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Integrating Emerging Technologies Into Chemical Safety Assessment
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Author :Council of Canadian Academies. Expert Panel on the Integrated Testing of Pesticides Publisher : ISBN 13 :9781926558370 Total Pages :291 pages Book Rating :4.5/5 (583 download)
Book Synopsis Integrating Emerging Technologies Into Chemical Safety Assessment by : Council of Canadian Academies. Expert Panel on the Integrated Testing of Pesticides
Download or read book Integrating Emerging Technologies Into Chemical Safety Assessment written by Council of Canadian Academies. Expert Panel on the Integrated Testing of Pesticides and published by . This book was released on 2012-01 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :The Expert Panel on the Integrated Testing of Pesticides Publisher :Council of CanadianAcademies ISBN 13 :1926558383 Total Pages :324 pages Book Rating :4.9/5 (265 download)
Book Synopsis Integrating Emerging Technologies Into Chemical Safety Assessment by : The Expert Panel on the Integrated Testing of Pesticides
Download or read book Integrating Emerging Technologies Into Chemical Safety Assessment written by The Expert Panel on the Integrated Testing of Pesticides and published by Council of CanadianAcademies. This book was released on 2012 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: "In May 2009, the Government of Canada, through the Pest Management Regulatory Agency (PMRA) of Health Canada, asked the Council of Canadian Academies to appoint an expert panel to answer the question, "What is the scientific status of the use of integrated testing strategies in the human and environmental regulatory risk assessment of pesticides?" The charge to the Panel was further specified in a series of sub-questions: [1] What is the state of the science of the tools and data sources associated with integrated testing strategies? [2] What is the current status of the use of integrated testing strategies for the risk assessment of pesticides, pharmaceuticals, industrial chemicals, and other chemical substances by regulatory agencies around the world? [3] Could there be potential impacts on the public's perception and confidence in regulatory risk assessment and risk management decisions for pesticides if integrated testing strategies were implemented?"--P. xiii-xiv.
Book Synopsis Chemical Testing Using New Approach Methodologies (NAMs) by : Amy J. Clippinger
Download or read book Chemical Testing Using New Approach Methodologies (NAMs) written by Amy J. Clippinger and published by Frontiers Media SA. This book was released on 2022-12-16 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The History of Alternative Test Methods in Toxicology by :
Download or read book The History of Alternative Test Methods in Toxicology written by and published by Academic Press. This book was released on 2018-10-20 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies. The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.
Book Synopsis Validation of Alternative Methods for Toxicity Testing by : Chantra Eskes
Download or read book Validation of Alternative Methods for Toxicity Testing written by Chantra Eskes and published by Springer. This book was released on 2016-09-26 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem cells and transcriptomics, and for methods derived from pathway-based concepts in toxicology. Validation of Alternative Methods for Toxicity Testing is divided into two sections, in the first, practical insights are given on the state-of-the-art and on approaches that have resulted in successfully validated and accepted alternative methods. The second section focuses on the evolution of validation principles and practice that are necessary to ensure fit-for-purpose validation that has the greatest impact on international regulatory acceptance of alternative methods. In this context validation needs to keep pace with the considerable scientific advancements being made in toxicology, the availability of sophisticated tools and techniques that can be applied in a variety of ways, and the increasing societal and regulatory demands for better safety assessment. This book will be a useful resource for scientists in the field of toxicology, both from industry and academia, developing new test methods, strategies or techniques, as well as Governmental and regulatory authorities interested in understanding the principles and practicalities of validation of alternative methods for toxicity testing.
Book Synopsis Aquatic Ecotoxicology by : Claude Amiard-Triquet
Download or read book Aquatic Ecotoxicology written by Claude Amiard-Triquet and published by Academic Press. This book was released on 2015-06-11 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aquatic Ecotoxicology: Advancing Tools for Dealing with Emerging Risks presents a thorough look at recent advances in aquatic ecotoxicology and their application in assessing the risk of well-known and emerging environmental contaminants. This essential reference, brought together by leading experts in the field, guides users through existing and novel approaches to environmental risk assessment, then presenting recent advances in the field of ecotoxicology, including omics-based technologies, biomarkers, and reference species. The book then demonstrates how these advances can be used to design and perform assays to discover the toxicological endpoints of emerging risks within the aquatic environment, such as nanomaterials, personal care products, PFOS and chemical mixtures. The text is an invaluable reference for any scientist who studies the effects of contaminants on organisms that live within aquatic environments. Provides the latest perspectives on emerging toxic risks to aquatic environments, such as nanomaterials, pharmaceuticals, chemical mixtures, and perfluorooctane sulfonate (PFOS) Offers practical guidance on recent advances to help in choosing the most appropriate toxicological assay Presents case studies and information on a variety of reference species to help put the ecotoxicological theory into practical risk assess
Book Synopsis Applications of Toxicogenomics in Safety Evaluation and Risk Assessment by : Darrell R. Boverhof
Download or read book Applications of Toxicogenomics in Safety Evaluation and Risk Assessment written by Darrell R. Boverhof and published by John Wiley & Sons. This book was released on 2011-10-11 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process – including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.
Author :CCPS (Center for Chemical Process Safety) Publisher :John Wiley & Sons ISBN 13 :0470935103 Total Pages :196 pages Book Rating :4.4/5 (79 download)
Book Synopsis Guidelines for Integrating Process Safety Management, Environment, Safety, Health, and Quality by : CCPS (Center for Chemical Process Safety)
Download or read book Guidelines for Integrating Process Safety Management, Environment, Safety, Health, and Quality written by CCPS (Center for Chemical Process Safety) and published by John Wiley & Sons. This book was released on 2010-09-07 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the years, companies have developed independent systems for managing process safety, environment, health, safety, and quality. Many aspects of these management systems are similar. Integrating EHS management systems can yield economies and improved system effectiveness. This book explains how integration reduces cost of delivery through a reduction in the number of management program steps and avoidance of redundancy; how it results in more effective programs, since the best practices can be combined into a single process; and how this integration brings a faster, and more cost effective response to new demands.
Book Synopsis Toxicogenomics in Predictive Carcinogenicity by : Michael D. Waters
Download or read book Toxicogenomics in Predictive Carcinogenicity written by Michael D. Waters and published by Royal Society of Chemistry. This book was released on 2016 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describes toxicogenomics methods in predictive carcinogenicity testing and cancer risk assessment. Addresses the use of stem cells and bioinformatics in toxicogenomics. For postgraduates, academics and industrialists.
Book Synopsis Biomarkers of Exposure, Effect and Susceptibility to Environmental and Occupational Chemicals by : Manosij Ghosh
Download or read book Biomarkers of Exposure, Effect and Susceptibility to Environmental and Occupational Chemicals written by Manosij Ghosh and published by Frontiers Media SA. This book was released on 2021-12-21 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Green Chemistry and Engineering by : Anne E. Marteel-Parrish
Download or read book Green Chemistry and Engineering written by Anne E. Marteel-Parrish and published by John Wiley & Sons. This book was released on 2013-10-10 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Promotes a green approach to chemistry and chemical engineering for a sustainable planet With this text as their guide, students will gain a new outlook on chemistry and engineering. The text fully covers introductory concepts in general, organic, inorganic, and analytical chemistry as well as biochemistry. At the same time, it integrates such concepts as greenhouse gas potential, alternative and renewable energy, solvent selection and recovery, and ecotoxicity. As a result, students learn how to design chemical products and processes that are sustainable and environmentally friendly. Green Chemistry and Engineering presents the green approach as an essential tool for tackling problems in chemistry. A novel feature of the text is its integration of introductory engineering concepts, making it easier for students to move from fundamental science to applications. Throughout this text, the authors integrate several features to help students understand and apply basic concepts in general chemistry as well as green chemistry, including: Comparisons of the environmental impact of traditional chemistry approaches with green chemistry approaches Analyses of chemical processes in the context of life-cycle principles, demonstrating how chemistry fits within the complex supply chain Applications of green chemistry that are relevant to students' lives and professional aspirations Examples of successful green chemistry endeavors, including Presidential Green Chemistry Challenge winners Case studies that encourage students to use their critical thinking skills to devise green chemistry solutions Upon completing this text, students will come to understand that chemistry is not antithetical to sustainability, but rather, with the application of green principles, chemistry is the means to a sustainable planet.
Author :CCPS (Center for Chemical Process Safety) Publisher :John Wiley & Sons ISBN 13 :1118795032 Total Pages :212 pages Book Rating :4.1/5 (187 download)
Book Synopsis Guidelines for Integrating Management Systems and Metrics to Improve Process Safety Performance by : CCPS (Center for Chemical Process Safety)
Download or read book Guidelines for Integrating Management Systems and Metrics to Improve Process Safety Performance written by CCPS (Center for Chemical Process Safety) and published by John Wiley & Sons. This book was released on 2016-02-23 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book combines the synergies between performance improvement systems to help ensure safe and reliable operations, streamline procedures and cross-system auditing, and supporting regulatory and corporate compliance requirements. Many metrics are common to more than one area, such that a well-designed and implemented integrated management system will reduce the load on the Process Safety, SHE, Security and Quality groups, and improve manufacturing efficiency and customer satisfaction. Systems to improve performance include: process safety; traditional safety, health and environment; and, product quality. Chapters include: Integrating Framework; Securing Support & Preparing for Implementation; Establishing Common Risk Management Systems – How to Integrate PSM into Other EH; Testing Implementation Approach; Developing and Agreeing on Metrics; Management Review; Tracking Integration Progress and Measuring Performance; Continuous Improvement; Communication of Results to Different Stakeholders; Case Studies; and Examples for Industry.
Book Synopsis Toxicity Testing in the 21st Century by : National Research Council
Download or read book Toxicity Testing in the 21st Century written by National Research Council and published by National Academies Press. This book was released on 2007-11-05 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.
Author :CCPS (Center for Chemical Process Safety) Publisher :John Wiley & Sons ISBN 13 :1118216202 Total Pages :336 pages Book Rating :4.1/5 (182 download)
Book Synopsis Guidelines for Process Safety Acquisition Evaluation and Post Merger Integration by : CCPS (Center for Chemical Process Safety)
Download or read book Guidelines for Process Safety Acquisition Evaluation and Post Merger Integration written by CCPS (Center for Chemical Process Safety) and published by John Wiley & Sons. This book was released on 2013-11-13 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is crucial for process safety professionals to be aware of best practices for post merger integration at any level. A compilation of industry best practices from both technical and financial perspectives, this book provides a single reference that addresses acquisitions and merger integration issues related to process safety. Presently, there are limited references on how to handle acquisitions in several different CCPS publications and almost no coverage of the post-merger integration issue, so this reference fills a notable gap in the coverage.
Book Synopsis Integrated Life-Cycle and Risk Assessment for Industrial Processes and Products by : Guido Sonnemann
Download or read book Integrated Life-Cycle and Risk Assessment for Industrial Processes and Products written by Guido Sonnemann and published by CRC Press. This book was released on 2018-10-10 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Life-cycle assessment is a methodology used to evaluate the environmental impacts of a product, process, or service during its life cycle, and risk assessment is a tool to evaluate potential hazards to human health and the environment introduced by pollutant emissions. The United Nations Sustainable Development Goals call for, among other objectives, responsible consumption and production by decoupling environmental resource use and environmental impacts from economic growth and human well-being. Life-cycle assessment and risk assessment are both analytical system approaches that allow scientists and other decision makers to address these issues and objectives according to the current understanding of environmental mechanisms. This book is the first attempt to illustrate the existing interfaces between life-cycle assessment and risk assessment and to indicate options for further integration of both tools. The second edition: Focuses on sustainability Considers new developments in life-cycle assessment and environmental risk assessment over the last ten years at the international level Introduces broader concepts and discussions on integrative versus the complementary use of life-cycle and risk assessments Extends the scope of integrated life-cycle and risk assessments to critical raw materials Includes more case studies and discusses engineered nanomaterials Featuring contributions from leading experts, Integrated Life-Cycle and Risk Assessment for Industrial Processes and Products is a great reference for graduate students and professionals in environmental management and intends to catalyze communication between life-cycle assessment and risk assessment experts and scientists in academia, industry, and governmental agencies. The practical format of the book—illustrated with flowcharts, examples, exercises, and concrete applications—makes it a useful manual for analyzing situations and making decisions.
Book Synopsis Toxicology and Risk Assessment by : Helmut Greim
Download or read book Toxicology and Risk Assessment written by Helmut Greim and published by John Wiley & Sons. This book was released on 2018-08-10 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a complete understanding of how our bodies respond to toxicants, and the principles used to assess the health risks of specific exposure scenarios Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition reflects recent advances in science and technology, and provides the scientific background and methodological issues to enable the reader to understand the basic principles in toxicology and to evaluate the health risks of specific exposure scenarios. Completely updated with the latest information, this book offers a concise introduction to the subject. It is divided into five sections: Principles in Toxicology, Organ Toxicology, Methods in Toxicology, Regulatory Toxicology, and Specific Toxicity. The 2nd Edition adds new chapters that cover recent scientific and technological advances and current topics including the endocrine system, alternatives to animal testing, risk assessment and thresholds for carcinogens, European and international regulation, nanomaterials, fuels, fragrances, and agrochemicals. Concentrates on the basic concepts of toxicology and provides sufficient information for the reader to become familiar with them in order to understand the principles and to evaluate the risks at given exposures 30% new chapters cover recent scientific and technological advances including alternatives to animal testing; genotoxic carcinogens; REACH regulations; nanomaterials; fuels; fragrances; PAHs; and agrochemicals Written by a team of international specialists, and edited by two outstanding scientists in the field Fully updated and expanded, Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition is an essential text for any student or researcher with an interest in toxicology and related risk assessments.
Book Synopsis Alternatives to Animal Testing by : Hajime Kojima
Download or read book Alternatives to Animal Testing written by Hajime Kojima and published by Springer. This book was released on 2018-12-27 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare. The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0.
