequential Methods with Applications to Clinical Trials surveys and extends current methods for planning and conducting interim analyses. It provides straightforward descriptions of group sequential hypothesis tests in a form suited for direct application to a wide variety of clinical trials. Medical statisticians engaged in any investigations planned with interim analyses will find this book a useful and important tool.
Download or read book Reading first impact study written by and published by . This book was released on 2008 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Design and Analysis of Sequential Clinical Trials by : John Whitehead
Download or read book The Design and Analysis of Sequential Clinical Trials written by John Whitehead and published by Horwood Publishing Limited. This book was released on 1983 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book details all aspects of sequential clinical trials from preliminary planning, through the monitoring of the trial, to the final analysis of the results.
Book Synopsis Strategy and Statistics in Clinical Trials by : Joseph Tal
Download or read book Strategy and Statistics in Clinical Trials written by Joseph Tal and published by Academic Press. This book was released on 2011-07-14 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: Delineates the statistical building blocks and concepts of clinical trials.
